All Relations between mesencephalon and prefrontal cortex

Publication Sentence Publish Date Extraction Date Species
Dmitrii S Traktirov, Ilya R Nazarov, Valeria S Artemova, Raul R Gainetdinov, Nina S Pestereva, Marina N Karpenk. Alterations in Serotonin Neurotransmission in Hyperdopaminergic Rats Lacking the Dopamine Transporter. Biomedicines. vol 11. issue 11. 2023-11-25. PMID:38001881. in this article we showed that knockout of the gene encoding dat leads not only to a profound dysregulation of dopamine neurotransmission in the striatum but also in the midbrain, prefrontal cortex, hippocampus, medulla oblongata and spinal cord. 2023-11-25 2023-11-28 rat
Laura Smedegaard Heisel, Freja Drost Andersen, Sâmia Joca, Lambert Kristiansen Sørensen, Ulf Simonsen, Jørgen Bo Hasselstrøm, Charlotte Uggerhøj Andersen, Kirstine Lykke Nielse. Combined in vivo metabolic effects of quetiapine and methadone in brain and blood of rats. Archives of toxicology. 2023-10-23. PMID:37870577. in this study, we employed untargeted metabolomics analysis and targeted analysis to examine the changes in drug metabolites and endogenous metabolites in the prefrontal cortex (pfc), midbrain, and blood of rats following acute co-administration of quetiapine and methadone. 2023-10-23 2023-11-08 rat
Kenta Abe, Yuki Kambe, Kei Majima, Zijing Hu, Makoto Ohtake, Ali Momennezhad, Hideki Izumi, Takuma Tanaka, Ashley Matunis, Emma Stacy, Takahide Itokazu, Takashi R Sato, Tatsuo K Sat. Enhanced Aversive Signals During Classical Conditioning in Dopamine Axons in Medial Prefrontal Cortex. bioRxiv : the preprint server for biology. 2023-09-04. PMID:37662305. midbrain dopamine neurons impact neural processing in the prefrontal cortex (pfc) through mesocortical projections. 2023-09-04 2023-09-07 mouse
Lewis S Crawford, Emily P Mills, A Peek, Vaughan G Macefield, Kevin A Keay, Luke A Henderso. Function and biochemistry of the dorsolateral prefrontal cortex during placebo analgesia: how the certainty of prior experiences shapes endogenous pain relief. Cerebral cortex (New York, N.Y. : 1991). 2023-07-06. PMID:37415068. moreover, we found placebo-related activation within the right dorsolateral prefrontal cortex and altered functional magnetic resonance imaging coupling between the dorsolateral prefrontal cortex and the midbrain periaqueductal gray, which also correlated with dorsolateral prefrontal cortex glutamate. 2023-07-06 2023-08-14 human
Jeong Pyo Seo, Heun Jae Ry. Neural Injury of the Dopaminergic Pathways in Patients with Middle Cerebral Artery Territory Infarct: A Diffusion Tensor Imaging Study. Brain sciences. vol 13. issue 6. 2023-06-28. PMID:37371405. the mesocortical tract (mct) and mesolimbic tract (mlt), dopaminergic pathways originating from the ventral tegmental area in the midbrain to the ventral striatum (nucleus accumbens) and prefrontal cortex, play a crucial role in regulating incentive salience. 2023-06-28 2023-08-14 Not clear
R Basanisi, K Marche, E Combrisson, P Apicella, A Brovell. Beta oscillations in monkey striatum encode reward prediction error signals. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2023-04-04. PMID:37015808. rpe signals are encoded in the neural activity of multiple brain areas, such as midbrain dopaminergic neurons, prefrontal cortex and striatum. 2023-04-04 2023-08-14 monkey
Gal Nir-Cohen, Tobias Egner, Yoav Kessle. The Neural Correlates of Updating and Gating in Procedural Working Memory. Journal of cognitive neuroscience. 2023-03-28. PMID:36976906. in neural terms, opening the gate to procedural wm was associated with activity in medial pfc, posterior parietal cortex (ppc), the basal ganglia (bg), thalamus, and midbrain, but only when the task set needed to be updated. 2023-03-28 2023-08-14 human
Matthew A Weber, Gemma de Choisy, Ramasamy Thangavel, Mackenzie M Conlon, Hisham A Abdelmotilib, Oday Halhouli, Qiang Zhang, Joel C Geerling, Nandakumar S Narayanan, Georgina M Aldridg. Alpha-synuclein pre-formed fibrils injected into prefrontal cortex primarily impact cortical and subcortical structures and lead to restricted behavioral impacts. bioRxiv : the preprint server for biology. 2023-02-13. PMID:36778400. we report that pfc pffs: 1) induced α-syn deposition in multiple cortical and subcortical regions with sparse aggregation in midbrain and brainstem nuclei; 2) did not affect interval timing or working memory but did mildly alter behavioral flexibility as measured by reversal learning; 3) increased open field exploration; and 4) did not affect susceptibility to model of cortical-dominant pathology adds to our understanding of the etiology of varied symptoms in pdd and lbd. 2023-02-13 2023-08-14 mouse
Akitoshi Ogawa, Takahiro Osada, Masaki Tanaka, Akimitsu Suda, Koji Nakajima, Satoshi Oka, Koji Kamagata, Shigeki Aoki, Yasushi Oshima, Sakae Tanaka, Nobutaka Hattori, Seiki Konish. Hypothalamic interaction with reward-related regions during subjective evaluation of foods. NeuroImage. 2022-11-11. PMID:36368500. the reward system implemented in the midbrain, ventral striatum, orbitofrontal cortex, and ventromedial prefrontal cortex evaluates and compares various types of rewards given to the organisms. 2022-11-11 2023-08-14 human
Bernardo Lopez-Torres, Irma Ares, Marta Martínez, Jorge-Enrique Maximiliano, María-Rosa Martínez-Larrañaga, Arturo Anadón, María-Aránzazu Martíne. Neurotoxicity induced by the pyrethroid lambda-cyhalothrin: Alterations in monoaminergic systems and dopaminergic and serotoninergic pathways in the rat brain. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2022-09-20. PMID:36126889. the effects of type ii pyrethroid lambda-cyhalothrin on dopamine (da) and serotonin (5-ht) synthesis in rat brain regions (striatum, hippocampus, prefrontal cortex, hypothalamus and midbrain) were studied. 2022-09-20 2023-08-14 rat
Kelly Barko, Micah Shelton, Xiangning Xue, Yvette Afriyie-Agyemang, Stephanie Puig, Zachary Freyberg, George C Tseng, Ryan W Logan, Marianne L Sene. Brain region- and sex-specific transcriptional profiles of microglia. Frontiers in psychiatry. vol 13. 2022-09-12. PMID:36090351. we also found evidence for a gradient of expression of microglia-specific transcripts across the rostral-to-caudal axes of the brain, with microglia extracted from the striatum exhibiting a transcriptional profile intermediate between that of the pfc and midbrain. 2022-09-12 2023-08-14 mouse
D Y Reyes-Bravo, P Villalobos-Aguilera, J T Almonte-Zepeda, M S Mendoza-Trejo, M Giordano, A Orozco, V M Rodrígue. Chronic atrazine exposure increases the expression of genes associated with GABAergic and glutamatergic systems in the brain of male albino rat. Frontiers in toxicology. vol 4. 2022-09-08. PMID:36071823. at the end of the atr treatment, the levels of mrna of several genes involved in the production, vesiculation, reuptake, and receptors of gaba and glu in the striatum (str), nucleus accumbens (nacc), prefrontal cortex (pfc), ventral midbrain (vmid) and hippocampus (hipp) were evaluated by absolute qpcr. 2022-09-08 2023-08-14 rat
Minzhe Yang, Qiangpei Fu, Chaolin Ma, Baoming L. Prefrontal Dopaminergic Regulation of Cue-Guided Risky Decision-Making Performance in Rats. Frontiers in behavioral neuroscience. vol 16. 2022-07-28. PMID:35898651. the pfc receives projections from the dopamine (da) system from the ventral tegmental area of the midbrain. 2022-07-28 2023-08-14 rat
Mohammad Fauzan, Saida Oubraim, Mei Yu, Sherrye T Glaser, Martin Kaczocha, Samir Haj-Dahman. Fatty Acid-Binding Protein 5 Modulates Brain Endocannabinoid Tone and Retrograde Signaling in the Striatum. Frontiers in cellular neuroscience. vol 16. 2022-07-25. PMID:35875351. to address this, we first profiled ecb levels across several brain areas in fabp5 knockout mice and wild-type controls and report that fabp5 deletion elevates aea levels in the striatum, prefrontal cortex, midbrain, and thalamus, as well as midbrain 2-ag levels. 2022-07-25 2023-08-14 mouse
Jed Wingrove, Owen O'Daly, Alfonso De Lara Rubio, Simon Hill, Magda Swedroska, Ben Forbes, Stephanie Amiel, Fernando Zelay. The influence of insulin on anticipation and consummatory reward to food intake: A functional imaging study on healthy normal weight and overweight subjects employing intranasal insulin delivery. Human brain mapping. 2022-07-21. PMID:35860945. however, increased central insulin concentrations produce marked differences between groups when anticipating sweet stimuli within the prefrontal cortex and midbrain as well as observed differences in the amygdala during consummatory responses. 2022-07-21 2023-08-14 human
Spencer B Huggett, Ami S Ikeda, John E McGeary, Karla R Kaun, Rohan H C Palme. Opioid Use Disorder and Alternative mRNA Splicing in Reward Circuitry. Genes. vol 13. issue 6. 2022-06-24. PMID:35741807. using publicly available rna-sequencing data, our study investigated the possible role of alternative mrna splicing in human brain tissue (dorsal-lateral prefrontal cortex (dlpfc), nucleus accumbens (nac), and midbrain) of 90 individuals with oud or matched controls. 2022-06-24 2023-08-14 human
Khurshid Jalal, Faisal Khan, Shazia Nawaz, Rushda Afroz, Kanwal Khan, Sadia Basharat Ali, Liangliang Hao, Saeed Ahmad Khan, Mohsin Kazi, Reaz Uddin, Darakhshan Jabeen Halee. Anxiolytic, anti-nociceptive and body weight reducing effects of L-lysine in rats: Relationship with brain serotonin an In-Vivo and In-Silico study. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 152. 2022-06-13. PMID:35696944. 5-hydroxytryptamine (5-ht, serotonin) metabolism, and tryptophan (trp) levels in the midbrain (mb), hippocampus (hp), and prefrontal cortex (pfc) were also determined. 2022-06-13 2023-08-14 rat
Emilio Merlo Pich, Laura Cavalleri, Caterina Toma, Ginetta Coll. Involvement of DA D3 Receptors in Structural Neuroplasticity of Selected Limbic Brain Circuits: Possible Role in Treatment-Resistant Depression. Current topics in behavioral neurosciences. 2022-05-10. PMID:35538302. since in mood disorders, depression and anhedonia have been proposed to be associated with impaired neuroplasticity and reduced daergic tone in brain circuits connecting prefrontal cortex, ventral striatum, amygdala, and ventral mesencephalon, activation of d3 receptors could provide a therapeutic benefit. 2022-05-10 2023-08-13 human
Tetsuo Ono, Kodai Hino, Tomoko Kimura, Yasuhiro Uchimura, Takashi Ashihara, Takako Higa, Hideto Kojima, Takashi Murakami, Jun Udagaw. Excessive folic acid intake combined with undernutrition during gestation alters offspring behavior and brain monoamine profiles. Congenital anomalies. 2022-05-09. PMID:35531602. these behavioral changes were accompanied by reduced dopamine in the prefrontal cortex (pfc), norepinephrine in the amygdala, and 5-hydroxytryptamine (5-ht) in the dorsal midbrain (dm), pfc, and amygdala where 5-ht neurons project from the dm. 2022-05-09 2023-08-13 Not clear
Ana Chegão, Mariana Guarda, Bruno M Alexandre, Liana Shvachiy, Mariana Temido-Ferreira, Inês Marques-Morgado, Bárbara Fernandes Gomes, Rune Matthiesen, Luísa V Lopes, Pedro R Florindo, Ricardo A Gomes, Patrícia Gomes-Alves, Joana E Coelho, Tiago Fleming Outeiro, Hugo Vicente Mirand. Glycation modulates glutamatergic signaling and exacerbates Parkinson's disease-like phenotypes. NPJ Parkinson's disease. vol 8. issue 1. 2022-04-26. PMID:35468899. swath mass spectrometry analysis, used to quantify changes in the brain proteome, revealed that mgo mainly increase glutamatergic-associated proteins in the midbrain (nmda, ampa, glutaminase, vglut and eaat1), but not in the prefrontal cortex, where it mainly affects the electron transport chain. 2022-04-26 2023-08-13 mouse