Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
Janina Deusser, Stefanie Schmidt, Benjamin Ettle, Sonja Plötz, Sabine Huber, Christian P Müller, Eliezer Masliah, Jürgen Winkler, Zacharias Koh. Serotonergic dysfunction in the A53T alpha-synuclein mouse model of Parkinson's disease. Journal of neurochemistry. vol 135. issue 3. 2016-02-10. PMID:26201615. |
a loss of serotonergic neurons or their projections into the hippocampus and alterations in serotonin release may be linked to these symptoms. |
2016-02-10 |
2023-08-13 |
mouse |
Shu-Juan Wu, Ren-Ye Wang, Ji-Xiong Xue, Jian-Chun Pa. [Effect of piperine on 5-HT and synaptophysin expression of rats with irritable bowel syndrome]. Yao xue xue bao = Acta pharmaceutica Sinica. vol 48. issue 12. 2016-02-02. PMID:24689235. |
the expressions of 5-ht and synaptophysin in the hippocampus and colon were determined by high performance liquid chromatography (hplc) and western blotting, respectively. |
2016-02-02 |
2023-08-12 |
rat |
Shu-Juan Wu, Ren-Ye Wang, Ji-Xiong Xue, Jian-Chun Pa. [Effect of piperine on 5-HT and synaptophysin expression of rats with irritable bowel syndrome]. Yao xue xue bao = Acta pharmaceutica Sinica. vol 48. issue 12. 2016-02-02. PMID:24689235. |
as compared with those in the normal control group, the expression of 5-ht significantly decreased, 5-hiaa/5-ht ratio significantly increased in the hippocampus of ibs model group (p<0.05), but opposite presentations were noted in the colon (p<0.05). |
2016-02-02 |
2023-08-12 |
rat |
Shu-Juan Wu, Ren-Ye Wang, Ji-Xiong Xue, Jian-Chun Pa. [Effect of piperine on 5-HT and synaptophysin expression of rats with irritable bowel syndrome]. Yao xue xue bao = Acta pharmaceutica Sinica. vol 48. issue 12. 2016-02-02. PMID:24689235. |
piperine improved the behavior of ibs rats, and reversed the levels of 5-ht and 5-hiaa, and 5-hiaa/5-ht proportion in the hippocampus and colon (p<0.05); besides, they significantly reverse the synaptophysin level in the hippocampus and colon (p<0.05). |
2016-02-02 |
2023-08-12 |
rat |
E J Connors, M M Migliore, S L Pillsbury, A N Shaik, A C Kentne. Environmental enrichment models a naturalistic form of maternal separation and shapes the anxiety response patterns of offspring. Psychoneuroendocrinology. vol 52. 2016-01-29. PMID:25437120. |
serotonin, corticosterone, gaba, glutamate) in prefrontal cortex and hippocampus as a function of ee, communal nesting (cn) and standard care (sc). |
2016-01-29 |
2023-08-13 |
rat |
Antonios Stamatakis, Theodora Kalpachidou, Androniki Raftogianni, Efstratia Zografou, Athanasia Tzanou, Stavroula Pondiki, Fotini Stylianopoulo. Rat dams exposed repeatedly to a daily brief separation from the pups exhibit increased maternal behavior, decreased anxiety and altered levels of receptors for estrogens (ERα, ERβ), oxytocin and serotonin (5-HT1A) in their brain. Psychoneuroendocrinology. vol 52. 2016-01-29. PMID:25486578. |
on postnatal days (pnd) 12 and 22, we determined in experimental and control dams levels of anxiety in the elevated plus maze (epm) as well as the levels of receptors for estrogens (erα, erβ), oxytocin (otr) and serotonin (5-ht1ar) in areas of the limbic system (prefrontal cortex-pfc, hippocampus, lateral septum-sl, medial preoptic area-mpoa, shell of nucleus accumbens-nac-sh, central-cea and basolateral-bla amygdala), involved in the regulation of maternal behavior. |
2016-01-29 |
2023-08-13 |
rat |
Yongjun Xu, Hui Sheng, Zhiping Tang, Jianqiang Lu, Xin N. Inflammation and increased IDO in hippocampus contribute to depression-like behavior induced by estrogen deficiency. Behavioural brain research. vol 288. 2016-01-27. PMID:25907742. |
the results showed that ovariectomy resulted in depression-like behavior in female rats and caused a decrease in 5-ht content and an increase in levels of ido, ifn-γ, il-6, toll like receptor (tlr)-4 and phosphorylated nf-κb (p65 subunit) in hippocampus but not in prefrontal cortex (pfc). |
2016-01-27 |
2023-08-13 |
rat |
Yongjun Xu, Hui Sheng, Zhiping Tang, Jianqiang Lu, Xin N. Inflammation and increased IDO in hippocampus contribute to depression-like behavior induced by estrogen deficiency. Behavioural brain research. vol 288. 2016-01-27. PMID:25907742. |
our study suggests that estrogen inhibits inflammation and activates of ido and maintains 5-ht level in hippocampus, thereby ameliorating depression-like behavior. |
2016-01-27 |
2023-08-13 |
rat |
Yuki Imoto, Toshihiko Kira, Mamiko Sukeno, Naoya Nishitani, Kazuki Nagayasu, Takayuki Nakagawa, Shuji Kaneko, Katsunori Kobayashi, Eri Segi-Nishid. Role of the 5-HT4 receptor in chronic fluoxetine treatment-induced neurogenic activity and granule cell dematuration in the dentate gyrus. Molecular brain. vol 8. 2016-01-19. PMID:25976618. |
chronic treatment with selective serotonin (5-ht) reuptake inhibitors (ssris) facilitates adult neurogenesis and reverses the state of maturation in mature granule cells (gcs) in the dentate gyrus (dg) of the hippocampus. |
2016-01-19 |
2023-08-13 |
Not clear |
C Bétry, D Overstreet, N Haddjeri, A L Pehrson, C Bundgaard, C Sanchez, A Mør. A 5-HT3 receptor antagonist potentiates the behavioral, neurochemical and electrophysiological actions of an SSRI antidepressant. Pharmacology, biochemistry, and behavior. vol 131. 2016-01-15. PMID:25697477. |
effects of s.c. administration of the compounds alone and in combination on extracellular levels of 5-ht were assessed in the ventral hippocampus of freely moving rats by microdialysis. |
2016-01-15 |
2023-08-13 |
rat |
C Bétry, D Overstreet, N Haddjeri, A L Pehrson, C Bundgaard, C Sanchez, A Mør. A 5-HT3 receptor antagonist potentiates the behavioral, neurochemical and electrophysiological actions of an SSRI antidepressant. Pharmacology, biochemistry, and behavior. vol 131. 2016-01-15. PMID:25697477. |
it partially prevented the suppressant effect of paroxetine on drn 5-ht neuronal firing and enhanced the paroxetine-induced increase of hippocampal extracellular 5-ht release. |
2016-01-15 |
2023-08-13 |
rat |
Momen W Alhaj, Sawsan A Zaitone, Yasser M Moustaf. Fluvoxamine alleviates seizure activity and downregulates hippocampal GAP-43 expression in pentylenetetrazole-kindled mice: role of 5-HT3 receptors. Behavioural pharmacology. vol 26. issue 4. 2016-01-13. PMID:25590967. |
repeated administration of fluvoxamine (20 mg/kg) in ptz-kindled mice suppressed seizure scores, protected against hippocampal neuronal loss, and downregulated gap-43 expression, without producing any signs of the 5-ht syndrome in healthy rats. |
2016-01-13 |
2023-08-13 |
mouse |
F Sarubbo, M R Ramis, S Aparicio, L Ruiz, S Esteban, A Miralles, D Morant. Improving effect of chronic resveratrol treatment on central monoamine synthesis and cognition in aged rats. Age (Dordrecht, Netherlands). vol 37. issue 3. 2016-01-13. PMID:25895558. |
the resveratrol treatment enhances serotonin (5-ht) levels in pineal gland, in hippocampus, and in striatum, and those of noradrenaline (na) in hippocampus and also dopamine (da) in striatum. |
2016-01-13 |
2023-08-13 |
rat |
Jana Tchekalarova, Ellen Loyens, Ilse Smolder. Effects of AT1 receptor antagonism on kainate-induced seizures and concomitant changes in hippocampal extracellular noradrenaline, serotonin, and dopamine levels in Wistar-Kyoto and spontaneously hypertensive rats. Epilepsy & behavior : E&B. vol 46. 2016-01-13. PMID:25922088. |
effects of at1 receptor antagonism on kainate-induced seizures and concomitant changes in hippocampal extracellular noradrenaline, serotonin, and dopamine levels in wistar-kyoto and spontaneously hypertensive rats. |
2016-01-13 |
2023-08-13 |
rat |
Jana Tchekalarova, Ellen Loyens, Ilse Smolder. Effects of AT1 receptor antagonism on kainate-induced seizures and concomitant changes in hippocampal extracellular noradrenaline, serotonin, and dopamine levels in Wistar-Kyoto and spontaneously hypertensive rats. Epilepsy & behavior : E&B. vol 46. 2016-01-13. PMID:25922088. |
the present study aimed to assess the effects of the selective at1 receptor antagonist zd7155 on kainic acid (ka)-induced status epilepticus (se) development and accompanying changes in the hippocampal extracellular (ec) neurotransmitter levels of noradrenaline (nad), serotonin (5-ht), and dopamine (da) in spontaneously hypertensive rats (shrs) and their parent strain wistar-kyoto (wky) rats, since monoamines are well-known neurotransmitters involved in mechanisms of both epilepsy and hypertension. |
2016-01-13 |
2023-08-13 |
rat |
Jana Tchekalarova, Ellen Loyens, Ilse Smolder. Effects of AT1 receptor antagonism on kainate-induced seizures and concomitant changes in hippocampal extracellular noradrenaline, serotonin, and dopamine levels in Wistar-Kyoto and spontaneously hypertensive rats. Epilepsy & behavior : E&B. vol 46. 2016-01-13. PMID:25922088. |
in vivo microdialysis demonstrated significant ka-induced increases of the hippocampal nad and da levels in shrs and of nad, 5-ht, and da in wky rats. |
2016-01-13 |
2023-08-13 |
rat |
Jana Tchekalarova, Ellen Loyens, Ilse Smolder. Effects of AT1 receptor antagonism on kainate-induced seizures and concomitant changes in hippocampal extracellular noradrenaline, serotonin, and dopamine levels in Wistar-Kyoto and spontaneously hypertensive rats. Epilepsy & behavior : E&B. vol 46. 2016-01-13. PMID:25922088. |
these results suggest a lack of direct relationship between ka-induced seizure susceptibility and adaptive changes of hippocampal nad, 5-ht, and da levels in the effects of zd7155 in wky rats and shrs. |
2016-01-13 |
2023-08-13 |
rat |
Saroj Kumar Das, Kalpana Barhwal, Sunil Kumar Hota, Mahendra Kumar Thakur, Ravi Bihari Srivastav. Disrupting monotony during social isolation stress prevents early development of anxiety and depression like traits in male rats. BMC neuroscience. vol 16. 2016-01-12. PMID:25880744. |
hippocampal serotonin and 5-hydroxy indole acetic acid (5-hiaa) levels were estimated along with the expression of phospho-insulin like growth factor-1 receptor (pigf-1r) and phospho cyclic amp response-element binding protein (pcreb). |
2016-01-12 |
2023-08-13 |
rat |
M Kusek, J Sowa, K Tokarski, G Hes. Impaired effect of activation of rat hippocampal 5-HT7 receptors, induced by treatment with the 5-HT7 receptor antagonist SB 269970. Journal of physiology and pharmacology : an official journal of the Polish Physiological Society. vol 66. issue 2. 2016-01-12. PMID:25903960. |
effects of the 5-ht(7) receptor antagonist sb 269970, administered for 14 days (1.25 mg/kg), were studied in ex vivo slices of rat hippocampus. |
2016-01-12 |
2023-08-13 |
rat |
M Kusek, J Sowa, K Tokarski, G Hes. Impaired effect of activation of rat hippocampal 5-HT7 receptors, induced by treatment with the 5-HT7 receptor antagonist SB 269970. Journal of physiology and pharmacology : an official journal of the Polish Physiological Society. vol 66. issue 2. 2016-01-12. PMID:25903960. |
these data demonstrate that repeated administration of sb 269970 impairs the reactivity of the ca1 hippocampal neuronal network to 5-ht(7) receptor activation. |
2016-01-12 |
2023-08-13 |
rat |