| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Nima Naderi, Bijan Shafaghi, Mohammad-Javad Khodayar, Mohammad-Reza Zarindas. Interaction between gamma-aminobutyric acid GABAB and cannabinoid CB1 receptors in spinal pain pathways in rat. European journal of pharmacology. vol 514. issue 2-3. 2005-07-21. PMID:15910802. |
cannabinoid cb1 receptors are co-localized with dorsal horn interneurons containing gamma-aminobutyric acid (gaba). |
2005-07-21 |
2023-08-12 |
rat |
| Lisa M Johanek, Donald A Simon. Cannabinoid agonist, CP 55,940, prevents capsaicin-induced sensitization of spinal cord dorsal horn neurons. Journal of neurophysiology. vol 93. issue 2. 2005-03-10. PMID:15385593. |
cannabinoid agonist, cp 55,940, prevents capsaicin-induced sensitization of spinal cord dorsal horn neurons. |
2005-03-10 |
2023-08-12 |
rat |
| Steven J R Elmes, Maulik D Jhaveri, Darren Smart, David A Kendall, Victoria Chapma. Cannabinoid CB2 receptor activation inhibits mechanically evoked responses of wide dynamic range dorsal horn neurons in naïve rats and in rat models of inflammatory and neuropathic pain. The European journal of neuroscience. vol 20. issue 9. 2005-03-04. PMID:15525273. |
cannabinoid cb2 receptor activation inhibits mechanically evoked responses of wide dynamic range dorsal horn neurons in naïve rats and in rat models of inflammatory and neuropathic pain. |
2005-03-04 |
2023-08-12 |
rat |
| A G Nackley, A M Zvonok, A Makriyannis, A G Hohman. Activation of cannabinoid CB2 receptors suppresses C-fiber responses and windup in spinal wide dynamic range neurons in the absence and presence of inflammation. Journal of neurophysiology. vol 92. issue 6. 2004-12-30. PMID:15317842. |
these data demonstrate that activation of cannabinoid cb2 receptors is sufficient to suppress neuronal activity at central levels of processing in the spinal dorsal horn. |
2004-12-30 |
2023-08-12 |
rat |
| Sara Kelly, Victoria Chapma. Cannabinoid CB1 receptor inhibition of mechanically evoked responses of spinal neurones in control rats, but not in rats with hindpaw inflammation. European journal of pharmacology. vol 474. issue 2-3. 2004-04-23. PMID:12921864. |
effects of spinal administration of a selective cannabinoid cb(1) receptor agonist, arachidonyl-2-chloroethylamide (acea), on mechanically evoked responses of dorsal horn neurones in control rats and rats with peripheral hindpaw carrageenan-induced inflammation were compared. |
2004-04-23 |
2023-08-12 |
rat |
| Aldric T Hama, Mark O Urba. Antihyperalgesic effect of the cannabinoid agonist WIN55,212-2 is mediated through an interaction with spinal metabotropic glutamate-5 receptors in rats. Neuroscience letters. vol 358. issue 1. 2004-04-21. PMID:15016425. |
in the current study, a possible interaction between spinal cord dorsal horn cannabinoid and mglu5 receptors was evaluated in rats with a peripheral nerve injury. |
2004-04-21 |
2023-08-12 |
rat |
| T Gutierrez, A G Nackley, M H Neely, K G Freeman, G L Edwards, A G Hohman. Effects of neurotoxic destruction of descending noradrenergic pathways on cannabinoid antinociception in models of acute and tonic nociception. Brain research. vol 987. issue 2. 2003-12-12. PMID:14499961. |
the cannabinoid agonist suppressed formalin-evoked fos protein expression, a marker of neuronal activity, in the lumbar dorsal horn of sham-operated rats, but no suppression was observed in lesioned rats. |
2003-12-12 |
2023-08-12 |
rat |
| T Gutierrez, A G Nackley, M H Neely, K G Freeman, G L Edwards, A G Hohman. Effects of neurotoxic destruction of descending noradrenergic pathways on cannabinoid antinociception in models of acute and tonic nociception. Brain research. vol 987. issue 2. 2003-12-12. PMID:14499961. |
these data indicate that the suppressive effect of the cannabinoid on formalin-evoked fos protein expression in the superficial dorsal horn was attenuated following destruction of descending noradrenergic pathways. |
2003-12-12 |
2023-08-12 |
rat |
| A G Nackley, A Makriyannis, A G Hohman. Selective activation of cannabinoid CB(2) receptors suppresses spinal fos protein expression and pain behavior in a rat model of inflammation. Neuroscience. vol 119. issue 3. 2003-09-12. PMID:12809695. |
these data provide evidence that actions at cannabinoid cb(2) receptors are sufficient to suppress inflammation-evoked neuronal activity at rostral levels of processing in the spinal dorsal horn, consistent with the ability of am1241 to normalize nociceptive thresholds and produce antinociception in inflammatory pain states. |
2003-09-12 |
2023-08-12 |
rat |
| A G Nackley, R L Suplita, A G Hohman. A peripheral cannabinoid mechanism suppresses spinal fos protein expression and pain behavior in a rat model of inflammation. Neuroscience. vol 117. issue 3. 2003-05-05. PMID:12617970. |
these data provide direct evidence that a peripheral cannabinoid mechanism suppresses the development of inflammation-evoked neuronal activity at the level of the spinal dorsal horn and implicate a role for cb(2) and cb(1) in peripheral cannabinoid modulation of inflammatory nociception. |
2003-05-05 |
2023-08-12 |
rat |
| Chiara Salio, Stéphane Doly, Jacqueline Fischer, Maria Fosca Franzoni, Marie Conrat. Neuronal and astrocytic localization of the cannabinoid receptor-1 in the dorsal horn of the rat spinal cord. Neuroscience letters. vol 329. issue 1. 2002-11-15. PMID:12161251. |
neuronal and astrocytic localization of the cannabinoid receptor-1 in the dorsal horn of the rat spinal cord. |
2002-11-15 |
2023-08-12 |
rat |
| Chiara Salio, Stéphane Doly, Jacqueline Fischer, Maria Fosca Franzoni, Marie Conrat. Neuronal and astrocytic localization of the cannabinoid receptor-1 in the dorsal horn of the rat spinal cord. Neuroscience letters. vol 329. issue 1. 2002-11-15. PMID:12161251. |
cannabinoids are involved in the control of pain at the spinal level through the cannabinoid receptor-1 (cb1) localized pre- and postsynaptically on primary afferent fibres and dorsal horn interneurones, respectively. |
2002-11-15 |
2023-08-12 |
rat |
| V Morisset, J Ahluwalia, I Nagy, L Urba. Possible mechanisms of cannabinoid-induced antinociception in the spinal cord. European journal of pharmacology. vol 429. issue 1-3. 2002-02-19. PMID:11698030. |
in agreement with these findings, neonatal capsaicin treatment that induces degeneration of capsaicin-sensitive, vanilloid vr1 receptor-expressing, thin, unmyelinated, nociceptive primary afferent fibres significantly reduced the cannabinoid cb(1) receptor immunostaining in the superficial spinal dorsal horn. |
2002-02-19 |
2023-08-12 |
Not clear |
| S Kelly, V Chapma. Selective cannabinoid CB1 receptor activation inhibits spinal nociceptive transmission in vivo. Journal of neurophysiology. vol 86. issue 6. 2002-01-28. PMID:11731561. |
here, effects of a potent cannabinoid cb1 receptor agonist arachidonyl-2-chloroethylamide (acea) on evoked responses of dorsal horn neurons in anesthetized rats were investigated. |
2002-01-28 |
2023-08-12 |
rat |
| C Salio, J Fischer, M F Franzoni, K Mackie, T Kaneko, M Conrat. CB1-cannabinoid and mu-opioid receptor co-localization on postsynaptic target in the rat dorsal horn. Neuroreport. vol 12. issue 17. 2002-01-11. PMID:11726775. |
in order to validate this hypothesis, a double labeling study of cb1 cannabinoid receptors and mu-opioid receptors in the dorsal horn of the rat spinal cord was performed. |
2002-01-11 |
2023-08-12 |
rat |
| E A Jennings, C W Vaughan, M J Christi. Cannabinoid actions on rat superficial medullary dorsal horn neurons in vitro. The Journal of physiology. vol 534. issue Pt 3. 2001-10-04. PMID:11483710. |
cannabinoid actions on rat superficial medullary dorsal horn neurons in vitro. |
2001-10-04 |
2023-08-12 |
rat |
| E A Jennings, C W Vaughan, M J Christi. Cannabinoid actions on rat superficial medullary dorsal horn neurons in vitro. The Journal of physiology. vol 534. issue Pt 3. 2001-10-04. PMID:11483710. |
these results suggest that, within the superficial medullary dorsal horn, cannabinoids presynaptically inhibit gabaergic and glycinergic neurotransmission. |
2001-10-04 |
2023-08-12 |
rat |
| E A Jennings, C W Vaughan, M J Christi. Cannabinoid actions on rat superficial medullary dorsal horn neurons in vitro. The Journal of physiology. vol 534. issue Pt 3. 2001-10-04. PMID:11483710. |
at the cellular level, the analgesic action of cannabinoids on these medullary dorsal horn neurons therefore differs from that of mu-opioids, which have both pre- and postsynaptic actions. |
2001-10-04 |
2023-08-12 |
rat |
| R Monhemius, J Azami, D L Green, M H Robert. CB1 receptor mediated analgesia from the Nucleus Reticularis Gigantocellularis pars alpha is activated in an animal model of neuropathic pain. Brain research. vol 908. issue 1. 2001-09-20. PMID:11457432. |
recent research has suggested a role for endogenous cannabinoids in the descending inhibition of dorsal horn cells via a supraspinal site of action. |
2001-09-20 |
2023-08-12 |
Not clear |
| L J Drew, J Harris, P J Millns, D A Kendall, V Chapma. Activation of spinal cannabinoid 1 receptors inhibits C-fibre driven hyperexcitable neuronal responses and increases [35S]GTPgammaS binding in the dorsal horn of the spinal cord of noninflamed and inflamed rats. The European journal of neuroscience. vol 12. issue 6. 2000-08-11. PMID:10886347. |
activation of spinal cannabinoid 1 receptors inhibits c-fibre driven hyperexcitable neuronal responses and increases [35s]gtpgammas binding in the dorsal horn of the spinal cord of noninflamed and inflamed rats. |
2000-08-11 |
2023-08-12 |
rat |