| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Xavier López-Gil, Francesc Artigas, Albert Adel. Unraveling monoamine receptors involved in the action of typical and atypical antipsychotics on glutamatergic and serotonergic transmission in prefrontal cortex. Current pharmaceutical design. vol 16. issue 5. 2010-06-25. PMID:19909228. |
atypical antipsychotic drugs might further act upon 5-ht(2a), 5-ht(1a) and alpha(1)-adrenoceptors present in pyramidal cells (including those projecting to the dorsal raphe nucleus), which would directly inhibit an excessive excitability of these cells. |
2010-06-25 |
2023-08-12 |
rat |
| G S Kranz, S Kasper, R Lanzenberge. Reward and the serotonergic system. Neuroscience. vol 166. issue 4. 2010-06-17. PMID:20109531. |
primate research using single-unit recording of neurons within the dorsal raphe nucleus argues for a serotonergic mediation of reward value, whereas studies using intracranial self-stimulation point to an important contribution of serotonin in modulating motivational aspects of rewarding brain stimulation. |
2010-06-17 |
2023-08-12 |
human |
| Rita J Valentino, Irwin Lucki, Elisabeth Van Bockstael. Corticotropin-releasing factor in the dorsal raphe nucleus: Linking stress coping and addiction. Brain research. vol 1314. 2010-06-07. PMID:19800322. |
here we discuss the major brain serotonin (5-ht) system, the dorsal raphe nucleus (drn)-5-ht system as a point of convergence that links these processes and how the stress-related neuropeptide, corticotropin-releasing factor (crf) directs this by a bimodal regulation of drn neuronal activity. |
2010-06-07 |
2023-08-12 |
human |
| Kiyoshi Kamiya, Masaki Fumoto, Hiromi Kikuchi, Tamami Sekiyama, Yuko Mohri-Lkuzawa, Masahiro Umino, Hideho Arit. Prolonged gum chewing evokes activation of the ventral part of prefrontal cortex and suppression of nociceptive responses: involvement of the serotonergic system. Journal of medical and dental sciences. vol 57. issue 1. 2010-05-20. PMID:20437764. |
several human and animal studies have reported that a direct connection exists between the prefrontal cortex (pfc) and 5-ht neurons in the dorsal raphe nucleus; therefore, we hypothesized that activation of the pfc region might be responsible for augmented 5-ht activity. |
2010-05-20 |
2023-08-12 |
human |
| Kiyoshi Kamiya, Masaki Fumoto, Hiromi Kikuchi, Tamami Sekiyama, Yuko Mohri-Lkuzawa, Masahiro Umino, Hideho Arit. Prolonged gum chewing evokes activation of the ventral part of prefrontal cortex and suppression of nociceptive responses: involvement of the serotonergic system. Journal of medical and dental sciences. vol 57. issue 1. 2010-05-20. PMID:20437764. |
these results support the hypothesis that activation of the ventral part of pfc during gum chewing evokes augmented activity of 5-ht neurons in the dorsal raphe nucleus, which in turn suppress nociceptive responses. |
2010-05-20 |
2023-08-12 |
human |
| Cristiano Nazzaro, Mario Barbieri, Katia Varani, Lorenzo Beani, Rita J Valentino, Anna Siniscalch. Swim stress enhances nociceptin/orphanin FQ-induced inhibition of rat dorsal raphe nucleus activity in vivo and in vitro: role of corticotropin releasing factor. Neuropharmacology. vol 58. issue 2. 2010-04-13. PMID:19747494. |
the effects of nociceptin/orphanin fq on putative serotonin (5ht) neurons of the dorsal raphe nucleus (drn), known to modulate the behavioral responses to stress, were investigated in vivo and in vitro. |
2010-04-13 |
2023-08-12 |
rat |
| Silke Heinisch, Lynn G Kirb. SDF-1alpha/CXCL12 enhances GABA and glutamate synaptic activity at serotonin neurons in the rat dorsal raphe nucleus. Neuropharmacology. vol 58. issue 2. 2010-04-13. PMID:19755127. |
sdf-1alpha/cxcl12 enhances gaba and glutamate synaptic activity at serotonin neurons in the rat dorsal raphe nucleus. |
2010-04-13 |
2023-08-12 |
rat |
| Silke Heinisch, Lynn G Kirb. SDF-1alpha/CXCL12 enhances GABA and glutamate synaptic activity at serotonin neurons in the rat dorsal raphe nucleus. Neuropharmacology. vol 58. issue 2. 2010-04-13. PMID:19755127. |
the purpose of this study was to investigate the neuroanatomical relationship and functional impact of the chemokine stromal cell-derived factor-1alpha/cxcl12 and its receptor, cxcr4, on the serotonin dorsal raphe nucleus (drn) system in the rat using anatomical and electrophysiological techniques. |
2010-04-13 |
2023-08-12 |
rat |
| Ali Jahanshahi, Lee Wei Lim, Harry W M Steinbusch, Veerle Visser-Vandewalle, Yasin Teme. Buspirone-induced changes in the serotonergic and non-serotonergic cells in the dorsal raphe nucleus of rats. Neuroscience letters. vol 473. issue 2. 2010-04-08. PMID:20178829. |
the main source of 5-ht in the forebrain is the dorsal raphe nucleus (drn). |
2010-04-08 |
2023-08-12 |
rat |
| Yun-Hee Sung, Mal-Soon Shin, Sehyung Cho, Hyung-Hwan Baik, Byung-Kwan Jin, Hyun-Kyung Chang, Eun-Kyu Lee, Chang-Ju Ki. Depression-like state in maternal rats induced by repeated separation of pups is accompanied by a decrease of cell proliferation and an increase of apoptosis in the hippocampus. Neuroscience letters. vol 470. issue 1. 2010-04-06. PMID:20043974. |
also, the expressions of serotonin (5-hydroxytryptamine) and tryptophan hydroxylase in the dorsal raphe were decreased in the mothers separated from their pups. |
2010-04-06 |
2023-08-12 |
rat |
| J Amat, R M Aleksejev, E Paul, L R Watkins, S F Maie. Behavioral control over shock blocks behavioral and neurochemical effects of later social defeat. Neuroscience. vol 165. issue 4. 2010-03-12. PMID:19909791. |
is is notable for inducing a large increase in dorsal raphe nucleus (drn) serotonergic (5-ht) activity as measured by extracellular levels of 5-ht within the drn, and sd did so as well. |
2010-03-12 |
2023-08-12 |
rat |
| M Victoria Puig, Akiya Watakabe, Mika Ushimaru, Tetsuo Yamamori, Yasuo Kawaguch. Serotonin modulates fast-spiking interneuron and synchronous activity in the rat prefrontal cortex through 5-HT1A and 5-HT2A receptors. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 30. issue 6. 2010-03-05. PMID:20147548. |
we found that 5-ht, released by electrical stimulation of the dorsal raphe nucleus (drn) in anesthetized rats, regulates the frequency and the amplitude of slow (<2 hz) waves in the pfc via 5-ht(2a) receptors (5-ht(2a)rs). |
2010-03-05 |
2023-08-12 |
rat |
| P Quérée, S Peters, T Shar. Further pharmacological characterization of 5-HT(2C) receptor agonist-induced inhibition of 5-HT neuronal activity in the dorsal raphe nucleus in vivo. British journal of pharmacology. vol 158. issue 6. 2010-02-25. PMID:19845681. |
further pharmacological characterization of 5-ht(2c) receptor agonist-induced inhibition of 5-ht neuronal activity in the dorsal raphe nucleus in vivo. |
2010-02-25 |
2023-08-12 |
Not clear |
| Jacobus J Dudok, Alexander J A Groffen, Menno P Witter, Pieter Voorn, Matthijs Verhag. Chronic activation of the 5-HT(2) receptor reduces 5-HT neurite density as studied in organotypic slice cultures. Brain research. vol 1302. 2010-02-23. PMID:19728996. |
here we studied the effect of serotonin and serotonin pharmacological compounds on the outgrowth of serotonergic projections using organotypic slice co-cultures of hippocampus and dorsal raphe nuclei. |
2010-02-23 |
2023-08-12 |
Not clear |
| F B Lima, M L Centeno, M E Costa, A P Reddy, J L Cameron, C L Bethe. Stress sensitive female macaques have decreased fifth Ewing variant (Fev) and serotonin-related gene expression that is not reversed by citalopram. Neuroscience. vol 164. issue 2. 2010-02-12. PMID:19671441. |
fev (fifth ewing variant) ets transcription factor, tryptophan hydroxylase 2 (tph2), the serotonin reuptake transporter (sert), and the 5ht1a autoreceptor were determined at 7-8 levels of the dorsal raphe nucleus with in situ hybridization (ish) using radiolabeled- and digoxygenin-incorporated riboprobes. |
2010-02-12 |
2023-08-12 |
monkey |
| S Heinisch, L G Kirb. Fractalkine/CX3CL1 enhances GABA synaptic activity at serotonin neurons in the rat dorsal raphe nucleus. Neuroscience. vol 164. issue 3. 2010-02-08. PMID:19748551. |
fractalkine/cx3cl1 enhances gaba synaptic activity at serotonin neurons in the rat dorsal raphe nucleus. |
2010-02-08 |
2023-08-12 |
rat |
| S Heinisch, L G Kirb. Fractalkine/CX3CL1 enhances GABA synaptic activity at serotonin neurons in the rat dorsal raphe nucleus. Neuroscience. vol 164. issue 3. 2010-02-08. PMID:19748551. |
immunohistochemistry was used to examine the colocalization of cx3cl1 or cx3cr1 with 5-ht in the rn, and whole-cell patch-clamp recordings in rat brain slices were used to determine the functional impact of cx3cl1 on 5-ht dorsal raphe nucleus (drn) neurons. |
2010-02-08 |
2023-08-12 |
rat |
| Dharmendra B Goswami, Warren L May, Craig A Stockmeier, Mark C Austi. Transcriptional expression of serotonergic regulators in laser-captured microdissected dorsal raphe neurons of subjects with major depressive disorder: sex-specific differences. Journal of neurochemistry. vol 112. issue 2. 2010-02-05. PMID:19878438. |
given the evidence that 5-ht neurotransmission is reduced in depressed subjects, it is possible that one or more of the 5-ht regulators may be altered in the dorsal raphe nucleus (dr) of depressed subjects. |
2010-02-05 |
2023-08-12 |
human |
| Tae-Soo Kim, Il-Gyu Ko, Yun-Hee Sung, Sung-Eun Kim, Bo-Kyun Kim, Seung-Kook Park, Mal-Soon Shin, Chang-Ju Kim, Sang-Jin Yoon, Khae-Hawn Ki. Vardenafil increases cell proliferation in the dentate gyrus through enhancement of serotonin expression in the rat dorsal raphe. Journal of Korean medical science. vol 24. issue 6. 2010-01-27. PMID:19949666. |
vardenafil increases cell proliferation in the dentate gyrus through enhancement of serotonin expression in the rat dorsal raphe. |
2010-01-27 |
2023-08-12 |
rat |
| Tae-Soo Kim, Il-Gyu Ko, Yun-Hee Sung, Sung-Eun Kim, Bo-Kyun Kim, Seung-Kook Park, Mal-Soon Shin, Chang-Ju Kim, Sang-Jin Yoon, Khae-Hawn Ki. Vardenafil increases cell proliferation in the dentate gyrus through enhancement of serotonin expression in the rat dorsal raphe. Journal of Korean medical science. vol 24. issue 6. 2010-01-27. PMID:19949666. |
this study was conducted to evaluate the effects of vardenafil (levitra), a phosphodiesterase-5 (pde-5) inhibitor, on cell proliferation in the hippocampal dentate gyrus and on 5-hyroxytryptamine (5-ht, serotonin) synthesis and tryptophan hydroxylase (tph) expression in the rat dorsal raphe nucleus. |
2010-01-27 |
2023-08-12 |
rat |