| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Robert Hitzemann, Angela R Ozburn, Denesa Lockwood, Tamara J Phillip. Modeling Brain Gene Expression in Alcohol Use Disorder with Genetic Animal Models. Current topics in behavioral neurosciences. 2023-11-20. PMID:37982929. |
both the animal and human data point to the importance for aud of changes in synaptic transmission (particularly glutamate and gaba transmission), of changes in the extracellular matrix (specifically including collagens, cadherins and protocadherins) and of changes in neuroimmune processes. |
2023-11-20 |
2023-11-29 |
human |
| Thuy Thi Nguyen, Hien Duong Thanh, Manh-Hung Do, Chaeyong Jun. Complement Regulatory Protein CD46 Manifests a Unique Role in Promoting the Migration of Bladder Cancer Cells. Chonnam medical journal. vol 59. issue 3. 2023-10-16. PMID:37840671. |
resulting data from a dna microarray using cd46-altered ht1376 bladder cancers demonstrated a pool of target genes, including complement c3 α chain (c3α), matrix gla protein (mgp), afap-as1, follicular dendritic cell secreted protein (fdcsp), mam domain containing 2 (mamdc2), gamma-aminobutyric acid a receptor pi (gabrp), transforming growth factor, beta-induced (tgfbi), a family of cytochrome p450 (cyp24a1), sialic acid binding ig-like lectin 6 (siglec6), metallothionein 1e (mt1e), and several members of cytokeratins. |
2023-10-16 |
2023-11-08 |
Not clear |
| Hairu Zhao, Bomi Park, Min-Jung Kim, Seok-Hyun Hwang, Tae-Jong Kim, Seung-Un Kim, Iksun Kwon, Jae Sung Hwan. The Effect of γ-Aminobutyric Acid Intake on UVB- Induced Skin Damage in Hairless Mice. Biomolecules & therapeutics. 2023-07-31. PMID:37524442. |
uvb radiation was found to significantly induce the production of matrix metalloproteinase 1 (mmp-1), but treatment with gaba resulted in the inhibition of mmp-1 production. |
2023-07-31 |
2023-08-14 |
mouse |
| Tian-Jiao Li, Jian Jiang, Ya-Ling Tang, Xin-Hua Lian. Insights into the leveraging of GABAergic signaling in cancer therapy. Cancer medicine. 2023-05-18. PMID:37199392. |
several studies have demonstrated that the gabaergic system may regulate tumor development via gaba receptors, downstream cyclic adenosine monophosphate (camp) pathway, epithelial growth factor receptor (egfr) pathway, akt pathway, mitogen-activated protein kinase (mapk) or extracellular signal-related kinases (erk) pathway, and matrix metalloproteinase (mmp) pathway, although the exact mechanism is unclear. |
2023-05-18 |
2023-08-14 |
Not clear |
| Chloe Delepine, Jennifer Shih, Keji Li, Pierre Gaudeaux, Mriganka Su. Differential effects of astrocyte manipulations on learned motor behavior and neuronal ensembles in the motor cortex. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2023-03-09. PMID:36894315. |
rna sequencing further supports a role for m1 astrocytes in motor learning and shows changes in astrocytic expression of glutamate transporter genes, gaba transporter genes, and extracellular matrix protein genes in mice that have acquired this learned behavior. |
2023-03-09 |
2023-08-14 |
mouse |
| Rodrigo J M Sousa, Susana C Ribeiro, José A B Baptista, Célia C G Silv. Evaluation of gamma-aminobutyric acid content in Portuguese cheeses with protected designation of origin status. The Journal of dairy research. 2023-02-17. PMID:36799037. |
this study provides information on the gaba content in different portuguese pdo cheeses and shows that hard or semi-hard ripened cheeses are a suitable matrix for gaba production by lactic acid bacteria. |
2023-02-17 |
2023-08-14 |
Not clear |
| Junyi Zhang, Mingzhu Xu, Tan Chen, Yafeng Zho. Bioinformatics Analysis of Common Differential Genes of Viral Myocarditis and Dilated Cardiomyopathy: Screening for Potential Pharmacological Compounds. Journal of cardiovascular development and disease. vol 9. issue 10. 2022-10-26. PMID:36286305. |
subgroup analysis of severe vmc cohort revealed 10 hub genes which mainly clustered in gaba channel activity, extracellular matrix remodeling and sarcomere dysfunction. |
2022-10-26 |
2023-08-14 |
Not clear |
| Tessa H de Bie, Michiel G J Balvers, Ric C H de Vos, Renger F Witkamp, Maarten A Jongsm. The influence of a tomato food matrix on the bioavailability and plasma kinetics of oral gamma-aminobutyric acid (GABA) and its precursor glutamate in healthy men. Food & function. 2022-07-19. PMID:35852458. |
the influence of a tomato food matrix on the bioavailability and plasma kinetics of oral gamma-aminobutyric acid (gaba) and its precursor glutamate in healthy men. |
2022-07-19 |
2023-08-14 |
Not clear |
| Ashleigh Willis, Judith A Pratt, Brian J Morri. BDNF and JNK Signaling Modulate Cortical Interneuron and Perineuronal Net Development: Implications for Schizophrenia-Linked 16p11.2 Duplication Syndrome. Schizophrenia bulletin. vol 47. issue 3. 2021-11-22. PMID:33067994. |
sz is characterized by cortical gamma-amino-butyric acid (gaba)ergic interneuron dysfunction and disruption to surrounding extracellular matrix structures, perineuronal nets (pnns). |
2021-11-22 |
2023-08-13 |
mouse |
| Moritoshi Hirono, Fuyuki Karube, Yuchio Yanagaw. Modulatory Effects of Monoamines and Perineuronal Nets on Output of Cerebellar Purkinje Cells. Frontiers in neural circuits. vol 15. 2021-07-16. PMID:34194302. |
second, we review the physiological roles of perineuronal nets (pnns), which are organized components of the extracellular matrix and enwrap the cell bodies and proximal processes, in gaba release from pcs to large glutamatergic dcn neurons and in cerebellar motor learning. |
2021-07-16 |
2023-08-13 |
Not clear |
| Mahesha M Poojary, Nicolò Dellarosa, Shahin Roohinejad, Mohamed Koubaa, Urszula Tylewicz, Federico Gómez-Galindo, Jorge A Saraiva, Marco Dalla Rosa, Francisco J Barb. Influence of Innovative Processing on γ-Aminobutyric Acid (GABA) Contents in Plant Food Materials. Comprehensive reviews in food science and food safety. vol 16. issue 5. 2020-12-29. PMID:33371613. |
gaba naturally occurs in plant materials and its concentrations may vary considerably, from traces up to μmol/g (dry basis) depending on plant matrix, germination stage, and processing conditions, among other factors. |
2020-12-29 |
2023-08-13 |
Not clear |
| Zhi-Qing Sun, Fan-Hua Meng, Li-Xiang Tu, Lei Su. Myricetin attenuates the severity of seizures and neuroapoptosis in pentylenetetrazole kindled mice by regulating the of BDNF-TrkB signaling pathway and modulating matrix metalloproteinase-9 and GABA Experimental and therapeutic medicine. vol 17. issue 4. 2020-10-01. PMID:30906480. |
myricetin attenuates the severity of seizures and neuroapoptosis in pentylenetetrazole kindled mice by regulating the of bdnf-trkb signaling pathway and modulating matrix metalloproteinase-9 and gaba currently available antiepileptic drugs are effective; however, frequently associated with adverse effects that limit their therapeutic value. |
2020-10-01 |
2023-08-13 |
mouse |
| Katja Bächli, Patrick R Schmidlin, Florian Wegehaupt, Frank Paqué, Liza Ramenzoni, Sander Botte. Remineralization of Artificial Dentin Caries Using Dentin and Enamel Matrix Proteins. Materials (Basel, Switzerland). vol 12. issue 13. 2020-09-30. PMID:31266157. |
next, the samples were randomly allocated into four groups: (a) an untreated negative control (con), (b) application of porcine dentin matrix proteins (dmp), (c) treatment with enamel matrix derivatives (emd, emdogain, straumann), and (d) amine fluoride application (amf, elmex fluid, gaba). |
2020-09-30 |
2023-08-13 |
human |
| Nemanja Rajkovic, Jelena Ciric, Nebojsa Milosevic, Jasna Saponji. Novel application of the gray-level co-occurrence matrix analysis in the parvalbumin stained hippocampal gyrus dentatus in distinct rat models of Parkinson's disease. Computers in biology and medicine. vol 115. 2020-09-22. PMID:31614228. |
to reveal the best choice of algorithm for parvalbumin-immunostained images of the hippocampal gyrus dentatus in two distinct rat models of parkinson's disease (pd), particularly in terms of extracting the crucial information from the image, we tested whether the impact of experimentally induced dopaminergic (hemiparkinsonism) vs. cholinergic (pd cholinopathy) innervation impairment on the parvalbumin stained gaba interneurons could be detected using two separate algorithms, the fractal box-count and the gray-level co-occurrence matrix analysis (glcm) algorithms. |
2020-09-22 |
2023-08-13 |
human |
| Dora Ravasz, Gergely Kacso, Viktoria Fodor, Kata Horvath, Vera Adam-Vizi, Christos Chinopoulo. Catabolism of GABA, succinic semialdehyde or gamma-hydroxybutyrate through the GABA shunt impair mitochondrial substrate-level phosphorylation. Neurochemistry international. vol 109. 2018-06-13. PMID:28300620. |
gaba is catabolized in the mitochondrial matrix through the gaba shunt, encompassing transamination to succinic semialdehyde followed by oxidation to succinate by the concerted actions of gaba transaminase (gaba-t) and succinic semialdehyde dehydrogenase (ssadh), respectively. |
2018-06-13 |
2023-08-13 |
mouse |
| Dora Ravasz, Gergely Kacso, Viktoria Fodor, Kata Horvath, Vera Adam-Vizi, Christos Chinopoulo. Catabolism of GABA, succinic semialdehyde or gamma-hydroxybutyrate through the GABA shunt impair mitochondrial substrate-level phosphorylation. Neurochemistry international. vol 109. 2018-06-13. PMID:28300620. |
here, we tested the hypothesis that the elevation in matrix succinate concentration caused by exogenous addition of gaba, succinic semialdehyde or ghb shifts the equilibrium of the reversible reaction catalyzed by succinate-coa ligase towards atp (or gtp) hydrolysis, effectively negating substrate-level phosphorylation (slp). |
2018-06-13 |
2023-08-13 |
mouse |
| Anitha Police, Vijay Kumar Shankar, S Narasimha Murth. RP-HPLC method for simultaneous estimation of vigabatrin, gamma-aminobutyric acid and taurine in biological samples. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. vol 1076. 2018-03-07. PMID:29396367. |
a rp-hplc method has been developed and validated for simultaneous estimation of vigabatrin, gaba and taurine using surrogate matrix. |
2018-03-07 |
2023-08-13 |
human |
| Nooshin Nikmaram, B N Dar, Shahin Roohinejad, Mohamed Koubaa, Francisco J Barba, Ralf Greiner, Stuart K Johnso. Recent advances in γ-aminobutyric acid (GABA) properties in pulses: an overview. Journal of the science of food and agriculture. vol 97. issue 9. 2017-12-14. PMID:28230263. |
with carbon dioxide), and fermentation (with lactic acid bacteria), gaba content increases in the plant matrix. |
2017-12-14 |
2023-08-13 |
human |
| Gaik Tamazian, Jeong Ho Chang, Sergey Knyazev, Eugene Stepanov, Kyung-Jin Kim, Yuri Porozo. Modeling conformational redox-switch modulation of human succinic semialdehyde dehydrogenase. Proteins. vol 83. issue 12. 2017-09-12. PMID:26422261. |
succinic semialdehyde dehydrogenase (ssadh) converts succinic semialdehyde (ssa) to succinic acid in the mitochondrial matrix and is involved in the metabolism of the inhibitory neurotransmitter γ-aminobutyric acid (gaba). |
2017-09-12 |
2023-08-13 |
human |
| Gülsel Yurtdaş Kırımlıoğlu, Yusuf Menceloğlu, Kevser Erol, Yasemin Yaza. In vitro/in vivo evaluation of gamma-aminobutyric acid-loadedN,N-dimethylacrylamide-based pegylated polymeric nanoparticles for brain delivery to treat epilepsy. Journal of microencapsulation. vol 33. issue 7. 2017-03-30. PMID:27606701. |
formulations showed smaller particle size, cationic zeta potential characteristic, possible gaba polymeric matrix interaction and prolonged release pattern. |
2017-03-30 |
2023-08-13 |
rat |