| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ning Jiang, Lin-Xi Fan, Yu-Jie Yang, Xin-Min Liu, Hai-Ying Lin, Li Gao, Qiong Wan. [Antidepressant effects of the extract of Dendrobium nobile Lindl on chronic unpredictable mild stress-induced depressive mice]. Sheng li xue bao : [Acta physiologica Sinica]. vol 69. issue 2. 2018-10-30. PMID:28435974. |
in comparison with the cums group, paroxetine obviously increased the da levels in the hippocampus and the cortex and the 5-ht level in the hippocampus (p < 0.05). |
2018-10-30 |
2023-08-13 |
mouse |
| Ning Jiang, Lin-Xi Fan, Yu-Jie Yang, Xin-Min Liu, Hai-Ying Lin, Li Gao, Qiong Wan. [Antidepressant effects of the extract of Dendrobium nobile Lindl on chronic unpredictable mild stress-induced depressive mice]. Sheng li xue bao : [Acta physiologica Sinica]. vol 69. issue 2. 2018-10-30. PMID:28435974. |
the 5-ht level in the 200 mg/kg dnl group was notably increased in both two brain regions (p < 0.05), but the 5-ht level in the 100 mg/kg dnl group was significantly increased only in the hippocampus (p < 0.01). |
2018-10-30 |
2023-08-13 |
mouse |
| Ning Jiang, Lin-Xi Fan, Yu-Jie Yang, Xin-Min Liu, Hai-Ying Lin, Li Gao, Qiong Wan. [Antidepressant effects of the extract of Dendrobium nobile Lindl on chronic unpredictable mild stress-induced depressive mice]. Sheng li xue bao : [Acta physiologica Sinica]. vol 69. issue 2. 2018-10-30. PMID:28435974. |
these findings indicate that the extract of dnl has an antidepressant-like effect on cums-induced depressive mice and its mechanism may be related to the changes in da and 5-ht in the hippocampus and cortex. |
2018-10-30 |
2023-08-13 |
mouse |
| Dasiel O Borroto-Escuela, Manuel Narváez, Patrizia Ambrogini, Luca Ferraro, Ismel Brito, Wilber Romero-Fernandez, Yuniesky Andrade-Talavera, Antonio Flores-Burgess, Carmelo Millon, Belen Gago, Jose Angel Narvaez, Yuji Odagaki, Miklos Palkovits, Zaida Diaz-Cabiale, Kjell Fux. Receptor⁻Receptor Interactions in Multiple 5-HT1A Heteroreceptor Complexes in Raphe-Hippocampal 5-HT Transmission and Their Relevance for Depression and Its Treatment. Molecules (Basel, Switzerland). vol 23. issue 6. 2018-10-22. PMID:29865267. |
the 5-ht1a⁻fgfr1 heteroreceptor complexes were involved in synergistically enhancing neuroplasticity in the hippocampus and in the dorsal raphe 5-ht nerve cells. |
2018-10-22 |
2023-08-13 |
rat |
| I V Karpova, V V Mikheev, V V Marysheva, N A Kuritcyna, N A Popkovskii, E R Bychkov, P D Shabano. [The effect of acute hypoxia with hypercapnia on the content of monoamines in symmetrical areas of the brain in albino mice]. Biomeditsinskaia khimiia. vol 64. issue 3. 2018-10-16. PMID:29964262. |
the concentrations of dopamine (da), serotonin (5-ht) and their metabolites dihydroxyphenylacetic (dopac), homovanilic (hva) and 5-hydroxyindolacetic (5-hiaa) acids were measured by hplc in the brain cortex, hippocampus and striatum of the right and the left hemispheres. |
2018-10-16 |
2023-08-13 |
mouse |
| Rui Yang, Wei Chen, Ye Lu, Yingke Li, Hongli Du, Songyan Gao, Xin Dong, Hongbin Yua. Dioscin relieves endotoxemia induced acute neuro-inflammation and protect neurogenesis via improving 5-HT metabolism. Scientific reports. vol 7. 2018-10-15. PMID:28059131. |
in addition, dioscin a natural steroidal saponin isolated from chinese medicinal herbs, enhanced the serotonergic system and produced anti-depressant effect by enhancing 5-ht levels in hippocampus. |
2018-10-15 |
2023-08-13 |
Not clear |
| Rui Yang, Wei Chen, Ye Lu, Yingke Li, Hongli Du, Songyan Gao, Xin Dong, Hongbin Yua. Dioscin relieves endotoxemia induced acute neuro-inflammation and protect neurogenesis via improving 5-HT metabolism. Scientific reports. vol 7. 2018-10-15. PMID:28059131. |
what is more, this finding was verified by metabolic analyses of hippocampus, indicating 5-ht related metabolic pathway was involved in the pathogenesis of endotoxemia induced acute neuro-inflammation. |
2018-10-15 |
2023-08-13 |
Not clear |
| Rui Yang, Wei Chen, Ye Lu, Yingke Li, Hongli Du, Songyan Gao, Xin Dong, Hongbin Yua. Dioscin relieves endotoxemia induced acute neuro-inflammation and protect neurogenesis via improving 5-HT metabolism. Scientific reports. vol 7. 2018-10-15. PMID:28059131. |
our in vivo and in vitro studies show dioscin protects hippocampus from endotoxemia induced cascade neuro-inflammation through neurotransmitter 5-ht and hmgb-1/tlr4 signaling pathway, which accounts for the dioscin therapeutic effect in behavioral tests. |
2018-10-15 |
2023-08-13 |
Not clear |
| Saiful Alom Siddique, Thangavel Tamilselvan, Manikkannan Vishnupriya, Elumalai Balamuruga. Evaluation of Neurotransmitter Alterations in Four Distinct Brain Regions After Rapid Eye Movement Sleep Deprivation (REMSD) Induced Mania-Like Behaviour in Swiss Albino Mice. Neurochemical research. vol 43. issue 6. 2018-10-15. PMID:29671235. |
quantitative determinations of da, 5-ht, ne and gaba concentrations in four distinct brain regions (cerebral cortex, hippocampus, midbrain, and pons) were determined by the spectrofluorimetric method. |
2018-10-15 |
2023-08-13 |
mouse |
| Wu Song, Yan Guo, Shuang Jiang, Lin Wei, Zhi Liu, Xiaoyan Wang, Ying S. Antidepressant Effects of the Ginsenoside Metabolite Compound K, Assessed by Behavioral Despair Test and Chronic Unpredictable Mild Stress Model. Neurochemical research. vol 43. issue 7. 2018-10-15. PMID:29790069. |
to investigate the underlying mechanism, the levels of endogenous noradrenaline, dopamine (da), 5-hydroxytryptamine (5-ht) and their metabolites in the prefrontal cortex (pfc) and hippocampus were detected by hplc coupled with electron detector. |
2018-10-15 |
2023-08-13 |
mouse |
| Ze-Qun Li, Zhi-Yuan Yan, Fu-Jun Lan, Yi-Qun Dong, Ye Xion. Suppression of NLRP3 inflammasome attenuates stress-induced depression-like behavior in NLGN3-deficient mice. Biochemical and biophysical research communications. vol 501. issue 4. 2018-10-09. PMID:29775613. |
cums up-regulated corticosterone (cort) in serum, and down-regulated serotonin (5-ht), norepinephrine (ne) and brain-derived neurotrophic factor (bdnf) in hippocampus of mice, which were significantly reversed by nlgn3 deficiency. |
2018-10-09 |
2023-08-13 |
mouse |
| Hiroshi Kawai, Megumi Machida, Takuya Ishibashi, Naomi Kudo, Yoichi Kawashima, Atsushi Mitsumot. Chronopharmacological Analysis of Antidepressant Activity of a Dual-Action Serotonin Noradrenaline Reuptake Inhibitor (SNRI), Milnacipran, in Rats. Biological & pharmaceutical bulletin. vol 41. issue 2. 2018-08-21. PMID:29386481. |
the serotonin turnover showed rhythms with a peak during zt18-zt22 in hippocampus. |
2018-08-21 |
2023-08-13 |
rat |
| Vandreza Cardoso Bortolotto, Franciane Cabral Pinheiro, Stífani Machado Araujo, Márcia Rósula Poetini, Bianca Santos Bertolazi, Mariane Trindade de Paula, Luana Barreto Meichtry, Francielli Polet de Almeida, Shanda de Freitas Couto, Cristiano Ricardo Jesse, Marina Prigo. Chrysin reverses the depressive-like behavior induced by hypothyroidism in female mice by regulating hippocampal serotonin and dopamine. European journal of pharmacology. vol 822. 2018-08-20. PMID:29355556. |
chrysin reverses the depressive-like behavior induced by hypothyroidism in female mice by regulating hippocampal serotonin and dopamine. |
2018-08-20 |
2023-08-13 |
mouse |
| Vandreza Cardoso Bortolotto, Franciane Cabral Pinheiro, Stífani Machado Araujo, Márcia Rósula Poetini, Bianca Santos Bertolazi, Mariane Trindade de Paula, Luana Barreto Meichtry, Francielli Polet de Almeida, Shanda de Freitas Couto, Cristiano Ricardo Jesse, Marina Prigo. Chrysin reverses the depressive-like behavior induced by hypothyroidism in female mice by regulating hippocampal serotonin and dopamine. European journal of pharmacology. vol 822. 2018-08-20. PMID:29355556. |
additionally, t3 and t4 levels were measured again, and serotonin (5ht), dopamine, and noradrenaline levels were analyzed in the prefrontal cortex and the hippocampus. |
2018-08-20 |
2023-08-13 |
mouse |
| Vandreza Cardoso Bortolotto, Franciane Cabral Pinheiro, Stífani Machado Araujo, Márcia Rósula Poetini, Bianca Santos Bertolazi, Mariane Trindade de Paula, Luana Barreto Meichtry, Francielli Polet de Almeida, Shanda de Freitas Couto, Cristiano Ricardo Jesse, Marina Prigo. Chrysin reverses the depressive-like behavior induced by hypothyroidism in female mice by regulating hippocampal serotonin and dopamine. European journal of pharmacology. vol 822. 2018-08-20. PMID:29355556. |
reduced levels of 5ht and dopamine in the prefrontal cortex and the hippocampus were observed in the hypothyroid mice than in the euthyroid mice. |
2018-08-20 |
2023-08-13 |
mouse |
| Vandreza Cardoso Bortolotto, Franciane Cabral Pinheiro, Stífani Machado Araujo, Márcia Rósula Poetini, Bianca Santos Bertolazi, Mariane Trindade de Paula, Luana Barreto Meichtry, Francielli Polet de Almeida, Shanda de Freitas Couto, Cristiano Ricardo Jesse, Marina Prigo. Chrysin reverses the depressive-like behavior induced by hypothyroidism in female mice by regulating hippocampal serotonin and dopamine. European journal of pharmacology. vol 822. 2018-08-20. PMID:29355556. |
chrysin treatment recovered 5ht content in both structures and dopamine content only in the hippocampus. |
2018-08-20 |
2023-08-13 |
mouse |
| Ning Jiang, Bei-Yue Zhang, Li-Ming Dong, Jing-Wei Lv, Cong Lu, Qiong Wang, Lin-Xi Fan, Hong-Xia Zhang, Rui-Le Pan, Xin-Min Li. Antidepressant effects of dammarane sapogenins in chronic unpredictable mild stress-induced depressive mice. Phytotherapy research : PTR. vol 32. issue 6. 2018-08-20. PMID:29468732. |
biochemical analysis of brain tissue and serum showed that ds treatment restored the decreased hippocampal neurotransmitter concentrations of serotonin, dopamine, norepinephrine (noradrenaline), and gamma-aminobutyric acid, and decreased the elevated of serum hormone levels (corticotrophin releasing factor, adrenocorticotrophic hormone, and corticosterone) induced by cums. |
2018-08-20 |
2023-08-13 |
mouse |
| Yanli Zhang, Kai Fan, Yanna Liu, Gang Liu, Xiaohan Yang, Jianmei M. Cathepsin C Aggravates Neuroinflammation Involved in Disturbances of Behaviour and Neurochemistry in Acute and Chronic Stress-Induced Murine Model of Depression. Neurochemical research. vol 43. issue 1. 2018-08-16. PMID:28623605. |
the results showed that cat c overexpression (cat c oe) promoted peripheral and central inflammatory response with significantly increased tnfα, il-1β and il-6 in serum, hippocampus and prefrontal cortex, and resultant upregulation of ido and downregulation of 5ht expression in brain, and thereby aggravated depression-like behaviours accessed by open field test, forced swim test and tail suspension test. |
2018-08-16 |
2023-08-13 |
mouse |
| Leandro Cattelan Souza, Cristiano R Jesse, Marcelo Gomes de Gomes, Lucian Del Fabbro, André Tiago Rossito Goes, Franciele Donato, Silvana Peterini Boeir. Activation of Brain Indoleamine-2,3-dioxygenase Contributes to Depressive-Like Behavior Induced by an Intracerebroventricular Injection of Streptozotocin in Mice. Neurochemical research. vol 42. issue 10. 2018-08-07. PMID:28631232. |
1-mt abrogates kynurenine production and normalizes brain-derived neurotrophic factor (bdnf) and the kynurenine/tryptophan ratio, but does not protect the biomarkers of the serotonin (5-ht) system in the hippocampus of stz-injected mice. |
2018-08-07 |
2023-08-13 |
mouse |
| Anastasia Diamantopoulou, Theodora Kalpachidou, Georgios Aspiotis, Ioannis Gampierakis, Fotini Stylianopoulou, Antonios Stamataki. An early experience of mild adversity involving temporary denial of maternal contact affects the serotonergic system of adult male rats and leads to a depressive-like phenotype and inability to adapt to a chronic social stress. Physiology & behavior. vol 184. 2018-08-01. PMID:29127070. |
the depressive-like and anxious phenotype of the der males was accompanied by changes in the serotonergic system, such as lower serotonin levels, higher serotonin turnover and higher levels of the type 1 serotonin receptor in the hippocampus. |
2018-08-01 |
2023-08-13 |
rat |