| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Giacomo Maddaloni, Sara Migliarini, Francesco Napolitano, Andrea Giorgi, Serena Nazzi, Daniele Biasci, Alessia De Felice, Marta Gritti, Anna Cavaccini, Alberto Galbusera, Sara Franceschi, Francesca Lessi, Marco La Ferla, Paolo Aretini, Chiara Maria Mazzanti, Raffaella Tonini, Alessandro Gozzi, Alessandro Usiello, Massimo Pasqualett. Serotonin depletion causes valproate-responsive manic-like condition and increased hippocampal neuroplasticity that are reversed by stress. Scientific reports. vol 8. issue 1. 2019-11-18. PMID:30087403. |
serotonin depletion causes valproate-responsive manic-like condition and increased hippocampal neuroplasticity that are reversed by stress. |
2019-11-18 |
2023-08-13 |
mouse |
| Giacomo Maddaloni, Sara Migliarini, Francesco Napolitano, Andrea Giorgi, Serena Nazzi, Daniele Biasci, Alessia De Felice, Marta Gritti, Anna Cavaccini, Alberto Galbusera, Sara Franceschi, Francesca Lessi, Marco La Ferla, Paolo Aretini, Chiara Maria Mazzanti, Raffaella Tonini, Alessandro Gozzi, Alessandro Usiello, Massimo Pasqualett. Serotonin depletion causes valproate-responsive manic-like condition and increased hippocampal neuroplasticity that are reversed by stress. Scientific reports. vol 8. issue 1. 2019-11-18. PMID:30087403. |
this work tests the hypothesis that the neurotransmitter serotonin (5-ht) is a key determinant of hippocampal neuroplasticity, and its absence leads to maladaptive behaviour relevant for bd. |
2019-11-18 |
2023-08-13 |
mouse |
| Giacomo Maddaloni, Sara Migliarini, Francesco Napolitano, Andrea Giorgi, Serena Nazzi, Daniele Biasci, Alessia De Felice, Marta Gritti, Anna Cavaccini, Alberto Galbusera, Sara Franceschi, Francesca Lessi, Marco La Ferla, Paolo Aretini, Chiara Maria Mazzanti, Raffaella Tonini, Alessandro Gozzi, Alessandro Usiello, Massimo Pasqualett. Serotonin depletion causes valproate-responsive manic-like condition and increased hippocampal neuroplasticity that are reversed by stress. Scientific reports. vol 8. issue 1. 2019-11-18. PMID:30087403. |
these findings delineate 5-ht as a critical determinant in bd associated maladaptive emotional responses and aberrant hippocampal neuroplasticity, and support the use of tph2-/- mice as a new research tool for mechanistic and therapeutic research in bipolar disorder. |
2019-11-18 |
2023-08-13 |
mouse |
| Amal Ahmed Abd El-Fattah, Atef Tadros Fahim, Nermin Abdel Hamid Sadik, Bassam Mohamed Al. Resveratrol and dimethyl fumarate ameliorate depression-like behaviour in a rat model of chronic unpredictable mild stress. Brain research. vol 1701. 2019-11-04. PMID:30244113. |
the depressive-like behaviour of rats induced by cums was revealed by an elevated serum corticosterone level and decreased serum and hippocampal serotonin levels. |
2019-11-04 |
2023-08-13 |
rat |
| Marcelo Gomes de Gomes, Leandro Cattelan Souza, André Rossito Goes, Lucian Del Fabbro, Carlos Borges Filho, Franciele Donato, Marina Prigol, Cristiane Luchese, Silvane Souza Roman, Robson Luiz Puntel, Silvana Peterini Boeira, Cristiano Ricardo Jess. Fish oil ameliorates sickness behavior induced by lipopolysaccharide in aged mice through the modulation of kynurenine pathway. The Journal of nutritional biochemistry. vol 58. 2019-10-28. PMID:29870875. |
moreover, we evaluated the ability of fo treatment on the regulation of neuroinflammation (levels of interleukin-1β, interleukin-6, tumor factor necrosis-α and interferon-γ), kp biomarkers (levels of tryptophan, kynurenine, kynurenic acid, 3-hydroxykynurenine and quinolinic acid and activities of indoleamine-2,3-dioxygenase, kynurenine monooxygenase and kynurenine aminotransferase) and serotonergic system (levels of serotonin and 5-hydroxyindoleactic acid) in the hippocampus, striatum and prefrontal cortex of lps-treated mice. |
2019-10-28 |
2023-08-13 |
mouse |
| Jenna L N Sprowles, Robyn M Amos-Kroohs, Amanda A Braun, Chiho Sugimoto, Charles V Vorhees, Michael T William. Developmental manganese, lead, and barren cage exposure have adverse long-term neurocognitive, behavioral and monoamine effects in Sprague-Dawley rats. Neurotoxicology and teratology. vol 67. 2019-10-25. PMID:29631003. |
pb altered neostriatal serotonin and norepinephrine, mn increased hippocampal serotonin in males, mn + barren-rearing increased neostriatal serotonin, and barren-rearing decreased neostriatal dopamine in males. |
2019-10-25 |
2023-08-13 |
rat |
| Vishnu N Thakare, Rajesh R Patil, Rajesh J Oswal, Valmik D Dhakane, Manoj K Aswar, Bhoomika M Pate. Therapeutic potential of silymarin in chronic unpredictable mild stress induced depressive-like behavior in mice. Journal of psychopharmacology (Oxford, England). vol 32. issue 2. 2019-10-24. PMID:29215318. |
in addition, neurobiochemical alterations, mainly monoamines, 5-ht, ne, da, neurotrophic factor bdnf, and cytokines, il-6, tnf-α, oxidant-antioxidant parameters by determining the malondialdehyde formation (an index of lipid peroxidation process), superoxide dismutase (sod) and catalase (cat) activity in hippocampus and cerebral cortex along with serum corticosterone were investigated. |
2019-10-24 |
2023-08-13 |
mouse |
| Vishnu N Thakare, Rajesh R Patil, Rajesh J Oswal, Valmik D Dhakane, Manoj K Aswar, Bhoomika M Pate. Therapeutic potential of silymarin in chronic unpredictable mild stress induced depressive-like behavior in mice. Journal of psychopharmacology (Oxford, England). vol 32. issue 2. 2019-10-24. PMID:29215318. |
our findings reveal that mice subjected to cums exhibited lower sucrose preference, increase immobility time without affecting general locomotion of the animals, and reduce bdnf, 5-ht, ne, and da level, increased serum corticosterone, il-6 and tnf-α along with an oxidant-antioxidant imbalance in the hippocampus and cerebral cortex. |
2019-10-24 |
2023-08-13 |
mouse |
| Vishnu N Thakare, Rajesh R Patil, Rajesh J Oswal, Valmik D Dhakane, Manoj K Aswar, Bhoomika M Pate. Therapeutic potential of silymarin in chronic unpredictable mild stress induced depressive-like behavior in mice. Journal of psychopharmacology (Oxford, England). vol 32. issue 2. 2019-10-24. PMID:29215318. |
thus, the possible mechanism involved in the antidepressant-like activity of silymarin is correlated to the alleviation of monoaminergic, neurogenesis (enhancing 5-ht, ne, and bdnf levels), and attenuation of inflammatory cytokines system and oxidative stress by modulation of corticosterone response, restoration of antioxidant defense system in cerebral cortex and hippocampus. |
2019-10-24 |
2023-08-13 |
mouse |
| Jia-Ning Xu, Li-Fang Chen, Jun Su, Zhi-Li Liu, Jie Chen, Qing-Fen Lin, Wei-Dong Mao, Dong She. The anxiolytic-like effects of ginsenoside Rg3 on chronic unpredictable stress in rats. Scientific reports. vol 8. issue 1. 2019-10-24. PMID:29773855. |
in addition, the decreased levels on progesterone, allopregnanolone, serotonin (5-ht) in the prefrontal cortex and hippocampus of chronic unpredictable stress (cus) were blocked by grg3 (20 and 40 mg/kg, i.g). |
2019-10-24 |
2023-08-13 |
rat |
| Xiao-Ming Si, Yu-Hua Tian, Sha-Sha Zhang, Hua Gao, Kun Liu, Jing-Yu Ji. Low molecular mass chondroitin sulfate suppresses chronic unpredictable mild stress-induced depression-like behavior in mice. Acta pharmaceutica (Zagreb, Croatia). vol 68. issue 3. 2019-10-21. PMID:31259700. |
further, there was a significant reduction of 5-ht level in the hippocampus region of depressed mice. |
2019-10-21 |
2023-08-13 |
mouse |
| Xiao-Ming Si, Yu-Hua Tian, Sha-Sha Zhang, Hua Gao, Kun Liu, Jing-Yu Ji. Low molecular mass chondroitin sulfate suppresses chronic unpredictable mild stress-induced depression-like behavior in mice. Acta pharmaceutica (Zagreb, Croatia). vol 68. issue 3. 2019-10-21. PMID:31259700. |
these novel results suggest that lmmcs produces an antidepressant-like effect in mice subjected to cums, which might be related, at least in part, to the increase of 5-ht concentration in the hippocampus. |
2019-10-21 |
2023-08-13 |
mouse |
| R Feio-Azevedo, V M Costa, D J Barbosa, A Teixeira-Gomes, I Pita, S Gomes, F C Pereira, M Duarte-Araújo, J A Duarte, F Marques, E Fernandes, M L Bastos, F Carvalho, J P Capel. Aged rats are more vulnerable than adolescents to "ecstasy"-induced toxicity. Archives of toxicology. vol 92. issue 7. 2019-10-07. PMID:29869127. |
mdma promoted serotonergic neurotoxicity only in the hippocampus of aged, but not in the adolescents' brain, and did not change the levels of dopamine or serotonin metabolite in the striatum of both groups. |
2019-10-07 |
2023-08-13 |
rat |
| Laura Micheli, Manuela Ceccarelli, Giorgio D'Andrea, Felice Tiron. Depression and adult neurogenesis: Positive effects of the antidepressant fluoxetine and of physical exercise. Brain research bulletin. vol 143. 2019-09-30. PMID:30236533. |
similarly, the antidepressant action of running also correlates with an increase of hippocampal neurogenesis and plasticity, although the gene pathways involved are only partially coincident with those of fluoxetine, such as those involved in serotonin metabolism and synapse formation. |
2019-09-30 |
2023-08-13 |
human |
| Satoko Hattori, Keizo Takao, Hiroshi Funakoshi, Tsuyoshi Miyakaw. Comprehensive behavioral analysis of tryptophan 2,3-dioxygenase (Tdo2) knockout mice. Neuropsychopharmacology reports. vol 38. issue 2. 2019-09-18. PMID:30106261. |
it has been reported that targeted deletion of the tdo2 gene in mice resulted in reduced anxiety-like behavior, enhanced exploratory activity and cognitive performance, and increased levels of trp and 5-ht in the hippocampus and midbrain. |
2019-09-18 |
2023-08-13 |
mouse |
| David D Kim, Alasdair M Barr, William G Honer, Ric M Procyshy. Exercise-induced hippocampal neurogenesis: 5-HT Molecular psychiatry. vol 23. issue 12. 2019-09-17. PMID:29422519. |
exercise-induced hippocampal neurogenesis: 5-ht |
2019-09-17 |
2023-08-13 |
Not clear |
| Rutuja Yawalkar, Harish Changotra, Girdhari Lal Gupt. Protective influences of N-acetylcysteine against alcohol abstinence-induced depression by regulating biochemical and GRIN2A, GRIN2B gene expression of NMDA receptor signaling pathway in rats. Neurochemistry international. vol 118. 2019-09-16. PMID:29704590. |
serotonin concentrations were measured in the plasma, hippocampus and pre-frontal cortex using the rat elisa kit. |
2019-09-16 |
2023-08-13 |
rat |
| Rutuja Yawalkar, Harish Changotra, Girdhari Lal Gupt. Protective influences of N-acetylcysteine against alcohol abstinence-induced depression by regulating biochemical and GRIN2A, GRIN2B gene expression of NMDA receptor signaling pathway in rats. Neurochemistry international. vol 118. 2019-09-16. PMID:29704590. |
the significant reversal effect of nac on the serotonin level following alcohol abstinence was greater in the hippocampus as compared to the third-day alcohol withdrawal group. |
2019-09-16 |
2023-08-13 |
rat |
| Francisca Taciana Sousa Rodrigues, Marcos Romário Matos de Souza, Camila Nayane de Carvalho Lima, Francisco Eliclécio Rodrigues da Silva, Deiziane Viana da Silva Costa, Cláudio Costa Dos Santos, Fábio Miyajima, Francisca Cléa F de Sousa, Silvânia Maria Mendes Vasconcelos, Tatiana Barichello, João Quevedo, Michael Maes, David F de Lucena, Danielle Maced. Major depression model induced by repeated and intermittent lipopolysaccharide administration: Long-lasting behavioral, neuroimmune and neuroprogressive alterations. Journal of psychiatric research. vol 107. 2019-09-12. PMID:30326340. |
six weeks after the last lps-exposure, we assessed behavioral despair and anhedonia, microglial activation, alterations in tryptophan, 5-ht, kynurenine, quinolinic acid (quin) levels and spermidine/spermine n1-acetyltransferase (sat1) expression in the hippocampus, both with and without fluoxetine administration. |
2019-09-12 |
2023-08-13 |
mouse |
| Lei Tang, Fei You, Xing Hu, Yun-Fei L. [Electroacupuncture improves insomnia by down-regulating peripheral benzodiazepine receptor expression in hippocampus, and up-regulating 5-HT, 5-HIAA, TNF-α and IL-1β contents in hypothalamus in insomnia rats]. Zhen ci yan jiu = Acupuncture research. vol 44. issue 8. 2019-09-10. PMID:31475488. |
[electroacupuncture improves insomnia by down-regulating peripheral benzodiazepine receptor expression in hippocampus, and up-regulating 5-ht, 5-hiaa, tnf-α and il-1β contents in hypothalamus in insomnia rats]. |
2019-09-10 |
2023-08-13 |
rat |