| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Alpen Ortug, Yurui Guo, Henry A Feldman, Yangming Ou, Jose Luis Alatorre Warren, Harrison Dieuveuil, Nicole T Baumer, Susan K Faja, Emi Takahash. Autism-associated brain differences can be observed in utero using MRI. Cerebral cortex (New York, N.Y. : 1991). vol 34. issue 4. 2024-04-11. PMID:38602735. |
our results showed that magnetic resonance imaging-based autism spectrum disorder biomarkers can be found as early as in the fetal period and suggested that the increased volume of the insular cortex may be the most promising magnetic resonance imaging-based fetal biomarker for the future emergence of autism spectrum disorders, along with some additional, potentially useful changes in regional volumes and hemispheric asymmetries. |
2024-04-11 |
2024-04-13 |
Not clear |
| Zihui Hua, Jun Hu, Huanke Zeng, Jiahui Li, Yibo Cao, Yiqun Ga. Auditory language comprehension among children and adolescents with autism spectrum disorder: An ALE meta-analysis of fMRI studies. Autism research : official journal of the International Society for Autism Research. vol 17. issue 3. 2024-03-25. PMID:38031655. |
furthermore, the between-group analysis showed that children and adolescents with autism, compared to those without autism, showed reduced activation in the right superior temporal gyrus, left middle temporal gyrus, and insula, whereas the autism group did not show increased activation in any of the regions relative to the non-autism group. |
2024-03-25 |
2024-03-27 |
Not clear |
| Emi Takahashi, Nina Allan, Rafael Peres, Alpen Ortug, Andre J W van der Kouwe, Briana Valli, Elizabeth Ethier, Jacob Levman, Nicole Baumer, Keita Tsujimura, Nauru Idalia Vargas-Maya, Trevor A McCracken, Rosa Lee, Alika K Maunake. Integration of structural MRI and epigenetic analyses hint at linked cellular defects of the subventricular zone and insular cortex in autism: Findings from a case study. Frontiers in neuroscience. vol 16. 2023-02-23. PMID:36817099. |
integration of structural mri and epigenetic analyses hint at linked cellular defects of the subventricular zone and insular cortex in autism: findings from a case study. |
2023-02-23 |
2023-08-14 |
Not clear |
| Lifei Xiao, Shucai Jiang, Yangyang Wang, Caibin Gao, Cuicui Liu, Xianhao Huo, Wenchao Li, Baorui Guo, Chaofan Wang, Yu Sun, Anni Wang, Yan Feng, Feng Wang, Tao Su. Continuous high-frequency deep brain stimulation of the anterior insula modulates autism-like behavior in a valproic acid-induced rat model. Journal of translational medicine. vol 20. issue 1. 2022-12-06. PMID:36474209. |
herein, we investigated the effects of continuous high-frequency deep brain stimulation in the anterior insula of rats exposed to vpa and explored cognitive functions, behavior, and molecular proteins connected to autism spectrum disorder. |
2022-12-06 |
2023-08-14 |
rat |
| Dustin Scheinost, Joseph Chang, Cheryl Lacadie, Emma Brennan-Wydra, Rachel Foster, Alexandra Boxberger, Suzanne Macari, Angelina Vernetti, R Todd Constable, Laura R Ment, Katarzyna Chawarsk. Hypoconnectivity between anterior insula and amygdala associates with future vulnerabilities in social development in a neurodiverse sample of neonates. Scientific reports. vol 12. issue 1. 2022-09-28. PMID:36171268. |
altered resting state functional connectivity (fc) involving the anterior insula (ains), a key node in the salience network, has been reported consistently in autism. |
2022-09-28 |
2023-08-14 |
human |
| Lingli Zhang, Chu-Chung Huang, Yuan Dai, Qiang Luo, Yiting Ji, Kai Wang, Shining Deng, Juehua Yu, Mingyu Xu, Xiujuan Du, Yun Tang, Chun Shen, Jianfeng Feng, Barbara J Sahakian, Ching-Po Lin, Fei L. Symptom improvement in children with autism spectrum disorder following bumetanide administration is associated with decreased GABA/glutamate ratios. Translational psychiatry. vol 10. issue 1. 2021-06-18. PMID:32066666. |
primary [children autism rating scale (cars)], secondary [clinical global impressions (cgi)], and exploratory [inhibitory (γ-aminobutyric acid, gaba) and excitatory (glutamate, glx) neurotransmitter concentrations measured in the insular cortex (ic) and visual cortex (vc) by magnetic resonance spectroscopy (mrs)] outcome measures were evaluated at baseline and at the 3-month follow-up. |
2021-06-18 |
2023-08-13 |
Not clear |
| Vinod Menon, Guillermo Gallardo, Mark A Pinsk, Van-Dang Nguyen, Jing-Rebecca Li, Weidong Cai, Demian Wasserman. Microstructural organization of human insula is linked to its macrofunctional circuitry and predicts cognitive control. eLife. vol 9. 2021-03-03. PMID:32496190. |
our findings open new possibilities for probing psychiatric and neurological disorders impacted by insular cortex dysfunction, including autism, schizophrenia, and fronto-temporal dementia. |
2021-03-03 |
2023-08-13 |
human |
| Xiaonan Guo, Xujun Duan, John Suckling, Heng Chen, Wei Liao, Qian Cui, Huafu Che. Partially impaired functional connectivity states between right anterior insula and default mode network in autism spectrum disorder. Human brain mapping. vol 40. issue 4. 2020-04-06. PMID:30367744. |
time-invariant resting-state functional connectivity studies have illuminated the crucial role of the right anterior insula (rai) in prominent social impairments of autism spectrum disorder (asd). |
2020-04-06 |
2023-08-13 |
Not clear |
| Xiaonan Guo, Xujun Duan, John Suckling, Heng Chen, Wei Liao, Qian Cui, Huafu Che. Partially impaired functional connectivity states between right anterior insula and default mode network in autism spectrum disorder. Human brain mapping. vol 40. issue 4. 2020-04-06. PMID:30367744. |
partially impaired functional connectivity states between right anterior insula and default mode network in autism spectrum disorder. |
2020-04-06 |
2023-08-13 |
Not clear |
| Marc-Antoine d'Albis, Pamela Guevara, Miguel Guevara, Charles Laidi, Jennifer Boisgontier, Samuel Sarrazin, Delphine Duclap, Richard Delorme, Federico Bolognani, Christian Czech, Céline Bouquet, Myriam Ly-Le Moal, Stefan Holiga, Anouck Amestoy, Isabelle Scheid, Alexandru Gaman, Marion Leboyer, Cyril Poupon, Jean-François Mangin, Josselin Houeno. Local structural connectivity is associated with social cognition in autism spectrum disorder. Brain : a journal of neurology. vol 141. issue 12. 2019-07-15. PMID:30423029. |
specific short-tract atypicalities in temporal lobe and insula were significantly associated with clinical manifestations of autism spectrum disorder such as social awareness, language structure, pragmatic skills and empathy, emphasizing their importance in social dysfunction. |
2019-07-15 |
2023-08-13 |
human |
| Jason S Nomi, Istvan Molnar-Szakacs, Lucina Q Uddi. Insular function in autism: Update and future directions in neuroimaging and interventions. Progress in neuro-psychopharmacology & biological psychiatry. vol 89. 2019-03-25. PMID:30381235. |
we summarize some of the recent work linking the insula to interventions in autism, including oxytocin-based pharmacological treatments and music therapy. |
2019-03-25 |
2023-08-13 |
human |
| Tianqi Wang, Xiaolong Zhang, Ang Li, Meifang Zhu, Shu Liu, Wen Qin, Jin Li, Chunshui Yu, Tianzi Jiang, Bing Li. Polygenic risk for five psychiatric disorders and cross-disorder and disorder-specific neural connectivity in two independent populations. NeuroImage. Clinical. vol 14. 2017-11-03. PMID:28275544. |
consistent altered functional connectivity was found with the bilateral insula: for the left supplementary motor area and the left superior temporal gyrus with the cross-disorder pgrs, for the left insula and right middle and superior temporal lobe associated with the pgrs for autism, for the bilateral midbrain, posterior cingulate, cuneus, and precuneus associated with the pgrs for bd, and for the left angular gyrus and the left dorsolateral prefrontal cortex associated with the pgrs for schizophrenia. |
2017-11-03 |
2023-08-13 |
Not clear |
| Takashi Yamada, Takashi Itahashi, Motoaki Nakamura, Hiromi Watanabe, Miho Kuroda, Haruhisa Ohta, Chieko Kanai, Nobumasa Kato, Ryu-Ichiro Hashimot. Altered functional organization within the insular cortex in adult males with high-functioning autism spectrum disorder: evidence from connectivity-based parcellation. Molecular autism. vol 7. 2017-10-23. PMID:27713815. |
altered functional organization within the insular cortex in adult males with high-functioning autism spectrum disorder: evidence from connectivity-based parcellation. |
2017-10-23 |
2023-08-13 |
Not clear |
| Martin Krause, Martin Brüne, Carsten Theis. Preparation of human formalin-fixed brain slices for electron microscopic investigations. Annals of anatomy = Anatomischer Anzeiger : official organ of the Anatomische Gesellschaft. vol 206. 2017-01-23. PMID:27136748. |
for example, von economo neurons (vens) mainly located in the anterior cingulate cortex and in the anterior part of the insula, which seem to play a role in a variety of neuropsychiatric conditions, including frontotemporal dementia, autism and schizophrenia, can hardly be studied in nonhuman animals. |
2017-01-23 |
2023-08-13 |
human |
| Paola Odriozola, Lucina Q Uddin, Charles J Lynch, John Kochalka, Tianwen Chen, Vinod Meno. Insula response and connectivity during social and non-social attention in children with autism. Social cognitive and affective neuroscience. vol 11. issue 3. 2016-10-07. PMID:26454817. |
insula response and connectivity during social and non-social attention in children with autism. |
2016-10-07 |
2023-08-13 |
Not clear |
| Yuanyue Zhou, Lijuan Shi, Xilong Cui, Suhong Wang, Xuerong Lu. Functional Connectivity of the Caudal Anterior Cingulate Cortex Is Decreased in Autism. PloS one. vol 11. issue 3. 2016-07-26. PMID:26985666. |
the fc (z-scores) between the left caudal acc and the right insula was negatively correlated with the stereotyped behaviors and restricted interests scores of the autism group. |
2016-07-26 |
2023-08-13 |
Not clear |
| Daniel Radeloff, Angela Ciaramidaro, Michael Siniatchkin, Daniela Hainz, Sabine Schlitt, Bernhard Weber, Fritz Poustka, Sven Bölte, Henrik Walter, Christine Margarete Freita. Structural alterations of the social brain: a comparison between schizophrenia and autism. PloS one. vol 9. issue 9. 2015-05-15. PMID:25188200. |
compared to patients with schizophrenia, patients with autism spectrum disorder displayed smaller gray matter volume in the left insula. |
2015-05-15 |
2023-08-13 |
human |
| Daniel Radeloff, Angela Ciaramidaro, Michael Siniatchkin, Daniela Hainz, Sabine Schlitt, Bernhard Weber, Fritz Poustka, Sven Bölte, Henrik Walter, Christine Margarete Freita. Structural alterations of the social brain: a comparison between schizophrenia and autism. PloS one. vol 9. issue 9. 2015-05-15. PMID:25188200. |
in regional data, patients with autism spectrum disorder compared to typically developed control subjects showed smaller gray matter volume in the amygdala, insula, and anterior medial prefrontal cortex. |
2015-05-15 |
2023-08-13 |
human |
| Daniel Radeloff, Angela Ciaramidaro, Michael Siniatchkin, Daniela Hainz, Sabine Schlitt, Bernhard Weber, Fritz Poustka, Sven Bölte, Henrik Walter, Christine Margarete Freita. Structural alterations of the social brain: a comparison between schizophrenia and autism. PloS one. vol 9. issue 9. 2015-05-15. PMID:25188200. |
disorder specific positive correlations were found between mentalizing ability and left amygdala volume in autism spectrum disorder, and hallucinatory behavior and insula volume in schizophrenia. |
2015-05-15 |
2023-08-13 |
human |
| Philip Gerard Gasquoin. Contributions of the insula to cognition and emotion. Neuropsychology review. vol 24. issue 2. 2014-09-12. PMID:24442602. |
neuroimaged abnormal grey matter volumes or activity levels in the insula have been associated with schizophrenia, eating disorders, anxiety and mood disorders, conduct disorder, autism, addiction, and chronic pain. |
2014-09-12 |
2023-08-12 |
Not clear |