| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Vanessa C Thompson, Antonio Hurtado-Coll, Dmitry Turbin, Ladan Fazli, Melanie L Lehman, Martin E Gleave, Colleen C Nelso. Relaxin drives Wnt signaling through upregulation of PCDHY in prostate cancer. The Prostate. vol 70. issue 10. 2010-06-15. PMID:20503398. |
in various tissues, relaxin increases angiogenesis and cell motility through upregulation of vascular endothelial growth factor, matrix metalloproteases, and nitric oxide, and therefore maybe an attractive target for cancer therapeutics. |
2010-06-15 |
2023-08-12 |
human |
| Qian-Qian Liang, Min Zhang, Quan Zhou, Qi Shi, Yong-Jun Wan. Muscone protects vertebral end-plate degeneration by antiinflammatory property. Clinical orthopaedics and related research. vol 468. issue 6. 2010-05-20. PMID:19763723. |
in vitro, muscone reversed il-1beta-induced upregulation of il-1beta, tumor necrosis factor alpha, cyclooxygenase 2, inducible nitric oxide synthase, matrix metalloproteinase 13, aggrecanase 2, and nitric oxide and downregulation of col2alpha1 and aggrecan. |
2010-05-20 |
2023-08-12 |
rat |
| L S Murdaugh, Z Wang, L V Del Priore, J Dillon, E R Gaillar. Age-related accumulation of 3-nitrotyrosine and nitro-A2E in human Bruch's membrane. Experimental eye research. vol 90. issue 5. 2010-04-22. PMID:20153746. |
during inflammation there is activation of inducible nitric oxide synthase and release of nitric oxide, which in principal could lead to non-enzymatic nitration within extracellular deposits and/or intrinsic extracellular matrix protein components of human bruch's membrane. |
2010-04-22 |
2023-08-12 |
human |
| Man-Hai Liu, Jui-Sheng Sun, Shaio-Wen Tsai, Shiow-Yunn Sheu, Ming-Hong Che. Icariin protects murine chondrocytes from lipopolysaccharide-induced inflammatory responses and extracellular matrix degradation. Nutrition research (New York, N.Y.). vol 30. issue 1. 2010-04-19. PMID:20116661. |
the synthesis of nitric oxide was analyzed, whereas the titer of glycosaminoglycan and total collagen were measured and the gene expressions (including inducible nitric oxide synthase [inos], matrix metalloproteinase [mmp]-1, mmp-3, and mmp-13) were evaluated. |
2010-04-19 |
2023-08-12 |
mouse |
| Man-Hai Liu, Jui-Sheng Sun, Shaio-Wen Tsai, Shiow-Yunn Sheu, Ming-Hong Che. Icariin protects murine chondrocytes from lipopolysaccharide-induced inflammatory responses and extracellular matrix degradation. Nutrition research (New York, N.Y.). vol 30. issue 1. 2010-04-19. PMID:20116661. |
the results showed that the viability of chondrocytes, extracellular matrix synthesis, was significantly decreased, whereas nitric oxide synthesis was significantly increased in the presence of 10(-5) g/ml lps. |
2010-04-19 |
2023-08-12 |
mouse |
| Man-Hai Liu, Jui-Sheng Sun, Shaio-Wen Tsai, Shiow-Yunn Sheu, Ming-Hong Che. Icariin protects murine chondrocytes from lipopolysaccharide-induced inflammatory responses and extracellular matrix degradation. Nutrition research (New York, N.Y.). vol 30. issue 1. 2010-04-19. PMID:20116661. |
icariin may exert its protective effects through inhibition of nitric oxide and mmp synthesis, and may then reduce the extracellular matrix destruction. |
2010-04-19 |
2023-08-12 |
mouse |
| Meenakshi Kushwaha, Joel M Anderson, Charles A Bosworth, Adinarayana Andukuri, William P Minor, Jack R Lancaster, Peter G Anderson, Brigitta C Brott, Ho-Wook Ju. A nitric oxide releasing, self assembled peptide amphiphile matrix that mimics native endothelium for coating implantable cardiovascular devices. Biomaterials. vol 31. issue 7. 2010-04-08. PMID:19913295. |
a nitric oxide releasing, self assembled peptide amphiphile matrix that mimics native endothelium for coating implantable cardiovascular devices. |
2010-04-08 |
2023-08-12 |
Not clear |
| Meenakshi Kushwaha, Joel M Anderson, Charles A Bosworth, Adinarayana Andukuri, William P Minor, Jack R Lancaster, Peter G Anderson, Brigitta C Brott, Ho-Wook Ju. A nitric oxide releasing, self assembled peptide amphiphile matrix that mimics native endothelium for coating implantable cardiovascular devices. Biomaterials. vol 31. issue 7. 2010-04-08. PMID:19913295. |
the nanofibrous matrix is formed by self-assembly of peptide amphiphiles (pas), which contain nitric oxide (no) donating residues, endothelial cell adhesive ligands composed of yigsr peptide sequence, and enzyme-mediated degradable sites. |
2010-04-08 |
2023-08-12 |
Not clear |
| Fausto Bruno dos Reis Almeida, Leandro Licursi de Oliveira, Marcelo Valle de Sousa, Maria Cristina Roque Barreira, Ebert Seixas Hann. Paracoccin from Paracoccidioides brasiliensis; purification through affinity with chitin and identification of N-acetyl-beta-D-glucosaminidase activity. Yeast (Chichester, England). vol 27. issue 2. 2010-03-26. PMID:19908201. |
paracoccin has been described to play a role in fungal adhesion to extracellular matrix components and to induce high and persistent levels of tnfalpha and nitric oxide production by macrophages. |
2010-03-26 |
2023-08-12 |
Not clear |
| Nicholas A Pullen, Helen L Fillmor. Induction of matrix metalloproteinase-1 and glioma cell motility by nitric oxide. Journal of neuro-oncology. vol 96. issue 2. 2010-03-25. PMID:19629394. |
induction of matrix metalloproteinase-1 and glioma cell motility by nitric oxide. |
2010-03-25 |
2023-08-12 |
Not clear |
| Nicholas A Pullen, Helen L Fillmor. Induction of matrix metalloproteinase-1 and glioma cell motility by nitric oxide. Journal of neuro-oncology. vol 96. issue 2. 2010-03-25. PMID:19629394. |
matrix metalloproteinase-1 (mmp-1), also known as interstitial collagenase, and the constitutive nitric oxide synthases (nos) have been shown to be over-expressed in high grade gliomas. |
2010-03-25 |
2023-08-12 |
Not clear |
| Sam L Teichman, Elaine Unemori, Thomas Dschietzig, Kirk Conrad, Adriaan A Voors, John R Teerlink, G Michael Felker, Marco Metra, Gad Cotte. Relaxin, a pleiotropic vasodilator for the treatment of heart failure. Heart failure reviews. vol 14. issue 4. 2010-02-25. PMID:19101795. |
the effects of relaxin include the production of nitric oxide, inhibition of endothelin, inhibition of angiotensin ii, production of vegf, and production of matrix metalloproteinases. |
2010-02-25 |
2023-08-12 |
human |
| Ai Guo, Lin Yang, Jun-Chao G. Membrane type-1 metalloproteinase mediates nitric oxide-induced activation of matrix metalloproteinase-13. Orthopedics. vol 32. issue 11. 2010-02-22. PMID:19902888. |
this article investigates the mechanism of activation of matrix metalloproteinase-13 induced by nitric oxide. |
2010-02-22 |
2023-08-12 |
human |
| Ai Guo, Lin Yang, Jun-Chao G. Membrane type-1 metalloproteinase mediates nitric oxide-induced activation of matrix metalloproteinase-13. Orthopedics. vol 32. issue 11. 2010-02-22. PMID:19902888. |
nitric oxide increased expressions of both matrix metalloproteinases and stimulated the proteolytic processing of metalloproteinase-13 from the pro-enzyme to the final active form. |
2010-02-22 |
2023-08-12 |
human |
| Lidiane Isabel Filippin, Andrea Janz Moreira, Norma Possa Marroni, Ricardo Machado Xavie. Nitric oxide and repair of skeletal muscle injury. Nitric oxide : biology and chemistry. vol 21. issue 3-4. 2010-01-25. PMID:19682596. |
this process depends on nitric oxide (no) production, metalloproteinase (mmp) activation and release of hepatocyte growth factor (hgf) from the extracellular matrix. |
2010-01-25 |
2023-08-12 |
Not clear |
| H C Korting, C Schöllman. Tetracycline actions relevant to rosacea treatment. Skin pharmacology and physiology. vol 22. issue 6. 2010-01-25. PMID:19786821. |
although data for skin diseases are relatively scanty, the following modes of action of tetracyclines seem to be most relevant for an effective treatment of acne and rosacea: inhibition of matrix metalloproteinases, downmodulation of cytokines, inhibition of cell movement and proliferation, inhibition of granuloma formation, inhibition of reactive oxygen species, nitric oxide, and angiogenesis, whereas inhibition of phospholipase a2 seems to be of lower importance. |
2010-01-25 |
2023-08-12 |
Not clear |
| Ali Gürkan, Gülnur Emingil, Gülperi Oktem, Nur Selvi, Beral Afacan, Tunç Ilgenli, Hüseyin Töz, Gül Atill. Immunohistochemical analysis of inducible and endothelial forms of nitric oxide synthase in cyclosporin A-induced gingival overgrowth. Journal of periodontology. vol 80. issue 10. 2010-01-15. PMID:19792854. |
the contribution of nitric oxide (no) to immune response and matrix degradation in the periodontal environment suggests a role for no and no-synthase (nos) activity in the pathogenesis of cyclosporin a (csa)-induced gingival overgrowth (go). |
2010-01-15 |
2023-08-12 |
Not clear |
| Justin B Maxhimer, Hubert B Shih, Jeffrey S Isenberg, Thomas W Miller, David D Robert. Thrombospondin-1/CD47 blockade following ischemia-reperfusion injury is tissue protective. Plastic and reconstructive surgery. vol 124. issue 6. 2010-01-11. PMID:19952644. |
however, the matrix glycoprotein thrombospondin-1 is induced following ischemia-reperfusion injury and limits nitric oxide signaling by engaging its cell surface receptor cd47. |
2010-01-11 |
2023-08-12 |
rat |
| Ana Paula Vendramini, Rafaela Fernanda Melo, Rosemary Adriana Chiérici Marcantonio, Iracilda Zepone Carlo. Biocompatibility of acellular dermal matrix graft evaluated in culture of murine macrophages. Journal of applied oral science : revista FOB. vol 14. issue 2. 2009-12-15. PMID:19089033. |
statistical analysis showed no significant difference (p nitric oxide and hydrogen peroxide by the macrophages exposed to acellular dermal matrix and the negative control. |
2009-12-15 |
2023-08-12 |
Not clear |
| S M Coope. A perspective on the use of minocycline for rheumatoid arthritis. Journal of clinical rheumatology : practical reports on rheumatic & musculoskeletal diseases. vol 5. issue 4. 2009-12-14. PMID:19078393. |
laboratory investigations that support a possible anti-arthritic action of tetracyclines through their effect on nitric oxide generation, matrix metalloprotease inhibition, and chondrocyte apoptosis are discussed. |
2009-12-14 |
2023-08-12 |
Not clear |