| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yolanda Gómez, Juan Pedro Vargas, Juan Carlos López, Manuel Portavell. Inhibition of brain NOS activity impair spatial learning acquisition in fish. Brain research bulletin. vol 164. 2021-10-29. PMID:32814090. |
nitric oxide plays a role in the long term potentiation mechanisms produced in the mammalian hippocampus during spatial learning. |
2021-10-29 |
2023-08-13 |
Not clear |
| Farimah Beheshti, Hamid Reza Akbari, Yousef Baghcheghi, Fatemeh Mansouritorghabeh, Sakineh Sadat Mortazavi Sani, Mahmoud Hossein. Beneficial effects of angiotensin converting enzyme inhibition on scopolamine-induced learning and memory impairment in rats, the roles of brain-derived neurotrophic factor, nitric oxide and neuroinflammation. Clinical and experimental hypertension (New York, N.Y. : 1993). vol 43. issue 6. 2021-10-04. PMID:33724113. |
in this study, the effects of ras inhibitor captopril (capto) on hippocampal bdnf, interleukin -6 (il-6), oxidative stress indicators, and nitric oxide (no) in scopolamine (sco)-induced memory impairment in rats were examined. |
2021-10-04 |
2023-08-13 |
rat |
| Yasser A Khadrawy, Eman N Hosny, Haitham S Mohamme. Protective effect of nanocurcumin against neurotoxicity induced by doxorubicin in rat's brain. Neurotoxicology. vol 85. 2021-09-22. PMID:33882267. |
this was associated with a significant rise in the levels of lipid peroxidation (183.99 %, 201.4 %) and nitric oxide (36.54 %, 55 %) and a significant reduction in reduced glutathione (13 %, 21.44 %) in the cortex and hippocampus, respectively. |
2021-09-22 |
2023-08-13 |
rat |
| Andrea Lewen, Thuy-Truc Ta, Tiziana Cesetti, Jan-Oliver Hollnagel, Ismini E Papageorgiou, Bruno Chausse, Oliver Kan. Neuronal gamma oscillations and activity-dependent potassium transients remain regular after depletion of microglia in postnatal cortex tissue. Journal of neuroscience research. vol 98. issue 10. 2021-09-17. PMID:32638411. |
the slice cultures featured well-preserved hippocampal cytoarchitecture and parvalbumin-positive interneuron networks, microglia with ramified morphology, and low basal levels of il-6, tnf-α, and nitric oxide (no). |
2021-09-17 |
2023-08-13 |
rat |
| Cheng-Ru Wu, Yi-Da Huang, Yong-Huei Hong, Ya-Hsin Liu, Manmath Narwane, Yu-Hsiang Chang, Trinh Kieu Dinh, Hsin-Tzu Hsieh, Yi-Jen Hseuh, Ping-Ching Wu, Chih-Wen Pao, Ting-Shan Chan, I-Jui Hsu, Yunching Chen, Hung-Chi Chen, Ting-Yu Chin, Tsai-Te L. Endogenous Conjugation of Biomimetic Dinitrosyl Iron Complex with Protein Vehicles for Oral Delivery of Nitric Oxide to Brain and Activation of Hippocampal Neurogenesis. JACS Au. vol 1. issue 7. 2021-09-04. PMID:34467346. |
endogenous conjugation of biomimetic dinitrosyl iron complex with protein vehicles for oral delivery of nitric oxide to brain and activation of hippocampal neurogenesis. |
2021-09-04 |
2023-08-13 |
Not clear |
| Ahmet Sevki Taskiran, Yasar Tastemu. The role of nitric oxide in anticonvulsant effects of lycopene supplementation on pentylenetetrazole-induced epileptic seizures in rats. Experimental brain research. vol 239. issue 2. 2021-07-28. PMID:33385251. |
inducible nitric oxide synthase (inos), neuronal nitric oxide synthase (nnos), and nitric oxide (no) levels were measured in the cortex and hippocampal brain regions using the elisa kits. |
2021-07-28 |
2023-08-13 |
rat |
| Xiaoyou Wei, Yaoying Ma, Fu Li, Haiyan He, Huaxing Huang, Chao Huang, Zhuo Chen, Dongjian Chen, Jinliang Chen, Xiaomei Yua. Acute Diallyl Disulfide Administration Prevents and Reveres Lipopolysaccharide-Induced Depression-Like Behaviors in Mice via Regulating Neuroinflammation and Oxido-Nitrosative Stress. Inflammation. vol 44. issue 4. 2021-07-19. PMID:33511484. |
mechanistic studies revealed that dads pre-treatment or post-treatment at the dose of 40 and 80 mg/kg prevented and reversed (i) lps-induced increases in interleukin-1β (il-1β), tumor necrosis factor-α (tnf-α), and nitric oxide (no) levels in the hippocampus and prefrontal cortex, (ii) lps-induced increases in contents of malondialdehyde (mda), a parameter reflecting high levels of oxidative stress, and (iii) lps-induced decreases in contents of gsh, a marker reflecting weakened anti-oxidative ability, in the hippocampus and prefrontal cortex in mice. |
2021-07-19 |
2023-08-13 |
mouse |
| Masaki Kajimoto, Muhammad Nuri, Justin R Sleasman, Kevin A Charette, Branden R Nelson, Michael A Portma. Inhaled nitric oxide reduces injury and microglia activation in porcine hippocampus after deep hypothermic circulatory arrest. The Journal of thoracic and cardiovascular surgery. vol 161. issue 6. 2021-07-12. PMID:32037238. |
inhaled nitric oxide reduces injury and microglia activation in porcine hippocampus after deep hypothermic circulatory arrest. |
2021-07-12 |
2023-08-13 |
Not clear |
| Lucineia Gainski Danielski, Amanda Della Giustina, Sandra Bonfante, Mariana Pereira de Souza Goldim, Larissa Joaquim, Kiuanne Lobo Metzker, Erica Bernardo Biehl, Thaynan Vieira, Fabiana Durante de Medeiros, Naiana da Rosa, Jaqueline Generoso, Lutiana Simoes, Hémelin Resende Farias, Isabela da Silva Lemos, Vijayasree Giridharan, Gislaine Tezza Rezin, Jucelia Jeremias Fortunato, Rafael Mariano Bitencourt, Emilio Luiz Streck, Felipe Dal-Pizzol, Tatiana Barichello, Fabricia Petronilh. NLRP3 Activation Contributes to Acute Brain Damage Leading to Memory Impairment in Sepsis-Surviving Rats. Molecular neurobiology. vol 57. issue 12. 2021-07-01. PMID:32870491. |
prefrontal cortex and hippocampus were isolated for cytokine analysis, microglial and astrocyte activation, oxidative stress measurements, nitric oxide formation, and mitochondrial respiratory chain activity at 24 h after clp. |
2021-07-01 |
2023-08-13 |
rat |
| Nilson Carlos Ferreira-Junior, Davi Campos Lagatta, Luciana Bärg Kuntze, Eduardo Akira Fujiwara, Egidi Mayara Silva Firmino, Anna Bárbara Borges-Assis, Leonardo Barbosa Moraes Resstel, Karla Nívea Sampai. Dorsal hippocampus cholinergic and nitrergic neurotransmission modulates the cardiac baroreflex function in rats. The European journal of neuroscience. vol 51. issue 4. 2021-06-21. PMID:31626713. |
hippocampal muscarinic receptors activation by acetylcholine might evoke nitric oxide synthesis, which is an important neuromodulator of cardiovascular responses. |
2021-06-21 |
2023-08-13 |
rat |
| Mouloud Lamtai, Sofia Azirar, Oussama Zghari, Sihame Ouakki, Aboubaker El Hessni, Abdelhalem Mesfioui, Ali Ouicho. Melatonin Ameliorates Cadmium-Induced Affective and Cognitive Impairments and Hippocampal Oxidative Stress in Rat. Biological trace element research. vol 199. issue 4. 2021-06-18. PMID:32613486. |
biochemical assays showed that rats intoxicated with cd significantly increased levels of nitric oxide (no) and lipid peroxidation (lpo), while the activities of catalase (cat) and superoxide dismutase (sod) were significantly decreased in the hippocampus. |
2021-06-18 |
2023-08-13 |
rat |
| Daniel Tonial Thomaz, Rafaela Rafognatto Andreguetti, Luisa Bandeira Binder, Débora da Luz Scheffer, Alisson Willms Corrêa, Fátima Regina Mena Barreto Silva, Carla Inês Tasc. Guanosine Neuroprotective Action in Hippocampal Slices Subjected to Oxygen and Glucose Deprivation Restores ATP Levels, Lactate Release and Glutamate Uptake Impairment: Involvement of Nitric Oxide. Neurochemical research. vol 45. issue 9. 2021-06-08. PMID:32666283. |
guanosine neuroprotective action in hippocampal slices subjected to oxygen and glucose deprivation restores atp levels, lactate release and glutamate uptake impairment: involvement of nitric oxide. |
2021-06-08 |
2023-08-13 |
rat |
| Daniel Tonial Thomaz, Rafaela Rafognatto Andreguetti, Luisa Bandeira Binder, Débora da Luz Scheffer, Alisson Willms Corrêa, Fátima Regina Mena Barreto Silva, Carla Inês Tasc. Guanosine Neuroprotective Action in Hippocampal Slices Subjected to Oxygen and Glucose Deprivation Restores ATP Levels, Lactate Release and Glutamate Uptake Impairment: Involvement of Nitric Oxide. Neurochemical research. vol 45. issue 9. 2021-06-08. PMID:32666283. |
this study was designed to investigate the involvement of nitric oxide (no) in the mechanisms related to the protective role of guanosine in rat hippocampal slices subjected to ogd followed by reoxygenation (ogd/r). |
2021-06-08 |
2023-08-13 |
rat |
| Haci Ömer Osmanlıoğlu, Mustafa Kemal Yıldırım, Yener Akyuva, Kenan Yıldızhan, Mustafa Nazıroğl. Morphine Induces Apoptosis, Inflammation, and Mitochondrial Oxidative Stress via Activation of TRPM2 Channel and Nitric Oxide Signaling Pathways in the Hippocampus. Molecular neurobiology. vol 57. issue 8. 2021-06-07. PMID:32524520. |
morphine induces apoptosis, inflammation, and mitochondrial oxidative stress via activation of trpm2 channel and nitric oxide signaling pathways in the hippocampus. |
2021-06-07 |
2023-08-13 |
Not clear |
| Mohammad Abbas Sheikholeslami, Shiva Ghafghazi, Ramin Pouriran, Seyed Erfan Mortazavi, Siavash Parvarde. Attenuating effect of paroxetine on memory impairment following cerebral ischemia-reperfusion injury in rat: The involvement of BDNF and antioxidant capacity. European journal of pharmacology. vol 893. 2021-05-17. PMID:33347827. |
a week after ischemia-reperfusion injury, passive avoidance memory, long-term potentiation (ltp), bdnf levels, total antioxidant capacity, the activity of antioxidant enzymes (including catalase, glutathione peroxidase, and superoxide dismutase), the concentration of malondialdehyde (mda), and nitric oxide (no) were investigated in the hippocampus. |
2021-05-17 |
2023-08-13 |
rat |
| Christina L Lebonville, Jacqueline E Paniccia, Shveta V Parekh, Lynde M Wangler, Meghan E Jones, Rita A Fuchs, Donald T Lysl. Expression of a heroin contextually conditioned immune effect in male rats requires CaMKIIα-expressing neurons in dorsal, but not ventral, subiculum and hippocampal CA1. Brain, behavior, and immunity. vol 89. 2021-04-27. PMID:32717403. |
our laboratory has shown that exposure to a heroin-paired context suppresses lipopolysaccharide (lps)-induced splenic nitric oxide (no) production in male rats, and this effect is mediated in part by the dorsal hippocampus (dhpc). |
2021-04-27 |
2023-08-13 |
rat |
| Shasha Song, Jingjiong Chen, Pinpin Xiao, Hao Duan, Yajun Zhou, Feng Wang, Hongmei Wang, Yuwu Zhao, Zhi Gen. Role of Macrophages in Status Epilepticus Predisposing to Alzheimer's Disease. Journal of Alzheimer's disease : JAD. vol 73. issue 1. 2021-04-19. PMID:31796682. |
previous studies have shown that status epilepticus prompts an overproduction of nitric oxide (no) by upregulation of no synthase ii (nos ii) to induce apoptosis of neuronal cells in the hippocampus, in a nuclear factor-kappab (nf-κb) signaling dependent manner. |
2021-04-19 |
2023-08-13 |
rat |
| Omar M E Abdel-Salam, Eman R Youness, Reham Shehab ElNemr Esmail, Nadia A Mohammed, Yasser A Khadrawy, Amany A Sleem, Amany Mamdouh Abdulazi. Protection by Neostigmine and Atropine Against Brain and Liver Injury Induced by Acute Malathion Exposure. Journal of nanoscience and nanotechnology. vol 18. issue 1. 2021-04-02. PMID:29768876. |
results indicated that compared with the saline group, malathion resulted in (i) higher brain malondialdehyde (mda) and nitric oxide (46.4% and 86.2%); (ii) decreased brain reduced glutathione (gsh) (67.6%); (iii) decreased brain paraoxonase-1 (pon1), acetylcholinesterase (ache) and butyrylcholinesterase (bche) activities (31.2%, 21.6% and 60%); (iv) decreased brain glucose (-38.1%); (v) neuronal degeneration in cortex and hippocampus and markedly increased glial fibrillary acidic protein (gfap) immunostaining in the hippocampus; (v) hydropic and fatty degeneration in liver. |
2021-04-02 |
2023-08-13 |
rat |
| Mouloud Lamtai, Sihame Ouakki, Oussama Zghari, Abdelghafour El Hamzaoui, Hajar Benmhammed, Sofia Azirar, Aboubaker El Hessni, Abdelhalem Mesfioui, Ali Ouicho. Neuroprotective effect of melatonin on nickel-induced affective and cognitive disorders and oxidative damage in rats. Environmental analysis, health and toxicology. vol 35. issue 4. 2021-02-02. PMID:33434425. |
alongside this, ni elevated hippocampal os markers like lipid peroxidation and nitric oxide formation with a decrease in superoxide dismutase and catalase activities. |
2021-02-02 |
2023-08-13 |
rat |
| Chun Wang, Zhaopeng Shen, Junhong Yu, Jieru Yang, Fei Meng, Xiaolu Jiang, Changliang Zh. Protective effects of enzyme degradation extract from The British journal of nutrition. vol 123. issue 9. 2021-01-25. PMID:31787131. |
the pyede also renewed the glutathione peroxidase (gsh-px), superoxide dismutase and total antioxidant capability activities, down-regulated the inducible nitric oxide synthase activity and nitric oxide levels, normalised the hippocampal neurons and modulated multiple neurotransmitter systems by inhibiting the activities of acetylcholinesterase and monoamine oxidase in the up-regulation of acetylcholine, dopamine and noradrenaline levels. |
2021-01-25 |
2023-08-13 |
mouse |