| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Wen Shan Yang, Zhen-Guo Shi, Xian-Zhe Dong, Ping Liu, Meng-Li Chen, Yuan H. Involvement of 5-HT-BDNF signaling axis in mediating synergistic antidepressant-like effects after combined administration of two oligosaccharide esters. Food science & nutrition. vol 9. issue 2. 2021-02-19. PMID:33598202. |
moreover, combined treatment of diss and tfsa also demonstrated enhanced levels of 5-hydroxytryptamine (5-ht), and stronger increase in the phosphorylation levels of creb, bdnf, and crtc1 proteins in the hippocampus. |
2021-02-19 |
2023-08-13 |
Not clear |
| Christina Veit, Andrew M Janczak, Birgit Ranheim, Judit Vas, Anna Valros, Dale A Sandercock, Petteri Piepponen, Daniela Dulgheriu, Janicke Nordgree. The Effect of LPS and Ketoprofen on Cytokines, Brain Monoamines, and Social Behavior in Group-Housed Pigs. Frontiers in veterinary science. vol 7. 2021-02-16. PMID:33585605. |
serotonin concentrations in the hypothalamus and noradrenaline concentrations in the hippocampus of sl pigs were significantly lower compared to those in kl pigs. |
2021-02-16 |
2023-08-13 |
Not clear |
| N A Krupina, N N Khlebnikova, V B Narkevich, P L Naplekova, V S Kudri. The Levels of Monoamines and Their Metabolites in the Brain Structures of Rats Subjected to Two- and Three-Month-Long Social Isolation. Bulletin of experimental biology and medicine. vol 168. issue 5. 2021-02-03. PMID:32249401. |
two-monthlong social isolation was accompanied by a reduction in serotonin content and its increased turnover judging from the 5-hiaa/5-ht ratio in the hippocampus; three-month-long isolation was associated with increased levels of serotonin and reduction in its turnover in the amygdala. |
2021-02-03 |
2023-08-13 |
rat |
| Xiaoxia Huang, Wu Li, Bangyan You, Wanpei Tang, Tingsheng Gan, Chao Feng, Congfa Li, Ruili Yan. Serum Metabonomic Study on the Antidepressant-like Effects of Ellagic Acid in a Chronic Unpredictable Mild Stress-Induced Mouse Model. Journal of agricultural and food chemistry. vol 68. issue 35. 2021-02-03. PMID:32786855. |
furthermore, ea attenuated the cums-induced hippocampal damage and significantly increased the brain-derived neurotrophic factor (bdnf) and the serotonin (5-ht) levels as well as suppressed the inflammatory response. |
2021-02-03 |
2023-08-13 |
mouse |
| Tao Yang, Xubo Wang, Lei Liu, Hanwen Chen, Na Wan. Ginkgolide-Platinum(II) Complex GPt(II) Exhibits Therapeutic Effect on Depression in Mice via Upregulation of DA and 5-HT Neurotransmitters. Medical science monitor : international medical journal of experimental and clinical research. vol 26. 2021-02-02. PMID:32484164. |
treatment of mice with gpt(ii) significantly elevated dopamine, bdnf, and serotonin levels in hippocampus tissues. |
2021-02-02 |
2023-08-13 |
mouse |
| Javed Iqbal, Frank Adu-Nti, Xuejiao Wang, Hui Qiao, Xin-Ming M. Sex difference in depression: Which animal models mimic it. Behavioral neuroscience. vol 134. issue 3. 2021-02-01. PMID:32223277. |
furthermore, to explore the underlying mechanisms, we used quantitative reverse transcriptase polymerase chain reaction to examine and compare the messenger rna (mrna) levels of various transcripts previously shown to be involved in psychiatric disorders in rna-sequencing/microarray studies including serotonin receptor-7, early growth response-2, histone deacetylase-2, roundabout guidance receptor-2 (robo2), serum/glucocorticoid regulated kinase-2, orthodenticle homeobox-2, parathyroid hormone-2 receptor, and neuronal pas domain protein-4 in the hippocampus after exposure of rats to scvs and cums. |
2021-02-01 |
2023-08-13 |
human |
| Lixing Chen, Zengyu Yao, Shanshan Qu, Jialing Zhang, Jiping Zhang, Zhinan Zhang, Yong Huang, Zheng Zhon. Electroacupuncture improves synaptic plasticity by regulating the 5-HT1A receptor in hippocampus of rats with chronic unpredictable mild stress. The Journal of international medical research. vol 48. issue 5. 2021-02-01. PMID:32363965. |
to investigate the antidepressant effects of electroacupuncture (ea) on chronic unpredictable mild stress (cums) in rats, as well as the effects of ea on hippocampal neurons, synaptic morphology, and 5-hydroxytryptamine (ht) receptor expression. |
2021-02-01 |
2023-08-13 |
rat |
| Salma A El-Marasy, Sally A El Awdan, Azza Hassan, Omar A Ahmed-Farid, Hanan A Ogal. Anti-depressant effect of cerebrolysin in reserpine-induced depression in rats: Behavioral, biochemical, molecular and immunohistochemical evidence. Chemico-biological interactions. vol 334. 2021-01-25. PMID:33279466. |
cbl elevated nor-epinephrine (ne), serotonin (5-ht), and dopamine (da) and reduced 5-hydroxyindoleacetic acid (5-htaa), 3,4-dihydroxyphenylacetic acid (dopac), and homovanillic acid (hva) cortical and hippocampal contents. |
2021-01-25 |
2023-08-13 |
rat |
| J M Carpenter, H E Gordon, H D Ludwig, J J Wagner, D A Harn, T Norberg, N M Filipo. Neurochemical and neuroinflammatory perturbations in two Gulf War Illness models: Modulation by the immunotherapeutic LNFPIII. Neurotoxicology. vol 77. 2021-01-22. PMID:31866310. |
serotonergic (5-ht) and dopaminergic (da) dyshomeostasis caused by gwi chemicals was apparent in multiple brain regions, primarily in the nucleus accumbens (5-ht) and hippocampus (5-ht, da) for both models. |
2021-01-22 |
2023-08-13 |
mouse |
| Ning Jiang, Hong Huang, Haixia Wang, Jingwei Lv, Guirong Zeng, Qiong Wang, Yu Bao, Ying Chen, Xin-Min Li. The antidepressant-like effects of Shen Yuan: Dependence on hippocampal BDNF-TrkB signaling activation in chronic social defeat depression-like mice. Phytotherapy research : PTR. 2021-01-21. PMID:33474783. |
sy decreased the serum levels of cort and increased hippocampal neurotransmitters (5-ht, da, and ne) in csds mice. |
2021-01-21 |
2023-08-13 |
mouse |
| Mennat-Allah M Hassan, Amany M Gad, Esther T Menze, Osama A Badary, Reem N El-Nag. Protective effects of morin against depressive-like behavior prompted by chronic unpredictable mild stress in rats: Possible role of inflammasome-related pathways. Biochemical pharmacology. vol 180. 2021-01-11. PMID:32652141. |
the morin-treated groups showed a great improvement in the biochemical parameters in both the cortex and hippocampus, where it significantly elevated the serotonin, epinephrine, and norepinephrine levels. |
2021-01-11 |
2023-08-13 |
rat |
| Katsunori Kobayashi, Yasunori Mikahara, Yuka Murata, Daiki Morita, Sumire Matsuura, Eri Segi-Nishida, Hidenori Suzuk. Predominant Role of Serotonin at the Hippocampal Mossy Fiber Synapse with Redundant Monoaminergic Modulation. iScience. vol 23. issue 4. 2021-01-10. PMID:32283526. |
predominant role of serotonin at the hippocampal mossy fiber synapse with redundant monoaminergic modulation. |
2021-01-10 |
2023-08-13 |
mouse |
| Katsunori Kobayashi, Yasunori Mikahara, Yuka Murata, Daiki Morita, Sumire Matsuura, Eri Segi-Nishida, Hidenori Suzuk. Predominant Role of Serotonin at the Hippocampal Mossy Fiber Synapse with Redundant Monoaminergic Modulation. iScience. vol 23. issue 4. 2021-01-10. PMID:32283526. |
we here show that endogenous monoamines can potentiate mf synaptic transmission in mouse hippocampal slices by activating the serotonin 5-ht |
2021-01-10 |
2023-08-13 |
mouse |
| Mei Huang, Wenqi He, Lakshmi Rajagopal, Andrea Kudwa, Dimitri E Grigoriadis, Herbert Y Meltze. Effects of NBI-98782, a selective vesicular monoamine transporter 2 (VMAT2) inhibitor, on neurotransmitter efflux and phencyclidine-induced locomotor activity: Relevance to tardive dyskinesia and antipsychotic action. Pharmacology, biochemistry, and behavior. vol 190. 2021-01-07. PMID:32084491. |
acute nbi-98782 and tetrabenazine decreased mpfc, dstr, hippocampus, and nac da, 5-ht, and ne efflux, while increasing that of dopac, hva, and 5-hiaa. |
2021-01-07 |
2023-08-13 |
mouse |
| Yi-Fan Jiang, Jian Liu, Jie Yang, Yuan Guo, Wei Hu, Jin Zhang, Xue-Mei La, Wen Xie, Hui-Sheng Wang, Li Zhan. Involvement of the Dorsal Hippocampus 5-HT1A Receptors in the Regulation of Depressive-Like Behaviors in Hemiparkinsonian Rats. Neuropsychobiology. vol 79. issue 3. 2021-01-04. PMID:31940619. |
lines of evidence have indicated that the hippocampus and serotonin 1a (5-ht1a) receptors are related to the regulation of depression. |
2021-01-04 |
2023-08-13 |
rat |
| Mariana de Souza Aranha Garcia-Gomes, Dennis Albert Zanatto, Orfa Yineth Galvis-Alonso, Jorge Mejia, Ana Tada Fonseca Brasil Antiorio, Pedro Kenzo Yamamoto, Márcia Carolina Millán Olivato, Thaísa Meira Sandini, Jorge Camilo Flório, Ivo Lebrun, Silvia Maria Gomes Massironi, Sandra Regina Alexandre-Ribeiro, Maria Martha Bernardi, Susan Ienne, Tiago Antonio de Souza, Maria Lúcia Zaidan Dagli, Claudia Madalena Cabrera Mor. Behavioral and neurochemical characterization of the spontaneous mutation tremor, a new mouse model of audiogenic seizures. Epilepsy & behavior : E&B. vol 105. 2020-12-29. PMID:32109856. |
comparing with wild type (wt) mice, the tremor mice showed higher hippocampal gene expression of egr3 and gabra1 and increased concentrations of noradrenalin (nor; p = .0012), serotonin (5ht; p = .0083), 5-hydroxyindoleacetic acid (5-hiaa; p = .0032), γ-amino butyric acid (gaba; p = .0123), glutamate (p = .0217) and aspartate (p = .0124). |
2020-12-29 |
2023-08-13 |
mouse |
| Suhyeon Kim, Ki-Bae Hong, Singeun Kim, Hyung Joo Suh, Kyungae J. Creatine and taurine mixtures alleviate depressive-like behaviour in Drosophila melanogaster and mice via regulating Akt and ERK/BDNF pathways. Scientific reports. vol 10. issue 1. 2020-12-21. PMID:32647316. |
in behavioural assessments, movement and sucrose preference of the cre/tau group increased to a similar level as in the positive control group; hippocampal catecholamine and serotonin levels increased significantly. |
2020-12-21 |
2023-08-13 |
mouse |
| Brittany E Dong, Hao Chen, Kazuko Sakat. BDNF deficiency and enriched environment treatment affect neurotransmitter gene expression differently across ages. Journal of neurochemistry. vol 154. issue 1. 2020-12-04. PMID:32222968. |
high-throughput quantitative reverse transcription polymerase chain reaction measured expression of 81 genes for dopamine, adrenaline, serotonin, gamma aminobutyric acid, glutamate, acetylcholine, and bdnf systems in the frontal cortex (fc) and hippocampus. |
2020-12-04 |
2023-08-13 |
mouse |
| Zhilan Peng, Cai Zhang, Ling Yan, Yongping Zhang, Zhiyou Yang, Jiajia Wang, Cai Son. EPA is More Effective than DHA to Improve Depression-Like Behavior, Glia Cell Dysfunction and Hippcampal Apoptosis Signaling in a Chronic Stress-Induced Rat Model of Depression. International journal of molecular sciences. vol 21. issue 5. 2020-12-01. PMID:32150824. |
lower hippocampal noradrenaline and 5-hydroxytryptamine concentrations in cums rats were also reversed by both epa and dha supplement. |
2020-12-01 |
2023-08-13 |
rat |
| Christopher B German. The Psilocybin-Telomere Hypothesis: An empirically falsifiable prediction concerning the beneficial neuropsychopharmacological effects of psilocybin on genetic aging. Medical hypotheses. vol 134. 2020-11-23. PMID:31634774. |
in order to substantiate the 'psilocybin-telomere hypothesis' potential neuropsychopharmacological, endocrinological, and genetic mechanisms of action are discussed (e.g., hpa-axis reactivity, hippocampal neurogenesis, neurotropic growth factors such as bdnf, 5-ht |
2020-11-23 |
2023-08-13 |
human |