| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Rozita H Anderberg, Jennifer E Richard, Caroline Hansson, Hans Nissbrandt, Filip Bergquist, Karolina P Skibick. GLP-1 is both anxiogenic and antidepressant; divergent effects of acute and chronic GLP-1 on emotionality. Psychoneuroendocrinology. vol 65. 2016-12-13. PMID:26724568. |
serotonin or serotonin-related genes were also measured in the amygdala, dr and the hippocampus. |
2016-12-13 |
2023-08-13 |
rat |
| Carla García-Barba, Laura Medina-Cej. Serotonin receptor antagonists increase fast ripple activity in rats treated with kainic acid. Brain research bulletin. vol 121. 2016-12-13. PMID:26772625. |
fast ripples (fr, 250-600 hz) are field potentials that occur only in those areas capable of generating seizures, such as the hippocampus, and modulation of fr by serotonin has been reported. |
2016-12-13 |
2023-08-13 |
rat |
| Carla García-Barba, Laura Medina-Cej. Serotonin receptor antagonists increase fast ripple activity in rats treated with kainic acid. Brain research bulletin. vol 121. 2016-12-13. PMID:26772625. |
for this purpose, the intracranial eeg recordings of the hippocampus from animals treated with ka and the serotonin antagonists way100135 and ritanserin (dose 0.2mg/kg, i.p) were analyzed. |
2016-12-13 |
2023-08-13 |
rat |
| Chih-Yuan Ko, Sheng-Chiang Wang, Yia-Ping Li. Sensorimotor gating deficits are inheritable in an isolation-rearing paradigm in rats. Behavioural brain research. vol 302. 2016-12-13. PMID:26778785. |
the third generation also exhibited lower levels of dopamine and serotonin in the mpfc and hippocampus; however, higher levels of both monoamines were measured in the striatum. |
2016-12-13 |
2023-08-13 |
rat |
| Jana Tchekalarova, Zlatina Nenchovska, Dimitrina Atanasova, Milena Atanasova, Lidia Kortenska, Miroslava Stefanova, Liana Alova, Nikolai Lazaro. Consequences of long-term treatment with agomelatine on depressive-like behavior and neurobiological abnormalities in pinealectomized rats. Behavioural brain research. vol 302. 2016-12-13. PMID:26779670. |
the effect of agomelatine on kcl-evoked serotonin (5-ht) release from the hippocampus, the activity of the hypothalamic-pituitary-adrenal (hpa) axis and neuronal loss in pinealectomized rats were assessed. |
2016-12-13 |
2023-08-13 |
rat |
| Jana Tchekalarova, Zlatina Nenchovska, Dimitrina Atanasova, Milena Atanasova, Lidia Kortenska, Miroslava Stefanova, Liana Alova, Nikolai Lazaro. Consequences of long-term treatment with agomelatine on depressive-like behavior and neurobiological abnormalities in pinealectomized rats. Behavioural brain research. vol 302. 2016-12-13. PMID:26779670. |
however, the drug corrected a depressive-like behavior (chronic and plastic effect), alleviated the enhanced kcl-evoked 5-ht release in the hippocampus, recovered the suppressed negative feedback inhibition of hpa axis and exerted a neuroprotection in pinealectomized rats. |
2016-12-13 |
2023-08-13 |
rat |
| Jana Tchekalarova, Zlatina Nenchovska, Dimitrina Atanasova, Milena Atanasova, Lidia Kortenska, Miroslava Stefanova, Liana Alova, Nikolai Lazaro. Consequences of long-term treatment with agomelatine on depressive-like behavior and neurobiological abnormalities in pinealectomized rats. Behavioural brain research. vol 302. 2016-12-13. PMID:26779670. |
our findings suggest that pinealectomy can model melancholic depression disorder while the antidepressant action of agomelatine is associated with a correction of 5-ht release in the hippocampus, dysregulated hpa system and neuroprotection in limbic structures. |
2016-12-13 |
2023-08-13 |
rat |
| K Silva, M C Carvalho, C M Padova. Tolerance to repeated stress in rats with lesions of the serotoninergic neurons of the Median Raphe Nucleus and chronically treated with imipramine. Behavioural brain research. vol 302. 2016-12-13. PMID:26795093. |
dorsal hippocampus and striatum were dissected and the levels of 5-ht and 5-hydroxy-indoleacetic acid (5-hiaa) measured by hplc analysis. |
2016-12-13 |
2023-08-13 |
rat |
| K Silva, M C Carvalho, C M Padova. Tolerance to repeated stress in rats with lesions of the serotoninergic neurons of the Median Raphe Nucleus and chronically treated with imipramine. Behavioural brain research. vol 302. 2016-12-13. PMID:26795093. |
hplc analysis showed significantly decreases on 5-ht and 5-hiaa levels in the hippocampus, but not in the striatum. |
2016-12-13 |
2023-08-13 |
rat |
| Saritha Krishna, Zhoumeng Lin, Claire B de La Serre, John J Wagner, Donald H Harn, Lacey M Pepples, Dylan M Djani, Matthew T Weber, Leena Srivastava, Nikolay M Filipo. Time-dependent behavioral, neurochemical, and metabolic dysregulation in female C57BL/6 mice caused by chronic high-fat diet intake. Physiology & behavior. vol 157. 2016-12-13. PMID:26852949. |
behaviorally, prolonged intake of hfd caused mice to be hypoactive and bury fewer marbles in a marble burying task; the latter was associated with significantly impaired hippocampal serotonin homeostasis. |
2016-12-13 |
2023-08-13 |
mouse |
| b' Jan Vevera, Karel Vale\\xc5\\xa1, Zden\\xc4\\x9bk Fi\\xc5\\xa1ar, Jana Hroudov\\xc3\\xa1, Namrata Singh, Ale\\xc5\\xa1 Stuchl\\xc3\\xadk, Petr Ka\\xc4\\x8der, Tereza Nekov\\xc3\\xa1\\xc5\\x99ov\\xc3\\xa. The effect of prolonged simvastatin application on serotonin uptake, membrane microviscosity and behavioral changes in the animal model. Physiology & behavior. vol 158. 2016-12-13. PMID:26917054.' |
we have studied selected biologic traits potentially affected by statin treatment - serotonin (5-ht) uptake in platelets, membrane microviscosity in erythrocytes, cholesterol level in the brain (amygdala; hippocampus and prefrontal cortex), as well as behavioral changes in an elevated plus maze and open field test in male long-evans rats, which were treated by simvastatin (30mg/kg per day) for 2 or 4weeks. |
2016-12-13 |
2023-08-13 |
rat |
| Yimin Qiu, Xiaojing Huang, Lina Huang, Liang Tang, Jihong Jiang, Lianhua Chen, Shitong L. 5-HT(1A) receptor antagonist improves behavior performance of delirium rats through inhibiting PI3K/Akt/mTOR activation-induced NLRP3 activity. IUBMB life. vol 68. issue 4. 2016-12-13. PMID:26946964. |
it was found that 5-hydroxy-3-indoleacetic acid (5-hiaa), 3,4-dihydroxyphenylacetic acid, and homovanillic acid concentrations in the csf of scopolamine-induced delirium rats were significantly increased, among which 5-hiaa was also increased in hippocampus and basolateral amygdala (bla), and 5-ht(1a) receptor was significantly higher in the hippocampuses and bla than other brain regions. |
2016-12-13 |
2023-08-13 |
rat |
| Mathieu Verdurand, Fabien Chauveau, Alexia Daoust, Anne-Laure Morel, Frédéric Bonnefoi, François Liger, Anne Bérod, Luc Zimme. Differential effects of amyloid-beta 1-40 and 1-42 fibrils on 5-HT1A serotonin receptors in rat brain. Neurobiology of aging. vol 40. 2016-12-13. PMID:26973100. |
this serotonergic reactivity paralleled results from clinical positron emission tomography studies with [(18)f]mppf revealing an overexpression of 5-ht(1a)r in the hippocampus of patients with mild cognitive impairment. |
2016-12-13 |
2023-08-13 |
rat |
| Mathieu Verdurand, Fabien Chauveau, Alexia Daoust, Anne-Laure Morel, Frédéric Bonnefoi, François Liger, Anne Bérod, Luc Zimme. Differential effects of amyloid-beta 1-40 and 1-42 fibrils on 5-HT1A serotonin receptors in rat brain. Neurobiology of aging. vol 40. 2016-12-13. PMID:26973100. |
because aβ40 and aβ42 isoforms are found in amyloid plaques, we tested in this study the hypothesis of a peptide- and region-specific 5-ht(1a)r reactivity by injecting them, separately, into the hippocampus or striatum of rats. |
2016-12-13 |
2023-08-13 |
rat |
| Mathieu Verdurand, Fabien Chauveau, Alexia Daoust, Anne-Laure Morel, Frédéric Bonnefoi, François Liger, Anne Bérod, Luc Zimme. Differential effects of amyloid-beta 1-40 and 1-42 fibrils on 5-HT1A serotonin receptors in rat brain. Neurobiology of aging. vol 40. 2016-12-13. PMID:26973100. |
[(18)f]mppf in vitro autoradiography revealed that aβ40 fibrils, but not aβ42, were triggering an overexpression of 5-ht(1a)r in the hippocampus and striatum of rat brains after 7 days. |
2016-12-13 |
2023-08-13 |
rat |
| A Ferrés-Coy, M Galofré, F Pilar-Cuéllar, R Vidal, V Paz, E Ruiz-Bronchal, L Campa, Á Pazos, J R Caso, J C Leza, G Alvarado, A Montefeltro, E M Valdizán, F Artigas, A Bortolozz. Therapeutic antidepressant potential of a conjugated siRNA silencing the serotonin transporter after intranasal administration. Molecular psychiatry. vol 21. issue 3. 2016-11-14. PMID:26100539. |
hence, c-sert-sirna (i) downregulated 5-ht1a-autoreceptors and facilitated forebrain serotonin neurotransmission, (ii) accelerated the proliferation of neuronal precursors and (iii) increased hippocampal complexity and plasticity. |
2016-11-14 |
2023-08-13 |
mouse |
| Chengjian Li, Haiou Tong, Qiongxian Yan, Shaoxun Tang, Xuefeng Han, Wenjun Xiao, Zhiliang Ta. L-Theanine Improves Immunity by Altering TH2/TH1 Cytokine Balance, Brain Neurotransmitters, and Expression of Phospholipase C in Rat Hearts. Medical science monitor : international medical journal of experimental and clinical research. vol 22. 2016-11-07. PMID:26922362. |
high-dose l-theanine administration increased the levels of dopamine and 5-hydroxytryptamine in the pituitary and hippocampus, resulting in decrease in corticosterone level in the serum. |
2016-11-07 |
2023-08-13 |
rat |
| Anna Haduch, Ewa Bromek, Jacek Wójcikowski, Krystyna Gołembiowska, Władysława A Danie. Melatonin Supports CYP2D-Mediated Serotonin Synthesis in the Brain. Drug metabolism and disposition: the biological fate of chemicals. vol 44. issue 3. 2016-10-24. PMID:26884482. |
we measured serotonin tissue content in some brain regions (the cortex, hippocampus, nucleus accumbens, striatum, thalamus, hypothalamus, brain stem, medulla oblongata, and cerebellum) (model a), as well as its extracellular concentration in the striatum using an in vivo microdialysis (model b) after melatonin injection (100 mg/kg i.p.) |
2016-10-24 |
2023-08-13 |
rat |
| Karen E Murray, Kerry J Ressler, Michael J Owen. In vivo investigation of escitalopram's allosteric site on the serotonin transporter. Pharmacology, biochemistry, and behavior. vol 141. 2016-10-19. PMID:26621784. |
microdialysis studies in the ventral hippocampus found no measurable decrease in extracellular serotonin response after local escitalopram challenge in mice without the allosteric site compared to mice with the site (p=0.297). |
2016-10-19 |
2023-08-13 |
mouse |
| Aude Muzerelle, Sophie Scotto-Lomassese, Jean François Bernard, Mariano Soiza-Reilly, Patricia Gaspa. Conditional anterograde tracing reveals distinct targeting of individual serotonin cell groups (B5-B9) to the forebrain and brainstem. Brain structure & function. vol 221. issue 1. 2016-10-17. PMID:25403254. |
we illustrate the distinctive and largely non-overlapping projection areas of these cell groups: for instance, dr (b7) projects to basal parts of the forebrain, such as the amygdala, whereas mr (b8) is the main 5-ht source to the hippocampus, septum, and mesopontine tegmental nuclei. |
2016-10-17 |
2023-08-13 |
mouse |