| Reference |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yuji Odagaki, Ryoichi Toyoshima, Toshio Yamauch. Trazodone and its active metabolite m-chlorophenylpiperazine as partial agonists at 5-HT1A receptors assessed by [35S]GTPgammaS binding. Journal of psychopharmacology (Oxford, England) vol 19 issue 3 2005 15888508 |
these effects were replicated in the 5-ht(1a) receptor-mediated [(35)s]gtpgamma(s) binding assay in native rat brain membranes (at least in hippocampal membranes), although the intrinsic activities of the compounds were low and differently ranked compared to those in cho/h5-ht(1a) cell membranes. |
2005-06-27 |
2022-01-12 |
Not clear |
| Izuru Matsumoto, Yuki Inoue, Takeshi Iwazaki, Geoff Pavey, Brian Dea. 5-HT2A and muscarinic receptors in schizophrenia: a postmortem study. Neuroscience letters vol 379 issue 3 2005 15843056 |
quantitative autoradiography was employed to measure [(3)h]ketanserin binding to 5-ht(2a) receptors and [(3)h]pirenzepine binding to both m1 and m4 receptors in brodmann's area 9 (ba9), caudate/putamen, and the hippocampal formation from six schizophrenic and six control subjects. |
2005-06-24 |
2022-01-13 |
Not clear |
| Claus Normann, Kristin Clar. Selective modulation of Ca(2+) influx pathways by 5-HT regulates synaptic long-term plasticity in the hippocampus. Brain research vol 1037 issue 1-2 2005 15777768 |
in patch-clamp experiments on hippocampal brain slices, we tested the modulation of different forms of synaptic plasticity by the neurotransmitter serotonin (5-ht) which is known to inhibit high-voltage activated ca(2+) channels. |
2005-06-16 |
2022-01-12 |
Not clear |
| Romina Soledad Almir\\xc3\\xb3n, Oscar Angel Ram\\xc3\\xadre. Participation of dorsal raphe nucleus in the behavioral alteration observed after discontinuation of chronic diazepam administration: possible neural circuitry involved. Synapse (New York, N.Y.) vol 56 issue 2 2005 15714479 |
in the present study, we investigated the involvement of the serotonergic (5-ht) system in the possible neural circuitry recruited during dz withdrawal and in the increased hippocampal synaptic plasticity associated with the discontinuation of chronic dz administration. |
2005-06-06 |
2022-01-12 |
Not clear |
| Romina Soledad Almir\\xc3\\xb3n, Oscar Angel Ram\\xc3\\xadre. Participation of dorsal raphe nucleus in the behavioral alteration observed after discontinuation of chronic diazepam administration: possible neural circuitry involved. Synapse (New York, N.Y.) vol 56 issue 2 2005 15714479 |
these results are discussed in terms of the participation of 5-ht system in the modulation of hippocampal plasticity developed on dz withdrawal. |
2005-06-06 |
2022-01-12 |
Not clear |
| Klaus Lieb, Lisa Biersack, Anne Waschbisch, Sonja Orlikowski, Ravi Shankar Akundi, Eduardo Candelario-Jalil, Michael H\\xc3\\xbcll, Bernd L Fiebic. Serotonin via 5-HT7 receptors activates p38 mitogen-activated protein kinase and protein kinase C epsilon resulting in interleukin-6 synthesis in human U373 MG astrocytoma cells. Journal of neurochemistry vol 93 issue 3 2005 15836614 |
previously, it has been demonstrated that 5-ht may induce interleukin (il)-6 expression in primary rat hippocampal astrocytes. |
2005-06-03 |
2022-01-12 |
Not clear |
| Anna Pittaluga, Daniela Segantini, Marco Feligioni, Maurizio Raiter. Extracellular protons differentially potentiate the responses of native AMPA receptor subtypes regulating neurotransmitter release. British journal of pharmacology vol 144 issue 2 2005 15665865 |
the effects of ph changes on the basal and evoked release of [(3)h]noradrenaline ([(3)h]na) and [(3)h]5-hydrohytryptamine ([(3)h]5-ht) from hippocampal synaptosomes and of [(3)h]dopamine ([(3)h]da) and [(3)h]acetylcholine ([(3)h]ach) from striatal and cortical synaptosomes were investigated in rat brain. |
2005-05-31 |
2022-01-12 |
Not clear |
| Martin E Keck, Simone B Sartori, Tobias Welt, Marianne B M\\xc3\\xbcller, Frauke Ohl, Florian Holsboer, Rainer Landgraf, Nicolas Singewal. Differences in serotonergic neurotransmission between rats displaying high or low anxiety/depression-like behaviour: effects of chronic paroxetine treatment. Journal of neurochemistry vol 92 issue 5 2005 15715667 |
hippocampal serotonin 1 a (5-ht1a) receptor mrna expression was reduced in hab rats, whereas 5-ht concentrations in hippocampal microdialysates did not differ between hab and lab rats under basal conditions. |
2005-04-28 |
2022-01-12 |
Not clear |
| Martin E Keck, Simone B Sartori, Tobias Welt, Marianne B M\\xc3\\xbcller, Frauke Ohl, Florian Holsboer, Rainer Landgraf, Nicolas Singewal. Differences in serotonergic neurotransmission between rats displaying high or low anxiety/depression-like behaviour: effects of chronic paroxetine treatment. Journal of neurochemistry vol 92 issue 5 2005 15715667 |
chronic paroxetine treatment markedly increased the stress-induced rise in hippocampal 5-ht in hab, but not lab rats. |
2005-04-28 |
2022-01-12 |
Not clear |
| Martin E Keck, Simone B Sartori, Tobias Welt, Marianne B M\\xc3\\xbcller, Frauke Ohl, Florian Holsboer, Rainer Landgraf, Nicolas Singewal. Differences in serotonergic neurotransmission between rats displaying high or low anxiety/depression-like behaviour: effects of chronic paroxetine treatment. Journal of neurochemistry vol 92 issue 5 2005 15715667 |
the findings indicate reduced hippocampal serotonergic transmission in hab rats as compared with lab rats, which is evident both at the presynaptic (5-ht release) and the postsynaptic (5-ht1a receptor) level. |
2005-04-28 |
2022-01-12 |
Not clear |
| Brian H Harvey, Carla Naciti, Linda Brand, Dan J Stei. Serotonin and stress: protective or malevolent actions in the biobehavioral response to repeated trauma? Annals of the New York Academy of Sciences vol 1032 issue 2005 15677425 |
pcpa, however, reversed stress-induced hippocampal 5ht(1a) receptor affinity changes, with flx narrowly missing significance. |
2005-04-19 |
2022-01-12 |
Not clear |
| Brian H Harvey, Carla Naciti, Linda Brand, Dan J Stei. Serotonin and stress: protective or malevolent actions in the biobehavioral response to repeated trauma? Annals of the New York Academy of Sciences vol 1032 issue 2005 15677425 |
that raised 5ht activity may mediate hippocampal 5ht(1a) receptor changes evoked by stress suggests a bidirectional role for 5ht in the development of ptsd. |
2005-04-19 |
2022-01-12 |
Not clear |
| Richard McQuade, Mel M Leitch, Sarah E Gartside, Allan H Youn. Effect of chronic lithium treatment on glucocorticoid and 5-HT1A receptor messenger RNA in hippocampal and dorsal raphe nucleus regions of the rat brain. Journal of psychopharmacology (Oxford, England) vol 18 issue 4 2005 15582915 |
chronic administration of lithium decreased mrna coding for post-synaptic 5-ht(1a) receptors in hippocampal subregions but not for somatodentritic 5-ht(1a) receptors in the dorsal raphe nucleus. |
2005-04-12 |
2022-01-12 |
Not clear |
| Laurent Bardin, Marie-Bernadette Assi\\xc3\\xa9, Martine P\\xc3\\xa9lissou, Isabelle Royer-Urios, Adrian Newman-Tancredi, Jean-Paul Ribet, Fran\\xc3\\xa7ois Sautel, Wouter Koek, Francis C Colpaer. Dual, hyperalgesic, and analgesic effects of the high-efficacy 5-hydroxytryptamine 1A (5-HT1A) agonist F 13640 [(3-chloro-4-fluoro-phenyl)-[4-fluoro-4-{[(5-methyl-pyridin-2-ylmethyl)-amino]-methyl}piperidin-1-yl]methanone, fumaric acid salt]: relationship with 5-HT1A receptor occupancy and kinetic parameters. The Journal of pharmacology and experimental therapeutics vol 312 issue 3 2005 15528450 |
administration of 0.63 mg/kg was obtained at 15 min and decreased to half its maximal value after about 1 h. the amount of f 13640 collected by means of in vivo microdialysis in hippocampal dialysates could be measured reliably after 0.63 and 2.5 mg/kg, reached its maximum at about 1 h, and fell to half of its maximal value at about 3 h. 5-hydroxytryptamine 1a (5-ht(1a)) receptor occupancy was estimated by ex vivo binding in rat brain sections. |
2005-04-05 |
2022-01-12 |
Not clear |
| Mathieu Wolff, Pierre Costet, Cornelius Gross, Ren\\xc3\\xa9 Hen, Louis Segu, Marie-Christine Buho. Age-dependent effects of serotonin-1A receptor gene deletion in spatial learning abilities in mice. Brain research. Molecular brain research vol 130 issue 1-2 2005 15519675 |
the serotonin (5-hydroxytryptamine, 5-ht) receptor 1a is involved in many physiological functions, including the regulation of learning and memory by acting either as an autoreceptor located on 5-ht neurons (raphe nuclei) or as a heteroreceptor on non-5-ht neurons, mainly in the hippocampal formation. |
2005-03-30 |
2022-01-12 |
Not clear |
| P Weikop, J Kehr, J Scheel-Kr\\xc3\\xbcge. The role of alpha1- and alpha2-adrenoreceptors on venlafaxine-induced elevation of extracellular serotonin, noradrenaline and dopamine levels in the rat prefrontal cortex and hippocampus. Journal of psychopharmacology (Oxford, England) vol 18 issue 3 2005 15358984 |
the role of adrenergic alpha1- and alpha2-adrenoreceptors in augmentation of venlafaxine-induced elevation of extracellular serotonin (5-ht),noradrenaline (na) and dopamine (da) levels in the rat prefrontal cortex (pfc) and hippocampus (hipp) was studied by in vivo microdialysis in anaesthetized rats. |
2005-03-17 |
2022-01-12 |
Not clear |
| P Weikop, J Kehr, J Scheel-Kr\\xc3\\xbcge. The role of alpha1- and alpha2-adrenoreceptors on venlafaxine-induced elevation of extracellular serotonin, noradrenaline and dopamine levels in the rat prefrontal cortex and hippocampus. Journal of psychopharmacology (Oxford, England) vol 18 issue 3 2005 15358984 |
the alpha1-adrenoreceptor antagonist prazosin given alone (0.3 mg/kg, s.c.) induced only a moderate reduction of hippocampal 5-ht and na levels. |
2005-03-17 |
2022-01-12 |
Not clear |
| P Weikop, J Kehr, J Scheel-Kr\\xc3\\xbcge. The role of alpha1- and alpha2-adrenoreceptors on venlafaxine-induced elevation of extracellular serotonin, noradrenaline and dopamine levels in the rat prefrontal cortex and hippocampus. Journal of psychopharmacology (Oxford, England) vol 18 issue 3 2005 15358984 |
the levels of 5-ht increased to 310%, an effect approximately twice the effect on na in the hipp. |
2005-03-17 |
2022-01-12 |
Not clear |
| P Weikop, J Kehr, J Scheel-Kr\\xc3\\xbcge. The role of alpha1- and alpha2-adrenoreceptors on venlafaxine-induced elevation of extracellular serotonin, noradrenaline and dopamine levels in the rat prefrontal cortex and hippocampus. Journal of psychopharmacology (Oxford, England) vol 18 issue 3 2005 15358984 |
pre-treatment with prazosin caused a significant attenuation of the venlafaxine induced 5-ht effect in the pfc, and a moderate increase in da levels in the hipp. |
2005-03-17 |
2022-01-12 |
Not clear |
| P Weikop, J Kehr, J Scheel-Kr\\xc3\\xbcge. The role of alpha1- and alpha2-adrenoreceptors on venlafaxine-induced elevation of extracellular serotonin, noradrenaline and dopamine levels in the rat prefrontal cortex and hippocampus. Journal of psychopharmacology (Oxford, England) vol 18 issue 3 2005 15358984 |
idazoxan had no effect on venlafaxine-induced elevation of extracellular 5-ht levels in either pfc or hipp and prazosin induced a decrease of 5-ht in the pfc. |
2005-03-17 |
2022-01-12 |
Not clear |