| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yiping Mu, Yang Zhang, Jie Wu, Qi L. NLRC5 attenuates inflammatory response in IL-1β-stimulated human osteoarthritis chondrocytes through the NF-κB signaling pathway. Aging. vol 13. issue 16. 2021-09-22. PMID:34438368. |
overexpression of nlrc5 in chondrocytes significantly suppressed il-1β-induced inflammatory response through inhibiting the production of multiple inflammatory mediators including inducible nitric oxide synthases (inos), and cyclooxygenase-2 (cox-2), prostaglandin e2 (pge2), no, tnf-α and il-6, as well matrix metalloproteinase 3 (mmp-3) and mmp-13. |
2021-09-22 |
2023-08-13 |
human |
| Alejandro F Prado, Rose I M Batista, Jose E Tanus-Santos, Raquel F Gerlac. Matrix Metalloproteinases and Arterial Hypertension: Role of Oxidative Stress and Nitric Oxide in Vascular Functional and Structural Alterations. Biomolecules. vol 11. issue 4. 2021-09-20. PMID:33923477. |
matrix metalloproteinases and arterial hypertension: role of oxidative stress and nitric oxide in vascular functional and structural alterations. |
2021-09-20 |
2023-08-13 |
Not clear |
| Alejandro F Prado, Rose I M Batista, Jose E Tanus-Santos, Raquel F Gerlac. Matrix Metalloproteinases and Arterial Hypertension: Role of Oxidative Stress and Nitric Oxide in Vascular Functional and Structural Alterations. Biomolecules. vol 11. issue 4. 2021-09-20. PMID:33923477. |
this mini-review article focuses on central mechanisms contributing to the vascular dysfunction and remodeling of hypertension, increased oxidative stress and impaired nitric oxide (no) bioavailability, which enhance vascular matrix metalloproteinase (mmp) activity. |
2021-09-20 |
2023-08-13 |
Not clear |
| Jingwen Chen, Eun Na, Sun Young Li. Effect of Fractions from Lycopus lucidus Turcz. Leaves on Genomic DNA Oxidation and Matrix Metalloproteinase Activity. Combinatorial chemistry & high throughput screening. 2021-09-10. PMID:34503410. |
leaves on genomic dna oxidation, nitric oxide (no) production and matrix metalloproteinase (mmp) activity. |
2021-09-10 |
2023-08-13 |
Not clear |
| Mazhar Pasha, Amy L Wooldridge, Raven Kirschenman, Floor Spaans, Sandra T Davidge, Christy-Lynn M Cook. Altered Vascular Adaptations to Pregnancy in a Rat Model of Advanced Maternal Age. Frontiers in physiology. vol 12. 2021-08-17. PMID:34393831. |
we hypothesize that advanced maternal age is associated with a more vasoconstrictive phenotype due to reduced nitric oxide (no) and increased activity of matrix metalloproteinases (mmps), contributing to impaired vascular adaptations to pregnancy. |
2021-08-17 |
2023-08-13 |
rat |
| Shlok Jindal, S Chockalingam, Siddhartha Sankar Ghosh, Gopinath Packirisam. Connexin and gap junctions: perspectives from biology to nanotechnology based therapeutics. Translational research : the journal of laboratory and clinical medicine. vol 235. 2021-08-13. PMID:33582245. |
asodn, antisense oligodeoxynucleotides; bmps, bone morphogenetic proteins; bmscs, bone marrow stem cells; bg, bioglass; cx, connexin; cxre, connexin-responsive elements; cocr nps, cobalt-chromium nanoparticles; cgamp, cyclic guanosine monophosphate-adenosine monophosphate; camp, cyclic adenosine monophosphate; erk1/2, extracellular signal-regulated kinase 1/2; emt, epithelial-mesenchymal transition; epa, eicosapentaenoic acids; fgfr1, fibroblast growth factor receptor 1; frap, fluorescence recovery after photobleaching; 5-fu, 5-fluorouracil; gj, gap junction; gjic, gap junctional intercellular communication; hgprtase, hypoxanthine phosphoribosyltransferase; hsv-tk, herpes virus thymidine kinase; hsa, human serum albumin; ha, hyaluronic acid; hdac, histone deacetylase; iri, ischemia reperfusion injury; il-6, interleukin-6; il-8, interleukin-8; ionps, iron-oxide nanoparticles; jnk, c-jun n-terminal kinase; lamp, local activation of molecular fluorescent probe; mscs, mesenchymal stem cells; mmp, matrix metalloproteinase; mi, myocardial infarction; mapk, mitogen-activated protein kinase; nf-κb, nuclear factor kappa b; no, nitric oxide; pkc, protein kinase c; qds, quantum dots; roi, region of interest; rgo, reduced graphene oxide; sirna, small interfering rna; tgf-β1, transforming growth factor-β1; tnf-α, tumor necrosis factor-α; ucn, upconversion nanoparticles; vegf, vascular endothelial growth factor. |
2021-08-13 |
2023-08-13 |
human |
| Nan Lyu, Zeyu Du, Hua Qiu, Peng Gao, Qin Yao, Kaiqin Xiong, Qiufen Tu, Xiangyang Li, Binghai Chen, Miao Wang, Guoqing Pan, Nan Huang, Zhilu Yan. Mimicking the Nitric Oxide-Releasing and Glycocalyx Functions of Endothelium on Vascular Stent Surfaces. Advanced science (Weinheim, Baden-Wurttemberg, Germany). vol 7. issue 21. 2021-07-07. PMID:33173746. |
typically, a nitric oxide (no, vasoactive mediator)-generating compound and an endothelial polysaccharide matrix molecule hyaluronan (ha) are sequentially immobilized on allylamine-plasma-deposited stents through aqueous amidation. |
2021-07-07 |
2023-08-13 |
Not clear |
| Zachary S Clayton, David A Hutton, Sophia A Mahoney, Douglas R Seal. Anthracycline chemotherapy-mediated vascular dysfunction as a model of accelerated vascular aging. Aging and cancer. vol 2. issue 1-2. 2021-07-04. PMID:34212156. |
a key mechanism involved in vascular dysfunction with aging is oxidative stress, which reduces the bioavailability of nitric oxide (no) and induces adverse changes to the extracellular matrix of the arterial wall (e.g., elastin fragmentation/degradation, collagen deposition) and an increase in advanced glycation end products, which form crosslinks in arterial wall structural proteins. |
2021-07-04 |
2023-08-13 |
Not clear |
| Thuan Thai, Fei Zhong, Lei Dang, Enoch Chan, Jacqueline Ku, Ernst Malle, Carolyn L Geczy, John F Keaney, Shane R Thoma. Endothelial-transcytosed myeloperoxidase activates endothelial nitric oxide synthase via a phospholipase C-dependent calcium signaling pathway. Free radical biology & medicine. vol 166. 2021-06-28. PMID:33539947. |
during vascular inflammation, the leukocyte-derived enzyme myeloperoxidase (mpo) is transcytosed across the endothelium and into the sub-endothelial extracellular matrix, where it promotes endothelial dysfunction by catalytically consuming nitric oxide (no) produced by endothelial no synthase (enos). |
2021-06-28 |
2023-08-13 |
Not clear |
| Arnab Mondal, Ryan Devine, Lori Estes, James Manuel, Priyadarshini Singha, Juhi Mancha, Marley Palmer, Hitesh Hand. Highly hydrophobic polytetrafluoroethylene particle immobilization via polydopamine anchor layer on nitric oxide releasing polymer for biomedical applications. Journal of colloid and interface science. vol 585. 2021-06-21. PMID:33190836. |
in the first bio-inspired approach, the functionality of nitric oxide (no) produced by endothelial cell lining of blood vessels is mimicked through incorporation of s-nitroso-n-acetylpenicillamine (snap) within a carbosil-2080a™ (carbosil) polymer composite matrix. |
2021-06-21 |
2023-08-13 |
Not clear |
| Lingli Kong, Laifang Wang, Qing Zhao, Guijuan Di, Huiqiang W. Rhodojaponin II inhibits TNF-α-induced inflammatory cytokine secretion in MH7A human rheumatoid arthritis fibroblast-like synoviocytes. Journal of biochemical and molecular toxicology. vol 34. issue 10. 2021-06-08. PMID:32613688. |
r-ii suppressed the levels of nitric oxide and prostaglandin e2, and inhibited messenger rna expression and concentrations of interleukin-1β (il-1β), il-6 and matrix metalloproteinase-1 in tnf-α-stimulated ra-flss. |
2021-06-08 |
2023-08-13 |
mouse |
| Se-Jin Lee, A Yeong Lee, Je-Oh Lim, Ji Hye Lee, Tae-Yang Jung, So-Won Pak, Woong-Il Kim, Yoon Soo Seo, Jong-Choon Kim, Je-Won Ko, In-Sik Shi. Effect of Yijin-Tang, an Oriental Traditional Formula, on Allergic Responses Using an Ovalbumin-Induced Murine Asthma Model. Evidence-based complementary and alternative medicine : eCAM. vol 2021. 2021-06-01. PMID:34055011. |
furthermore, yte suppressed the expression of matrix metalloproteinase-9 and phosphorylation of erk in the lungs, which in turn led to a reduction in inducible nitric oxide synthases and an elevation in reduced glutathione and heme oxygenase-1. |
2021-06-01 |
2023-08-13 |
mouse |
| Cezmi A Akdis, Peter D Arkwright, Marie-Charlotte Brüggen, William Busse, Massimo Gadina, Emma Guttman-Yassky, Kenji Kabashima, Yasutaka Mitamura, Laura Vian, Jianni Wu, Oscar Palomare. Type 2 immunity in the skin and lungs. Allergy. vol 75. issue 7. 2021-05-14. PMID:32319104. |
il-13 contributes to maturation, activation, nitric oxide production and differentiation of epithelia, production of mucus as well as smooth muscle contraction, and extracellular matrix generation. |
2021-05-14 |
2023-08-13 |
Not clear |
| Qiuying Cai, Yulin Li, Fan Lyu, Mingming Zhou, Kuiqing Lu, Xiaoyue Tang, Dongxia Ren, Qilin Bao, Dan Wang, Yun L. Effects of All-Trans Retinoic Acid on the Optimization of Synovial Explant Induced by Tumor Necrosis Factor Alpha. Journal of nutritional science and vitaminology. vol 66. issue 4. 2021-05-10. PMID:32863302. |
in tnf-α-experiment, the secretion of nitric oxide (no), interleukin-6 (il-6), vascular endothelial growth factor (vegf), and matrix metalloproteinase-9 (mmp-9) increased significantly after tnf-α stimulation without pathological damage to the synovium. |
2021-05-10 |
2023-08-13 |
rat |
| Seon-Mi Yu, Song Ja Ki. Simvastatin prevents articular chondrocyte dedifferentiation induced by nitric oxide by inhibiting the expression of matrix metalloproteinases 1 and 13. Experimental biology and medicine (Maywood, N.J.). vol 243. issue 15-16. 2021-04-20. PMID:32459510. |
simvastatin prevents articular chondrocyte dedifferentiation induced by nitric oxide by inhibiting the expression of matrix metalloproteinases 1 and 13. |
2021-04-20 |
2023-08-13 |
Not clear |
| Seon-Mi Yu, Song Ja Ki. Simvastatin prevents articular chondrocyte dedifferentiation induced by nitric oxide by inhibiting the expression of matrix metalloproteinases 1 and 13. Experimental biology and medicine (Maywood, N.J.). vol 243. issue 15-16. 2021-04-20. PMID:32459510. |
in this work we show that simvastatin (svt) inhibits dedifferentiation by nitric oxide by blocking the expression of matrix metalloproteinases 1 and 13. |
2021-04-20 |
2023-08-13 |
Not clear |
| Fang Yuan, Jian-Li Xie, Ke-Yin Liu, Jian-Liang Shan, Yu-Gang Sun, Wang-Gui Yin. Xanthan gum protects temporomandibular chondrocytes from IL‑1β through Pin1/NF‑κB signaling pathway. Molecular medicine reports. vol 22. issue 2. 2021-04-15. PMID:32626995. |
the expression of monocyte chemoattractive protein‑1 (mcp‑1), inducible nitric oxide synthase (inos), collagens, matrix metalloproteinases (mmps), peptidyl‑prolyl isomerase 1 (pin1) and phosphorylated nuclear factor κb (nf‑κb) p65 (p‑p65) was analyzed by quantitative pcr or western blotting. |
2021-04-15 |
2023-08-13 |
rat |
| Ryan Devine, Marcus J Goudie, Priyadarshini Singha, Chad Schmiedt, Megan Douglass, Elizabeth J Brisbois, Hitesh Hand. Mimicking the Endothelium: Dual Action Heparinized Nitric Oxide Releasing Surface. ACS applied materials & interfaces. vol 12. issue 18. 2021-03-03. PMID:32271542. |
surface modification was accomplished via heparin surface immobilization (hep) and the inclusion of a nitric oxide (no) donor into the sr polymeric matrix to achieve synergistic effects (hep-no-sr). |
2021-03-03 |
2023-08-13 |
Not clear |
| Ling-Yuh Shyu, Ke-Min Chen, Cheng-You Lu, Shih-Chan La. Regulation of Proinflammatory Enzymes by Peroxisome Proliferator-Activated Receptor Gamma in Astroglia Infected with Toxoplasma gondii. The Journal of parasitology. vol 106. issue 5. 2021-02-02. PMID:32916705. |
our results showed that matrix metalloprotease (mmp)-2, mmp-9, cyclooxygenase-2 (cox-2), prostaglandin (pge)-2, inducible nitric-oxide synthase (inos), and nitric oxide (no) were significantly increased in t. gondii-infected astroglia. |
2021-02-02 |
2023-08-13 |
Not clear |
| Anne Steins, Remy Klaassen, Igor Jacobs, Matthias C Schabel, Monique G J T B van Lier, Eva A Ebbing, Stefanie J Hectors, Sander W Tas, Chrissta X Maracle, Cornelis J A Punt, Maria Siebes, Jacques J G H M Bergman, Jan Paul Medema, Johanna W Wilmink, Ron A A Mathot, Gustav J Strijkers, Maarten F Bijlsma, Hanneke W M van Laarhove. Rapid stromal remodeling by short-term VEGFR2 inhibition increases chemotherapy delivery in esophagogastric adenocarcinoma. Molecular oncology. vol 14. issue 4. 2021-02-01. PMID:31733011. |
assessment of the extracellular matrix (ecm) revealed that short-term anti-angiogenic treatment drastically remodels the tumor stroma by inducing nitric oxide synthesis and hyaluronan degradation, thereby dilating the vasculature and improving intratumoral chemotherapy delivery. |
2021-02-01 |
2023-08-13 |
Not clear |