| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Michelle M Karth, Brittany J Baugher, Nicole Daly, Melinda D Karth, Stephen C Gironda, Benjamin D Sach. Brain 5-HT Deficiency Prevents Antidepressant-Like Effects of High-Fat-Diet and Blocks High-Fat-Diet-Induced GSK3β Phosphorylation in the Hippocampus. Frontiers in molecular neuroscience. vol 12. 2020-09-30. PMID:31920532. |
however, genetic brain 5-ht deficiency blocks hfd-induced reductions in forced swim immobility and prevents hfd-induced increases in hippocampal gsk3β phosphorylation despite having no significant effects on hfd-induced changes in body weight or anxiety-like behavior. |
2020-09-30 |
2023-08-13 |
mouse |
| Jun Zhao, Huiling Tian, Hongtao Song, Xu Wang, Tong Luo, Liya Ai, Yumin Fang, Jianghao Zhao, Saiyin Chao-Ke-Tu, Zhigang L. Effect of Electroacupuncture on Reuptake of Serotonin via miRNA-16 Expression in a Rat Model of Depression. Evidence-based complementary and alternative medicine : eCAM. vol 2019. 2020-09-30. PMID:31929820. |
the current study aimed to investigate the effects and mechanisms of electroacupuncture (ea) treatment applied to bai hui (gv20) and yin tang (gv29) acupoints (1 ma, 2 hz, continuous wave, 20 minutes) for 28 days in a rat model of chronic unpredictable mild stress (cums) on reuptake of serotonin (5-hydroxytryptamine (5-ht)) and mirna-16 levels in the hippocampus and serum. |
2020-09-30 |
2023-08-13 |
rat |
| Jun Zhao, Huiling Tian, Hongtao Song, Xu Wang, Tong Luo, Liya Ai, Yumin Fang, Jianghao Zhao, Saiyin Chao-Ke-Tu, Zhigang L. Effect of Electroacupuncture on Reuptake of Serotonin via miRNA-16 Expression in a Rat Model of Depression. Evidence-based complementary and alternative medicine : eCAM. vol 2019. 2020-09-30. PMID:31929820. |
after ea treatment for 4 weeks, behavioral changes and indices including 5-ht transporter (sert), 5-ht, and mirna-16 levels in the hippocampus and serum were examined. |
2020-09-30 |
2023-08-13 |
rat |
| Jun Zhao, Huiling Tian, Hongtao Song, Xu Wang, Tong Luo, Liya Ai, Yumin Fang, Jianghao Zhao, Saiyin Chao-Ke-Tu, Zhigang L. Effect of Electroacupuncture on Reuptake of Serotonin via miRNA-16 Expression in a Rat Model of Depression. Evidence-based complementary and alternative medicine : eCAM. vol 2019. 2020-09-30. PMID:31929820. |
significantly increased 5-ht levels were observed, and mirna-16 levels were significantly decreased in the hippocampus and serum of depressed rats. |
2020-09-30 |
2023-08-13 |
rat |
| Jun Zhao, Huiling Tian, Hongtao Song, Xu Wang, Tong Luo, Liya Ai, Yumin Fang, Jianghao Zhao, Saiyin Chao-Ke-Tu, Zhigang L. Effect of Electroacupuncture on Reuptake of Serotonin via miRNA-16 Expression in a Rat Model of Depression. Evidence-based complementary and alternative medicine : eCAM. vol 2019. 2020-09-30. PMID:31929820. |
in conclusion, the antidepressant effects of ea treatment may be affected via inhibition of 5-ht reuptake, upregulation of 5-ht levels, and inhibition of mirna-16 expression in the hippocampus and serum. |
2020-09-30 |
2023-08-13 |
rat |
| Efstathios Garoflos, Theofanis Panagiotaropoulos, Stavroula Pondiki, Antonios Stamatakis, Eleni Philippidis, Fotini Stylianopoulo. Cellular mechanisms underlying the effects of an early experience on cognitive abilities and affective states. Annals of general psychiatry. vol 4. 2020-09-29. PMID:15876359. |
in the present study we investigated the effects of neonatal handling, an animal model of early experience, on spatial learning and memory, on hippocampal glucocorticoid (gr), mineralocorticoid (mr) and type 1a serotonin (5-ht1a) receptors, as well as brain derived neurotrophic factor (bdnf), and on circulating leptin levels, of male rats. |
2020-09-29 |
2023-08-12 |
rat |
| Charles V Vorhees, Devon L Graham, Robyn M Amos-Kroohs, Amanda A Braun, Curtis E Grace, Tori L Schaefer, Matthew R Skelton, Keith M Erikson, Michael Aschner, Michael T William. Effects of developmental manganese, stress, and the combination of both on monoamines, growth, and corticosterone. Toxicology reports. vol 1. 2020-09-29. PMID:25574457. |
mn increased hippocampal dopamine at p11 and p29 and 5-ht at p29 regardless of housing or sex. |
2020-09-29 |
2023-08-13 |
rat |
| Liping Huang, Minzhen Deng, Yongqi Fang, Ling L. Dynamic changes of five neurotransmitters and their related enzymes in various rat tissues following β-asarone and levodopa co-administration. Experimental and therapeutic medicine. vol 10. issue 4. 2020-09-29. PMID:26622527. |
by contrast, no statistically significant differences were observed in the serotonin (5-ht) levels among the plasma, hippocampus, cortex and striatum. |
2020-09-29 |
2023-08-13 |
rat |
| Mario F Juruena, Bruno Agustini, Anthony J Cleare, Allan H Youn. A translational approach to clinical practice via stress-responsive glucocorticoid receptor signaling. Stem cell investigation. vol 4. 2020-09-29. PMID:28275643. |
there is evidence that the expression and function of gr in the hippocampus, mainly mr, is regulated by the stimulation of 5-ht receptors. |
2020-09-29 |
2023-08-13 |
human |
| Mario F Juruena, Bruno Agustini, Anthony J Cleare, Allan H Youn. A translational approach to clinical practice via stress-responsive glucocorticoid receptor signaling. Stem cell investigation. vol 4. 2020-09-29. PMID:28275643. |
stressful stimuli increase 5-ht release and turnover in the hippocampus, and it seems reasonable to suggest that some of the changes in mineralocorticoid and gr expression may be mediated, in part at least, by the increase in 5-ht. |
2020-09-29 |
2023-08-13 |
human |
| Yong Xu, Lei Ma, Wei Jiang, Yuhong Li, Gang Wang, Rena L. Study of Sex Differences in Duloxetine Efficacy for Depression in Transgenic Mouse Models. Frontiers in cellular neuroscience. vol 11. 2020-09-29. PMID:29163055. |
we also measured the sex-specific effect of duloxetine on dopamine and serotonin (5-ht) metabolisms in frontal cortex and hippocampus (hpc). |
2020-09-29 |
2023-08-13 |
mouse |
| Ying-Cong Yu, Jing Li, Meixi Zhang, Jian-Chun Pan, Ying Yu, Jian-Bo Zhang, Liang Zheng, Jian-Min Si, Ying X. Resveratrol Improves Brain-Gut Axis by Regulation of 5-HT-Dependent Signaling in the Rat Model of Irritable Bowel Syndrome. Frontiers in cellular neuroscience. vol 13. 2020-09-29. PMID:30800058. |
these abnormalities were accompanied by reduced 5-hydroxytryptamine (5-ht) level in the hippocampus and increased 5-ht expression in the gut (ileum and colon) after cacs. |
2020-09-29 |
2023-08-13 |
rat |
| Fauziah Nuraini Kurdi, Rostika Flor. Physical Exercise Increased Brain-Derived Neurotrophic Factor in Elderly Population with Depression. Open access Macedonian journal of medical sciences. vol 7. issue 13. 2020-09-29. PMID:31456825. |
brain-derived neurotrophic factor (bdnf) plays a role in maintaining the survival of neuronal cells and in the regulation of synapse plasticity, affecting serotonin production in the hippocampus and thus the depressive symptoms. |
2020-09-29 |
2023-08-13 |
Not clear |
| Meng Yu, Hong-Mei Jia, Tao Zhang, Hai Shang, Hong-Wu Zhang, Li-Yan Ma, Zhong-Mei Zo. Gut Microbiota is the Key to the Antidepressant Effect of Chaihu-Shu-Gan-San. Metabolites. vol 10. issue 2. 2020-09-28. PMID:32050718. |
the mediation of csgs on hippocampal levels of serotonin (5-ht) and glutamic acid (glu) was also receded with the antibiotic treatment. |
2020-09-28 |
2023-08-13 |
rat |
| N V Kudryashov, T S Kalinina, A A Shimshirt, A V Volkova, V B Narkevich, P L Naplekova, K A Kasabov, V S Kudrin, T A Voronina, V P Fisenk. The Behavioral and Neurochemical Aspects of the Interaction between Antidepressants and Unpredictable Chronic Mild Stress. Acta naturae. vol 12. issue 1. 2020-09-28. PMID:32477600. |
after a 28-day exposure to stress, we observed an increase in depressive reaction in a forced swim test in mice, as well as reduced hippocampal levels of serotonin (5-hydroxytryptamine, 5-ht) and 5-hydroxyindoleacetic acid (5-hiaa) and an increased hypothalamic level of noradrenaline (na). |
2020-09-28 |
2023-08-13 |
mouse |
| N V Kudryashov, T S Kalinina, A A Shimshirt, A V Volkova, V B Narkevich, P L Naplekova, K A Kasabov, V S Kudrin, T A Voronina, V P Fisenk. The Behavioral and Neurochemical Aspects of the Interaction between Antidepressants and Unpredictable Chronic Mild Stress. Acta naturae. vol 12. issue 1. 2020-09-28. PMID:32477600. |
the antidepressant-like effect of fluoxetine - but not of amitriptyline - after a single injection coincided with an increase in the 5-ht turnover in the hippocampus. |
2020-09-28 |
2023-08-13 |
mouse |
| Juan C Brenes, Jaime Fornaguera, Andrey Sequeira-Corder. Environmental Enrichment and Physical Exercise Attenuate the Depressive-Like Effects Induced by Social Isolation Stress in Rats. Frontiers in pharmacology. vol 11. 2020-09-28. PMID:32547399. |
afterward, the hippocampal serotonin contents, its metabolite, and turnover were measured. |
2020-09-28 |
2023-08-13 |
rat |
| Héctor González-Pardo, Jorge L Arias, Eneritz Gómez-Lázaro, Isabel López Taboada, Nélida M Conej. Sex-Specific Effects of Early Life Stress on Brain Mitochondrial Function, Monoamine Levels and Neuroinflammation. Brain sciences. vol 10. issue 7. 2020-09-28. PMID:32674298. |
in addition, ms males had lower serotonin levels and increased serotonin turnover in the prefrontal cortex and the hippocampus. |
2020-09-28 |
2023-08-13 |
rat |
| Sang-Seo Park, Hye-Sang Park, Tae-Woon Kim, Sam-Jun Le. Effects of swimming exercise on social isolation-induced memory impairment and apoptosis in old rats. Journal of exercise rehabilitation. vol 16. issue 3. 2020-09-28. PMID:32724780. |
immunohistochemistry for tryptophan hydroxylase (tph) and 5-ht in the dorsal raphe and for doublecortin (dcx) in the hippocampal dentate gyrus was conducted. |
2020-09-28 |
2023-08-13 |
rat |
| Xiao-Juan Ren, Qing-Quan Wang, Xing-Ping Zhang, Guan-Ying Wang, Tao Liu, Ning Deng, De-Qi Ya. Establishment of a rat model with ageing insomnia induced by D-galactosef and para-chlorophenylalanine. Experimental and therapeutic medicine. vol 20. issue 4. 2020-09-28. PMID:32855692. |
the relative expression of hippocampal il-6, tnf-α, nf-κb and mglur2 mrna of the pcpa+d-gal-induced ageing insomnia group was higher, while the relative expression of 5-ht |
2020-09-28 |
2023-08-13 |
rat |