Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
Q S Yan, S E Ya. Serotonin-1B receptor-mediated inhibition of [(3)H]GABA release from rat ventral tegmental area slices. Journal of neurochemistry. vol 79. issue 4. 2001-12-20. PMID:11723184. |
in order to assess a role of 5-ht(1b) receptors for regulation of gaba transmission in the ventral tegmental area (vta), vta slices from the rat were incubated with [(3)h]gaba and beta-alanine, and superfused in the presence of nipecotic acid and aminooxyacetic acid. |
2001-12-20 |
2023-08-12 |
rat |
Q S Yan, S E Ya. Serotonin-1B receptor-mediated inhibition of [(3)H]GABA release from rat ventral tegmental area slices. Journal of neurochemistry. vol 79. issue 4. 2001-12-20. PMID:11723184. |
the results support the hypothesis that 5-ht(1b) receptors within the vta can function as heteroreceptors to inhibit gaba release. |
2001-12-20 |
2023-08-12 |
rat |
L R McMahon, M Filip, K A Cunningha. Differential regulation of the mesoaccumbens circuit by serotonin 5-hydroxytryptamine (5-HT)2A and 5-HT2C receptors. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 21. issue 19. 2001-10-11. PMID:11567068. |
to test this hypothesis, the present study measured cocaine-evoked locomotor activity after bilateral microinjection of selective 5-ht(2a)r and 5-ht(2c)r antagonists into the ventral tegmental area (vta) or the nucleus accumbens (nac) shell. |
2001-10-11 |
2023-08-12 |
Not clear |
L R McMahon, M Filip, K A Cunningha. Differential regulation of the mesoaccumbens circuit by serotonin 5-hydroxytryptamine (5-HT)2A and 5-HT2C receptors. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 21. issue 19. 2001-10-11. PMID:11567068. |
these findings are the first to demonstrate that the behavioral effects of cocaine are generated in part by activation of 5-ht(2a)rs in the vta and by activation of 5-ht(2c)rs in the nac shell. |
2001-10-11 |
2023-08-12 |
Not clear |
Q S Yan, S E Ya. Activation of 5-HT(1B/1D) receptors in the mesolimbic dopamine system increases dopamine release from the nucleus accumbens: a microdialysis study. European journal of pharmacology. vol 418. issue 1-2. 2001-09-27. PMID:11334865. |
this study was designed to investigate the role of 5-hydroxytryptamine (5-ht)(1b) receptors located in the ventral tegmental area and nucleus accumbens in the modulation of accumbal dopaminergic transmission. |
2001-09-27 |
2023-08-12 |
rat |
Q S Yan, S E Ya. Activation of 5-HT(1B/1D) receptors in the mesolimbic dopamine system increases dopamine release from the nucleus accumbens: a microdialysis study. European journal of pharmacology. vol 418. issue 1-2. 2001-09-27. PMID:11334865. |
the selective 5-ht(1b) receptor agonist cp 93129 [3-(1,2,5,6-tetrahydro-4-pyridyl)pyrrolo[3,2-b]pyrid-5-one] was administered into the ventral tegmental area or nucleus accumbens of freely moving sprague-dawley rats via retrograde microdialysis. |
2001-09-27 |
2023-08-12 |
rat |
Q S Yan, S E Ya. Activation of 5-HT(1B/1D) receptors in the mesolimbic dopamine system increases dopamine release from the nucleus accumbens: a microdialysis study. European journal of pharmacology. vol 418. issue 1-2. 2001-09-27. PMID:11334865. |
these results are not in opposition to the concept that 5-ht(1b) receptors within the ventral tegmental area and nucleus accumbens are all involved in the modulation of dopamine release in the terminal area of the mesolimbic dopamine system. |
2001-09-27 |
2023-08-12 |
rat |
V Di Matteo, A De Blasi, C Di Giulio, E Esposit. Role of 5-HT(2C) receptors in the control of central dopamine function. Trends in pharmacological sciences. vol 22. issue 5. 2001-08-02. PMID:11339973. |
substantial evidence suggests that the functional status of the mesocorticolimbic dopamine (da) system originating in the ventral tegmental area is under a phasic and tonic inhibitory control by the 5-ht system that acts by stimulating 5-ht(2c) receptor subtypes. |
2001-08-02 |
2023-08-12 |
Not clear |
M D Doherty, V M Picke. Targeting of serotonin 1A receptors to dopaminergic neurons within the parabrachial subdivision of the ventral tegmental area in rat brain. The Journal of comparative neurology. vol 433. issue 3. 2001-07-12. PMID:11298363. |
targeting of serotonin 1a receptors to dopaminergic neurons within the parabrachial subdivision of the ventral tegmental area in rat brain. |
2001-07-12 |
2023-08-12 |
rat |
M D Doherty, V M Picke. Targeting of serotonin 1A receptors to dopaminergic neurons within the parabrachial subdivision of the ventral tegmental area in rat brain. The Journal of comparative neurology. vol 433. issue 3. 2001-07-12. PMID:11298363. |
potential targets for these 5-ht1a-mediated actions of 5-ht include mesocortical and mesolimbic dopaminergic neurons having partially segregated distribution in the parabrachial and paranigral subdivisions of the ventral tegmental area (vta), respectively. |
2001-07-12 |
2023-08-12 |
rat |
Y Minabe, K Hashimoto, K I Watanabe, C R Ashb. Acute and repeated administration of the selective 5-HT(2A) receptor antagonist M100907 significantly alters the activity of midbrain dopamine neurons: an in vivo electrophysiological study. Synapse (New York, N.Y.). vol 40. issue 2. 2001-07-05. PMID:11252021. |
we examined the effect of the acute and repeated administration of m100907 (formerly mdl 100907), a selective 5-ht(2a) receptor antagonist, on spontaneously active dopamine (da) neurons in the substantia nigra pars compacta (snc) and ventral tegmental area (vta) of rats. |
2001-07-05 |
2023-08-12 |
rat |
V Hillegaart, O Magnusson, S Ahleniu. A9 and A10 dopamine nuclei as a site of action for effects of 8-OH-DPAT on locomotion in the rat. Pharmacology, biochemistry, and behavior. vol 67. issue 1. 2001-01-04. PMID:11113484. |
the 5-hydroxytryptamine (5-ht) 5-ht(1a) receptor agonist 8-hydroxy-2-(di-n-propylamino)tetralin (8-oh-dpat) was applied locally (0-5 microg bilaterally) into either the substantia nigra (a9) or the ventral tegmental area (a10) of adult male wistar rats, and 10 min later spontaneous motor activity was observed in an open field ( approximately 0.5 m(2)) for 30 min. |
2001-01-04 |
2023-08-12 |
rat |
A R Ase, C Strazielle, C Hébert, M I Botez, R LaLonde, L Descarries, T A Reade. Central serotonin system in Dystonia musculorum mutant mice: biochemical, autoradiographic and immunocytochemical data. Synapse (New York, N.Y.). vol 37. issue 3. 2000-10-06. PMID:10881040. |
quantification of the binding to 5-ht transporters showed increases in the medial geniculate nucleus (+14%), medial (+24%) and lateral (+18%) hypothalamus, interpeduncular (+13%), vestibular (+22%), and deep cerebellar nuclei (+37%) of dt(j)/dt mice, and decreases in the ventral tegmental area (-13%), median and linear raphe nuclei (-20%), as well as in the solitary complex (-35%). |
2000-10-06 |
2023-08-12 |
mouse |
K Yoshimoto, S Ueda, B Kato, Y Takeuchi, Y Kawai, K Noritake, M Yasuhar. Alcohol enhances characteristic releases of dopamine and serotonin in the central nucleus of the amygdala. Neurochemistry international. vol 37. issue 4. 2000-10-02. PMID:10825577. |
in the present study, the effect of ethanol (etoh) on the release of dopamine (da) and serotonin (5-ht) was studied in the central amygdaloid nucleus (ceamy), and projecting excitatory afferents to the ventral tegmental area (vta), of freely moving wistar rats by brain microdialysis. |
2000-10-02 |
2023-08-12 |
rat |
K Yoshimoto, S Ueda, B Kato, Y Takeuchi, Y Kawai, K Noritake, M Yasuhar. Alcohol enhances characteristic releases of dopamine and serotonin in the central nucleus of the amygdala. Neurochemistry international. vol 37. issue 4. 2000-10-02. PMID:10825577. |
overall, the present findings are not sufficient to conclude whether etoh acts directly or indirectly on the major monoamine nerve cells in the ceamy, but the degree of acute etoh action affected the differences in time at the peak response on etoh-induced da and 5-ht releases in the ceamy via vta. |
2000-10-02 |
2023-08-12 |
rat |
V Di Matteo, G Di Giovanni, M Di Mascio, E Esposit. Biochemical and electrophysiological evidence that RO 60-0175 inhibits mesolimbic dopaminergic function through serotonin(2C) receptors. Brain research. vol 865. issue 1. 2000-07-21. PMID:10814735. |
the selective 5-ht(2c) receptor antagonist sb 242084 completely blocked the inhibitory action of ro 60-0175 on accumbal da release and on the firing rate of vta da cells. |
2000-07-21 |
2023-08-12 |
Not clear |
V Di Matteo, G Di Giovanni, M Di Mascio, E Esposit. Biochemical and electrophysiological evidence that RO 60-0175 inhibits mesolimbic dopaminergic function through serotonin(2C) receptors. Brain research. vol 865. issue 1. 2000-07-21. PMID:10814735. |
on the contrary, both (+/-)-doi, a mixed 5-ht(2a/2c) receptor agonist, and the selective 5-ht(2b) agonist bw 723c86, did not affect either da release in the nucleus accumbens or the firing rate of vta da cells. |
2000-07-21 |
2023-08-12 |
Not clear |
M D Doherty, V M Picke. Ultrastructural localization of the serotonin 2A receptor in dopaminergic neurons in the ventral tegmental area. Brain research. vol 864. issue 2. 2000-07-03. PMID:10802024. |
ultrastructural localization of the serotonin 2a receptor in dopaminergic neurons in the ventral tegmental area. |
2000-07-03 |
2023-08-12 |
rat |
M D Doherty, V M Picke. Ultrastructural localization of the serotonin 2A receptor in dopaminergic neurons in the ventral tegmental area. Brain research. vol 864. issue 2. 2000-07-03. PMID:10802024. |
serotonin (5-hydroxytryptamine, 5-ht) 2a receptor antagonists are clinically effective antipsychotics that may differentially target mesocortical and mesolimbic dopaminergic neurons having partially segregated distribution in the parabrachial (pb) and paranigral (pn) ventral tegmental area (vta). |
2000-07-03 |
2023-08-12 |
rat |
K Ikemoto, A Nishimura, N Okado, M Mikuni, K Nishi, I Nagats. Human midbrain dopamine neurons express serotonin 2A receptor: an immunohistochemical demonstration. Brain research. vol 853. issue 2. 2000-06-21. PMID:10640637. |
we demonstrated intense serotonin (5-ht) 2a receptor immunoreactivity in the human ventral tegmental area (vta) using by a recently raised antibody against 5-ht2a receptor. |
2000-06-21 |
2023-08-12 |
human |