| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Melkamu Alemu Abame, Yang He, Song Wu, Zhifei Xie, Jian Zhang, Xudong Gong, Chunhui Wu, Jingshan She. Chronic administration of synthetic cannabidiol induces antidepressant effects involving modulation of serotonin and noradrenaline levels in the hippocampus. Neuroscience letters. vol 744. 2021-04-30. PMID:33388355. |
chronic cbd 100 mg/kg administration resulted in significant increases in serotonin (5-ht) and noradrenaline (na) levels in the hippocampus (hpc). |
2021-04-30 |
2023-08-13 |
mouse |
| Sheng Wei, Xiwen Geng, Zifa Li, Kaiyong Xu, Minghui Hu, Hongyun Wu, Wei Shi, Mingqi Qia. A forced swim-based rat model of premenstrual depression: effects of hormonal changes and drug intervention. Aging. vol 12. issue 23. 2021-04-27. PMID:33229622. |
further, the model rats showed significant changes in the serum levels of estrogen and progesterone, hippocampal levels of allopregnanolone, 5-hydroxytryptamine, norepinephrine, and γ-aminobutyric acid (gaba), and in the expression of gaba |
2021-04-27 |
2023-08-13 |
rat |
| Claudia Fuchs, Laura Gennaccaro, Elisa Ren, Giuseppe Galvani, Stefania Trazzi, Giorgio Medici, Manuela Loi, Erin Conway, Orrin Devinsky, Roberto Rimondini, Elisabetta Cian. Pharmacotherapy with sertraline rescues brain development and behavior in a mouse model of CDKL5 deficiency disorder. Neuropharmacology. vol 167. 2021-04-23. PMID:31469994. |
here we show a dysregulation of hippocampal and cortical serotonergic (5-ht) receptor expression in heterozygous cdkl5 knockout (ko) female mice, suggesting that impaired 5-ht neurotransmission contributes to cdd. |
2021-04-23 |
2023-08-13 |
mouse |
| Ji-Duo Shen, Yue-Wen Zhang, Bao-Ying Wang, Li Bai, Shuai-Fei Lu, Lei-Lei Zhu, Ming Bai, Yu-Cheng Li, Er-Ping X. Effects of resveratrol on the levels of ATP, 5-HT and GAP-43 in the hippocampus of mice exposed to chronic unpredictable mild stress. Neuroscience letters. vol 735. 2021-04-23. PMID:32621948. |
effects of resveratrol on the levels of atp, 5-ht and gap-43 in the hippocampus of mice exposed to chronic unpredictable mild stress. |
2021-04-23 |
2023-08-13 |
mouse |
| Marta Barenys, Ingrid Reverte, Stefan Masjosthusmann, Jesús Gómez-Catalán, Ellen Fritsch. Developmental neurotoxicity of MDMA. A systematic literature review summarized in a putative adverse outcome pathway. Neurotoxicology. vol 78. 2021-04-21. PMID:31812710. |
in rat, postnatal exposure towards mdma also caused locomotor deficits as well as impaired spatial learning that might be associated with decreased serotonin levels in the hippocampus. |
2021-04-21 |
2023-08-13 |
mouse |
| Sadia Basharat Ali, Khalid Mahmood, Raheel Saeed, Tabinda Salman, Muhammad Iqbal Choudhary, Darakhshan Jabeen Halee. Elevated anxiety, hypoactivity, memory deficits, decreases of brain serotonin and 5-HT-1A receptors expression in rats treated with omeprazole. Toxicological research. vol 37. issue 2. 2021-04-21. PMID:33868980. |
associated changes in brain serotonin (5-hydroxytryptamine; 5-ht) and dopamine metabolism and the expression of 5-ht-1a receptors in the raphe and hippocampus were also determined. |
2021-04-21 |
2023-08-13 |
rat |
| Silvia Vincentiis, Juliana A Alcantara, Patricia Rzezak, Daniel S Kerr, Wagner F Gattaz, Helio van der Linden, Bernardo Dos Santos, Francisco Arruda, Tiffany Chaim-Avancini, Mauricio H Serpa, Fernando Fernandes, Ricardo A Moreno, Geraldo F Busatto, Ruda Alessi, Renata Demarque, Kette D Valent. Genetic polymorphisms of the serotonin transporter are not related with depression in temporal lobe epilepsy caused by hippocampal sclerosis. Epilepsy & behavior : E&B. vol 117. 2021-04-20. PMID:33639436. |
genetic polymorphisms of the serotonin transporter are not related with depression in temporal lobe epilepsy caused by hippocampal sclerosis. |
2021-04-20 |
2023-08-13 |
Not clear |
| Hidekazu Tanaka, Toshinori Sawano, Naoko Konishi, Risako Harada, Chiaki Takeuchi, Yuki Shin, Hiroko Sugiura, Jin Nakatani, Takahiro Fujimoto, Kanato Yamagat. Serotonin induces Arcadlin in hippocampal neurons. Neuroscience letters. vol 721. 2021-04-19. PMID:31981722. |
serotonin induces arcadlin in hippocampal neurons. |
2021-04-19 |
2023-08-13 |
human |
| Swati Sahoo, Prashant S Kharkar, Niteshkumar U Sahu, Brijesh . Anxiolytic activity of Psidium guajava in mice subjected to chronic restraint stress and effect on neurotransmitters in brain. Phytotherapy research : PTR. vol 35. issue 3. 2021-04-19. PMID:33034100. |
neurotransmitters such as monoamines (serotonin, norepinephrine, and dopamine), γ-aminobutyric acid (gaba), and glutamate were estimated in different regions of the brain (cortex, hippocampus, and cerebellum and brain stem). |
2021-04-19 |
2023-08-13 |
mouse |
| Chengping Luo, Huimin Fan, Shaojun Li, Yuling Zo. Therapeutic of Candesartan and Music Therapy in Diabetic Retinopathy with Depression in Rats. Evidence-based complementary and alternative medicine : eCAM. vol 2021. 2021-04-10. PMID:33833815. |
angiotensin ii (ang ii) in peripheral blood and neurotransmitters, including serotonin (5-ht), dopamine (da), and norepinephrine (ne) in the hippocampus, was measured by enzyme linked immunosorbent assay (elisa). |
2021-04-10 |
2023-08-13 |
rat |
| Chengping Luo, Huimin Fan, Shaojun Li, Yuling Zo. Therapeutic of Candesartan and Music Therapy in Diabetic Retinopathy with Depression in Rats. Evidence-based complementary and alternative medicine : eCAM. vol 2021. 2021-04-10. PMID:33833815. |
compared with the control group, the apoptosis of retinal cells was significantly higher, the contents of 5-ht, da, and ne in the hippocampus were significantly lower, ang ii level in peripheral blood was significantly higher, and the expression of bdnf and c-fos in the hippocampus decreased significantly in the model group. |
2021-04-10 |
2023-08-13 |
rat |
| Carina Meinke, Meagan A Quinlan, Krista C Paffenroth, Fiona E Harrison, Cristina Fenollar-Ferrer, Rania M Katamish, Isabel Stillman, Sammanda Ramamoorthy, Randy D Blakel. Serotonin Transporter Ala276 Mouse: Novel Model to Assess the Neurochemical and Behavioral Impact of Thr276 Phosphorylation In Vivo. Neurochemical research. 2021-04-08. PMID:33830406. |
similarly, no genotype differences were evident in midbrain or hippocampal 5-ht levels, midbrain and hippocampal sert mrna or midbrain protein levels, nor in midbrain synaptosomal 5-ht uptake kinetics. |
2021-04-08 |
2023-08-13 |
mouse |
| Jodi L Pawluski, Rafaella Paravatou, Alan Even, Gael Cobraiville, Marianne Fillet, Nikolaos Kokras, Christina Dalla, Thierry D Charlie. Effect of sertraline on central serotonin and hippocampal plasticity in pregnant and non-pregnant rats. Neuropharmacology. vol 166. 2021-04-02. PMID:31935392. |
effect of sertraline on central serotonin and hippocampal plasticity in pregnant and non-pregnant rats. |
2021-04-02 |
2023-08-13 |
rat |
| Jodi L Pawluski, Rafaella Paravatou, Alan Even, Gael Cobraiville, Marianne Fillet, Nikolaos Kokras, Christina Dalla, Thierry D Charlie. Effect of sertraline on central serotonin and hippocampal plasticity in pregnant and non-pregnant rats. Neuropharmacology. vol 166. 2021-04-02. PMID:31935392. |
results show that pregnant females have significantly higher serum levels of sertraline compared to non-pregnant females but that rates of serotonin turnover in the hippocampus and pfc are similar between pregnant and non-pregnant females. |
2021-04-02 |
2023-08-13 |
rat |
| Nikolay N Dygalo, Tatyana S Kalinina, Galina T Shishkin. Stress-induced expression pattern of glutamate signaling genes associated with anhedonia. Stress (Amsterdam, Netherlands). vol 23. issue 6. 2021-03-24. PMID:32814471. |
main features of the expression patterns include the decrease in mrna levels for ampa and nmda subunits in the midbrain and hippocampus that is consistent with the hypothesis that "monoamine (serotonin)-glutamate/gaba long neural circuit" involved in mood regulation. |
2021-03-24 |
2023-08-13 |
human |
| Eleni Siopi, Grégoire Chevalier, Lida Katsimpardi, Soham Saha, Mathilde Bigot, Carine Moigneu, Gérard Eberl, Pierre-Marie Lled. Changes in Gut Microbiota by Chronic Stress Impair the Efficacy of Fluoxetine. Cell reports. vol 30. issue 11. 2021-03-23. PMID:32187541. |
the fecal transfer induces despair-like behavior, decreases neurogenesis in the hippocampus (hpc), and impairs the antidepressant and neurogenic effects of a standard selective serotonin (5-ht) reuptake inhibitor, fluoxetine (flx). |
2021-03-23 |
2023-08-13 |
mouse |
| Feng Zhu, Ruijin Guo, Wei Wang, Yanmei Ju, Qi Wang, Qingyan Ma, Qiang Sun, Yajuan Fan, Yuying Xie, Zai Yang, Zhuye Jie, Binbin Zhao, Liang Xiao, Lin Yang, Tao Zhang, Bing Liu, Liyang Guo, Xiaoyan He, Yunchun Chen, Ce Chen, Chengge Gao, Xun Xu, Huanming Yang, Jian Wang, Yonghui Dang, Lise Madsen, Susanne Brix, Karsten Kristiansen, Huijue Jia, Xiancang M. Transplantation of microbiota from drug-free patients with schizophrenia causes schizophrenia-like abnormal behaviors and dysregulated kynurenine metabolism in mice. Molecular psychiatry. vol 25. issue 11. 2021-03-15. PMID:31391545. |
these mice also showed elevation of the kynurenine-kynurenic acid pathway of tryptophan degradation in both periphery and brain, as well as increased basal extracellular dopamine in prefrontal cortex and 5-hydroxytryptamine in hippocampus, compared with their counterparts receiving feces from healthy controls. |
2021-03-15 |
2023-08-13 |
mouse |
| Yotam Sagi, Lucian Medrihan, Katia George, Miles Barney, Kathryn A McCabe, Paul Greengar. Emergence of 5-HT5A signaling in parvalbumin neurons mediates delayed antidepressant action. Molecular psychiatry. vol 25. issue 6. 2021-03-09. PMID:30804492. |
here we show, in mice, that hippocampal parvalbumin interneurons express functionally silent serotonin 5a receptors, which translocate to the cell membrane and become active upon chronic, but not acute, treatment with a selective serotonin reuptake inhibitor (ssri). |
2021-03-09 |
2023-08-13 |
mouse |
| Zainab Eydipour, Mohammad Nasehi, Salar Vaseghi, Seyed Hamid Jamaldini, Mohammad-Reza Zarrindas. The role of 5-HT4 serotonin receptors in the CA1 hippocampal region on memory acquisition impairment induced by total (TSD) and REM sleep deprivation (RSD). Physiology & behavior. vol 215. 2021-03-04. PMID:31863855. |
the role of 5-ht4 serotonin receptors in the ca1 hippocampal region on memory acquisition impairment induced by total (tsd) and rem sleep deprivation (rsd). |
2021-03-04 |
2023-08-13 |
Not clear |
| Melodi A Bowman, Melissa Vitela, Kyra M Clarke, Wouter Koek, Lynette C Daw. Serotonin Transporter and Plasma Membrane Monoamine Transporter Are Necessary for the Antidepressant-Like Effects of Ketamine in Mice. International journal of molecular sciences. vol 21. issue 20. 2021-02-25. PMID:33066466. |
using high-speed chronoamperometry to measure real-time clearance of serotonin from ca3 region of hippocampus in vivo, we found ketamine robustly inhibited serotonin clearance in wild-type mice, an effect that was lost in mice constitutively lacking sert or pmat. |
2021-02-25 |
2023-08-13 |
mouse |