| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| A Sheldrick, S Camara, M Ilieva, P Riederer, T M Miche. Brain-derived neurotrophic factor (BDNF) and neurotrophin 3 (NT3) levels in post-mortem brain tissue from patients with depression compared to healthy individuals - a proof of concept study. European psychiatry : the journal of the Association of European Psychiatrists. vol 46. 2018-05-18. PMID:29102768. |
therefore, we examined the concentration of brain-derived neurotrophic factor (bdnf) and neurotrophin 3 (nt3) in different brain regions (cortex, cingulate gyrus, thalamus, hippocampus, putamen and nucleus caudatus) of 21 individuals - 7 patients of which 4 patients with major depressive disorder (mdd) and overall age 86.8±5 years who received antidepressant pharmacotherapy (selective serotonin re-uptake inhibitors [ssri]; tricyclic antidepressants [tca]), 3 patients with mdd without antidepressant treatment and overall age 84.3±5 years versus 14 unaffected subjects at age 70.3±13.8. |
2018-05-18 |
2023-08-13 |
human |
| Gisela H Maia, Cátia S Brazete, Joana I Soares, Liliana L Luz, Nikolai V Lukoyano. Serotonin depletion increases seizure susceptibility and worsens neuropathological outcomes in kainate model of epilepsy. Brain research bulletin. vol 134. 2018-05-07. PMID:28716398. |
loss of hippocampal neurons and spatial memory deficits associated with kainic acid treatment were exacerbated by prior depletion of serotonin. |
2018-05-07 |
2023-08-13 |
rat |
| Vishnu N Thakare, Manoj K Aswar, Yogesh P Kulkarni, Rajesh R Patil, Bhoomika M Pate. Silymarin ameliorates experimentally induced depressive like behavior in rats: Involvement of hippocampal BDNF signaling, inflammatory cytokines and oxidative stress response. Physiology & behavior. vol 179. 2018-05-01. PMID:28711395. |
behavioral (ambulatory and rearing activity and immobility time), neurochemical [serotonin (5-ht), dopamine (da), norepinephrine (ne) and brain derived neurotrophic factor (bdnf) level], biochemical (mda formation, il-6, tnf-α and antioxidants) changes in hippocampus and cerebral cortex along with serum corticosterone were investigated. |
2018-05-01 |
2023-08-13 |
mouse |
| Vishnu N Thakare, Manoj K Aswar, Yogesh P Kulkarni, Rajesh R Patil, Bhoomika M Pate. Silymarin ameliorates experimentally induced depressive like behavior in rats: Involvement of hippocampal BDNF signaling, inflammatory cytokines and oxidative stress response. Physiology & behavior. vol 179. 2018-05-01. PMID:28711395. |
rats subjected to obx elicited significant increase in immobility time, ambulatory and rearing behaviors, reduced bdnf level, 5-ht, da, ne and antioxidant parameters along with increased serum corticosterone, mda formation, il-6, and tnf-α in hippocampus and cerebral cortex compared to sham operated rats. |
2018-05-01 |
2023-08-13 |
mouse |
| Vishnu N Thakare, Manoj K Aswar, Yogesh P Kulkarni, Rajesh R Patil, Bhoomika M Pate. Silymarin ameliorates experimentally induced depressive like behavior in rats: Involvement of hippocampal BDNF signaling, inflammatory cytokines and oxidative stress response. Physiology & behavior. vol 179. 2018-05-01. PMID:28711395. |
administration of with silymarin significantly attenuated immobility time, ambulatory and rearing behaviors, serum corticosterone and improved bdnf expression, 5-ht, da, ne and antioxidant paradigms in cerebral cortex as well as hippocampus. |
2018-05-01 |
2023-08-13 |
mouse |
| Vishnu N Thakare, Manoj K Aswar, Yogesh P Kulkarni, Rajesh R Patil, Bhoomika M Pate. Silymarin ameliorates experimentally induced depressive like behavior in rats: Involvement of hippocampal BDNF signaling, inflammatory cytokines and oxidative stress response. Physiology & behavior. vol 179. 2018-05-01. PMID:28711395. |
thus, silymarin exhibits anti-depressant-like activity in obx rats due to alterations in several neurotransmitters, endocrine and immunologic systems, including bdnf, 5-ht, da, ne, mda formation, il-6, and tnf-α in hippocampus and cerebral cortex as well as serum corticosterone. |
2018-05-01 |
2023-08-13 |
mouse |
| Yuki Asai, Yukiko Sakakibara, Masayuki Nadai, Miki Kato. Effect of carbamazepine on expression of UDP-glucuronosyltransferase 1A6 and 1A7 in rat brain. Drug metabolism and pharmacokinetics. vol 32. issue 6. 2018-05-01. PMID:29158009. |
ugt1a6 and ugt1a7 mrnas were induced by cbz in the cerebellum, piriform cortex, and hippocampus (ugt1a6: 3.1-, 2.4-, and 1.9-fold, respectively, ugt1a7: 2.3-, 1.6-, and 3.1-fold, respectively); serotonin glucuronidation, which is catalyzed by ugt1a6, was also increased by 2.8-, 1.7-, and 1.8-fold in these regions, respectively. |
2018-05-01 |
2023-08-13 |
rat |
| Ekaterina Y Bazhenova, Nadezhda A Sinyakova, Elizabeth A Kulikova, Irina A Kazarinova, Daria V Bazovkina, Raul R Gainetdinov, Alexander V Kuliko. No effect of C1473G polymorphism in the tryptophan hydroxylase 2 gene on the response of the brain serotonin system to chronic fluoxetine treatment in mice. Neuroscience letters. vol 653. 2018-04-27. PMID:28579486. |
fluoxetine significantly attenuated 5-ht levels in the cortex and striatum, 5-hiaa concentrations in the cortex, hippocampus, striatum and midbrain, and tph2 gene expression in the midbrain. |
2018-04-27 |
2023-08-13 |
mouse |
| Mary Gemmel, Mariah Hazlett, Eszter Bögi, Sonsoles De Lacalle, Lesley A Hill, Nikolaos Kokras, Geoffrey L Hammond, Christina Dalla, Thierry D Charlier, Jodi L Pawlusk. Perinatal fluoxetine effects on social play, the HPA system, and hippocampal plasticity in pre-adolescent male and female rats: Interactions with pre-gestational maternal stress. Psychoneuroendocrinology. vol 84. 2018-04-24. PMID:28735226. |
perinatal fluoxetine also increased serum corticosteroid binding globulin levels, 5-ht levels in the hippocampus, and pre-synaptic density assessed via synaptophysin in the dentate gyrus. |
2018-04-24 |
2023-08-13 |
rat |
| Yan-Hai Li, Lei Han, Kenneth Lap Kei Wu, Ying-Shing Cha. Activation of 5-HT Neuropharmacology. vol 123. 2018-04-17. PMID:28483393. |
the neuromodulator serotonin (5-ht) is known to modulate ltd in neural circuits of the cerebral cortex and the hippocampus. |
2018-04-17 |
2023-08-13 |
Not clear |
| Mathieu Verdurand, Luc Zimme. Hippocampal 5-HT Neuropharmacology. vol 123. 2018-04-17. PMID:28647411. |
hippocampal 5-ht there is increasing evidence that the serotonergic system is highly dysfunctional in alzheimer's disease (ad), and this could be related to cognitive impairments associated with dementia. |
2018-04-17 |
2023-08-13 |
Not clear |
| Moshe Gross, Emanuel Stanciu, Dvora Kenigsbuch-Sredni, Benjamin Sredni, Albert Pinhaso. The immunomodulatory tellurium compound ammonium trichloro (dioxoethylene-O,O') tellurate reduces anxiety-like behavior and corticosterone levels of submissive mice. Behavioural pharmacology. vol 28. issue 6. 2018-04-16. PMID:28590303. |
anxiolytic-like effects of as101 may be attributed to the modulation of the regulatory influence integrin of αvβ3 upon the serotonin transporter, suggesting a multifaceted mechanism by which as101 buffers the hypothalamic-pituitary-adrenal axis response to injection stress, enabling recovery of hippocampal bdnf expression and anxiety-like behavior in sub mice. |
2018-04-16 |
2023-08-13 |
mouse |
| Christine N Yohn, Mark M Gergues, Benjamin Adam Samuel. The role of 5-HT receptors in depression. Molecular brain. vol 10. issue 1. 2018-04-16. PMID:28646910. |
finally, we will discuss how recent studies into serotonin receptors have implicated specific neural circuitry in mediating the antidepressant response, with a focus being placed on the hippocampus. |
2018-04-16 |
2023-08-13 |
Not clear |
| Soledad Récamier-Carballo, Erika Estrada-Camarena, Carolina López-Rubalcav. Maternal separation induces long-term effects on monoamines and brain-derived neurotrophic factor levels on the frontal cortex, amygdala, and hippocampus: differential effects after a stress challenge. Behavioural pharmacology. vol 28. issue 7. 2018-04-16. PMID:28704274. |
the present study analyzed the effect of ms, in adult mice, on brain-derived neurotrophic factor (bdnf), serotonin (5-ht), and dopamine (da) levels, and the turnover rate in the hippocampus, frontal cortex, and amygdala, and brain regions that are associated with emotion. |
2018-04-16 |
2023-08-13 |
mouse |
| Soledad Récamier-Carballo, Erika Estrada-Camarena, Carolina López-Rubalcav. Maternal separation induces long-term effects on monoamines and brain-derived neurotrophic factor levels on the frontal cortex, amygdala, and hippocampus: differential effects after a stress challenge. Behavioural pharmacology. vol 28. issue 7. 2018-04-16. PMID:28704274. |
finally, the hippocampus showed increased 5-ht and da activity, but not increased bdnf after the stress challenge in ms mice. |
2018-04-16 |
2023-08-13 |
mouse |
| Manar Mohammed El Tabaa, Samia Salem Sokkar, Ehab Sayed Ramadan, Inas Zakria Abd El Salam, Anis Zai. Neuroprotective role of Ginkgo biloba against cognitive deficits associated with Bisphenol A exposure: An animal model study. Neurochemistry international. vol 108. 2018-04-13. PMID:28366721. |
additionally, hippocampal levels of da, ne and 5-ht were measured. |
2018-04-13 |
2023-08-13 |
rat |
| Marina Pádua-Reis, Nayara S Aquino, Vinícius E M Oliveira, Raphael E Szawka, Marco A M Prado, Vânia F Prado, Grace S Pereir. Reduced Vesicular Acetylcholine Transporter favors antidepressant behaviors and modulates serotonin and dopamine in female mouse brain. Behavioural brain research. vol 330. 2018-04-09. PMID:28461009. |
moreover, female homozygous vacht kd mice exhibited higher levels of dopamine and serotonin in the striatum, and increased dopamine in the hippocampus. |
2018-04-09 |
2023-08-13 |
mouse |
| Vanessa Marques da Silva Leal, Vivian Taciany Bonassoli, Lígia Mendes Soares, Humberto Milani, Rúbia M Weffort de Oliveir. Depletion of 5 hydroxy-triptamine (5-HT) affects the antidepressant-like effect of neuronal nitric oxide synthase inhibitor in mice. Neuroscience letters. vol 656. 2018-04-05. PMID:28746839. |
we also investigated if the antidepressant-like effect of nnos inhibitor, 7ni, was dependent on hippocampal serotonin. |
2018-04-05 |
2023-08-13 |
mouse |
| Vanessa Marques da Silva Leal, Vivian Taciany Bonassoli, Lígia Mendes Soares, Humberto Milani, Rúbia M Weffort de Oliveir. Depletion of 5 hydroxy-triptamine (5-HT) affects the antidepressant-like effect of neuronal nitric oxide synthase inhibitor in mice. Neuroscience letters. vol 656. 2018-04-05. PMID:28746839. |
it was also demonstrated that the effect of 7ni was dependent of hippocampal serotonin. |
2018-04-05 |
2023-08-13 |
mouse |
| S Caldenhove, L G J M Borghans, A Blokland, A Sambet. Role of acetylcholine and serotonin in novelty processing using an oddball paradigm. Behavioural brain research. vol 331. 2018-04-03. PMID:28511977. |
previous research has shown that acetylcholine (ach) can interact with serotonin (5-ht) at the hippocampal level, which may have consequences for cognitive functioning. |
2018-04-03 |
2023-08-13 |
human |