| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Indranil Sinha, Kevin K Hannawa, Gorav Ailawadi, Derek T Woodrum, John W Ford, Peter K Henke, James C Stanley, Matthew J Eagleton, Gilbert R Upchurc. The nitric oxide donor DETA-NONOate decreases matrix metalloproteinase-9 expression and activity in rat aortic smooth muscle and abdominal aortic explants. Annals of vascular surgery. vol 20. issue 1. 2006-08-22. PMID:16378139. |
our objective was to examine the role of an exogenous nitric oxide (no) donor, deta-nonoate (deta), on matrix metalloproteinase (mmp)-9, mmp-2, and tissue inhibitor of matrix metalloproteinases (timp)-1 expression and activity in interleukin (il)-1beta-induced rat aortic smooth muscle cells (ra-smcs) and rat aortic explants (raes). |
2006-08-22 |
2023-08-12 |
rat |
| Rita Rezzani, Luigi Fabrizio Rodella, Sandra Tengattini, Francesca Bonomini, Olga Pechánová, Stanislava Kojsová, Ramaroson Andriantsitohaina, Rossella Bianch. Protective role of polyphenols in cyclosporine A-induced nephrotoxicity during rat pregnancy. The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society. vol 54. issue 8. 2006-08-09. PMID:16618940. |
ihc analysis considered two proteins responsible for nephrotoxicity in adult rats: inducible nitric oxide (inos) and matrix metalloproteinase-2 (mmp2). |
2006-08-09 |
2023-08-12 |
rat |
| Estery C Mbvundula, Rowena A D Bunning, K D Rainsfor. Arthritis and cannabinoids: HU-210 and Win-55,212-2 prevent IL-1alpha-induced matrix degradation in bovine articular chondrocytes in-vitro. The Journal of pharmacy and pharmacology. vol 58. issue 3. 2006-07-07. PMID:16536902. |
it is concluded that biologically stable synthetic cannabinoids protect cartilage matrix from degradation induced by cytokines and this effect is possibly cb-receptor mediated and involves effects on prostaglandin and nitric oxide metabolism. |
2006-07-07 |
2023-08-12 |
cattle |
| Adriana Grigoraş, Alina Floarea-Strat, C Cotuţiu, Manuela Stanc. [New data about hepatic sinusoidal endothelial cell]. Revista medico-chirurgicala a Societatii de Medici si Naturalisti din Iasi. vol 109. issue 3. 2006-06-27. PMID:16607755. |
liver sinusoidal endothelial cells may function as antigen-presenting cells (apc) and are also active in the secretion of cytokines, eicosanoids, endothelin-1, nitric oxide and some extracellular matrix components. |
2006-06-27 |
2023-08-12 |
Not clear |
| Atsushi Iwakura, Shubha Shastry, Corinne Luedemann, Hiromichi Hamada, Atsuhiko Kawamoto, Raj Kishore, Yan Zhu, Gangjian Qin, Marcy Silver, Tina Thorne, Liz Eaton, Haruchika Masuda, Takayuki Asahara, Douglas W Losord. Estradiol enhances recovery after myocardial infarction by augmenting incorporation of bone marrow-derived endothelial progenitor cells into sites of ischemia-induced neovascularization via endothelial nitric oxide synthase-mediated activation of matrix metalloproteinase-9. Circulation. vol 113. issue 12. 2006-04-14. PMID:16534014. |
estradiol enhances recovery after myocardial infarction by augmenting incorporation of bone marrow-derived endothelial progenitor cells into sites of ischemia-induced neovascularization via endothelial nitric oxide synthase-mediated activation of matrix metalloproteinase-9. |
2006-04-14 |
2023-08-12 |
Not clear |
| Da-wei Guan, Rui Zhao, Yu D. [Expressions of NOS isoforms and roles of NO during skin wound healing]. Fa yi xue za zhi. vol 20. issue 4. 2006-04-07. PMID:15751659. |
nitric oxide synthase (nos) isoforms, as important factors during skin wound healing, synthesize nitric oxide (no) which may be involved in the whole event of skin wound healing and play important roles in cell proliferation, differentiation and apoptosis, angiogenesis, matrix deposits and remolding. |
2006-04-07 |
2023-08-12 |
Not clear |
| Arkadiusz Surazynski, Yongmin Liu, Wojciech Miltyk, James M Phan. Nitric oxide regulates prolidase activity by serine/threonine phosphorylation. Journal of cellular biochemistry. vol 96. issue 5. 2006-03-20. PMID:16167338. |
nitric oxide (no), a versatile signaling molecule, regulates many processes including collagen synthesis and matrix remodeling and, thereby, may modulate angiogenesis, tumor invasiveness, and metastasis. |
2006-03-20 |
2023-08-12 |
Not clear |
| G Verbrugge. Chondroprotective drugs in degenerative joint diseases. Rheumatology (Oxford, England). vol 45. issue 2. 2006-03-06. PMID:16278282. |
collagenase, proteoglycanase and matrix metalloproteinase activities, the expression of inducible nitric oxide synthase, the increased release of nitric oxide, and the secretion of prostaglandin e(2), il-6 and il-8, have been shown to possess disease-modifying oa drug (dmoad) activities in experimental models of oa and in human subjects with finger joint and knee oa. |
2006-03-06 |
2023-08-12 |
human |
| Neetu Tyagi, Karni S Moshal, David Lominadze, Alexander V Ovechkin, Suresh C Tyag. Homocysteine-dependent cardiac remodeling and endothelial-myocyte coupling in a 2 kidney, 1 clip Goldblatt hypertension mouse model. Canadian journal of physiology and pharmacology. vol 83. issue 7. 2006-02-08. PMID:16091784. |
furthermore, we hypothesize that hcy increases reactive oxygen species, generates nitrotyrosine, activates latent matrix metalloproteinase, and decreases the levels of endothelial nitric oxide in response to antagonizing ppar-gamma. |
2006-02-08 |
2023-08-12 |
mouse |
| Neetu Tyagi, Karni S Moshal, David Lominadze, Alexander V Ovechkin, Suresh C Tyag. Homocysteine-dependent cardiac remodeling and endothelial-myocyte coupling in a 2 kidney, 1 clip Goldblatt hypertension mouse model. Canadian journal of physiology and pharmacology. vol 83. issue 7. 2006-02-08. PMID:16091784. |
our results suggest that fibrosis between the endothelium and myocytes leads to an endothelial-myocyte disconnection and uncoupling by hcy accumulation secondary to increased reactive oxygen species, nitrotyrosine, matrix metalloproteinase, and decreased endothelial nitric oxide in response to antagonizing ppar-gamma. |
2006-02-08 |
2023-08-12 |
mouse |
| Shu Feng, Natalia V Bogatcheva, Aparna A Kamat, Anne Truong, Alexander I Agoulni. Endocrine effects of relaxin overexpression in mice. Endocrinology. vol 147. issue 1. 2006-02-03. PMID:16223865. |
the levels of previously defined targets of relaxin signaling, such as matrix metalloproteinases 2 and 9, vascular endothelial growth factor, or nitric oxide, were similar in the sera of the transgenic and wild-type mice. |
2006-02-03 |
2023-08-12 |
mouse |
| Dilek Yavuz, Halil Tuğtepe, Sule Cetinel, Suheyla Uyar, Handan Kaya, Goncagül Haklar, Sabahat Civelek, Oguzhan Deyneli, Tangül San, Gülden Burçak, Sema Akali. Collagen ultrastructure and TGF-beta1 expression preserved with aminoguanidine during wound healing in diabetic rats. Endocrine research. vol 31. issue 3. 2006-01-19. PMID:16392625. |
in this study, we evaluated the effects of aminoguanidine, which is an advanced glycation and nitric oxide (no) synthase inhibitor, on extracellular matrix protein expression, collagen configuration, and nitrite/nitrate levels in wounds of diabetic rats. |
2006-01-19 |
2023-08-12 |
rat |
| B Baggio, E Musacchio, G Priant. Polyunsaturated fatty acids and renal fibrosis: pathophysiologic link and potential clinical implications. Journal of nephrology. vol 18. issue 4. 2005-12-13. PMID:16245238. |
the mechanisms by which pufa can favorably interfere with some stages in renal fibrosis processes, such as mesangial cell activation and proliferation and extracellular matrix protein synthesis, include the regulation of some pro-inflammatory cytokine production, renin and nitric oxide (no) systems and peroxisome proliferator-activated receptor gene expression. |
2005-12-13 |
2023-08-12 |
human |
| M Caraglia, S Beninati, G Giuberti, A M D'Alessandro, A Lentini, A Abbruzzese, G Bove, F Landolfi, F Rossi, E Lampa, M Costantin. Alternative therapy of earth elements increases the chondroprotective effects of chondroitin sulfate in mice. Experimental & molecular medicine. vol 37. issue 5. 2005-11-30. PMID:16264272. |
since oa is characterized by an increase of the production of nitric oxide (no) by chondrocytes in extracellular matrix with its consequent elevation in serum and synovial fluid, we have evaluated the effects of the treatments on serum no levels. |
2005-11-30 |
2023-08-12 |
mouse |
| Yves Castier, Ralf P Brandes, Guy Leseche, Alain Tedgui, Stéphanie Lehou. p47phox-dependent NADPH oxidase regulates flow-induced vascular remodeling. Circulation research. vol 97. issue 6. 2005-11-03. PMID:16109921. |
chronic alterations in blood flow elicit an adaptive response that tends to normalize shear stress, involving nitric oxide (no) and matrix metalloproteinases (mmps). |
2005-11-03 |
2023-08-12 |
mouse |
| Amedea Barozzi Seabra, Gabriela Freitas Pereira de Souza, Lilian Lúcia da Rocha, Marcos Nogueira Eberlin, Marcelo Ganzarolli de Oliveir. S-nitrosoglutathione incorporated in poly(ethylene glycol) matrix: potential use for topical nitric oxide delivery. Nitric oxide : biology and chemistry. vol 11. issue 3. 2005-09-30. PMID:15566973. |
s-nitrosoglutathione incorporated in poly(ethylene glycol) matrix: potential use for topical nitric oxide delivery. |
2005-09-30 |
2023-08-12 |
Not clear |
| L B Valdez, S Lores Arnaiz, J Bustamante, S Alvarez, L E Costa, A Boveri. Free radical chemistry in biological systems. Biological research. vol 33. issue 2. 2005-09-12. PMID:15693272. |
nitric oxide reacts with o2- in a termination reaction in the mitochondrial matrix, yielding peroxynitrite (onoo-), which is a strong oxidizing and nitrating species. |
2005-09-12 |
2023-08-12 |
Not clear |
| Wenjie Wang, Serena Viappiani, Jolanta Sawicka, Richard Schul. Inhibition of endogenous nitric oxide in the heart enhances matrix metalloproteinase-2 release. British journal of pharmacology. vol 145. issue 1. 2005-07-28. PMID:15711589. |
inhibition of endogenous nitric oxide in the heart enhances matrix metalloproteinase-2 release. |
2005-07-28 |
2023-08-12 |
rat |
| Wenjie Wang, Serena Viappiani, Jolanta Sawicka, Richard Schul. Inhibition of endogenous nitric oxide in the heart enhances matrix metalloproteinase-2 release. British journal of pharmacology. vol 145. issue 1. 2005-07-28. PMID:15711589. |
matrix metalloproteinase (mmp) activity is upregulated in pathologies such as atherosclerosis during which endogenous nitric oxide (no) biosynthesis is reduced. |
2005-07-28 |
2023-08-12 |
rat |
| M E Pirker, S Montedonico, U Rolle, H Austvoll, P Pur. Regional differences in nitrergic neuronal density in the developing porcine urinary bladder. Pediatric surgery international. vol 21. issue 3. 2005-07-19. PMID:15570429. |
nitric oxide (no) is involved in normal bladder physiology by regulating local arteriolar tone and smooth muscle relaxation and modulating the production of extracellular matrix proteins in vitro. |
2005-07-19 |
2023-08-12 |
Not clear |