| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Li-Tao Yi, Jing Li, Qing Liu, Di Geng, Ya-Fei Zhou, Xiao-Qing Ke, Huan Chen, Lian-Jin Wen. Antidepressant-like effect of oleanolic acid in mice exposed to the repeated forced swimming test. Journal of psychopharmacology (Oxford, England). vol 27. issue 5. 2013-11-26. PMID:23151611. |
furthermore, chronic administration of oleanolic acid significantly increased serotonin (5-ht) levels (frontal cortex: 44.5%, 41.9%, 27.5% for 10, 20, 40 mg/kg; hippocampus: 57.2%, 80.9% for 10, 20 mg/kg), decreased 5-hydroxyindoleacetic acid (5-hiaa)/5-ht ratio (frontal cortex: 31.6%, 30.1%, 23.5%; hippocampus: 40.6%, 47.7%, 29.2% for 10, 20, 40 mg/kg) and elevated norepinephrine (ne) levels (hippocampus: 20 mg/kg, 45.4%) but did not alter dopamine (da) levels. |
2013-11-26 |
2023-08-12 |
mouse |
| Alvaro L García-García, Elisabet Venzala, Natalia Elizalde, M J Ramírez, Ahinoa Urbiola, Joaquin Del Rio, Laurence Lanfumey, Rosa M Torder. Regulation of serotonin (5-HT) function by a VGLUT1 dependent glutamate pathway. Neuropharmacology. vol 70. 2013-11-26. PMID:23168115. |
these mice showed decreased induced neuronal activity in 5-ht cells bodies and in different forebrain areas, as well as decreased hippocampal cell proliferation and 5-ht turnover. |
2013-11-26 |
2023-08-12 |
mouse |
| G L Kovács, J Kishonti, K Lissák, G Telegd. Dose-dependent dual effect of corticosterone on cerebral 5-HT metabolism. Neurochemical research. vol 2. issue 3. 2013-11-26. PMID:24272058. |
a 1.0 mg/kg dose of corticosterone increased the serotonin content and turnover in the hypothalamus and mesencephalon 30 min after administration; however, it was ineffective on dorsal hippocampus and frontal and parietal cortex. |
2013-11-26 |
2023-08-12 |
Not clear |
| Nathan C Mitchell, Georgianna G Gould, Corey M Smolik, Wouter Koek, Lynette C Daw. Antidepressant-like drug effects in juvenile and adolescent mice in the tail suspension test: Relationship with hippocampal serotonin and norepinephrine transporter expression and function. Frontiers in pharmacology. vol 4. 2013-11-05. PMID:24191152. |
antidepressant-like drug effects in juvenile and adolescent mice in the tail suspension test: relationship with hippocampal serotonin and norepinephrine transporter expression and function. |
2013-11-05 |
2023-08-12 |
mouse |
| Nathan C Mitchell, Georgianna G Gould, Corey M Smolik, Wouter Koek, Lynette C Daw. Antidepressant-like drug effects in juvenile and adolescent mice in the tail suspension test: Relationship with hippocampal serotonin and norepinephrine transporter expression and function. Frontiers in pharmacology. vol 4. 2013-11-05. PMID:24191152. |
the smaller antidepressant response of juveniles was not related to either maximal binding (b max) or affinity (k d) for [(3)h]citalopram binding to the serotonin transporter (sert) in hippocampus, which did not vary significantly among ages. |
2013-11-05 |
2023-08-12 |
mouse |
| Darrick T Balu, Jill R Turner, Bethany R Brookshire, Tiffany E Hill-Smith, Julie A Blendy, Irwin Luck. Brain monoamines and antidepressant-like responses in MRL/MpJ versus C57BL/6J mice. Neuropharmacology. vol 67. 2013-11-04. PMID:23220293. |
however, acute administration of the selective serotonin reuptake inhibitor citalopram produced an increase in extracellular serotonin in the ventral hippocampus of mrl/mpj mice that was twice as large as achieved in c57bl/6j mice. |
2013-11-04 |
2023-08-12 |
mouse |
| Darrick T Balu, Jill R Turner, Bethany R Brookshire, Tiffany E Hill-Smith, Julie A Blendy, Irwin Luck. Brain monoamines and antidepressant-like responses in MRL/MpJ versus C57BL/6J mice. Neuropharmacology. vol 67. 2013-11-04. PMID:23220293. |
the greater effects in mrl/mpj mice on 5-ht levels were not maintained after local perfusion of citalopram, suggesting that mechanisms outside of the hippocampus were responsible for the greater effect of citalopram after systemic injection. |
2013-11-04 |
2023-08-12 |
mouse |
| Darrick T Balu, Jill R Turner, Bethany R Brookshire, Tiffany E Hill-Smith, Julie A Blendy, Irwin Luck. Brain monoamines and antidepressant-like responses in MRL/MpJ versus C57BL/6J mice. Neuropharmacology. vol 67. 2013-11-04. PMID:23220293. |
the density of serotonin and norepinephrine transporters in the hippocampus was significantly higher in mrl/mpj mice. |
2013-11-04 |
2023-08-12 |
mouse |
| Darrick T Balu, Jill R Turner, Bethany R Brookshire, Tiffany E Hill-Smith, Julie A Blendy, Irwin Luck. Brain monoamines and antidepressant-like responses in MRL/MpJ versus C57BL/6J mice. Neuropharmacology. vol 67. 2013-11-04. PMID:23220293. |
in addition, the expression of 5-ht(1a) mrna was lower in the hippocampus, 5-ht(1b) mrna was higher in the hippocampus and brainstem and sert mrna was higher in the brain stem of mrl/mpj mice. |
2013-11-04 |
2023-08-12 |
mouse |
| Kazuya Miyagawa, Minoru Tsuji, Hiroshi Taked. [Possible involvement of histone acetylation in the development of emotional resistance to stress stimuli]. Nihon shinkei seishin yakurigaku zasshi = Japanese journal of psychopharmacology. vol 32. issue 5-6. 2013-11-01. PMID:23373313. |
in addition, dna microarray analysis showed that such a pretreatment with 5-ht(1a) receptor agonist produces changes in several gene transcriptions in the hippocampus including the reduction of histone deacetylase 10. |
2013-11-01 |
2023-08-12 |
mouse |
| Teresa F Burke, Tushar Advani, Megumi Adachi, Lisa M Monteggia, Julie G Hensle. Sensitivity of hippocampal 5-HT1A receptors to mild stress in BDNF-deficient mice. The international journal of neuropsychopharmacology. vol 16. issue 3. 2013-10-31. PMID:22575584. |
decreases in hippocampal 5-ht(1a) receptor function induced by mild stress in bdnf-deficient mice were prevented by administration of the selective serotonin reuptake inhibitor fluoxetine, which increased activation of trkb, the high affinity receptor for bdnf, in wild-type and bdnf(+/-) mice. |
2013-10-31 |
2023-08-12 |
mouse |
| Teresa F Burke, Tushar Advani, Megumi Adachi, Lisa M Monteggia, Julie G Hensle. Sensitivity of hippocampal 5-HT1A receptors to mild stress in BDNF-deficient mice. The international journal of neuropsychopharmacology. vol 16. issue 3. 2013-10-31. PMID:22575584. |
in hippocampal cultures, bdnf increased the capacity of 5-ht(1a) receptors to activate g proteins, an effect eliminated by the knockout of trkb, confirming trkb activation increases 5-ht(1a) receptor function. |
2013-10-31 |
2023-08-12 |
mouse |
| Teresa F Burke, Tushar Advani, Megumi Adachi, Lisa M Monteggia, Julie G Hensle. Sensitivity of hippocampal 5-HT1A receptors to mild stress in BDNF-deficient mice. The international journal of neuropsychopharmacology. vol 16. issue 3. 2013-10-31. PMID:22575584. |
the mechanisms underlying the sensitivity of hippocampal 5-ht(1a) receptors to mild stress and decreased bdnf expression remain to be elucidated and may have important implications for the emotional and cognitive impairments associated with stress-related mental illness. |
2013-10-31 |
2023-08-12 |
mouse |
| Shlomit Jacobson-Pick, Marie-Claude Audet, Robyn Jane McQuaid, Rahul Kalvapalle, Hymie Anisma. Social agonistic distress in male and female mice: changes of behavior and brain monoamine functioning in relation to acute and chronic challenges. PloS one. vol 8. issue 4. 2013-10-30. PMID:23565195. |
these treatments, like a stressor comprising physical restraint, increased plasma corticosterone and elicited variations of norepinephrine and serotonin levels and turnover within the prefrontal cortex, hippocampus and central amygdala. |
2013-10-30 |
2023-08-12 |
mouse |
| Yan Fan, Ping Chen, Ying Li, Meng-Yang Zh. Effects of chronic social defeat on expression of dopamine β-hydroxylase in rat brains. Synapse (New York, N.Y.). vol 67. issue 6. 2013-10-29. PMID:23389997. |
however, treatment with fluoxetine, an antidepressant with specific inhibition for serotonin transport, only selectively blocked increased dopamine β-hydroxylase protein levels in the hippocampus caused by csd. |
2013-10-29 |
2023-08-12 |
rat |
| Alvaro Llorente-Berzal, Carmen Manzanedo, Manuel Daza-Losada, Manuel Valero, Meritxell López-Gallardo, María A Aguilar, Marta Rodríguez-Arias, José Miñarro, Maria-Paz Vivero. Sex-dependent effects of early maternal deprivation on MDMA-induced conditioned place preference in adolescent rats: possible neurochemical correlates. Toxicology. vol 311. issue 1-2. 2013-10-25. PMID:23246480. |
animals were sacrificed on pnd 68-75 and levels of serotonin (5-ht) and its metabolite 5-hydroxyindole acetic acid were measured in the striatum, hippocampus and cortex, while the expression of hippocampal cb1 cannabinoid receptor (cb1r) and circulating levels of corticosterone and leptin were also measured. |
2013-10-25 |
2023-08-12 |
rat |
| Alvaro Llorente-Berzal, Carmen Manzanedo, Manuel Daza-Losada, Manuel Valero, Meritxell López-Gallardo, María A Aguilar, Marta Rodríguez-Arias, José Miñarro, Maria-Paz Vivero. Sex-dependent effects of early maternal deprivation on MDMA-induced conditioned place preference in adolescent rats: possible neurochemical correlates. Toxicology. vol 311. issue 1-2. 2013-10-25. PMID:23246480. |
a reduction in striatal and cortical 5-ht levels, increased expression of hippocampal cb1r and a marked trend towards higher circulating leptin levels were observed in mdma-treated md males. |
2013-10-25 |
2023-08-12 |
rat |
| Yuka Okada, Ken Tachibana, Shinya Yanagita, Ken Taked. Prenatal exposure to zinc oxide particles alters monoaminergic neurotransmitter levels in the brain of mouse offspring. The Journal of toxicological sciences. vol 38. issue 3. 2013-10-23. PMID:23665935. |
we also found changes of the levels of serotonin in the hypothalamus, and of the levels of 5-hiaa (5-ht metabolite) in the prefrontal cortex and hippocampus in the zno np-exposed group. |
2013-10-23 |
2023-08-12 |
mouse |
| Tushar Arora, Malay Bhowmik, Razia Khanam, Divya Vohor. Oxcarbazepine and fluoxetine protect against mouse models of obsessive compulsive disorder through modulation of cortical serotonin and CREB pathway. Behavioural brain research. vol 247. 2013-10-21. PMID:23473877. |
oxcarbazepine (oxc), a second generation antiepileptic drug, enhances hippocampal serotonin (5-ht) levels. |
2013-10-21 |
2023-08-12 |
mouse |
| Jennifer Do, Susan Schen. Self-administered MDMA produces dose- and time-dependent serotonin deficits in the rat brain. Addiction biology. vol 18. issue 3. 2013-10-17. PMID:21955305. |
in this study, tissue levels of 5ht in the frontal cortex, striatum and hippocampus were measured following different levels of self-administered mdma. |
2013-10-17 |
2023-08-12 |
rat |