| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Helen M Collins, L Sophie Gullino, Dersu Ozdemir, Caroline Lazarenco, Yulia Sudarikova, Elizabeth Daly, Fuencisla Pilar Cuéllar, Raquel Pinacho, David M Bannerman, Trevor Shar. Rebound activation of 5-HT neurons following SSRI discontinuation. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 2024-04-12. PMID:38609530. |
next, immunohistochemistry experiments found that paroxetine discontinuation increased c-fos expression in midbrain 5-ht (tph2 positive) neurons, adding further evidence for a hyperexcitable 5-ht system. |
2024-04-12 |
2024-04-15 |
mouse |
| L Sophie Gullino, Cara Fuller, Poppy Dunn, Helen M Collins, Salah El Mestikawy, Trevor Shar. Evidence for a Role of 5-HT-glutamate Co-releasing Neurons in Acute Stress Mechanisms. ACS chemical neuroscience. 2024-02-20. PMID:38377469. |
a major subpopulation of midbrain 5-hydroxytryptamine (5-ht) neurons expresses the vesicular glutamate transporter 3 (vglut3) and co-releases 5-ht and glutamate, but the function of this co-release is unclear. |
2024-02-20 |
2024-02-23 |
mouse |
| Zhifang Wang, Menglin Kou, Qiyue Deng, Haotian Yu, Jilin Mei, Jing Gao, Wen Fu, Baile Nin. Acupuncture Activates IRE1/XBP1 Endoplasmic Reticulum Stress Pathway in Parkinson's Disease Model Rats. Behavioural brain research. 2024-01-24. PMID:38266778. |
firstly, we assessed the behavioral changes in pd rats, the modulation of dopamine (da) and 5-hydroxytryptamine (5-ht) levels in the striatum, as well as the alteration in α-synuclein (α-syn) levels in the midbrain, aiming to evaluate the efficacy of acupuncture in pd treatment. |
2024-01-24 |
2024-01-27 |
rat |
| Zhifang Wang, Menglin Kou, Qiyue Deng, Haotian Yu, Jilin Mei, Jing Gao, Wen Fu, Baile Nin. Acupuncture Activates IRE1/XBP1 Endoplasmic Reticulum Stress Pathway in Parkinson's Disease Model Rats. Behavioural brain research. 2024-01-24. PMID:38266778. |
additionally, it increased the levels of da and 5-ht in the striatum while decreasing the levels of α-syn in the midbrain. |
2024-01-24 |
2024-01-27 |
rat |
| Zhifang Wang, Menglin Kou, Qiyue Deng, Haotian Yu, Jilin Mei, Jing Gao, Wen Fu, Baile Nin. Acupuncture Activates IRE1/XBP1 Endoplasmic Reticulum Stress Pathway in Parkinson's Disease Model Rats. Behavioural brain research. 2024-01-24. PMID:38266778. |
based on these results, we concluded that acupuncture may enhance the behavior of pd rats by activating the ire1/xbp1 er stress pathway, associated with the reduction of midbrain α-syn expression and the increase in striatal da and 5-ht levels in unilateral 6-ohda lesioned rats. |
2024-01-24 |
2024-01-27 |
rat |
| Christopher J O'Connell, Evan L Reeder, Jacob A Hymore, Ryan S Brown, Gabrielle A Notorgiacomo, Sean M Collins, Gary A Gudelsky, Matthew J Robso. Transcriptomic dynamics governing serotonergic dysregulation in the dorsal raphe nucleus following mild traumatic brain injury. Experimental neurology. 2024-01-21. PMID:38246304. |
5-ht neurons originate in the raphe nucleus (rn) of the midbrain and project throughout the brain to regulate diverse behavioral phenotypes. |
2024-01-21 |
2024-01-24 |
Not clear |
| Xiahai Zheng, Jing Lin, Zhenzhen Wang, Zhenming Zeng, Haoxiong Che. Research of the analgesic effects and central nervous system impact of electroacupuncture therapy in rats with knee osteoarthritis. Heliyon. vol 10. issue 1. 2024-01-16. PMID:38226224. |
dopamine (da), norepinephrine (ne), 5-hydroxytryptamine (5-ht), β-endorphin (β-ep), and leucine-enkephalin (l-enk) were detected in the midbrain and spinal cord of lumbar enlargement. |
2024-01-16 |
2024-01-18 |
rat |
| Xiahai Zheng, Jing Lin, Zhenzhen Wang, Zhenming Zeng, Haoxiong Che. Research of the analgesic effects and central nervous system impact of electroacupuncture therapy in rats with knee osteoarthritis. Heliyon. vol 10. issue 1. 2024-01-16. PMID:38226224. |
the incubation period of thermal pain and foot contraction was decreased in the koa group versus blank group, the lequesne mg score was increased, da, ne, 5-ht, β-ep, and l-enk in the midbrain and spinal cord were increased, and synovial tissue il-1β protein expression was increased ( |
2024-01-16 |
2024-01-18 |
rat |
| Mahnoush Mahdiar, Nahid Mohammadzade, Amirsina Homayooni, Fahimeh Haji Akhoundi, Fatemeh Kashaninasab, Babak Zamani, Seyed Vahid Shariat, Mohammadreza Shalbafan, Mohammad Rohan. Raphe Nuclei Echogenicity and Diameter of Third Ventricle in Schizophrenia Measured by Transcranial Sonography. Basic and clinical neuroscience. vol 14. issue 4. 2023-12-05. PMID:38050567. |
to address these issues, the present study assessed midbrain rn, as the main source of brain serotonin, and dtv, as an index of atrophy, by transcranial sonography (tcs) in a group of patients with schizophrenia. |
2023-12-05 |
2023-12-10 |
Not clear |
| Laura Smedegaard Heisel, Freja Drost Andersen, Sâmia Joca, Lambert Kristiansen Sørensen, Ulf Simonsen, Jørgen Bo Hasselstrøm, Charlotte Uggerhøj Andersen, Kirstine Lykke Nielse. Combined in vivo metabolic effects of quetiapine and methadone in brain and blood of rats. Archives of toxicology. 2023-10-23. PMID:37870577. |
accumulation of serotonin in the midbrain was additionally observed in the mtd group, but not in the qtp + mtd group. |
2023-10-23 |
2023-11-08 |
rat |
| Licia Vellucci, Mariateresa Ciccarelli, Elisabetta Filomena Buonaguro, Michele Fornaro, Giordano D'Urso, Giuseppe De Simone, Felice Iasevoli, Annarita Barone, Andrea de Bartolomei. The Neurobiological Underpinnings of Obsessive-Compulsive Symptoms in Psychosis, Translational Issues for Treatment-Resistant Schizophrenia. Biomolecules. vol 13. issue 8. 2023-08-26. PMID:37627285. |
an integrative view exploring this topic should take into account the following aspects: (i) the implication for glutamate, dopamine, and serotonin neurotransmission as demonstrated by genetic findings; (ii) the growing neuroimaging evidence of the common brain regions and dysfunctional circuits involved in both diseases; (iii) the pharmacological modulation of dopaminergic, serotoninergic, and glutamatergic systems as current therapeutic strategies in schizophrenia ocs; (iv) the recent discovery of midbrain dopamine neurons and dopamine d1- and d2-like receptors as orchestrating hubs in repetitive and psychotic behaviors; (v) the contribution of n-methyl-d-aspartate receptor subunits to both psychosis and ocd neurobiology. |
2023-08-26 |
2023-09-07 |
Not clear |
| Patrizia Ambrogini, Davide Lattanzi, Marica Pagliarini, Michael Di Palma, Stefano Sartini, Riccardo Cuppini, Kjell Fuxe, Dasiel Oscar Borroto-Escuel. 5HT1AR-FGFR1 Heteroreceptor Complexes Differently Modulate GIRK Currents in the Dorsal Hippocampus and the Dorsal Raphe Serotonin Nucleus of Control Rats and of a Genetic Rat Model of Depression. International journal of molecular sciences. vol 24. issue 8. 2023-04-28. PMID:37108630. |
the midbrain raphe serotonin (5ht) neurons provide the main ascending serotonergic projection to the forebrain, including hippocampus, which has a role in the pathophysiology of depressive disorder. |
2023-04-28 |
2023-08-14 |
rat |
| Ying S Chao, Jeffrey Parrilla-Carrero, Maya Eid, Oliver P Culver, Tyler B Jackson, Rachel Lipat, Makoto Taniguchi, Thomas C Jho. Innate cocaine-seeking vulnerability arising from loss of serotonin-mediated aversive effects of cocaine in rats. Cell reports. vol 42. issue 5. 2023-04-21. PMID:37083325. |
however, cocaine also blocks serotonin uptake, which we show drives, in rats, individually variable aversive effects that depend on serotonin 2c receptors (5-ht2crs) in the rostromedial tegmental nucleus (rmtg), a major gabaergic afferent to midbrain dopamine neurons. |
2023-04-21 |
2023-08-14 |
rat |
| D V Sherbakov, A B Arefieva, P D Komleva, A E Iz'urov, N V Khotskin, D V Bazovkina, A V Kuliko. [Alterations in the Level of mRNA of TPH1, TPH2 Genes, Tryptophan Hydroxylase Activity and Serotonin Metabolism in Mouse Brain Five Days after Lipopolysaccharide Administration]. Molekuliarnaia biologiia. vol 57. issue 2. 2023-03-31. PMID:37000657. |
in the frontal cortex, hippocampus, striatum, hypothalamus, and midbrain the concentrations of 5-ht and its main metabolite, 5-hydroxyindole acetic acid (5-hiaa), and tph activity were assayed using hplc, while tph1 and tph2 mrna were quantified using quantitative real-time rt-pcr. |
2023-03-31 |
2023-08-14 |
mouse |
| D V Sherbakov, A B Arefieva, P D Komleva, A E Iz'urov, N V Khotskin, D V Bazovkina, A V Kuliko. [Alterations in the Level of mRNA of TPH1, TPH2 Genes, Tryptophan Hydroxylase Activity and Serotonin Metabolism in Mouse Brain Five Days after Lipopolysaccharide Administration]. Molekuliarnaia biologiia. vol 57. issue 2. 2023-03-31. PMID:37000657. |
a significant increase of 5-ht and 5-hiaa levels in the midbrain as well as decrease of 5-hiaa concentration and tph activity in hypothalamus in mice treated with lps and saline compared with intact animals was revealed. |
2023-03-31 |
2023-08-14 |
mouse |
| D V Sherbakov, A B Arefieva, P D Komleva, A E Iz'urov, N V Khotskin, D V Bazovkina, A V Kuliko. [Alterations in the Level of mRNA of TPH1, TPH2 Genes, Tryptophan Hydroxylase Activity and Serotonin Metabolism in Mouse Brain Five Days after Lipopolysaccharide Administration]. Molekuliarnaia biologiia. vol 57. issue 2. 2023-03-31. PMID:37000657. |
the highest concentration of tph2 gene mrna was observed in the midbrain in 5-ht neuron bodies, while this gene mrna level was lower in 5-ht endings (cortex, hippocampus, striatum, and hypothalamus). |
2023-03-31 |
2023-08-14 |
mouse |
| Baile Ning, Zhifang Wang, Qian Wu, Qiyue Deng, Qing Yang, Jing Gao, Wen Fu, Ying Deng, Bingxin Wu, Xichang Huang, Jilin Mei, Wenbin F. Acupuncture inhibits autophagy and repairs synapses by activating the mTOR pathway in Parkinson's disease depression model rats. Brain research. 2023-03-13. PMID:36914042. |
firstly, observing the behavioral changes of the dpd rat model, the regulation of monoamine neurotransmitters dopamine (da) and 5-hydroxytryptamine (5-ht) in the midbrain, the change of α-synuclein (α-syn) in the striatum, the efficacy of acupuncture in the treatment of dpd was discussed. |
2023-03-13 |
2023-08-14 |
rat |
| Haejun Lee, Young Hee Sung, Kyung Hoon Hwan. Additional Role of Midbrain F-18 FP-CIT Uptake on PET in Evaluation of Essential Tremor and Parkinsonism. Current medical imaging. 2023-02-03. PMID:36734891. |
its uptake in other areas of the brain, such as serotonin transporters (sert) in the midbrain or thalamus, is also recognised. |
2023-02-03 |
2023-08-14 |
Not clear |
| Toshiyuki Fujita, Naoya Aoki, Chihiro Mori, Shouta Serizawa, Fumiko Kihara-Negishi, Koichi J Homma, Shinji Yamaguch. Dopaminergic nuclei in the chick midbrain express serotonin receptor subfamily genes. Frontiers in physiology. vol 13. 2022-11-25. PMID:36425295. |
recently, midbrain dopaminergic neurons were shown to be innervated by serotonergic neurons and modulated by 5-ht, with the crosstalk between serotonergic and dopaminergic systems attracting increased attention. |
2022-11-25 |
2023-08-14 |
chicken |
| Paul W Andrews, Catherine Bosyj, Luke Brenton, Laura Green, Paul J Gasser, Christopher A Lowry, Virginia M Picke. All the brain's a stage for serotonin: the forgotten story of serotonin diffusion across cell membranes. Proceedings. Biological sciences. vol 289. issue 1986. 2022-11-02. PMID:36321487. |
in the conventional model of serotonin neurotransmission, serotonin released by neurons in the midbrain raphe nuclei exerts its actions on forebrain neurons by interacting with a large family of post-synaptic receptors. |
2022-11-02 |
2023-08-14 |
Not clear |