Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
Małgorzata Filip, Iwona Papla, Ewa Nowak, Klaudia Czepiel, Edmund Przegalińsk. Effects of 5-HT1B receptor ligands microinjected into the ventral tegmental area on cocaine discrimination in rats. European journal of pharmacology. vol 459. issue 2-3. 2003-08-25. PMID:12524152. |
the present study investigated the role of 5-ht(1b) receptors in the ventral tegmental area in the discriminative stimulus effects of cocaine in rats. |
2003-08-25 |
2023-08-12 |
rat |
Małgorzata Filip, Iwona Papla, Ewa Nowak, Klaudia Czepiel, Edmund Przegalińsk. Effects of 5-HT1B receptor ligands microinjected into the ventral tegmental area on cocaine discrimination in rats. European journal of pharmacology. vol 459. issue 2-3. 2003-08-25. PMID:12524152. |
after reaching the cocaine-saline discrimination criterion, the rats were stereotaxically implanted with bilateral cannulae in the ventral tegmental area and were then microinjected with selective 5-ht(1b) receptor ligands. |
2003-08-25 |
2023-08-12 |
rat |
Arata Watanabe, Yoshihiro Tohyama, Khanh Q Nguyen, Shu Hasegawa, Guy Debonnel, Mirko Diksi. Regional brain serotonin synthesis is increased in the olfactory bulbectomy rat model of depression: an autoradiographic study. Journal of neurochemistry. vol 85. issue 2. 2003-05-14. PMID:12675923. |
5-ht synthesis rates were significantly decreased in the dorsal and medial raphe nuclei, but there was no significant change the ventral tegmental area and the locus coeruleus following obx. |
2003-05-14 |
2023-08-12 |
human |
Zachary A Rodd-Henricks, David L McKinzie, Roberto I Melendez, Nada Berry, James M Murphy, William J McBrid. Effects of serotonin-3 receptor antagonists on the intracranial self-administration of ethanol within the ventral tegmental area of Wistar rats. Psychopharmacology. vol 165. issue 3. 2003-05-07. PMID:12447605. |
previous work from our laboratory indicated that wistar rats will self-administer ethanol (etoh) directly into the posterior ventral tegmental area (vta) and that 5-ht(3) antagonists will inhibit etoh-stimulated somatodendritic release of dopamine within the vta. |
2003-05-07 |
2023-08-12 |
rat |
John F Neumaier, Evelyn S Vincow, Andreas Arvanitogiannis, Roy A Wise, William A Carlezo. Elevated expression of 5-HT1B receptors in nucleus accumbens efferents sensitizes animals to cocaine. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 22. issue 24. 2003-01-23. PMID:12486179. |
for example, serotonin actions at 5-ht1b receptors in the ventral tegmental area (vta) modulate cocaine-induced dopamine release in the nucleus accumbens (nacc) and alter the rewarding and stimulant properties of cocaine. |
2003-01-23 |
2023-08-12 |
Not clear |
Zheng-Xiong Xi, Elliot A Stei. GABAergic mechanisms of opiate reinforcement . Alcohol and alcoholism (Oxford, Oxfordshire). vol 37. issue 5. 2002-11-26. PMID:12217944. |
in this review, we focus on the neurochemical substrates of opiate reinforcement and review the role of da and non-da substrates, including opioid, gaba, glutamate and serotonin on opiate-reinforced behaviour and the activity of dopaminergic and gabaergic neurons in the vta and the nacc. |
2002-11-26 |
2023-08-12 |
Not clear |
Vincenzo Di Matteo, Marisa Cacchio, Camillo Di Giulio, Ennio Esposit. Role of serotonin(2C) receptors in the control of brain dopaminergic function. Pharmacology, biochemistry, and behavior. vol 71. issue 4. 2002-09-11. PMID:11888564. |
there is substantial evidence that the functional status of mesocorticolimbic dopaminergic (da) system originating in the ventral tegmental area (vta) is under a phasic and tonic inhibitory control by the serotonergic system, which acts by stimulating serotonin(2c) (5-ht(2c)) receptor subtypes. |
2002-09-11 |
2023-08-12 |
human |
Feng C Zhou, Klaus-Peter Lesch, Dennis L Murph. Serotonin uptake into dopamine neurons via dopamine transporters: a compensatory alternative. Brain research. vol 942. issue 1-2. 2002-09-04. PMID:12031859. |
da neurons containing 5-ht are seen in the substantia nigra and ventral tegmental area (vta), but not in other brain areas of 5-htt -/- mice. |
2002-09-04 |
2023-08-12 |
mouse |
Veronica Bisagno, Deveroux Ferguson, Victoria N Luin. Short toxic methamphetamine schedule impairs object recognition task in male rats. Brain research. vol 940. issue 1-2. 2002-08-29. PMID:12020880. |
in striatum da and 5-ht were depleted by 65% and 79%, respectively, no significant changes were found in pre-frontal cortex, hippocampus, ventral tegmental area (vta) or substantia nigra. |
2002-08-29 |
2023-08-12 |
rat |
Wenxia Zhou, Kathryn A Cunningham, Mary L Thoma. Estrogen regulation of gene expression in the brain: a possible mechanism altering the response to psychostimulants in female rats. Brain research. Molecular brain research. vol 100. issue 1-2. 2002-08-13. PMID:12008023. |
twenty-seven days later, brain tissue was collected to study e(2) effects on mrna expression for da d(1)-like (d(1)) and d(2)-like (d(2s), d(2l), d(3)) receptors, da transporter (dat), 5-ht(1a), 5-ht(1b), 5-ht(2a), 5-ht(2c) receptors, and 5-ht transporter (sert) as well as eralpha and erbeta in amygdala, hypothalamus, nucleus accumbens, midbrain, and ventral tegmental area (vta). |
2002-08-13 |
2023-08-12 |
rat |
C Nocjar, B L Roth, E A Pehe. Localization of 5-HT(2A) receptors on dopamine cells in subnuclei of the midbrain A10 cell group. Neuroscience. vol 111. issue 1. 2002-07-18. PMID:11955720. |
recent electrophysiological and behavioral studies suggest that 5-ht modulates dopaminergic neurons in the ventral tegmental area via activation of 5-ht(2a) receptors. |
2002-07-18 |
2023-08-12 |
rat |
C Nocjar, B L Roth, E A Pehe. Localization of 5-HT(2A) receptors on dopamine cells in subnuclei of the midbrain A10 cell group. Neuroscience. vol 111. issue 1. 2002-07-18. PMID:11955720. |
it is currently unknown if 5-ht(2a) receptors mediate their actions on dopaminergic neurons in the ventral tegmental area via direct or indirect mechanisms. |
2002-07-18 |
2023-08-12 |
rat |
C Nocjar, B L Roth, E A Pehe. Localization of 5-HT(2A) receptors on dopamine cells in subnuclei of the midbrain A10 cell group. Neuroscience. vol 111. issue 1. 2002-07-18. PMID:11955720. |
this study investigated whether 5-ht(2a) receptors were localized on dopamine cells within the a10 dopamine subnuclei of the rat, including the ventral tegmental area. |
2002-07-18 |
2023-08-12 |
rat |
C Nocjar, B L Roth, E A Pehe. Localization of 5-HT(2A) receptors on dopamine cells in subnuclei of the midbrain A10 cell group. Neuroscience. vol 111. issue 1. 2002-07-18. PMID:11955720. |
though more rare, non-dopaminergic neurons also expressed 5-ht(2a) receptor immunoreactivity in the ventral tegmental area. |
2002-07-18 |
2023-08-12 |
rat |
C Nocjar, B L Roth, E A Pehe. Localization of 5-HT(2A) receptors on dopamine cells in subnuclei of the midbrain A10 cell group. Neuroscience. vol 111. issue 1. 2002-07-18. PMID:11955720. |
these findings provide an anatomical basis for the physiological modulation of dopamine neurons in the rostral ventral tegmental area either directly, by 5-ht(2a) receptors localized on dopamine cells, or indirectly, through a non-dopaminergic mechanism. |
2002-07-18 |
2023-08-12 |
rat |
C Nocjar, B L Roth, E A Pehe. Localization of 5-HT(2A) receptors on dopamine cells in subnuclei of the midbrain A10 cell group. Neuroscience. vol 111. issue 1. 2002-07-18. PMID:11955720. |
interestingly, 5-ht(2a) receptors were expressed on dopamine neurons in several a10 subnuclei that project to mesolimbic forebrain regions implicated in drug addiction, and recent evidence indicates that ventral tegmental area 5-ht(2a) receptor activation may modulate reward-related behavior in rodents. |
2002-07-18 |
2023-08-12 |
rat |
R M Torack, J W Miller, K A Rot. Deafferentation-induced abnormal neurofilament phosphorylation in red nucleus neurones. Neuropathology and applied neurobiology. vol 27. issue 6. 2002-05-01. PMID:11903927. |
we previously developed a rodent model of hippocampal deafferentation involving bilateral destructive lesions of the ventrotegmental area (vta), septum of the medial forebrain and entorhinal cortex combined with pharmacological inhibition of serotonin 5-ht2 and dopamine d1 receptors. |
2002-05-01 |
2023-08-12 |
human |
S Chatelin, R Wehrlé, P Mercier, D Morello, C Sotelo, M J Webe. Neuronal promoter of human aromatic L-amino acid decarboxylase gene directs transgene expression to the adult floor plate and aminergic nuclei induced by the isthmus. Brain research. Molecular brain research. vol 97. issue 2. 2002-03-21. PMID:11750071. |
a large degree of co-expression was observed with tyrosine-hydroxylase (th) in the sn and vta, and with serotonin (5-ht) in the dorsal raphe nucleus. |
2002-03-21 |
2023-08-12 |
mouse |
M Shirane, K Nakamur. Aniracetam enhances cortical dopamine and serotonin release via cholinergic and glutamatergic mechanisms in SHRSP. Brain research. vol 916. issue 1-2. 2002-01-14. PMID:11597608. |
local perfusion of mecamylamine, a nicotinic acetylcholine (nach) and n-methyl-d-aspartate (nmda) receptor antagonist, into the ventral tegmental area (vta) and dorsal raphe nucleus (drn) completely blocked da and 5-ht release, respectively, in the pfc elicited by orally administered aniracetam. |
2002-01-14 |
2023-08-12 |
rat |
F Yamane, H Okazawa, P Blier, M Diksi. Reduction in serotonin synthesis following acute and chronic treatments with paroxetine, a selective serotonin reuptake inhibitor, in rat brain: an autoradiographic study with alpha-[14C]methyl-L-tryptophan(2). Biochemical pharmacology. vol 62. issue 11. 2002-01-02. PMID:11728384. |
in the first series of experiments, an acute intraperitoneal injection of paroxetine (10 mg/kg) produced a significant reduction in 5-ht synthesis in brain structures containing serotonergic cell bodies (the dorsal, median, and pallidum raphe nuclei), as well as in most projection areas: the ventral tegmental area, median forebrain bundle, hippocampus ca3 region, and nigrostriatal structures (substantia nigra, lateral and medial caudate nuclei). |
2002-01-02 |
2023-08-12 |
rat |