| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ayoub Rezqaoui, Soufiane Boumlah, Aboubaker El Hessni, Mohamed Yassine El Brouzi, Abdelghafour El Hamzaoui, Laila Ibouzine-Dine, Samir Benkirane, Manal Adnani, Abdelhalem Mesfiou. Evaluating the Protective Effects of Melatonin Against Chronic Iron Administration in Male Wistar Rats: a Comparative Analysis of Affective, Cognitive, and Oxidative Stress with EDTA Chelator. Biological trace element research. 2023-12-25. PMID:38146034. |
the results indicate that chronic exposure to iron sulfate induced anxiety-like depressive behavior, and cognitive impairment also increased the levels of lipid peroxidation and nitric oxide, and reduced the activity of catalase in the hippocampus and prefrontal cortex in male wistar rats, suggesting the induction of oxidative stress. |
2023-12-25 |
2023-12-28 |
rat |
| Amanda J Sales, Sâmia R L Joca, Elaine Del Bel, Francisco S Guimarãe. The antidepressant-like effect of doxycycline is associated with decreased nitric oxide metabolite levels in the prefrontal cortex. Behavioural brain research. 2023-11-16. PMID:37972712. |
the antidepressant-like effect of doxycycline is associated with decreased nitric oxide metabolite levels in the prefrontal cortex. |
2023-11-16 |
2023-11-20 |
mouse |
| Shahrzad Molavinia, Mehrad Nikravesh, Marzieh Pashmforoosh, Hossein Rajabi Vardanjani, Mohammad Javad Khodaya. Zingerone Alleviates Morphine Tolerance and Dependence in Mice by Reducing Oxidative Stress-Mediated NLRP3 Inflammasome Activation. Neurochemical research. 2023-10-20. PMID:37864024. |
the levels of thiobarbituric acid reactive substances (tbars), nitric oxide (no), total thiol (tt), and glutathione peroxidase (gpx) were measured in the prefrontal cortex. |
2023-10-20 |
2023-11-08 |
mouse |
| Shiva Saljoughi, Hadi Kalantar, Reza Azadnasab, Mohammad Javad Khodaya. Neuroprotective effects of dimethyl fumarate against manic-like behavior induced by ketamine in rats. Naunyn-Schmiedeberg's archives of pharmacology. 2023-04-27. PMID:37103520. |
the levels of total sulfhydryl groups (total sh), thiobarbituric acid reactive substances (tbars), nitric oxide (no), and tumor necrosis factor-alpha (tnf-α), as well as the activity of antioxidant enzymes including catalase (cat), superoxide dismutase (sod), and glutathione peroxidase (gpx) in the prefrontal cortex (pfc) and hippocampus (hpc), were measured. |
2023-04-27 |
2023-08-14 |
rat |
| Ayoub Rezqaoui, Laila Ibouzine-Dine, Abdelghafour Elhamzaoui, Mohamed Yassine El Brouzi, Amal Dimaoui, Aboubaker El Hessni, Abdelhalem Mesfiou. Potential Role of Oxidative Stress in the Effects of Chronic Administration of Iron on Affective and Cognitive Behavior on Male Wistar Rat. Biological trace element research. 2023-01-22. PMID:36683122. |
we noted that chronic exposure to iron can be associated with the appearance of a state of oxidative stress in the hippocampus and the prefrontal cortex demonstrated by an increase in lipid peroxidation, an increase in nitric oxide, and also by disturbances in the antioxidant defense systems following a determination of the concentrations of catalase. |
2023-01-22 |
2023-08-14 |
rat |
| Mohammadmehdi Hassanzadeh-Taheri, Atiyeh Ahmadi-Zohan, Mahtab Mohammadifard, Mehran Hossein. Rosmarinic acid attenuates lipopolysaccharide-induced neuroinflammation and cognitive impairment in rats. Journal of chemical neuroanatomy. vol 117. 2021-11-26. PMID:34314849. |
ra significantly alleviated the hip and pfc levels of malondialdehyde (mda) and nitric oxide (nox) and enhanced the superoxide dismutase (sod) activity. |
2021-11-26 |
2023-08-13 |
rat |
| Sonia Irais González-Cano, Israel Camacho-Abrego, Alfonso Diaz, Fidel de la Cruz, Julio César Morales-Medina, Gonzalo Flore. Prenatal exposure to propionic acid induces altered locomotion and reactive astrogliosis in male rats. Journal of chemical neuroanatomy. vol 117. 2021-11-26. PMID:34384873. |
therefore, in the present study we aimed to evaluate the effects of prenatal ppa exposure on locomotor behavior and astrocyte number, as well as on levels of nitric oxide (no), synaptophysin (syp; a marker of synaptic plasticity), and metallothionein 3 (mt-iii; a marker of reactive oxygen species and zinc metabolism), in the prefrontal cortex (pfc) of male rats. |
2021-11-26 |
2023-08-13 |
rat |
| Paloma T Birmann, Angela M Casaril, Daniela Hartwig, Raquel G Jacob, Fabiana K Seixas, Tiago Collares, Lucielli Savegnag. A novel pyrazole-containing selenium compound modulates the oxidative and nitrergic pathways to reverse the depression-pain syndrome in mice. Brain research. vol 1741. 2021-09-01. PMID:32417177. |
reversed stz-induced alterations in the levels of reactive oxygen species, nitric oxide, and lipid peroxidation and the superoxide dismutase and catalase activities in the prefrontal cortices (pfc) and hippocampi (hc) of mice. |
2021-09-01 |
2023-08-13 |
mouse |
| Xiaoyou Wei, Yaoying Ma, Fu Li, Haiyan He, Huaxing Huang, Chao Huang, Zhuo Chen, Dongjian Chen, Jinliang Chen, Xiaomei Yua. Acute Diallyl Disulfide Administration Prevents and Reveres Lipopolysaccharide-Induced Depression-Like Behaviors in Mice via Regulating Neuroinflammation and Oxido-Nitrosative Stress. Inflammation. vol 44. issue 4. 2021-07-19. PMID:33511484. |
mechanistic studies revealed that dads pre-treatment or post-treatment at the dose of 40 and 80 mg/kg prevented and reversed (i) lps-induced increases in interleukin-1β (il-1β), tumor necrosis factor-α (tnf-α), and nitric oxide (no) levels in the hippocampus and prefrontal cortex, (ii) lps-induced increases in contents of malondialdehyde (mda), a parameter reflecting high levels of oxidative stress, and (iii) lps-induced decreases in contents of gsh, a marker reflecting weakened anti-oxidative ability, in the hippocampus and prefrontal cortex in mice. |
2021-07-19 |
2023-08-13 |
mouse |
| Lucineia Gainski Danielski, Amanda Della Giustina, Sandra Bonfante, Mariana Pereira de Souza Goldim, Larissa Joaquim, Kiuanne Lobo Metzker, Erica Bernardo Biehl, Thaynan Vieira, Fabiana Durante de Medeiros, Naiana da Rosa, Jaqueline Generoso, Lutiana Simoes, Hémelin Resende Farias, Isabela da Silva Lemos, Vijayasree Giridharan, Gislaine Tezza Rezin, Jucelia Jeremias Fortunato, Rafael Mariano Bitencourt, Emilio Luiz Streck, Felipe Dal-Pizzol, Tatiana Barichello, Fabricia Petronilh. NLRP3 Activation Contributes to Acute Brain Damage Leading to Memory Impairment in Sepsis-Surviving Rats. Molecular neurobiology. vol 57. issue 12. 2021-07-01. PMID:32870491. |
prefrontal cortex and hippocampus were isolated for cytokine analysis, microglial and astrocyte activation, oxidative stress measurements, nitric oxide formation, and mitochondrial respiratory chain activity at 24 h after clp. |
2021-07-01 |
2023-08-13 |
rat |
| I Berkiks, A Mesfioui, A Ouichou, R Nakache, D C Ajonijebu, A El Hessn. Affective Behavior Shows Sex Differences in Mid-adulthood Rats Following Postnatal Immune Stimulation. Neuroscience. vol 421. 2020-09-30. PMID:31672643. |
our data further demonstrated a significant increase in microglial complexity and increased levels of tumor necrosis factor (tnfα), nitric oxide (nox), and lipid peroxidation in the prefrontal cortex of female rats compared to their male counterparts and phosphate-buffered saline (pbs) littermate controls. |
2020-09-30 |
2023-08-13 |
rat |
| Md Mamun Al-Amin, Waich Mahmud, Mst Shahnaj Pervin, S M Ridwanul Islam, Muhammad Ashikur Rahman, Artyom Zinchenk. Astaxanthin ameliorates scopolamine-induced spatial memory deficit via reduced cortical-striato-hippocampal oxidative stress. Brain research. vol 1710. 2020-07-08. PMID:30552898. |
the mice were then euthanized and prefrontal cortex (pfc), striatum (st), hippocampus (hp), and liver tissues were assayed for antioxidant enzymes, glutathione (gsh), superoxide dismutase (sod), catalase (cat), and nitric oxide (no). |
2020-07-08 |
2023-08-13 |
mouse |
| Marina Zaric, Dunja Drakulic, Milorad Dragic, Ivana Gusevac Stojanovic, Natasa Mitrovic, Ivana Grkovic, Jelena Martinovi. Molecular Alterations and Effects of Acute Dehydroepiandrosterone Treatment Following Brief Bilateral Common Carotid Artery Occlusion: Relevance to Transient Ischemic Attack. Neuroscience. vol 410. 2020-01-31. PMID:31095985. |
i/r induced nitric oxide burst in hip and pfc was accompanied with increased neuronal nitric oxide synthase protein level exclusively in hip. |
2020-01-31 |
2023-08-13 |
rat |
| Guillermina Tellez-Merlo, Julio Cèsar Morales-Medina, Israel Camacho-Ábrego, Ismael Juárez-Díaz, Patricia Aguilar-Alonso, Fidel de la Cruz, Tommaso Iannitti, Gonzalo Flore. Prenatal immune challenge induces behavioral deficits, neuronal remodeling, and increases brain nitric oxide and zinc levels in the male rat offspring. Neuroscience. vol 406. 2020-01-02. PMID:30797024. |
we also evaluated the effects of lps on nitric oxide (no) and zinc (zn) levels in seven brain areas (pfc, vh, amygdala, brainstem, striatum and dorsal hippocampus) at pd35 and pd60. |
2020-01-02 |
2023-08-13 |
rat |
| Xi Jiang, Lei Chen, Lailai Shen, Ziwei Chen, Lexing Xu, Jiajia Zhang, Xuefeng Y. Trans-astaxanthin attenuates lipopolysaccharide-induced neuroinflammation and depressive-like behavior in mice. Brain research. vol 1649. issue Pt A. 2019-11-20. PMID:27559013. |
moreover, trans-astaxanthin at 80mg/kg was demonstrated to effectively antagonize inos, nnos and cox-2 expression, both at mrna and protein levels, nitric oxide (no) levels, via regulating nf-κb in the hippocampus and pfc. |
2019-11-20 |
2023-08-13 |
mouse |
| Ana Carolina Issy, Maurício Dos-Santos-Pereira, João Francisco Cordeiro Pedrazzi, Regina Celia Cussa Kubrusly, Elaine Del-Be. The role of striatum and prefrontal cortex in the prevention of amphetamine-induced schizophrenia-like effects mediated by nitric oxide compounds. Progress in neuro-psychopharmacology & biological psychiatry. vol 86. 2019-04-15. PMID:29555252. |
the role of striatum and prefrontal cortex in the prevention of amphetamine-induced schizophrenia-like effects mediated by nitric oxide compounds. |
2019-04-15 |
2023-08-13 |
Not clear |
| b' Daniela P Stocher, Caroline P Klein, Andr\\xc3\\xa9 B Saccomori, Pauline M August, Nicolli C Martins, Pablo R G Couto, Martine E K Hagen, Cristiane Matt\\xc3\\xa. Maternal high-salt diet alters redox state and mitochondrial function in newborn rat offspring\'s brain. The British journal of nutrition. vol 119. issue 9. 2019-04-03. PMID:29502538.' |
a significant increase in hypothalamic nitric oxide levels and mitochondrial superoxide in the hippocampus and prefrontal cortex was observed in the maternal high-salt group. |
2019-04-03 |
2023-08-13 |
rat |
| Rong Pu, Run-Hui Shao, Jun Lu, Shu-Ying Jin, Ya T. [Acupuncture Alleviated Depressive-like Behavior by Down-regulating NF-κB, iNOS and NO Levels in Prefrontal Cortex of Depression Rats]. Zhen ci yan jiu = Acupuncture research. vol 43. issue 4. 2019-04-03. PMID:29888575. |
to observe the effect of acupuncture intervention on depressive-like behavior and nuclear factor-κb (nf-κb), inducible nitric oxide synthase (inos) and nitric oxide (no) levels in the prefrontal cortex in chronic stress induced depression rats, so as to explore its mechanism underlying antidepressant effect. |
2019-04-03 |
2023-08-13 |
rat |
| Vitor Silva Pereira, Betina Elfving, Sâmia R L Joca, Gregers Wegene. Ketamine and aminoguanidine differentially affect Bdnf and Mtor gene expression in the prefrontal cortex of adult male rats. European journal of pharmacology. vol 815. 2018-07-05. PMID:28947331. |
the aim of this study was to investigate whether the behavioural effects induced by the inhibition of nitric oxide (no) synthesis by aminoguanidine or n-methyl-d-aspartate (nmda) receptor blockade by ketamine would affect the gene expression of bdnf and mtor in the ventromedial prefrontal cortex in rats. |
2018-07-05 |
2023-08-13 |
rat |
| Tingxu Yan, Lei Shang, Mengshi Wang, Chenning Zhang, Xu Zhao, Kaishun Bi, Ying Ji. Lignans from Schisandra chinensis ameliorate cognition deficits and attenuate brain oxidative damage induced by D-galactose in rats. Metabolic brain disease. vol 31. issue 3. 2018-01-12. PMID:26847610. |
further biochemical examination indicated that pe could attenuate the activities decreasing of superoxide dismutase (sod), catalase (cat), the total antioxidant (t-aoc) induced by d-gal, and maintain the normal levels of glutathione (gsh), malondialdehyde (mda) and nitric oxide (no) in the serum, prefrontal cortex, striatum and hippocampus of the brain of related rat, selectively. |
2018-01-12 |
2023-08-13 |
rat |