| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Vergine Chavushyan, Senik Matinyan, Margarita Danielyan, Michail Aghajanov, Konstantin Yenkoya. Embryonic proteoglycans regulate monoamines in the rat frontal cortex and hippocampus in Alzheimer's disease-like pathology. Neurochemistry international. vol 140. 2021-09-02. PMID:32853753. |
results showed that the levels of monoamines and especially norepinephrine in the target ad brain structures were found elevated, except serotonin, which was unaffected in the hippocampus, but decreased in the frontal cortex. |
2021-09-02 |
2023-08-13 |
rat |
| Oliver Stiedl, Eugenia Kuteeva, Tomas Hökfelt, Sven Ove Ögre. Injection of galanin into the dorsal hippocampus impairs emotional memory independent of 5-HT Behavioural brain research. vol 405. 2021-09-02. PMID:33607166. |
injection of galanin into the dorsal hippocampus impairs emotional memory independent of 5-ht there is evidence that interaction between the neuropeptide galanin and the 5-ht |
2021-09-02 |
2023-08-13 |
Not clear |
| Vibe G Frokjae. Pharmacological sex hormone manipulation as a risk model for depression. Journal of neuroscience research. vol 98. issue 7. 2021-08-26. PMID:32399989. |
the gnrha model work points to an estradiol-dependent depressive response in healthy women undergoing short-term sex hormone manipulation with gnrha, which is linked to serotonin transporter changes (a key regulator of synaptic serotonin), a disengagement of hippocampus, and overengagement of brain networks recruited when processing emotional salient information. |
2021-08-26 |
2023-08-13 |
human |
| Noreen Samad, Farheen Hafeez, Imran Imra. D-galactose induced dysfunction in mice hippocampus and the possible antioxidant and neuromodulatory effects of selenium. Environmental science and pollution research international. 2021-08-23. PMID:34424474. |
the neurochemical assessment showed that d-gal-induced increased serotonin metabolism and decreased acetylcholine levels in the hippocampus were restored by repeated treatment of se. |
2021-08-23 |
2023-08-13 |
mouse |
| Lara Costa, Alessandra Tempio, Enza Lacivita, Marcello Leopoldo, Lucia Cirann. Serotonin 5-HT7 receptors require cyclin-dependent kinase 5 to rescue hippocampal synaptic plasticity in a mouse model of Fragile X Syndrome. The European journal of neuroscience. 2021-08-18. PMID:33949019. |
serotonin 5-ht7 receptors require cyclin-dependent kinase 5 to rescue hippocampal synaptic plasticity in a mouse model of fragile x syndrome. |
2021-08-18 |
2023-08-13 |
mouse |
| Lara Costa, Alessandra Tempio, Enza Lacivita, Marcello Leopoldo, Lucia Cirann. Serotonin 5-HT7 receptors require cyclin-dependent kinase 5 to rescue hippocampal synaptic plasticity in a mouse model of Fragile X Syndrome. The European journal of neuroscience. 2021-08-18. PMID:33949019. |
we have previously demonstrated that activation of serotonin 5-ht7 receptors reverses mglur-ltd in the hippocampus of wild-type and fmr1 ko mice, thus correcting a synaptic dysfunction typically observed in this disease model. |
2021-08-18 |
2023-08-13 |
mouse |
| He Yu, Zhong-Mei He, Kun Shi, Yan Zhao, Ying Zong, Jian-Ming Li, Wei-Jia Chen, Rui D. [Study on antidepressant effect of total alkaloids of Fibraurea recisa]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 46. issue 14. 2021-08-18. PMID:34402292. |
this study aimed to investigate the antidepressant effects of total alkaloids of fibraurea recisa in ht22 cells damaged by corticosterone (cort) in vitro and in a mouse model of chronic unpredictable mild stress (cums) as well as the underlying mechanisms.in cellular experiments,the viability of cort-damaged ht22 cells was detected using cell counting kit-8 (cck-8),and the cell apoptosis was detected by hoechst 33258 staining.in animal experiments,c57bl/6n mice were randomly divided into the control group,model group,low (100 mg·kg~(-1)),medium (200 mg·kg~(-1)) and high (400 mg·kg~(-1))-dose of total alkaloids of f.recisa groups,and positive control group.after 21 days of cums exposure,their depressive behaviors were observed in behavioral and morris water maze tests.the serum levels of 5-hydroxytryptamine (5-ht),dopamine (da),and norepinephrine (ne) were assessed by elisa.the expression levels of apoptosis-related proteins bcl-2,bax and cleaved caspase-3 in ht22 cells and mouse hippocampus were detected by western blot.the results suggested that total alkaloids of f.recisa alleviated the damage of ht22 cells induced by cort in a dose-dependent manner.the hoechst 33258 staining uncovered that total alkaloids of f.recisa better reduced the blue spots and inhibited cell apoptosis.the results of animal experiments showed that total alkaloids of f.recisa significantly improved the depression-like behaviors of mice and increased the serum levels of 5-ht,da and ne as compared with those in the model group.the western blot assays revealed a significant up-regulation of bcl-2 protein expression,but an obvious reduction in bax and cleaved caspase-3protein expression in the total alkaloids of f.recisa group.in conclusion,total alkaloids of f.recisa inhibited depression possibly by regulating the apoptosis-related protein expression or elevating the monoamine neurotransmitter levels in the brain. |
2021-08-18 |
2023-08-13 |
mouse |
| Claudia Villani, Giuseppina Sacchetti, Mirjana Carli, Roberto W Invernizz. Fluoxetine rescues rotarod motor deficits in Mecp2 heterozygous mouse model of Rett syndrome via brain serotonin. Neuropharmacology. vol 176. 2021-08-13. PMID:32652084. |
mecp2 null mice, which responded poorly to fluoxetine in the rotarod, showed reduced 5-ht synthesis in the prefrontal cortex, hippocampus and striatum, and reduced efficacy of fluoxetine in raising extracellular 5-ht as compared to female mutants. |
2021-08-13 |
2023-08-13 |
mouse |
| Jun-Qi Yao, Chang Liu, Zeng-Liang Jin, Yan-Qin Liu, Yong-Yu Yin, Xin-Xin Fang, Yu-Hua Ran, Li-Ming Zhang, Yun-Feng L. Serotonergic transmission is required for the anxiolytic-like behavioral effects of YL-IPA08, a selective ligand targeting TSPO. Neuropharmacology. vol 178. 2021-08-12. PMID:32693005. |
furthermore, we found that yl-ipa08 increased the extracellular levels of 5-ht in the rat ventral hippocampus in freely moving rat using the rapid and validated hplc coupled with microdialysis. |
2021-08-12 |
2023-08-13 |
mouse |
| Zhicheng Jin, Jianer Ling, Jing Yu, Mengzi He, Pingping Ni, Fang Zhang, Yizhen Wan. Serotonin 2A receptor function and depression-like behavior in rats model of hypothyroidism. Experimental brain research. vol 239. issue 8. 2021-08-12. PMID:34106297. |
tt[formula: see text] and tt[formula: see text] levels were measured after the behavior tests and the expression levels of 5-ht[formula: see text] receptor and 5-ht[formula: see text] receptor proteins were analyzed in the hippocampus and prefrontal cortex. |
2021-08-12 |
2023-08-13 |
rat |
| Rachel E Martin, Madison T Green, Jessica A Kinkade, Robert R Schmidt, Tess E Willemse, A Katrin Schenk, Jiude Mao, Cheryl S Rosenfel. Maternal Oxycodone Treatment Results in Neurobehavioral Disruptions in Mice Offspring. eNeuro. vol 8. issue 4. 2021-08-12. PMID:34312305. |
in the hippocampus, prenatal exposure to oxy caused sex-dependent differences in expression of genes encoding opioid receptors and those involved in serotonin signaling. |
2021-08-12 |
2023-08-13 |
mouse |
| Clarissa Tavares Dias, Haidar Tafner Curi, Tanyara Baliani Payolla, Simone Ferreira Lemes, Isadora Carolina Betim Pavan, Marcio Alberto Torsoni, Fernando Moreira Simabuco, Rafael Herling Lambertucci, Cristiano Mendes da Silv. Maternal high-fat diet stimulates proinflammatory pathway and increases the expression of Tryptophan Hydroxylase 2 (TPH2) and brain-derived neurotrophic factor (BDNF) in adolescent mice hippocampus. Neurochemistry international. vol 139. 2021-08-11. PMID:32652271. |
this study aims to evaluate maternal hfd effects, during pregnancy and lactation, upon dams/mice offspring nutritional status, protein and gene expression of inflammatory pathway (jnk, pjnk and tnf-α), serotonin system molecules (tryptophan hydroxylase 2 (tph2), key-enzyme of serotonin synthesis, serotonin transporter (sert); 5-ht1a serotonergic receptor (5-ht1a)) and brain derived neurotrophic factor (bdnf) on recently weaned mice offspring hippocampus. |
2021-08-11 |
2023-08-13 |
mouse |
| Clarissa Tavares Dias, Haidar Tafner Curi, Tanyara Baliani Payolla, Simone Ferreira Lemes, Isadora Carolina Betim Pavan, Marcio Alberto Torsoni, Fernando Moreira Simabuco, Rafael Herling Lambertucci, Cristiano Mendes da Silv. Maternal high-fat diet stimulates proinflammatory pathway and increases the expression of Tryptophan Hydroxylase 2 (TPH2) and brain-derived neurotrophic factor (BDNF) in adolescent mice hippocampus. Neurochemistry international. vol 139. 2021-08-11. PMID:32652271. |
however, the tph2 increase in hfd-offspring did not alter hippocampal serotonin levels quantified through elisa. |
2021-08-11 |
2023-08-13 |
mouse |
| Francesca Zoratto, Clelia Buccheri, Romina Mura, Luisa Altabella, Marion Vanneste, Marie Villotte, Giovanni Laviola, Francois Dauphin, Eleni Paizanis, Walter Adriani, Rossella Canes. Anatomical and behavioral impact of a lentiviral tool tapping onto hippocampal serotonin reuptake in rats. Synapse (New York, N.Y.). vol 74. issue 4. 2021-08-10. PMID:31587367. |
anatomical and behavioral impact of a lentiviral tool tapping onto hippocampal serotonin reuptake in rats. |
2021-08-10 |
2023-08-13 |
rat |
| Melinda Hersey, Jennifer L Woodruff, Nicholas Maxwell, Alia T Sadek, Maria K Bykalo, Ian Bain, Claudia A Grillo, Gerardo G Piroli, Parastoo Hashemi, Lawrence P Reaga. High-fat diet induces neuroinflammation and reduces the serotonergic response to escitalopram in the hippocampus of obese rats. Brain, behavior, and immunity. vol 96. 2021-08-06. PMID:34010713. |
obesity, a condition of chronic mild inflammation including obesity-induced neuroinflammation, is proposed to contribute to decreases in synaptic concentrations of neurotransmitters like serotonin (5ht) by decreasing 5ht synthesis in the dorsal raphe nucleus (drn) and/or affecting 5ht reuptake in drn target regions like the hippocampus. |
2021-08-06 |
2023-08-13 |
human |
| Melinda Hersey, Jennifer L Woodruff, Nicholas Maxwell, Alia T Sadek, Maria K Bykalo, Ian Bain, Claudia A Grillo, Gerardo G Piroli, Parastoo Hashemi, Lawrence P Reaga. High-fat diet induces neuroinflammation and reduces the serotonergic response to escitalopram in the hippocampus of obese rats. Brain, behavior, and immunity. vol 96. 2021-08-06. PMID:34010713. |
in real time using fast scan cyclic voltammetry (fscv), we observed no changes in basal levels of hippocampal 5ht; however responses to escitalopram were significantly impaired in the hippocampus of obese rats compared to diet resistant rats and control rats. |
2021-08-06 |
2023-08-13 |
human |
| Melinda Hersey, Jennifer L Woodruff, Nicholas Maxwell, Alia T Sadek, Maria K Bykalo, Ian Bain, Claudia A Grillo, Gerardo G Piroli, Parastoo Hashemi, Lawrence P Reaga. High-fat diet induces neuroinflammation and reduces the serotonergic response to escitalopram in the hippocampus of obese rats. Brain, behavior, and immunity. vol 96. 2021-08-06. PMID:34010713. |
further studies revealed that these neurochemical observations could be explained by increases in serotonin transporter (sert) expression in the hippocampus driven by elevated neuroinflammation. |
2021-08-06 |
2023-08-13 |
human |
| Margherita Tassan Mazzocco, Fabrizia Claudia Guarnieri, Elena Monzani, Fabio Benfenati, Flavia Valtorta, Stefano Coma. Dysfunction of the serotonergic system in the brain of synapsin triple knockout mice is associated with behavioral abnormalities resembling synapsin-related human pathologies. Progress in neuro-psychopharmacology & biological psychiatry. vol 105. 2021-07-19. PMID:33058959. |
levels of 5-ht and da in the frontal cortex and hippocampus of wt and tko mice were also assessed using a high-performance liquid chromatography. |
2021-07-19 |
2023-08-13 |
mouse |
| Margherita Tassan Mazzocco, Fabrizia Claudia Guarnieri, Elena Monzani, Fabio Benfenati, Flavia Valtorta, Stefano Coma. Dysfunction of the serotonergic system in the brain of synapsin triple knockout mice is associated with behavioral abnormalities resembling synapsin-related human pathologies. Progress in neuro-psychopharmacology & biological psychiatry. vol 105. 2021-07-19. PMID:33058959. |
finally, hippocampal 5-ht levels were lower in tko than in wt mice. |
2021-07-19 |
2023-08-13 |
mouse |
| Margherita Tassan Mazzocco, Fabrizia Claudia Guarnieri, Elena Monzani, Fabio Benfenati, Flavia Valtorta, Stefano Coma. Dysfunction of the serotonergic system in the brain of synapsin triple knockout mice is associated with behavioral abnormalities resembling synapsin-related human pathologies. Progress in neuro-psychopharmacology & biological psychiatry. vol 105. 2021-07-19. PMID:33058959. |
overall, syns deletion in mice leads to a reduction in drn 5-ht firing activity and hippocampal 5-ht levels along with behavioral alterations reminiscent of human neuropsychiatric conditions associated with syn dysfunction. |
2021-07-19 |
2023-08-13 |
mouse |