| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Lian-Zhi Cheng, Jia-Mei Zhou, Jun-Long Ma, Fan-Jing Wang, Kai Cheng, Qian Chen, Hui-Lun Yuan, Ai-Juan Jian. [Tetrahydropalmatine alleviated diabetic neuropathic pain by inhibiting activation of microglia via p38 MAPK signaling pathway]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 47. issue 9. 2022-05-09. PMID:35531701. |
the protein expression levels of ox42, inducible nitric oxide synthase(inos), cd206, p38, and p-p38 were determined by western blot, the fluorescence expression levels of ox42 and p-p38 in the dorsal horn of the rat spinal cord by immunofluorescence, the mrna content of p38 and ox42 in rat spinal cord tissue by qrt-pcr, and levels of nitric oxide(no), interleukin-1β(il-1β), interleukin-6(il-6), tumor necrosis factor-α(tnf-α), interleukin-10(il-10), and serum fasting insulin(fins) by enzyme-linked immunosorbent assay(elisa). |
2022-05-09 |
2023-08-13 |
rat |
| Sheu-Ran Choi, Dae-Hyun Roh, Seo-Yeon Yoon, Hoon-Seong Choi, Suk-Yun Kang, Ho-Jae Han, Alvin James Beitz, Jang-Hern Le. Astrocyte D-serine modulates the activation of neuronal NOS leading to the development of mechanical allodynia in peripheral neuropathy. Molecular pain. vol 15. 2019-08-12. PMID:30900515. |
intrathecal administration of the serine racemase inhibitor, l-serine o-sulfate potassium salt (lsos) or the d-serine degrading enzyme, d-amino acid oxidase (daao) on post-operative days 0-3 significantly reduced the cci-induced increase in nitric oxide (no) levels and nicotinamide adenine dinucleotide phosphate-diaphorase staining in lumbar dorsal horn neurons, as well as the cci-induced decrease in phosphorylation (ser847) of nnos (pnnos) on day 3 post-cci surgery. |
2019-08-12 |
2023-08-13 |
mouse |
| Dongmei Wang, Yaping Xue, Yanhua Yan, Minjie Lin, Jiajia Yang, Jianzhong Huang, Yanguo Hon. Reversal of neurochemical alterations in the spinal dorsal horn and dorsal root ganglia by Mas-related gene (Mrg) receptors in a rat model of spinal nerve injury. Neurobiology of disease. vol 91. 2018-02-20. PMID:27018398. |
bam8-22 (10nmol) inhibited snl-induced upregulation of neuronal nitric oxide synthesis (nnos) and phosphorylation of cyclic amp response element-binding protein (p-creb) in the spinal dorsal horn. |
2018-02-20 |
2023-08-13 |
rat |
| José María Flores Ramos, Laurent Devoize, Amélie Descheemaeker, Jean-Louis Molat, Philippe Luccarini, Radhouane Dalle. The nitric oxide donor, isosorbide dinitrate, induces a cephalic cutaneous hypersensitivity, associated with sensitization of the medullary dorsal horn. Neuroscience. vol 344. 2017-11-09. PMID:28057535. |
the nitric oxide donor, isosorbide dinitrate, induces a cephalic cutaneous hypersensitivity, associated with sensitization of the medullary dorsal horn. |
2017-11-09 |
2023-08-13 |
human |
| José María Flores Ramos, Laurent Devoize, Amélie Descheemaeker, Jean-Louis Molat, Philippe Luccarini, Radhouane Dalle. The nitric oxide donor, isosorbide dinitrate, induces a cephalic cutaneous hypersensitivity, associated with sensitization of the medullary dorsal horn. Neuroscience. vol 344. 2017-11-09. PMID:28057535. |
combining behavioral, immunohistochemical, and in vivo electrophysiological approaches, this study investigated the effect of systemic administration of the nitric oxide donor, isosorbide dinitrate (isdn), on cephalic and extracephalic cutaneous sensitivity and on neuronal activation within the medullary dorsal horn (mdh) in the rat. |
2017-11-09 |
2023-08-13 |
human |
| Tong-nan Li, Qing-jun Li, Wen-bin Li, Xiao-cai Sun, Shu-qin L. [Effect of CGRP receptor antagonist CGRP8-37 on nociceptive response, NOS expression and NO content in the dorsal horn of spinal cord during formalin-induced inflammatory pain in rats]. Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology. vol 20. issue 3. 2012-12-07. PMID:21192428. |
to study the effect of cgrp receptor antagonist cgrp8-37 on nociceptive response and expression of nitric oxide synthase (nos) and content of nitric oxide (no) in the dorsal horn of the spinal cord of rats during formalin-induced inflammatory pain. |
2012-12-07 |
2023-08-12 |
rat |
| Yara Cury, Gisele Picolo, Vanessa Pacciari Gutierrez, Sergio Henrique Ferreir. Pain and analgesia: The dual effect of nitric oxide in the nociceptive system. Nitric oxide : biology and chemistry. vol 25. issue 3. 2012-06-29. PMID:21723953. |
nitric oxide is an important neurotransmitter involved in the nociceptive process and, in the dorsal horn of the spinal cord, it contributes to the development of central sensitization. |
2012-06-29 |
2023-08-12 |
Not clear |
| Gui-He Zhang, Miao-Miao Lv, Shuang Wang, Lei Chen, Nian-Song Qian, Yu Tang, Xu-Dong Zhang, Peng-Cheng Ren, Chang-Jun Gao, Xu-De Sun, Li-Xian X. Spinal astrocytic activation is involved in a virally-induced rat model of neuropathic pain. PloS one. vol 6. issue 9. 2012-04-13. PMID:21969850. |
results showed that nitric oxide (no) produced by inducible nitric oxide synthase mediated the development of spinal astrocytic activation, and activated astrocytes dramatically increased interleukin-1β expression which induced n-methyl-d-aspartic acid receptor (nmdar) phosphorylation in spinal dorsal horn neurons to strengthen pain transmission. |
2012-04-13 |
2023-08-12 |
rat |
| Xiao-Gao Jin, Shao-Rui Chen, Xue-Hong Cao, Li Li, Hui-Lin Pa. Nitric oxide inhibits nociceptive transmission by differentially regulating glutamate and glycine release to spinal dorsal horn neurons. The Journal of biological chemistry. vol 286. issue 38. 2011-11-23. PMID:21813646. |
nitric oxide inhibits nociceptive transmission by differentially regulating glutamate and glycine release to spinal dorsal horn neurons. |
2011-11-23 |
2023-08-12 |
rat |
| Hwi-Seok Jung, Hong-Bin Jeon, Ik-Sung Jeon, Bum-Jun Lee, Hyun-Woo Yoo, Dong-Kuk Ahn, Dong-Ho You. Preventing Extracellular Diffusion of Trigeminal Nitric Oxide Enhances Formalin-induced Orofacial Pain. The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology. vol 13. issue 5. 2011-07-14. PMID:19915701. |
nitric oxide (no), a diffusible gas, is produced in the central nervous system, including the spinal cord dorsal horn and the trigeminal nucleus, the first central areas processing nociceptive information from periphery. |
2011-07-14 |
2023-08-12 |
rat |
| Ke Wang, Xiao-Hui Xiang, Fei He, Li-Bo Lin, Rong Zhang, Xing-Jie Ping, Ji-Sheng Han, Ning Guo, Qing-Hua Zhang, Cai-Lian Cui, Guo-Ping Zha. Transcriptome profiling analysis reveals region-distinctive changes of gene expression in the CNS in response to different moderate restraint stress. Journal of neurochemistry. vol 113. issue 6. 2010-08-06. PMID:20218974. |
transcriptome profiling analysis showed that at acute stage stress-related genes were up-regulated in arcuate nucleus; fight-or-flight behavior-related genes were up-regulated in periaqueductal gray, while nitric oxide and gaba signal transmission-related genes were up-regulated in spinal dorsal horn. |
2010-08-06 |
2023-08-12 |
rat |
| A Sasaki, T Mabuchi, K Serizawa, I Takasaki, T Andoh, K Shiraki, S Ito, Y Kuraish. Different roles of nitric oxide synthase-1 and -2 between herpetic and postherpetic allodynia in mice. Neuroscience. vol 150. issue 2. 2008-04-03. PMID:17997045. |
the results suggest that herpetic and postherpetic allodynia is mediated by nitric oxide in the dorsal horn and that nos2 and nos1 are responsible for herpetic and postherpetic allodynia, respectively. |
2008-04-03 |
2023-08-12 |
mouse |
| Hiroshi Ikeda, Kei Kusudo, Kazuyuki Muras. Nitric oxide-dependent long-term potentiation revealed by real-time imaging of nitric oxide production and neuronal excitation in the dorsal horn of rat spinal cord slices. The European journal of neuroscience. vol 23. issue 7. 2006-05-30. PMID:16623850. |
nitric oxide-dependent long-term potentiation revealed by real-time imaging of nitric oxide production and neuronal excitation in the dorsal horn of rat spinal cord slices. |
2006-05-30 |
2023-08-12 |
rat |
| R Necke. Embryonic development of choline acetyltransferase and nitric oxide synthase in the spinal cord of pigeons and chickens with special reference to the superficial dorsal horn. Anatomy and embryology. vol 210. issue 2. 2005-11-22. PMID:16044318. |
in the pigeon, choline acetyltransferase-positive superficial dorsal horn neurons appear only on the day of hatching (e18), whereas nitric oxide synthase-positive neurons can be first detected at stage e14. |
2005-11-22 |
2023-08-12 |
rat |
| Stephen B McMahon, William B J Cafferty, Fabien Marchan. Immune and glial cell factors as pain mediators and modulators. Experimental neurology. vol 192. issue 2. 2005-05-16. PMID:15755561. |
a small number of molecules were also identified as central pain mediators, most notably glutamate and substance p released from central nociceptive nerve terminals, and, starting at that time, appreciation that nitric oxide might be produced by dorsal horn neurons and act as a diffusible transmitter to increase excitability of central pain circuits. |
2005-05-16 |
2023-08-12 |
Not clear |
| Luigia Cristino, Fulvio Florenzano, Marina Bentivoglio, Vittorio Guglielmott. Nitric oxide synthase expression and cell changes in dorsal root ganglia and spinal dorsal horn of developing and adult Rana esculenta indicate a role of nitric oxide in limb metamorphosis. The Journal of comparative neurology. vol 472. issue 4. 2004-05-25. PMID:15065117. |
nitric oxide synthase expression and cell changes in dorsal root ganglia and spinal dorsal horn of developing and adult rana esculenta indicate a role of nitric oxide in limb metamorphosis. |
2004-05-25 |
2023-08-12 |
Not clear |
| Luigia Cristino, Fulvio Florenzano, Marina Bentivoglio, Vittorio Guglielmott. Nitric oxide synthase expression and cell changes in dorsal root ganglia and spinal dorsal horn of developing and adult Rana esculenta indicate a role of nitric oxide in limb metamorphosis. The Journal of comparative neurology. vol 472. issue 4. 2004-05-25. PMID:15065117. |
in view of such plastic changes and implications of nitric oxide (no) in neural developmental shaping, we examined via histochemistry and immunohistochemistry its synthetic enzyme nitric oxide synthase (nos) in dorsal root ganglia (drgs) and dorsal horn of the developing and adult frog rana esculenta. |
2004-05-25 |
2023-08-12 |
Not clear |
| Kristina S Vikman, Russell H Hill, Eva Backström, Brita Robertson, Krister Kristensso. Interferon-gamma induces characteristics of central sensitization in spinal dorsal horn neurons in vitro. Pain. vol 106. issue 3. 2004-02-18. PMID:14659507. |
treatment of cultured dorsal horn neurons with ifn-gamma for 2 weeks resulted in a significantly reduced clustering of alpha-amino-3-hydroxy-5-methylisoxazole (ampa) receptor subunit 1 (glur1) that was dependent on nitric oxide. |
2004-02-18 |
2023-08-12 |
Not clear |
| D Schulte, J Milla. The effects of high- and low-intensity percutaneous stimulation on nitric oxide levels and spike activity in the superficial laminae of the spinal cord. Pain. vol 103. issue 1-2. 2003-07-21. PMID:12749968. |
nitric oxide (no) was measured using a new electrochemical method with a carbon fibre microelectrode at depths of up to 400 microm in the lumbar dorsal horn of the anaesthetised rat. |
2003-07-21 |
2023-08-12 |
rat |
| D Schulte, J Milla. The effects of high- and low-intensity percutaneous stimulation on nitric oxide levels and spike activity in the superficial laminae of the spinal cord. Pain. vol 103. issue 1-2. 2003-07-21. PMID:12749968. |
these results show that tetanic activity in afferent fibres increases no synthesis in the dorsal horn and that inhibition of nitric oxide synthesis may be associated with a selective attenuation of the spike responses to c-fibre inputs. |
2003-07-21 |
2023-08-12 |
rat |