| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| A Bortolozzi, A Castañé, J Semakova, N Santana, G Alvarado, R Cortés, A Ferrés-Coy, G Fernández, M C Carmona, M Toth, J C Perales, A Montefeltro, F Artiga. Selective siRNA-mediated suppression of 5-HT1A autoreceptors evokes strong anti-depressant-like effects. Molecular psychiatry. vol 17. issue 6. 2012-11-07. PMID:21808255. |
in parallel, c-1a-sirna administration markedly decreased 5-ht(1a)-autoreceptor expression and suppressed 8-oh-dpat-induced hypothermia (a pre-synaptic 5-ht(1a)r effect in mice) without affecting post-synaptic 5-ht(1a)r expression in hippocampus and prefrontal cortex. |
2012-11-07 |
2023-08-12 |
mouse |
| Silvia Racca, Francesca Piccione, Angela Spaccamiglio, Vitina M A Carriero, Silvia De Francia, Luigi Cangemi, Paola Esculapio, Mauro Papotti, Giuseppe Migliaretti, Paolo Portaleone, Francesco Di Carlo, Giuliana Abbadess. Effects of sub-chronic nandrolone administration on hormonal adaptive response to acute stress in rats. Psychoneuroendocrinology. vol 37. issue 8. 2012-11-05. PMID:22226432. |
acute rs produced the following effects: increase in cort (in blood) and acth (both in blood and in pituitary corticotropes), gr depletion in hippocampus and hypothalamus cytosol and gr translocation in hippocampus nuclear fraction, cortical serotonin re-uptake stimulation and hippocampus cytosolic erk2 activation. |
2012-11-05 |
2023-08-12 |
rat |
| M E Haahr, P M Rasmussen, K Madsen, L Marner, C Ratner, N Gillings, W F C Baaré, G M Knudse. Obesity is associated with high serotonin 4 receptor availability in the brain reward circuitry. NeuroImage. vol 61. issue 4. 2012-11-05. PMID:22709820. |
we found in humans a strong positive association between body mass index and the 5-ht(4)r density bilaterally in the two reward ‘hot spots’ nucleus accumbens and ventral pallidum, and additionally in the left hippocampal region and orbitofrontal cortex. |
2012-11-05 |
2023-08-12 |
Not clear |
| Wei Song, Hillel Zukor, Shih-Hsiung Lin, Jacob Hascalovici, Adrienne Liberman, Ayda Tavitian, Jeannie Mui, Hojatollah Vali, Xin-Kang Tong, Sanjeev K Bhardwaj, Lalit K Srivastava, Edith Hamel, Hyman M Schippe. Schizophrenia-like features in transgenic mice overexpressing human HO-1 in the astrocytic compartment. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 32. issue 32. 2012-10-26. PMID:22875919. |
herein, we demonstrate that selective overexpression of the stress protein heme oxygenase-1 (ho-1) in astrocytes of novel gfap.hmox1 transgenic mice results in subcortical oxidative stress and mitochondrial damage/autophagy; diminished neuronal reelin content (males); induction of nurr1 and pitx3 with attendant suppression of their targeting mirnas, 145 and 133b; increased tyrosine hydroxylase and α-synuclein expression with downregulation of the targeting mir-7b of the latter; augmented dopamine and serotonin levels in basal ganglia; reduced d1 receptor binding in nucleus accumbens; axodendritic pathology and altered hippocampal cytoarchitectonics; impaired neurovascular coupling; attenuated prepulse inhibition (males); and hyperkinetic behavior. |
2012-10-26 |
2023-08-12 |
mouse |
| Laura Cristina Berumen, Angelina Rodríguez, Ricardo Miledi, Guadalupe García-Alcoce. Serotonin receptors in hippocampus. TheScientificWorldJournal. vol 2012. 2012-10-19. PMID:22629209. |
serotonin receptors in hippocampus. |
2012-10-19 |
2023-08-12 |
Not clear |
| Laura Cristina Berumen, Angelina Rodríguez, Ricardo Miledi, Guadalupe García-Alcoce. Serotonin receptors in hippocampus. TheScientificWorldJournal. vol 2012. 2012-10-19. PMID:22629209. |
serotonin is an ancient molecular signal and a recognized neurotransmitter brainwide distributed with particular presence in hippocampus. |
2012-10-19 |
2023-08-12 |
Not clear |
| Lin Xia, Claudine Deloménie, Indira David, Quentin Rainer, Myriam Marouard, Hervé Delacroix, Denis J David, Alain M Gardier, Jean-Philippe Guillou. Ventral hippocampal molecular pathways and impaired neurogenesis associated with 5-HT₁A and 5-HT₁B receptors disruption in mice. Neuroscience letters. vol 521. issue 1. 2012-10-15. PMID:22622174. |
as ventral hippocampus is a key region in the mediation and genesis of anxiety, we explored the transcriptome changes induced by the genetic inactivation of these two receptors in 5-ht(1a/1b)(-/-) mice. |
2012-10-15 |
2023-08-12 |
mouse |
| Lin Xia, Claudine Deloménie, Indira David, Quentin Rainer, Myriam Marouard, Hervé Delacroix, Denis J David, Alain M Gardier, Jean-Philippe Guillou. Ventral hippocampal molecular pathways and impaired neurogenesis associated with 5-HT₁A and 5-HT₁B receptors disruption in mice. Neuroscience letters. vol 521. issue 1. 2012-10-15. PMID:22622174. |
furthermore, immunohistochemistry experiments studying adult hippocampal neurogenesis in adult 5-ht(1a/1b)(-/-) mice showed a decreased survival, but not proliferation of newborn cells in our model. |
2012-10-15 |
2023-08-12 |
mouse |
| Jeannine Baumgartner, Cornelius M Smuts, Linda Malan, Myrtha Arnold, Benjamin K Yee, Laura E Bianco, Mark V Boekschoten, Michael Müller, Wolfgang Langhans, Richard F Hurrell, Michael B Zimmerman. In male rats with concurrent iron and (n-3) fatty acid deficiency, provision of either iron or (n-3) fatty acids alone alters monoamine metabolism and exacerbates the cognitive deficits associated with combined deficiency. The Journal of nutrition. vol 142. issue 8. 2012-10-10. PMID:22739376. |
dopamine (da) receptor d1 was upregulated in the hippocampus of fe+dha/epa rats (fold-change = 1.25; p < 0.05) and there were significant fe x dha/epa interactions on serotonin (5-ht) in the ob and on the da metabolite dihydroxyphenylacetic acid in the fc and striatum. |
2012-10-10 |
2023-08-12 |
rat |
| Katharine Herrick-Davis, Ellinor Grinde, Tara Lindsley, Ann Cowan, Joseph E Mazurkiewic. Oligomer size of the serotonin 5-hydroxytryptamine 2C (5-HT2C) receptor revealed by fluorescence correlation spectroscopy with photon counting histogram analysis: evidence for homodimers without monomers or tetramers. The Journal of biological chemistry. vol 287. issue 28. 2012-10-09. PMID:22593582. |
fcs was used to record fluctuations in fluorescence intensity arising from fluorescence-tagged 5-hydroxytryptamine 2c (5-ht(2c)) receptors diffusing within the plasma membrane of hek293 cells and rat hippocampal neurons. |
2012-10-09 |
2023-08-12 |
rat |
| J R Seckl, K L Dickson, G Fin. Central 5,7-dihydroxytryptamine lesions decrease hippocampal glucocorticoid and mineralocorticoid receptor messenger ribonucleic Acid expression. Journal of neuroendocrinology. vol 2. issue 6. 2012-10-02. PMID:19215437. |
there is an extensive serotoninergic (5-ht) innervation of the hippocampus which interacts with corticosteroid-sensitive cells. |
2012-10-02 |
2023-08-12 |
rat |
| J R Seckl, K L Dickson, G Fin. Central 5,7-dihydroxytryptamine lesions decrease hippocampal glucocorticoid and mineralocorticoid receptor messenger ribonucleic Acid expression. Journal of neuroendocrinology. vol 2. issue 6. 2012-10-02. PMID:19215437. |
we have investigated the effect of intracerebroventricular 5,7-dihydroxytryptamine lesions of 5-ht neurons on glucocorticoid and mineralocorticoid receptor messenger ribonucleic acid (mrna) expression in the rat hippocampus using in situ hybridization histochemistry. |
2012-10-02 |
2023-08-12 |
rat |
| J R Seckl, K L Dickson, G Fin. Central 5,7-dihydroxytryptamine lesions decrease hippocampal glucocorticoid and mineralocorticoid receptor messenger ribonucleic Acid expression. Journal of neuroendocrinology. vol 2. issue 6. 2012-10-02. PMID:19215437. |
thus the 5-ht innervation regulates hippocampal corticosteroid receptor mrna expression. |
2012-10-02 |
2023-08-12 |
rat |
| M Fekete, G Hartmann, D Zakirov, L Halvax, K Lissá. Effect of dopamine on the hypothalamo-pituitary-adrenocortical system after injection in the nucleus raphe dorsalis. Neuroscience letters. vol 4. issue 3-4. 2012-10-02. PMID:19604944. |
dopamine (da) injected into the dorsal raphe nucleus (drn) increased plasma corticosterone (pcs) level as well as serotonin (5-ht) content in the mesencephalon and hippocampus 30 min after the administration. |
2012-10-02 |
2023-08-12 |
rat |
| M Fekete, G Hartmann, D Zakirov, L Halvax, K Lissá. Effect of dopamine on the hypothalamo-pituitary-adrenocortical system after injection in the nucleus raphe dorsalis. Neuroscience letters. vol 4. issue 3-4. 2012-10-02. PMID:19604944. |
pcs level and 5-ht content of the hypothalamus in da-treated + stressed animals did not differ from the values found in da-treated rats, but mesencephalic and hippocampal 5-ht content did not increase. |
2012-10-02 |
2023-08-12 |
rat |
| B E Sumner, R Rosie, G Fin. Relative density of 5-hydroxytryptamine receptor subtype mRNAs in female rat neuroendocrine brain determined by in situ hybridization histochemistry. Molecular and cellular neurosciences. vol 3. issue 3. 2012-10-02. PMID:19912863. |
in other brain regions the highest contents of 5-ht(1a), 5-ht(1c), and 5-ht(2) receptor mrnas were found in hippocampus, choroid plexus, and cingulate and frontal cortices, respectively. |
2012-10-02 |
2023-08-12 |
rat |
| M Hamon, D L Nelson, M Mallat, S Bourgoi. Are 5-HT receptors involved in the sprouting of serotoninergic terminals following neonatal 5,7-dihydroxytryptamine treatment in the rat? Neurochemistry international. vol 3. issue 1. 2012-10-02. PMID:20487810. |
the neonatal administration of 5,7-dihydroxytryptamine to rats (100 mg kg(?1) s.c. on the 1st and 2nd day after birth) resulted in marked reductions in serotoninergic presynaptic markers ([(3)h]-5-ht synaptosomal uptake, tryptophan hydroxylase activity and endogenous 5-ht content) in various forebrain areas, particularly the cerebral cortex and the hippocampus. |
2012-10-02 |
2023-08-12 |
rat |
| G Szabó, G L Kovács, L Baláspiri, G Telegd. Dose-related effect of the oxytocin fragment (prolyl-leucyl-glycinamide) on ?-MPT-induced catecholamine disappearance and serotonin level in rat brain. Neurochemistry international. vol 3. issue 6. 2012-10-02. PMID:20487841. |
the serotonin level was increased in the hypothalamus, in the striatum and decreased in the dorsal hippocampus. |
2012-10-02 |
2023-08-12 |
rat |
| E Azmitia, M J Brennan, D Quartermai. Adult development of the hippocampal-serotonin system of C57BL/6N mice; analysis of high-affinity uptake of (3)H-5HT in slices and synaptosomes. Neurochemistry international. vol 5. issue 1. 2012-10-02. PMID:20487920. |
the saturable and specific high-affinity uptake of [(3)h]serotonin ([(3)h]5ht) (5 x 10(?8) m) was studied in slices from the hippocampus, parietal cortex, septum-preoptic area, and hypothalamus of male 2, 6, 12 and 24-32 month old c57bl/6n mice. |
2012-10-02 |
2023-08-12 |
mouse |
| E Azmitia, M J Brennan, D Quartermai. Adult development of the hippocampal-serotonin system of C57BL/6N mice; analysis of high-affinity uptake of (3)H-5HT in slices and synaptosomes. Neurochemistry international. vol 5. issue 1. 2012-10-02. PMID:20487920. |
hippocampal [(3)h]5-ht uptake showed a significant biphasic relationship to age, with lower values in the 2 and 24-32 month old mice compared to 6 month old mice. |
2012-10-02 |
2023-08-12 |
mouse |