| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Huihui Tan, Chengxue Du, Li Zhang, Yuan Guo, Yaxin Yang, Qingfeng Sun, Qiaojun Zhang, Libo L. Lesions of the lateral habenula excite dopamine neurons in the ventral tegmental area and serotonin neurons in the dorsal raphe nuclei in hemiparkinsonian rats. Brain research. 2024-04-08. PMID:38588847. |
lesions of the lateral habenula excite dopamine neurons in the ventral tegmental area and serotonin neurons in the dorsal raphe nuclei in hemiparkinsonian rats. |
2024-04-08 |
2024-04-11 |
rat |
| Huihui Tan, Chengxue Du, Li Zhang, Yuan Guo, Yaxin Yang, Qingfeng Sun, Qiaojun Zhang, Libo L. Lesions of the lateral habenula excite dopamine neurons in the ventral tegmental area and serotonin neurons in the dorsal raphe nuclei in hemiparkinsonian rats. Brain research. 2024-04-08. PMID:38588847. |
the lateral habenula (lhb) projects to the ventral tegmental area (vta) and dorsal raphe nuclei (drn) that deliver dopamine (da) and serotonin (5-ht) to cortical and limbic regions such as the medial prefrontal cortex (mpfc), hippocampus and basolateral amygdala (bla). |
2024-04-08 |
2024-04-11 |
rat |
| Huihui Tan, Chengxue Du, Li Zhang, Yuan Guo, Yaxin Yang, Qingfeng Sun, Qiaojun Zhang, Libo L. Lesions of the lateral habenula excite dopamine neurons in the ventral tegmental area and serotonin neurons in the dorsal raphe nuclei in hemiparkinsonian rats. Brain research. 2024-04-08. PMID:38588847. |
here, we used electrophysiological and neurochemical approaches to explore the effects of lhb lesions on the firing activity of vta and drn neurons, as well as the levels of da and 5-ht in related brain regions in unilateral 6-ydroxydopamie (6-ohda)-induced pd rats. |
2024-04-08 |
2024-04-11 |
rat |
| Huihui Tan, Chengxue Du, Li Zhang, Yuan Guo, Yaxin Yang, Qingfeng Sun, Qiaojun Zhang, Libo L. Lesions of the lateral habenula excite dopamine neurons in the ventral tegmental area and serotonin neurons in the dorsal raphe nuclei in hemiparkinsonian rats. Brain research. 2024-04-08. PMID:38588847. |
we found that compared to sham lesions, lesions of the lhb increased the firing rate of da neurons in the vta and 5-ht neurons in the drn, but decreased the firing rate of gabaergic neurons in the same nucleus. |
2024-04-08 |
2024-04-11 |
rat |
| Cruz Reyes-Vasquez, Zachary Jones, Bin Tang, Nachum Dafn. Dopamine, Norepinephrine and Serotonin Participate Differently in Methylphenidate Action in Concomitant Behavioral and Ventral Tegmental Area, Locus Coeruleus and Dorsal Raphe Neuronal Study in Young Rats. International journal of molecular sciences. vol 24. issue 23. 2023-12-09. PMID:38068951. |
dopamine, norepinephrine and serotonin participate differently in methylphenidate action in concomitant behavioral and ventral tegmental area, locus coeruleus and dorsal raphe neuronal study in young rats. |
2023-12-09 |
2023-12-17 |
rat |
| Cruz Reyes-Vasquez, Zachary Jones, Bin Tang, Nachum Dafn. Dopamine, Norepinephrine and Serotonin Participate Differently in Methylphenidate Action in Concomitant Behavioral and Ventral Tegmental Area, Locus Coeruleus and Dorsal Raphe Neuronal Study in Young Rats. International journal of molecular sciences. vol 24. issue 23. 2023-12-09. PMID:38068951. |
concomitant behavioral and neuronal recording from the ventral tegmental area (vta), locus coeruleus (lc), and from the dorsal raphe (dr) nucleus, which are the sources of da, ne, and 5-ht to the mesocorticolimbic circuit, were investigated following acute and repetitive (chronic) saline, 0.6, 2.5, or 10.0 mg/kg mpd. |
2023-12-09 |
2023-12-17 |
rat |
| Cruz Reyes-Vasquez, Zachary Jones, Bin Tang, Nachum Dafn. Dopamine, Norepinephrine and Serotonin Participate Differently in Methylphenidate Action in Concomitant Behavioral and Ventral Tegmental Area, Locus Coeruleus and Dorsal Raphe Neuronal Study in Young Rats. International journal of molecular sciences. vol 24. issue 23. 2023-12-09. PMID:38068951. |
thus, each brain area responds differently to each mpd dose used, suggesting that da, ne, and 5-ht in the vta, lc, and dr exert different effects. |
2023-12-09 |
2023-12-17 |
rat |
| Can Tao, Guang-Wei Zhang, Junxiang J Huang, Zhong Li, Huizhong W Tao, Li I Zhan. The medial preoptic area mediates depressive-like behaviors induced by ovarian hormone withdrawal through distinct GABAergic projections. Nature neuroscience. 2023-07-31. PMID:37524978. |
these projections enhance activity of dopaminergic neurons in the vta and serotonergic neurons in the dorsal raphe, respectively, with increased release of dopamine and serotonin, possibly through disinhibition mechanisms. |
2023-07-31 |
2023-08-14 |
mouse |
| Anthony Yuan, Catherine Claussen, Zachary Jones, Bin Tang, Nachum Dafn. Methylphenidate induces a different response in the dorsal raphe as compared to ventral tegmental area and locus coeruleus: behavioral and concomitant neuronal recordings in adult rats. Journal of neural transmission (Vienna, Austria : 1996). 2023-06-30. PMID:37391573. |
this study recorded from adult freely behaving rats a total of 1170 neurons, 403 from the ventral tegmental area (vta), 409 from locus coeruleus (lc), and 356 from dorsal raphe (dr) nucleus, which are the main sources of da, ne, and 5-ht to the mesocorticolimbic circuitry, respectively. |
2023-06-30 |
2023-08-14 |
rat |
| Daniil Grinchii, Lubica Lacinova, Eliyahu Dremenco. Effects of the acute administration of delta-opioid receptor ligands on the excitability of rat hippocampal glutamate and brainstem monoamine neurons in vivo. General physiology and biophysics. vol 42. issue 3. 2023-04-26. PMID:37098742. |
the present study aimed to investigate the acute effects of these ligands on the firing activity of hippocampal cornu ammonis 1/3 (ca1/3) glutamate, dorsal raphe nucleus (drn) serotonin (5-ht), locus coeruleus (lc) noradrenaline, and ventral tegmental area (vta) dopamine neurons in in vivo conditions. |
2023-04-26 |
2023-08-14 |
rat |
| Daniil Grinchii, Lubica Lacinova, Eliyahu Dremenco. Effects of the acute administration of delta-opioid receptor ligands on the excitability of rat hippocampal glutamate and brainstem monoamine neurons in vivo. General physiology and biophysics. vol 42. issue 3. 2023-04-26. PMID:37098742. |
snc80, administered first at 1-3 mg/kg, dose-dependently inhibited ca1/3 glutamate, drn 5-ht, and vta dopamine neurons. |
2023-04-26 |
2023-08-14 |
rat |
| Marianna Mazza, Georgios Demetrios Kotzalidis, Giuseppe Marano, Domenico De Berardis, Giovanni Martinotti, Enrico Romagnoli, Giuseppe Biondi-Zoccai, Antonio Abbate, Gabriele San. Lorcaserin: worthy of further insights? Results from recent research. CNS & neurological disorders drug targets. 2023-04-03. PMID:37005521. |
lorcaserin is a 3-benzazepine that binds 5-ht2c serotonin receptors in the hypothalamus, where it mediates lack of hunger and/or satiety, and in the ventral tegmental area, the site of origin of the mesolimbic and mesocortical dopaminergic projections, which mediate pleasure and reward. |
2023-04-03 |
2023-08-14 |
Not clear |
| Yuma Nagai, Yuri Kisaka, Kento Nomura, Naoya Nishitani, Chihiro Andoh, Masashi Koda, Hiroyuki Kawai, Kaoru Seiriki, Kazuki Nagayasu, Atsushi Kasai, Hisashi Shirakawa, Takanobu Nakazawa, Hitoshi Hashimoto, Shuji Kanek. Dorsal raphe serotonergic neurons preferentially reactivate dorsal dentate gyrus cell ensembles associated with positive experience. Cell reports. vol 42. issue 3. 2023-02-23. PMID:36821440. |
furthermore, we revealed that dopaminergic signaling induced by activation of drn 5-ht neurons projecting to the ventral tegmental area mediates an increase in active coping behavior and positive ddg ensemble reactivation. |
2023-02-23 |
2023-08-14 |
Not clear |
| Andrew J Newell, Victoria A Kapps, Yuheng Cai, Mani Ratnam Rai, Genevieve St Armour, Brian M Horman, Kylie D Rock, Shannah K Witchey, Alon Greenbaum, Heather B Patisau. Maternal Organophosphate Flame Retardant Exposure Alters the Developing Mesencephalic Dopamine System in Fetal Rat. Toxicological sciences : an official journal of the Society of Toxicology. 2022-12-23. PMID:36562574. |
maternal opfr exposure induced morphological changes to the putative ventral tegmental area and substantia nigra in both sexes and reduced the overall volume of this structure in males, while 5-ht nuclei were unchanged. |
2022-12-23 |
2023-08-14 |
human |
| Courtney K Broadfoot, Charles Lenell, Cynthia A Kelm-Nelson, Michelle R Ciucc. Effects of social isolation on 50-kHz ultrasonic vocalizations, affective state, cognition, and neurotransmitter concentrations in the ventral tegmental and locus coeruleus of adult rats. Behavioural brain research. 2022-10-14. PMID:36241070. |
at 10 months, vta and lc samples were assayed for dopamine, norepinephrine, and serotonin using high performance liquid chromatography. |
2022-10-14 |
2023-08-14 |
rat |
| Courtney K Broadfoot, Charles Lenell, Cynthia A Kelm-Nelson, Michelle R Ciucc. Effects of social isolation on 50-kHz ultrasonic vocalizations, affective state, cognition, and neurotransmitter concentrations in the ventral tegmental and locus coeruleus of adult rats. Behavioural brain research. 2022-10-14. PMID:36241070. |
we tested the hypotheses that isolation 1) diminishes vocalizations and cognition, 2) increases anxiety and depression, and 3) increases levels of dopamine, norepinephrine, and serotonin in the vta and lc. |
2022-10-14 |
2023-08-14 |
rat |
| Courtney K Broadfoot, Charles Lenell, Cynthia A Kelm-Nelson, Michelle R Ciucc. Effects of social isolation on 50-kHz ultrasonic vocalizations, affective state, cognition, and neurotransmitter concentrations in the ventral tegmental and locus coeruleus of adult rats. Behavioural brain research. 2022-10-14. PMID:36241070. |
dopamine and serotonin and their respective metabolites were significantly increased in the vta in isolated rats. |
2022-10-14 |
2023-08-14 |
rat |
| Daniil Grinchii, Marius C Hoener, Talah Khoury, Roman Dekhtiarenko, Reyhaneh Nejati Bervanlou, Daniela Jezova, Eliyahu Dremenco. Effects of acute and chronic administration of trace amine-associated receptor 1 (TAAR1) ligands on in vivo excitability of central monoamine-secreting neurons in rats. Molecular psychiatry. 2022-08-31. PMID:36045279. |
acute ro5256390 suppressed, and ro5263397 stimulated serotonin (5-ht) neurons of the dorsal raphe nucleus (drn) and dopamine neurons of the ventral tegmental area (vta) in brain slices, suggesting that the behavioral effects of taar1 ligands involve 5-ht and dopamine. |
2022-08-31 |
2023-08-14 |
rat |
| Daniil Grinchii, Marius C Hoener, Talah Khoury, Roman Dekhtiarenko, Reyhaneh Nejati Bervanlou, Daniela Jezova, Eliyahu Dremenco. Effects of acute and chronic administration of trace amine-associated receptor 1 (TAAR1) ligands on in vivo excitability of central monoamine-secreting neurons in rats. Molecular psychiatry. 2022-08-31. PMID:36045279. |
excitability of 5-ht neurons of the drn, noradrenaline neurons of the locus coeruleus (lc), and dopamine neurons of the vta was assessed using single-unit electrophysiology in anesthetized rats. |
2022-08-31 |
2023-08-14 |
rat |
| Daniil Grinchii, Marius C Hoener, Talah Khoury, Roman Dekhtiarenko, Reyhaneh Nejati Bervanlou, Daniela Jezova, Eliyahu Dremenco. Effects of acute and chronic administration of trace amine-associated receptor 1 (TAAR1) ligands on in vivo excitability of central monoamine-secreting neurons in rats. Molecular psychiatry. 2022-08-31. PMID:36045279. |
chronic ro5256390 increased excitability of 5-ht neurons of the drn and dopamine neurons of the vta. |
2022-08-31 |
2023-08-14 |
rat |