| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Harue Yanagimura, Mika Sasaki, Hiroshi Baba, Yoshinori Kamiy. Influence of the descending pain-inhibiting serotonergic pathway on the antihyperalgesic effect of gabapentin in neuropathic pain model rats. Neuroscience research. 2023-11-09. PMID:37944901. |
immunohistochemical analysis of serotonin in the spinal dorsal horn revealed a slight, albeit statistically insignificant, increase in 5-ht levels in snl rats compared to naive rats. |
2023-11-09 |
2023-11-20 |
rat |
| Nathan Cramer, Yadong Ji, Maureen A Kane, Nageswara R Pilli, Alberto Castro, Luca Posa, Gabrielle Van Patten, Radi Masri, Asaf Kelle. Elevated serotonin in mouse spinal dorsal horn is pronociceptive. eNeuro. 2023-11-09. PMID:37945351. |
elevated serotonin in mouse spinal dorsal horn is pronociceptive. |
2023-11-09 |
2023-11-20 |
mouse |
| Danielle Diniz Aguiar, Júlia Alvarenga Petrocchi, Grazielle Caroline da Silva, Virgínia Soares Lemos, Marina Gomes Miranda E Castor, Andrea de Castro Perez, Igor Dimitri Gama Duarte, Thiago Roberto Lima Romer. Participation of the cannabinoid system and the NO/cGMP/K Neuroscience letters. 2023-10-28. PMID:37898181. |
participation of the cannabinoid system and the no/cgmp/k it has already been shown that serotonin can release endocannabinoids at the spinal cord level, culminating in inhibition of the dorsal horn. |
2023-10-28 |
2023-11-08 |
Not clear |
| Nathan Cramer, Yadong Ji, Maureen Kane, Nageswara Pilli, Luca Posa, Gabrielle Van Patten, Radi Masri, Asaf Kelle. Elevated serotonin in mouse spinal dorsal horn is pronociceptive. bioRxiv : the preprint server for biology. 2023-08-30. PMID:37645759. |
elevated serotonin in mouse spinal dorsal horn is pronociceptive. |
2023-08-30 |
2023-09-07 |
mouse |
| Yuhki Ueda, Daisuke Uta, Hidemasa Furue, Yoshitaka Ohtub. An electrophysiological method for evaluation of topical antipruritic drugs on itch-related neuronal activities in the spinal cord in hairless mice. European journal of pharmacology. 2023-05-19. PMID:37207968. |
to establish an assessment of topical antipruritic drugs applied to skin using in vivo extracellular recording from neurons in the superficial dorsal horn, we examined the relationships between itch-related biting behavior and spinal neuronal responses elicited by intradermal injection of pruritogen serotonin (5-ht) in hairless mice. |
2023-05-19 |
2023-08-14 |
mouse |
| Carolina Medin. Shockwave Therapy in Veterinary Rehabilitation. The Veterinary clinics of North America. Small animal practice. 2023-03-24. PMID:36964030. |
eswt has been shown to increase the expression of cytokines and growth factors leading to decreased inflammation, neovascularization, and cellular proliferation; activation of osteogenesis by osteoblast differentiation and then by increased proliferation; inhibition of cartilage degeneration and rebuilding of subchondral bone; and increased serotonin in the dorsal horn and descending inhibition of pain signals. |
2023-03-24 |
2023-08-14 |
Not clear |
| Cheng-Jie Li, Li-Ge Zhang, Lu-Bing Liu, Meng-Qi An, Li-Guo Dong, Han-Ying Gu, Yong-Ping Dai, Fen Wang, Cheng-Jie Mao, Chun-Feng Li. Inhibition of Spinal 5-HT3 Receptor and Spinal Dorsal Horn Neuronal Excitability Alleviates Hyperalgesia in a Rat Model of Parkinson's Disease. Molecular neurobiology. 2022-09-28. PMID:36168076. |
our previous study demonstrated that 6-ohda induced pd model manifested hyperalgesia to thermal and mechanical stimuli and decreased serotonin (5-hydroxytryptamine; 5-ht) in the spinal dorsal horn (sdh). |
2022-09-28 |
2023-08-14 |
rat |
| Kanza M Khan, Gabrielle Bierlein-De La Rosa, Natalie Biggerstaff, Govindhasamy Pushpavathi Selvakumar, Ruixiang Wang, Suzanne Mason, Michael E Dailey, Catherine A Marcinkiewc. Adolescent ethanol drinking promotes hyperalgesia, neuroinflammation and serotonergic deficits in mice that persist into adulthood. Brain, behavior, and immunity. 2022-07-30. PMID:35907582. |
5-ht expression was also reduced in the thalamus, anterior cingulate cortex (acc) and amygdala as well as the lumbar dorsal horn of the spinal cord. |
2022-07-30 |
2023-08-14 |
mouse |
| Franck Aby, Louis-Etienne Lorenzo, Zoé Grivet, Rabia Bouali-Benazzouz, Hugo Martin, Stéphane Valerio, Sara Whitestone, Dominique Isabel, Walid Idi, Otmane Bouchatta, Philippe De Deurwaerdere, Antoine G Godin, Cyril Herry, Xavier Fioramonti, Marc Landry, Yves De Koninck, Pascal Fossa. Switch of serotonergic descending inhibition into facilitation by a spinal chloride imbalance in neuropathic pain. Science advances. vol 8. issue 30. 2022-07-27. PMID:35895817. |
we used an optogenetic approach to manipulate serotonin (5-ht) neurons of the nucleus raphe magnus that project to the dorsal horn of the spinal cord. |
2022-07-27 |
2023-08-14 |
mouse |
| Shanshan Li, Suhong Zhao, Yi Guo, Yuanzhen Yang, Jin Huang, Jiaqi Wang, Shanshan Lu, Bin Wang, Chao Chai, Zhifang Xu, Yenlie Chi. Clinical Efficacy and Potential Mechanisms of Acupoint Stimulation Combined With Chemotherapy in Combating Cancer: A Review and Prospects. Frontiers in oncology. vol 12. 2022-05-13. PMID:35547876. |
it was found that acupoint stimulation attenuated cipn and gi by modulating the 5-hydroxytryptamine system in dorsal root ganglia, the dorsal horn of the spinal cord, and the duodenum by reducing oxidative stress and neuroinflammation. |
2022-05-13 |
2023-08-13 |
Not clear |
| Anne R de Kort, Elbert A Joosten, Eline M Versantvoort, Jacob Patijn, Dick Tibboel, Nynke J van den Hooge. Anatomical changes in descending serotonergic projections from the rostral ventromedial medulla to the spinal dorsal horn following repetitive neonatal painful procedures. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience. 2022-04-08. PMID:35393725. |
when animals reached adulthood, tissue was collected for quantitative immunohistochemical analysis of serotonin (5-hydroxytryptamine, 5-ht) in the rvm and spinal dorsal horn. |
2022-04-08 |
2023-08-13 |
rat |
| Anne R de Kort, Elbert A Joosten, Eline M Versantvoort, Jacob Patijn, Dick Tibboel, Nynke J van den Hooge. Anatomical changes in descending serotonergic projections from the rostral ventromedial medulla to the spinal dorsal horn following repetitive neonatal painful procedures. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience. 2022-04-08. PMID:35393725. |
both repetitive noxious and tactile procedures in the neonate decreased the 5-ht staining intensity in the adult ipsilateral, but not contralateral spinal dorsal horn. |
2022-04-08 |
2023-08-13 |
rat |
| Liting Sun, Changgeng Peng, Elbert Joosten, Chi Wai Cheung, Fei Tan, Wencheng Jiang, Xiafeng She. Spinal Cord Stimulation and Treatment of Peripheral or Central Neuropathic Pain: Mechanisms and Clinical Application. Neural plasticity. vol 2021. 2021-11-24. PMID:34721569. |
evidence from recent research publications indicates that nociceptive processing at peripheral and central sensory systems is thought to be modulated by scs through (i) inhibition of the ascending nociceptive transmission by the release of analgesic neurotransmitters such as gaba and endocannabinoids at the spinal dorsal horn; (ii) facilitation of the descending inhibition by release of noradrenalin, dopamine, and serotonin acting on their receptors in the spinal cord; and (iii) activation of a variety of supraspinal brain areas related to pain perception and emotion. |
2021-11-24 |
2023-08-13 |
Not clear |
| Ana Carolina P Campos, Miriã B Berzuíno, Gabriela R Barbosa, Helena M R C Freire, Patricia S Lopes, Danielle V Assis, Erich T Fonoff, Rosana L Pagan. Motor Cortex Stimulation Reversed Hypernociception, Increased Serotonin in Raphe Neurons, and Caused Inhibition of Spinal Astrocytes in a Parkinson's Disease Rat Model. Cells. vol 10. issue 5. 2021-11-15. PMID:34064617. |
the immunoreactivity of dopamine in the substantia nigra and serotonin in the nucleus raphe magnus (nrm) and the neuronal, astrocytic, and microglial activation in the dorsal horn of the spinal cord were evaluated. |
2021-11-15 |
2023-08-13 |
rat |
| Tadanao Hiroki, Takashi Suto, Jo Ohta, Shigeru Saito, Hideaki Obat. Spinal γ-Aminobutyric Acid Interneuron Plasticity Is Involved in the Reduced Analgesic Effects of Morphine on Neuropathic Pain. The journal of pain. 2021-11-15. PMID:34678470. |
systemic administration of morphine increases serotonin (5-ht) in the spinal dorsal horn (sdh), which attenuates the analgesic effects of morphine on neuropathic pain through spinal 5-ht3 receptors. |
2021-11-15 |
2023-08-13 |
rat |
| Huy Tran, Varun Sagi, Sarita Jarrett, Elise F Palzer, Rajendra D Badgaiyan, Kalpna Gupt. Diet and companionship modulate pain via a serotonergic mechanism. Scientific reports. vol 11. issue 1. 2021-09-14. PMID:33526805. |
additionally, 5-ht production improved at the rostral ventromedial medulla and 5-ht accumulated at the dorsal horn of the spinal cord of sickle mice, suggesting the involvement of the descending pain pathway in the analgesic response. |
2021-09-14 |
2023-08-13 |
mouse |
| Theeradej Thaweerattanasinp, Derin Birch, Mingchen C Jiang, Matthew C Tresch, David J Bennett, Charles J Heckman, Vicki M Tysselin. Bursting interneurons in the deep dorsal horn develop increased excitability and sensitivity to serotonin after chronic spinal injury. Journal of neurophysiology. vol 123. issue 5. 2021-06-25. PMID:32208883. |
bursting interneurons in the deep dorsal horn develop increased excitability and sensitivity to serotonin after chronic spinal injury. |
2021-06-25 |
2023-08-13 |
Not clear |
| José Tiago Costa-Pereira, Paula Serrão, Isabel Martins, Isaura Tavare. Serotoninergic pain modulation from the rostral ventromedial medulla (RVM) in chemotherapy-induced neuropathy: The role of spinal 5-HT3 receptors. The European journal of neuroscience. vol 51. issue 8. 2021-06-21. PMID:31691396. |
the 5-ht content at the spinal dorsal horn assessed by hplc was higher in paclitaxel-injected animals. |
2021-06-21 |
2023-08-13 |
rat |
| José Tiago Costa-Pereira, Paula Serrão, Isabel Martins, Isaura Tavare. Serotoninergic pain modulation from the rostral ventromedial medulla (RVM) in chemotherapy-induced neuropathy: The role of spinal 5-HT3 receptors. The European journal of neuroscience. vol 51. issue 8. 2021-06-21. PMID:31691396. |
the immunohistochemical analysis of 5-ht also showed increased expression at the superficial dorsal horn (laminae i-ii) of paclitaxel-injected animals. |
2021-06-21 |
2023-08-13 |
rat |
| Man Li, Mingxin Zhu, Qiaoqiao Xu, Fengfei Ding, Yuke Tian, Min Zhan. Sensation of TRPV1 via 5-hydroxytryptamine signaling modulates pain hypersensitivity in a 6-hydroxydopamine induced mice model of Parkinson's disease. Biochemical and biophysical research communications. vol 521. issue 4. 2020-08-03. PMID:31708101. |
in 6-ohda-lesioned mice model of pd, trpv1 sensitization might be implicated in the maintenance of behavioral hypersensitivity by enhanced descending 5-ht pain facilitation and dorsal horn 5-ht3ar mechanism. |
2020-08-03 |
2023-08-13 |
mouse |