| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Nahid Akhtar, Mark Js Miller, Tariq M Haqq. Effect of a Herbal-Leucine mix on the IL-1β-induced cartilage degradation and inflammatory gene expression in human chondrocytes. BMC complementary and alternative medicine. vol 11. 2011-12-27. PMID:21854562. |
the objective of this study was to investigate the anti-inflammatory/chondroprotective potential of a herbal and amino acid mixture containing extract of the uncaria tomentosa, boswellia spp., lepidium meyenii and l-leucine on the il-1β-induced production of nitric oxide (no), glycosaminoglycan (gag), matrix metalloproteinases (mmps), aggrecan (acan) and type ii collagen (col2a1) in human oa chondrocytes and oa cartilage explants. |
2011-12-27 |
2023-08-12 |
human |
| Anat Elmann, Sharon Mordechay, Hilla Erlank, Alona Telerman, Miriam Rindner, Rivka Ofi. Anti-neuroinflammatory effects of the extract of Achillea fragrantissima. BMC complementary and alternative medicine. vol 11. 2011-12-27. PMID:22018032. |
during the neuroinflammatory process, microglial cells release proinflammatory mediators such as cytokines, matrix metalloproteinases (mmp), reactive oxygen species (ros) and nitric oxide (no). |
2011-12-27 |
2023-08-12 |
Not clear |
| Lin Yang, Ai Guo, Jun-Chao G. c-Jun N-terminal kinase and nuclear factor κB mediate nitric oxide-induced expression of matrix metalloproteinase-13. International orthopaedics. vol 35. issue 8. 2011-12-06. PMID:20524115. |
the purpose of this study was to investigate the mechanism of expression of matrix metalloproteinase-13 (mmp-13) induced by nitric oxide (no). |
2011-12-06 |
2023-08-12 |
human |
| I Pérez-Torres, V Guarner, M El Hafidi, G Baño. Sex hormones, metabolic syndrome and kidney. Current topics in medicinal chemistry. vol 11. issue 13. 2011-12-05. PMID:21463253. |
among the metabolic systems that can be modulated by sex hormones in the kidney, the more important are: renin-angiotensin-aldosterone system, arachidonic acid metabolism, nitric oxide system and renal extra-cellular matrix proteins. |
2011-12-05 |
2023-08-12 |
Not clear |
| Mesia M Steed, Suresh C Tyag. Mechanisms of cardiovascular remodeling in hyperhomocysteinemia. Antioxidants & redox signaling. vol 15. issue 7. 2011-12-01. PMID:21126196. |
nitric oxide (no) is a potential regulator of matrix metalloproteinase (mmp) activity in mmp-no-timp (tissue inhibitor of metalloproteinase) inhibitory tertiary complex. |
2011-12-01 |
2023-08-12 |
mouse |
| Ignacio Boron, Sebastián A Suárez, Fabio Doctorovich, Marcelo A Martí, Sara E Bar. A protective protein matrix improves the discrimination of nitroxyl from nitric oxide by MnIII protoporphyrinate IX in aerobic media. Journal of inorganic biochemistry. vol 105. issue 8. 2011-11-01. PMID:21726766. |
a protective protein matrix improves the discrimination of nitroxyl from nitric oxide by mniii protoporphyrinate ix in aerobic media. |
2011-11-01 |
2023-08-12 |
Not clear |
| Carlos Tarin, Begoña Lavin, Monica Gomez, Marta Saura, Antonio Diez-Juan, Carlos Zaragoz. The extracellular matrix metalloproteinase inducer EMMPRIN is a target of nitric oxide in myocardial ischemia/reperfusion. Free radical biology & medicine. vol 51. issue 2. 2011-10-27. PMID:21570464. |
the extracellular matrix metalloproteinase inducer emmprin is a target of nitric oxide in myocardial ischemia/reperfusion. |
2011-10-27 |
2023-08-12 |
mouse |
| S Liarte, I Cabas, E Chaves-Pozo, M Arizcun, J Meseguer, V Mulero, A García-Ayal. Natural and synthetic estrogens modulate the inflammatory response in the gilthead seabream (Sparus aurata L.) through the activation of endothelial cells. Molecular immunology. vol 48. issue 15-16. 2011-10-26. PMID:21683448. |
thus, e(2) was able to increase the production of nitric oxide (no) and up-regulate the expression of the key activation markers, interleukin-1β, cc chemokine ligand 4, interleukin-8, e-selectin and matrix metalloproteinase 9, when used alone or combined with bacterial dna. |
2011-10-26 |
2023-08-12 |
Not clear |
| Drew E Glaser, Robert M Gower, Nicholas E Lauer, Kayan Tam, Alicia A Blancas, Albert J Shih, Scott I Simon, Kara E McCloske. Functional characterization of embryonic stem cell-derived endothelial cells. Journal of vascular research. vol 48. issue 5. 2011-10-20. PMID:21625175. |
we explore several physiologically relevant functions of esc-derived ec (esc-ec), such as its capacity to produce nitric oxide (no), regulate permeability, activate and express surface molecules for the recruitment of leukocytes in response to inflammatory stimuli, migrate and grow new blood vessels, lay down extracellular matrix, and take up low-density lipoproteins. |
2011-10-20 |
2023-08-12 |
mouse |
| Nian-Hong Chen, Jian-Jiang Zhon. p53 is important for the anti-invasion of ganoderic acid T in human carcinoma cells. Phytomedicine : international journal of phytotherapy and phytopharmacology. vol 18. issue 8-9. 2011-10-14. PMID:21353507. |
furthermore, comparing the ratios of hct-116 p53(+/+) and p53(-/-) cells, p53 modified ga-t inhibition of migration and adhesion and ga-t promotion of cell aggregation, and p53 also modified ga-t inhibition of nf-κb nuclear translocation, iκbα degradation, and down-regulation of urokinase-type plaminogen activator (upa), matrix metalloproteinase-2/9 (mmp-2/9), inducible nitric oxide synthase (inos/nos2) protein expression and inducible nitric oxide (no) production. |
2011-10-14 |
2023-08-12 |
human |
| Bruna Romana-Souza, Marcela Otranto, Taís Fontoura Almeida, Luis Cristóvão Porto, Andréa Monte-Alto-Cost. Stress-induced epinephrine levels compromise murine dermal fibroblast activity through β-adrenoceptors. Experimental dermatology. vol 20. issue 5. 2011-09-16. PMID:21366703. |
in addition, the blockade of β3-adrenoceptors reversed the increase in fibroblast proliferation and nitric oxide synthesis as well as the reduction of fibroblast migration, akt phosphorylation and active matrix metalloproteinase-2 expression induced by epinephrine. |
2011-09-16 |
2023-08-12 |
mouse |
| R Sandeep Varma, G Ashok, S Vidyashankar, P Patki, Krishna S Nandakuma. Ethanol extract of Justicia gendarussa inhibits lipopolysaccharide stimulated nitric oxide and matrix metalloproteinase-9 expression in murine macrophage. Pharmaceutical biology. vol 49. issue 6. 2011-08-29. PMID:21554007. |
ethanol extract of justicia gendarussa inhibits lipopolysaccharide stimulated nitric oxide and matrix metalloproteinase-9 expression in murine macrophage. |
2011-08-29 |
2023-08-12 |
Not clear |
| Hui-Hsin Wang, Hsi-Lung Hsieh, Chuen-Mao Yan. Nitric oxide production by endothelin-1 enhances astrocytic migration via the tyrosine nitration of matrix metalloproteinase-9. Journal of cellular physiology. vol 226. issue 9. 2011-08-17. PMID:21660948. |
nitric oxide production by endothelin-1 enhances astrocytic migration via the tyrosine nitration of matrix metalloproteinase-9. |
2011-08-17 |
2023-08-12 |
rat |
| Megan Leigh Killian, Barbara Zielinska, Tumul Gupta, Tammy Lynn Haut Donahu. In vitro inhibition of compression-induced catabolic gene expression in meniscal explants following treatment with IL-1 receptor antagonist. Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association. vol 16. issue 2. 2011-08-16. PMID:21331553. |
in vitro, 20% dynamic compressive strains on meniscal tissue explants have resulted in an increase in the release of sulfated glycosaminoglycans (gag) and nitric oxide (no) from the tissue explants and increased expression of matrix metalloproteinases (mmp) and interleukin-1α (il-1α). |
2011-08-16 |
2023-08-12 |
Not clear |
| Fan Jiang, Catherine W T Chang, Gregory J Dustin. Cytoprotection by natural and synthetic polyphenols in the heart: novel mechanisms and perspectives. Current pharmaceutical design. vol 16. issue 37. 2011-08-01. PMID:21247397. |
polyphenols exert myocardial protective effects via antioxidant activities, preservation of nitric oxide, antiinflammatory activities and modulation of matrix metalloproteinases. |
2011-08-01 |
2023-08-12 |
Not clear |
| Cristiana Griffoni, Serena Di Molfetta, Luca Fantozzi, Cristiana Zanetti, Proto Pippia, Vittorio Tomasi, Enzo Spisn. Modification of proteins secreted by endothelial cells during modeled low gravity exposure. Journal of cellular biochemistry. vol 112. issue 1. 2011-07-19. PMID:21069737. |
in endothelial cells (ec), it has been shown that modeled low gravity impairs nitric oxide synthesis, cell adhesion, extracellular matrix composition, cytoskeleton organization, cytokines, and growth factors secretion. |
2011-07-19 |
2023-08-12 |
human |
| Alireza Moeen Rezakhanlou, Chris Miller, Bevin McMullin, Abdi Ghaffari, Rosa Garcia, Aziz Ghahar. Gaseous nitric oxide exhibits minimal effect on skin fibroblast extracellular matrix gene expression and immune cell viability. Cell biology international. vol 35. issue 4. 2011-07-14. PMID:21155711. |
gaseous nitric oxide exhibits minimal effect on skin fibroblast extracellular matrix gene expression and immune cell viability. |
2011-07-14 |
2023-08-12 |
mouse |
| M Kirchmeyer, J Deffaud, S Sebillaud, D Moulin, M Koufany, P Netter, A Bianchi, J-Y Jouzea. Evidence for species differences in the regulation of MMPs by all-trans retinoic acid in cytokine-stimulated chondrocytes. Biorheology. vol 45. issue 3-4. 2011-07-13. PMID:18836242. |
in inflammatory conditions, chondrocytes produce large amounts of matrix metalloproteases (mmp) and nitric oxide (no) thought to contribute to joint degradation. |
2011-07-13 |
2023-08-12 |
human |
| Sandra L Silva, Catarina Osório, Ana R Vaz, Andreia Barateiro, Ana S Falcão, Rui F M Silva, Dora Brite. Dynamics of neuron-glia interplay upon exposure to unconjugated bilirubin. Journal of neurochemistry. vol 117. issue 3. 2011-06-10. PMID:21275990. |
conditioned medium from ucb-challenged neurons, although down-regulating tumor necrosis factor-α and interleukin-1β promoted the release of interleukin-6 and nitric oxide, the activation of matrix metalloproteinase-9, and cell death, as compared with ucb-direct effects on microglia. |
2011-06-10 |
2023-08-12 |
Not clear |
| Beatriz Martín-Fernández, Natalia de las Heras, María Miana, Sandra Ballesteros, Carmen Delgado, Su Song, Thomas Hintze, Victoria Cachofeiro, Vicente Laher. Structural, functional, and molecular alterations produced by aldosterone plus salt in rat heart: association with enhanced serum and glucocorticoid-regulated kinase-1 expression. Journal of cardiovascular pharmacology. vol 57. issue 1. 2011-06-01. PMID:20980916. |
relative heart weight, collagen content, messenger rna expression of transforming growth factor beta, connective tissue growth factor, matrix metalloproteinase 2, tissue inhibitor of metalloproteinases 2, tumor necrosis factor alpha, interleukin-1[beta], p22phox, endothelial nitric oxide synhtase, and sgk-1 were increased (p < 0.05) in aldosterone + salt-treated rats, being reduced by spironolactone (p < 0.05). |
2011-06-01 |
2023-08-12 |
rat |