| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Mostafa El Mansari, Agnes Crnic, Chris Oosterhof, Pierre Blie. Long-term administration of the antidepressant vilazodone modulates rat brain monoaminergic systems. Neuropharmacology. vol 99. 2016-08-30. PMID:26362359. |
a previous in vivo microdialysis experiment showed that a single administration of vilazodone, dose-dependently increases extracellular 5-ht but not norepinephrine (ne) or dopamine (da) levels in rat medial prefrontal cortex and ventral hippocampus. |
2016-08-30 |
2023-08-13 |
human |
| Mostafa El Mansari, Agnes Crnic, Chris Oosterhof, Pierre Blie. Long-term administration of the antidepressant vilazodone modulates rat brain monoaminergic systems. Neuropharmacology. vol 99. 2016-08-30. PMID:26362359. |
after repeated vilazodone regimen, while there was no change in sensitivity of 5-ht1a receptors, the enhancement in 5-ht transmission yielded an increase in the tonic activation of these receptors located in the hippocampus. |
2016-08-30 |
2023-08-13 |
human |
| Giuseppe Musumeci, Paola Castrogiovanni, Sergio Castorina, Rosa Imbesi, Marta Anna Szychlinska, Soraya Scuderi, Carla Loreto, Salvatore Giunt. Changes in serotonin (5-HT) and brain-derived neurotrophic factor (BDFN) expression in frontal cortex and hippocampus of aged rat treated with high tryptophan diet. Brain research bulletin. vol 119. issue Pt A. 2016-08-29. PMID:26444078. |
changes in serotonin (5-ht) and brain-derived neurotrophic factor (bdfn) expression in frontal cortex and hippocampus of aged rat treated with high tryptophan diet. |
2016-08-29 |
2023-08-13 |
rat |
| Giuseppe Musumeci, Paola Castrogiovanni, Sergio Castorina, Rosa Imbesi, Marta Anna Szychlinska, Soraya Scuderi, Carla Loreto, Salvatore Giunt. Changes in serotonin (5-HT) and brain-derived neurotrophic factor (BDFN) expression in frontal cortex and hippocampus of aged rat treated with high tryptophan diet. Brain research bulletin. vol 119. issue Pt A. 2016-08-29. PMID:26444078. |
since 5-ht is closely associated to bdnf, we aimed to investigate the effect of high trp diet on 5-ht levels and bdnf expression in frontal cortex (fc) and hippocampus (hp) of aged rats. |
2016-08-29 |
2023-08-13 |
rat |
| Giuseppe Musumeci, Paola Castrogiovanni, Sergio Castorina, Rosa Imbesi, Marta Anna Szychlinska, Soraya Scuderi, Carla Loreto, Salvatore Giunt. Changes in serotonin (5-HT) and brain-derived neurotrophic factor (BDFN) expression in frontal cortex and hippocampus of aged rat treated with high tryptophan diet. Brain research bulletin. vol 119. issue Pt A. 2016-08-29. PMID:26444078. |
interestingly, immunohistochemical analyses confirmed that high trp diet significantly elevates the number of 5-ht immunoreactive fibers in both brain areas tested and this correlated with bdnf increase in the fc and hippocampal regions ca1, ca2, ca3 and a strikingly down-regulation of neurotrophin levels in the dentate gyrus (dg) of aged rats. |
2016-08-29 |
2023-08-13 |
rat |
| Tzu-Wei Lin, Yu-Fan Liu, Yao-Hsiang Shih, Shean-Jen Chen, Tung-Yi Huang, Chia-Yuan Chang, Chi-Hsiang Lien, Lung Yu, Shun-Hua Chen, Yu-Min Ku. Neurodegeneration in Amygdala Precedes Hippocampus in the APPswe/ PS1dE9 Mouse Model of Alzheimer's Disease. Current Alzheimer research. vol 12. issue 10. 2016-08-26. PMID:26502818. |
furthermore, reduction of 5-ht and elevation of aβ levels also occurred earlier in the amygdala and were more pronounced than those in the hippocampus. |
2016-08-26 |
2023-08-13 |
mouse |
| Tzu-Wei Lin, Yu-Fan Liu, Yao-Hsiang Shih, Shean-Jen Chen, Tung-Yi Huang, Chia-Yuan Chang, Chi-Hsiang Lien, Lung Yu, Shun-Hua Chen, Yu-Min Ku. Neurodegeneration in Amygdala Precedes Hippocampus in the APPswe/ PS1dE9 Mouse Model of Alzheimer's Disease. Current Alzheimer research. vol 12. issue 10. 2016-08-26. PMID:26502818. |
negative correlations between the levels of 5-ht and aβ were evident in the amygdala, but not in the hippocampus. |
2016-08-26 |
2023-08-13 |
mouse |
| Priscilla B Pail, Kesiane M Costa, Carlos E Leite, Maria M Campo. Comparative pharmacological evaluation of the cathinone derivatives, mephedrone and methedrone, in mice. Neurotoxicology. vol 50. 2016-08-24. PMID:26254738. |
methedrone caused a 2-fold increment of tissue dopamine in the nucleus accumbens and in the striatum, and a 1.5-fold increment of serotonin tissue levels in the hippocampus and striatum. |
2016-08-24 |
2023-08-13 |
mouse |
| Jing Sun, Fangyan Wang, Guangliang Hong, Mengqi Pang, Hailing Xu, Haixiao Li, Feng Tian, Renchi Fang, Ye Yao, Jiaming Li. Antidepressant-like effects of sodium butyrate and its possible mechanisms of action in mice exposed to chronic unpredictable mild stress. Neuroscience letters. vol 618. 2016-08-22. PMID:26957230. |
then changes of nissl's body in the hippocampus, brain serotonin (5-ht) concentration, brain-derived neurotrophic factor (bdnf) and tight junctions (tjs) proteins level were assessed to explore the antidepressant mechanisms. |
2016-08-22 |
2023-08-13 |
mouse |
| Jing Sun, Fangyan Wang, Guangliang Hong, Mengqi Pang, Hailing Xu, Haixiao Li, Feng Tian, Renchi Fang, Ye Yao, Jiaming Li. Antidepressant-like effects of sodium butyrate and its possible mechanisms of action in mice exposed to chronic unpredictable mild stress. Neuroscience letters. vol 618. 2016-08-22. PMID:26957230. |
our results showed that cums caused significant depression-like behaviors, neuropathological changes, and decreased brain 5-ht concentration, tjs protein levels and bdnf expression in the hippocampus. |
2016-08-22 |
2023-08-13 |
mouse |
| Jing Sun, Fangyan Wang, Guangliang Hong, Mengqi Pang, Hailing Xu, Haixiao Li, Feng Tian, Renchi Fang, Ye Yao, Jiaming Li. Antidepressant-like effects of sodium butyrate and its possible mechanisms of action in mice exposed to chronic unpredictable mild stress. Neuroscience letters. vol 618. 2016-08-22. PMID:26957230. |
however, nab treatment significantly ameliorated behavioral deficits of the cums-induced mice, increased 5-ht concentration, increased bdnf expression, and up-regulated occludin and zonula occludens-1(zo-1) protein levels in the hippocampus, which demonstrated that nab could partially restore cums-induced blood-brain barrier (bbb) impairments. |
2016-08-22 |
2023-08-13 |
mouse |
| Ana Carolina de Moura, Virgínia Meneghini Lazzari, Roberta Oriques Becker, Mirela Severo Gil, Carina Anicet Ruthschilling, Grasiela Agnes, Silvana Almeida, Ana Beatriz Gorini da Veiga, Aldo Bolten Lucion, Márcia Giovenard. Gene expression in the CNS of lactating rats with different patterns of maternal behavior. Neuroscience research. vol 99. 2016-08-19. PMID:26003743. |
this study aimed to analyze the gene expression of the receptors for dopamine (drd1a), prolactin (prlr), serotonin (htr1a, htr1b), estrogen (esr1, esr2), and of bdnf in the olfactory bulb (ob), hippocampus (hp), prefrontal cortex (pfc), and striatum (st) of wistar rats from three groups: ll (n = 8); hl (n = 8); virgin females in diestrus (d; n = 6). |
2016-08-19 |
2023-08-13 |
rat |
| J Tchekalarova, M Shishmanova, D Atanasova, M Stefanova, L Alova, N Lazarov, K Georgiev. Effect of endurance training on seizure susceptibility, behavioral changes and neuronal damage after kainate-induced status epilepticus in spontaneously hypertensive rats. Brain research. vol 1625. 2016-08-15. PMID:26319691. |
the release of 5-ht in the hippocampus was measured using a liquid scintillation method and neuronal damage was analyzed by hematoxylin and eosin staining. |
2016-08-15 |
2023-08-13 |
rat |
| J Tchekalarova, M Shishmanova, D Atanasova, M Stefanova, L Alova, N Lazarov, K Georgiev. Effect of endurance training on seizure susceptibility, behavioral changes and neuronal damage after kainate-induced status epilepticus in spontaneously hypertensive rats. Brain research. vol 1625. 2016-08-15. PMID:26319691. |
while the anticonvulsant and positive behavioral effects of endurance training were accompanied by an increase of 5-ht release in the hippocampus, it did not exert neuroprotective activity. |
2016-08-15 |
2023-08-13 |
rat |
| J Tchekalarova, M Shishmanova, D Atanasova, M Stefanova, L Alova, N Lazarov, K Georgiev. Effect of endurance training on seizure susceptibility, behavioral changes and neuronal damage after kainate-induced status epilepticus in spontaneously hypertensive rats. Brain research. vol 1625. 2016-08-15. PMID:26319691. |
our results indicate that prior exercise is an effective means to attenuate ka-induced seizures and comorbid behavioral changes in a model of hypertension and epilepsy suggesting a potential influence of hippocampal 5-ht on a comorbid depression. |
2016-08-15 |
2023-08-13 |
rat |
| S Liang, T Wang, X Hu, J Luo, W Li, X Wu, Y Duan, F Ji. Administration of Lactobacillus helveticus NS8 improves behavioral, cognitive, and biochemical aberrations caused by chronic restraint stress. Neuroscience. vol 310. 2016-08-15. PMID:26408987. |
l. helveticus ns8 also resulted in lower plasma corticosterone (cort) and adrenocorticotropic hormone (acth) levels, higher plasma interleukin-10 (il-10) levels, restored hippocampal serotonin (5-ht) and norepinephrine (ne) levels, and more hippocampal brain-derived neurotrophic factor (bdnf) mrna expression than in chronic stress rats. |
2016-08-15 |
2023-08-13 |
rat |
| Min Sun, Ke Wang, Yan Yu, Wen-Ting Su, Xin-Xin Jiang, Jian Yang, Jun Jia, Xiao-Min Wan. Electroacupuncture Alleviates Depressive-Like Symptoms and Modulates BDNF Signaling in 6-Hydroxydopamine Rats. Evidence-based complementary and alternative medicine : eCAM. vol 2016. 2016-08-15. PMID:27525025. |
ea treatment did not alter dopamine, norepinephrine, and serotonin levels in the striatum and hippocampus. |
2016-08-15 |
2023-08-13 |
rat |
| M Kondo, Y Nakamura, Y Ishida, S Shimad. The 5-HT3 receptor is essential for exercise-induced hippocampal neurogenesis and antidepressant effects. Molecular psychiatry. vol 20. issue 11. 2016-08-02. PMID:25403840. |
in this study, analysis of the 5-ht type 3a receptor subunit-deficient (htr3a(-/-)) mice revealed that lack of the 5-ht type 3 (5-ht3) receptor resulted in loss of exercise-induced hippocampal neurogenesis and antidepressant effects, but not of learning enhancement. |
2016-08-02 |
2023-08-13 |
mouse |
| M Kondo, Y Nakamura, Y Ishida, S Shimad. The 5-HT3 receptor is essential for exercise-induced hippocampal neurogenesis and antidepressant effects. Molecular psychiatry. vol 20. issue 11. 2016-08-02. PMID:25403840. |
these findings demonstrate that the 5-ht3 receptor is the critical target of 5-ht action in the brain following exercise, and is indispensable for hippocampal neurogenesis and antidepressant effects induced by exercise. |
2016-08-02 |
2023-08-13 |
mouse |
| Rajeshwari R Solanki, Jamie L Scholl, Michael J Watt, Kenneth J Renner, Gina L Forste. Amphetamine Withdrawal Differentially Increases the Expression of Organic Cation Transporter 3 and Serotonin Transporter in Limbic Brain Regions. Journal of experimental neuroscience. vol 10. 2016-08-01. PMID:27478387. |
amphetamine withdrawal increases anxiety and stress sensitivity related to blunted ventral hippocampus (vhipp) and enhances the central nucleus of the amygdala (cea) serotonin responses. |
2016-08-01 |
2023-08-13 |
rat |