| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yan Li, Kang Li, Lu Mao, Xiuguo Han, Kai Zhang, Changqing Zhao, Jie Zha. Cordycepin inhibits LPS-induced inflammatory and matrix degradation in the intervertebral disc. PeerJ. vol 4. 2016-05-18. PMID:27190710. |
in our study, we used a rat np cell culture and an intervertebral disc (ivd) organ culture model to examine the inhibitory effects of cordycepin on lipopolysaccharide (lps)-induced gene expression and the production of matrix degradation enzymes (mmp-3, mmp-13, adamts-4, and adamts-5) and oxidative stress-associated factors (nitric oxide and pge2). |
2016-05-18 |
2023-08-13 |
rat |
| In-Sik Shin, Na-Rae Shin, Chan-Mi Jeon, Ok-Kyoung Kwon, Ju-Mi Hong, Hui-Seong Kim, Sei-Ryang Oh, Kyung-Seop Ah. Thuja orientalis reduces airway inflammation in ovalbumin-induced allergic asthma. Molecular medicine reports. vol 12. issue 3. 2016-05-17. PMID:26063078. |
to was shown to reduce nitric oxide production and reduce the relative mrna expression levels of inducible nitric oxide synthase (inos), interleukin (il)‑6, cyclooxygenase‑2, matrix metalloproteinase (mmp)‑9, and tumor necrosis factor‑α in raw264.7 cells stimulated with lps. |
2016-05-17 |
2023-08-13 |
mouse |
| Na-Rae Shin, In-Sik Shin, Chan-Mi Jeon, Ju-Mi Hong, Ok-Kyoung Kwon, Hui-Seong Kim, Sei-Ryang Oh, Kyu-Woung Hahn, Kyung-Seop Ah. Zingiber mioga (Thunb.) Roscoe attenuates allergic asthma induced by ovalbumin challenge. Molecular medicine reports. vol 12. issue 3. 2016-05-17. PMID:26063513. |
in lps‑stimulated raw264.7 cells, zm significantly decreased nitric oxide (no) and tumor necrosis factor (tnf)‑α production in a concentration‑dependent manner, and mrna expression of inducible no synthase (inos), tnf‑α and matrix metalloproteinase (mmp)‑9 was reduced. |
2016-05-17 |
2023-08-13 |
mouse |
| Qinghong Li, Lisa M Freeman, John E Rush, Gordon S Huggins, Adam D Kennedy, Jeffrey A Labuda, Dorothy P Laflamme, Steven S Hanna. Veterinary Medicine and Multi-Omics Research for Future Nutrition Targets: Metabolomics and Transcriptomics of the Common Degenerative Mitral Valve Disease in Dogs. Omics : a journal of integrative biology. vol 19. issue 8. 2016-04-29. PMID:26154239. |
transcriptomics analysis identified 812 differentially expressed transcripts in left ventricle samples and 263 in mitral valve samples, representing changes in energy metabolism, antioxidant function, nitric oxide signaling, and extracellular matrix homeostasis pathways. |
2016-04-29 |
2023-08-13 |
Not clear |
| Anatoly P Burlaka, Irina I Ganusevich, Marat R Gafurov, Sergey M Lukin, Evgeny P Sidori. Stomach Cancer: Interconnection between the Redox State, Activity of MMP-2, MMP-9 and Stage of Tumor Growth. Cancer microenvironment : official journal of the International Cancer Microenvironment Society. vol 9. issue 1. 2016-04-25. PMID:26905073. |
superoxide generation rates, nitric oxide (no) levels, concentrations of active forms of matrix metalloproteinases mmp-2 and mmp-9 in tumor and adjacent tissues of patients with stomach cancer at different disease stages were measured by electron spin resonance (esr) including spin-trapping and polyacrylamide gel zymography. |
2016-04-25 |
2023-08-13 |
Not clear |
| Yasir Akhtar Khan, Sadiq Umar, Syed M A Abid. Somatic antigens of tropical liver flukes ameliorate collagen-induced arthritis in wistar rats. PloS one. vol 10. issue 5. 2016-04-18. PMID:25992888. |
hind paw thickness; serum interleukins, il-4 and il-10, tumor necrosis factor-α (tnf-α) and interferon-γ (ifn-γ); expression level of matrix metalloproteinases (mmps) -2, -9, -13 and nitric oxide (no) in knee joints and patellar morphology. |
2016-04-18 |
2023-08-13 |
rat |
| Xiu Chen, Peng Lu, Lin Chen, Su-jin Yang, Hong-Yu Shen, Dan-dan Yu, Xiao-hui Zhang, Shan-liang Zhong, Jian-hua Zhao, Jin-hai Tan. Perioperative propofol-paravertebral anesthesia decreases the metastasis and progression of breast cancer. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine. vol 36. issue 11. 2016-04-07. PMID:26383520. |
among them, ppa participates in several bioprocesses in the development of breast cancer, including inhibiting hypoxia-inducible factor (hif) activity, elevating serum concentration of nitric oxide index (nox), depression of the neuroepithelial cell transforming gene 1 (net1) signal pathway, blocking the nuclear factor kappa b (nf-κb) pathway following an decreased expression of matrix metalloproteinase (mmp), increasing nk cytotoxicity, and affecting transforming growth factor (tgf)-β-targeted ras and her2/neu gene pathways. |
2016-04-07 |
2023-08-13 |
Not clear |
| Frederic Oprenyeszk, Christelle Sanchez, Jean-Emile Dubuc, Véronique Maquet, Catherine Henrist, Philippe Compère, Yves Henroti. Chitosan enriched three-dimensional matrix reduces inflammatory and catabolic mediators production by human chondrocytes. PloS one. vol 10. issue 5. 2016-04-01. PMID:26020773. |
interleukin (il)-6 and -8, prostaglandin (pg) e2, matrix metalloproteinases (mmps), hyaluronan and aggrecan were quantified directly in the culture supernatant by specific elisa and nitric oxide (no) by using a colorimetric method based on the griess reaction. |
2016-04-01 |
2023-08-13 |
human |
| Stephanie E Martinez, Yufei Chen, Emmanuel A Ho, Steven A Martinez, Neal M Davie. Pharmacological effects of a C-phycocyanin-based multicomponent nutraceutical in an in-vitro canine chondrocyte model of osteoarthritis. Canadian journal of veterinary research = Revue canadienne de recherche veterinaire. vol 79. issue 3. 2016-03-30. PMID:26130858. |
the nutraceutical preparation as a whole, its individual constituents, as well as carprofen were evaluated at concentrations of 0 to 250 μg/ml for reduction of the following inflammatory mediators and indicators of catabolism of the extracellular matrix: prostaglandin e2 (pge2), tumor necrosis factor-α (tfn-α), interleukin-6 (il-6), metalloproteinase-3 (mmp-3), nitric oxide, and sulfated glycosaminoglycans (sgags). |
2016-03-30 |
2023-08-13 |
Not clear |
| Susan E Lacy, Chengbin Wu, Dominic J Ambrosi, Chung-Ming Hsieh, Sahana Bose, Renee Miller, Donna M Conlon, Edit Tarcsa, Ravi Chari, Tariq Ghayur, Rajesh V Kamat. Generation and characterization of ABT-981, a dual variable domain immunoglobulin (DVD-Ig(TM)) molecule that specifically and potently neutralizes both IL-1α and IL-1β. mAbs. vol 7. issue 3. 2016-03-22. PMID:25764208. |
interleukin-1 (il-1) cytokines such as il-1α, il-1β, and il-1ra contribute to immune regulation and inflammatory processes by exerting a wide range of cellular responses, including expression of cytokines and chemokines, matrix metalloproteinases, and nitric oxide synthetase. |
2016-03-22 |
2023-08-13 |
human |
| Joanne F Garbincius, Daniel E Michel. Dystrophin-glycoprotein complex regulates muscle nitric oxide production through mechanoregulation of AMPK signaling. Proceedings of the National Academy of Sciences of the United States of America. vol 112. issue 44. 2016-03-02. PMID:26483453. |
patients deficient in dystrophin, a protein that links the cytoskeleton to the extracellular matrix via the dystrophin-glycoprotein complex (dgc), exhibit muscular dystrophy, cardiomyopathy, and impaired muscle nitric oxide (no) production. |
2016-03-02 |
2023-08-13 |
mouse |
| Fanny Comblain, Christelle Sanchez, Isabelle Lesponne, Marc Balligand, Samuel Serisier, Yves Henroti. Curcuminoids extract, hydrolyzed collagen and green tea extract synergically inhibit inflammatory and catabolic mediator's synthesis by normal bovine and osteoarthritic human chondrocytes in monolayer. PloS one. vol 10. issue 3. 2016-02-22. PMID:25799427. |
in interleukin-1β-stimulated human chondrocytes, nitric oxide, interleukin-6 and matrix metalloproteinase 3 productions were significantly reduced by curcuminoids extract alone or in combination with hydrolyzed collagen and green tea extract. |
2016-02-22 |
2023-08-13 |
human |
| Anna Santoro, Javier Conde, Morena Scotece, Vanessa Abella, Verónica López, Jesús Pino, Rodolfo Gómez, Juan Jesús Gómez-Reino, Oreste Gualill. Choosing the right chondrocyte cell line: Focus on nitric oxide. Journal of orthopaedic research : official publication of the Orthopaedic Research Society. vol 33. issue 12. 2016-02-22. PMID:26016689. |
nitric oxide (no) has been considered a catabolic factor that contributes to oa pathology by inducing chondrocytes apoptosis, matrix metalloproteinases synthesis, and pro-inflammatory cytokines expression. |
2016-02-22 |
2023-08-13 |
human |
| Franco Capsoni, Anna Maria Ongari, Caterina Lonati, Riccardo Accetta, Stefano Gatti, Anna Catani. α-Melanocyte-stimulating-hormone (α-MSH) modulates human chondrocyte activation induced by proinflammatory cytokines. BMC musculoskeletal disorders. vol 16. 2016-02-04. PMID:26093672. |
since human chondrocytes express α-msh receptors, we evaluated the role of the peptide in modulating chondrocyte production of pro-inflammatory cytokines, matrix metalloproteinases (mmps), tissue inhibitors of mmps (timps), inducible nitric oxide synthase (inos) and nitric oxide (no) in response to interleukin-1β (il-1β) and tumor necrosis factor-α (tnf-α). |
2016-02-04 |
2023-08-13 |
human |
| Nicole Poythress Waters, Aaron M Stoker, Ferris M Pfeiffer, James L Coo. Biomarkers Affected by Impact Severity during Osteochondral Injury. The journal of knee surgery. vol 28. issue 3. 2016-01-14. PMID:24858662. |
culture media were assessed for prostaglandin e2 (pge2); nitric oxide; granulocyte macrophage colony-stimulating factor (gm-csf); interferon gamma (ifnγ); interleukin (il)-2, -4, -6, -7, -8, -10, -15, -18; interferon gamma-induced protein 10 (ip-10); keratinocyte-derived chemoattractant (kc); monocyte chemoattractant protein-1 (mcp-1); tumor necrosis factor alpha (tnfα); and matrix metalloproteinase-2, -3, -8, -9, -13. |
2016-01-14 |
2023-08-13 |
Not clear |
| Phillip Simmers, Arsela Gishto, Narendra Vyavahare, Chandrasekhar R Kothapall. Nitric oxide stimulates matrix synthesis and deposition by adult human aortic smooth muscle cells within three-dimensional cocultures. Tissue engineering. Part A. vol 21. issue 7-8. 2016-01-05. PMID:25597545. |
nitric oxide stimulates matrix synthesis and deposition by adult human aortic smooth muscle cells within three-dimensional cocultures. |
2016-01-05 |
2023-08-13 |
human |
| Phillip Simmers, Arsela Gishto, Narendra Vyavahare, Chandrasekhar R Kothapall. Nitric oxide stimulates matrix synthesis and deposition by adult human aortic smooth muscle cells within three-dimensional cocultures. Tissue engineering. Part A. vol 21. issue 7-8. 2016-01-05. PMID:25597545. |
here, we report the benefits of exogenous nitric oxide (no) cues, delivered from s-nitrosoglutathione (gsno), to cell proliferation and matrix deposition by adult human aortic smcs (ha-smcs) within three-dimensional (3d) biomimetic cocultures. |
2016-01-05 |
2023-08-13 |
human |
| Changming Yang, Xianqiong Gong, Qing Ai, Pu Ge, Ling Lin, Li Zhan. 5-Aminoimidazole-4-carboxamide-1-β-d-ribofuranoside alleviated carbon tetrachloride-induced acute hepatitis in mice. International immunopharmacology. vol 25. issue 2. 2016-01-04. PMID:25711693. |
treatment with aicar also inhibited the increase of myeloperoxidase (mpo), the induction of tnf-α, il-6, inducible nitric oxide synthase (inos), nitric oxide and the upregulation of matrix metalloproteinase 2 (mmp-2), mmp-3 and mmp-9 in mice exposed to ccl4. |
2016-01-04 |
2023-08-13 |
mouse |
| Clare L Thompson, Habiba Yasmin, Anna Varone, Anna Wiles, C Antony Poole, Martin M Knigh. Lithium chloride prevents interleukin-1β induced cartilage degradation and loss of mechanical properties. Journal of orthopaedic research : official publication of the Orthopaedic Research Society. vol 33. issue 10. 2015-11-25. PMID:26174175. |
in an inflammatory model of cartilage destruction, lithium chloride blocked interleukin-1β signaling in the form of nitric oxide and prostaglandin e2 release and prevented matrix catabolism such that the loss of mechanical integrity observed with interleukin-1β alone was inhibited. |
2015-11-25 |
2023-08-13 |
human |
| Huai-Dong Li, Qing-Xiang Zhang, Zhi Mao, Xing-Jie Xu, Nai-Yi Li, Hui Zhan. Exogenous interleukin-10 attenuates hyperoxia-induced acute lung injury in mice. Experimental physiology. vol 100. issue 3. 2015-11-16. PMID:25480159. |
our results showed that exogenous il-10 treatment alleviated hyperoxia-induced acute lung injury in mice, possibly by regulating neutrophil recruitment and the subsequent generation of cytokines, nitric oxide and matrix metalloproteinases. |
2015-11-16 |
2023-08-13 |
mouse |