| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Bruno P Guiard, Franck Chenu, Mostafa El Mansari, Pierre Blie. Characterization of the electrophysiological properties of triple reuptake inhibitors on monoaminergic neurons. The international journal of neuropsychopharmacology. vol 14. issue 2. 2011-09-02. PMID:20149268. |
the present in-vivo electrophysiological study was undertaken to determine the effects of the triple reuptake inhibitors sep-225289 and dov216303 on the neuronal activities of locus coeruleus (lc) ne, ventral tegmental area (vta) da and dorsal raphe (dr) 5-ht neurons. |
2011-09-02 |
2023-08-12 |
Not clear |
| Bruno P Guiard, Franck Chenu, Mostafa El Mansari, Pierre Blie. Characterization of the electrophysiological properties of triple reuptake inhibitors on monoaminergic neurons. The international journal of neuropsychopharmacology. vol 14. issue 2. 2011-09-02. PMID:20149268. |
administered acutely, sep-225289 and dov216303 dose-dependently decreased the spontaneous firing rate of lc ne, vta da and dr 5-ht neurons through the activation of α₂, d₂ and 5-ht(₁a) autoreceptors, respectively. |
2011-09-02 |
2023-08-12 |
Not clear |
| Bruno P Guiard, Franck Chenu, Mostafa El Mansari, Pierre Blie. Characterization of the electrophysiological properties of triple reuptake inhibitors on monoaminergic neurons. The international journal of neuropsychopharmacology. vol 14. issue 2. 2011-09-02. PMID:20149268. |
both compounds predominantly inhibited the firing rate of lc ne neurons while producing only a partial decrease in vta da and dr 5-ht neuronal discharge. |
2011-09-02 |
2023-08-12 |
Not clear |
| Ming Gao, Hong-Yuan Chu, Guo-Zhang Jin, Zhang-Jin Zhang, Jie Wu, Xue-Chu Zhe. l-Stepholidine-induced excitation of dopamine neurons in rat ventral tegmental area is associated with its 5-HT(1A) receptor partial agonistic activity. Synapse (New York, N.Y.). vol 65. issue 5. 2011-06-23. PMID:20803620. |
l-stepholidine-induced excitation of dopamine neurons in rat ventral tegmental area is associated with its 5-ht(1a) receptor partial agonistic activity. |
2011-06-23 |
2023-08-12 |
rat |
| S Nullmeier, P Panther, H Dobrowolny, M Frotscher, S Zhao, H Schwegler, R Wol. Region-specific alteration of GABAergic markers in the brain of heterozygous reeler mice. The European journal of neuroscience. vol 33. issue 4. 2011-05-31. PMID:21226776. |
in the present study using immunocytochemical procedures, we investigated hrm and wild-type mice (wt) for differences in the numbers and densities of glutamic acid decarboxylase (gad)67 and parvalbumin (parv)-immunoreactive (ir) neurons in the hippocampus, tyrosine hydroxylase (th)-ir neurons in the ventral tegmental area (vta) and substantia nigra (sn), and serotonin transporter (5-ht-t)-ir neurons of the raphe nuclei. |
2011-05-31 |
2023-08-12 |
mouse |
| Flavie Kersanté, Jin-Ya Wang, Jin-Chung Chen, Catherine Mollereau, Jean-Marie Zaja. Anti-opioid effects of neuropeptide FF receptors in the ventral tegmental area. Neuroscience letters. vol 488. issue 3. 2011-05-02. PMID:21111027. |
a stable npff(2) receptor agonist, dnpa, was injected into the ventral tegmental area (vta) and the release of dopamine and serotonin within the nucleus accumbens (nac), induced by intraperitoneal injection of morphine, was monitored using the brain microdialysis, in non-constrained rat. |
2011-05-02 |
2023-08-12 |
rat |
| Keiko Ohoyama, Satoshi Yamamura, Tatsuya Hamaguchi, Masanori Nakagawa, Eishi Motomura, Takashi Shiroyama, Hisashi Tanii, Motohiro Okad. Effect of novel atypical antipsychotic, blonanserin, on extracellular neurotransmitter level in rat prefrontal cortex. European journal of pharmacology. vol 653. issue 1-3. 2011-05-02. PMID:21147094. |
to clarify the mechanisms of action of blonanserin, an atypical antipsychotic drug, we studied the effects of systemic administration of blonanserin and risperidone on extracellular levels of norepinephrine, dopamine, serotonin, gaba and glutamate in the medial prefrontal cortex using microdialysis, and neuronal firing in the ventral tegmental area, locus coeruleus, dorsal raphe nucleus and mediodorsal thalamic nucleus using radiotelemetry. |
2011-05-02 |
2023-08-12 |
rat |
| Nanna Hovelsø, Thomas Nicolaj Sager, Arne Mør. Combination of escitalopram and a 5-HT(₁A) receptor antagonist selectively decreases the extracellular levels of dopamine in the nucleus accumbens relative to striatum through 5-HT(₂C) receptor stimulation; suggestive of antipsychotic potential. Pharmacology, biochemistry, and behavior. vol 97. issue 3. 2011-04-11. PMID:20937301. |
serotonin 5-ht(₂c) receptors are widely distributed throughout the brain located on gabaergic interneurons and afferent neurons in the ventral tegmental area and substantia nigra. |
2011-04-11 |
2023-08-12 |
rat |
| Taiki Takahash. Toward molecular neuroeconomics of obesity. Medical hypotheses. vol 75. issue 4. 2010-12-22. PMID:20462703. |
it is suggested that neurobiological substrates such as adiponectin, dopamine (d2 receptors), endocannabinoids, ghrelin, leptin, nesfatin-1, norepinephrine, orexin, oxytocin, serotonin, vasopressin, cck, glp-1, mch, pyy, and stress hormones (e.g., crf) in the brain (e.g., ofc, vta, nacc, and the hypothalamus) may determine parameters in the economic theory of obesity. |
2010-12-22 |
2023-08-12 |
Not clear |
| Zachary A Rodd, Richard L Bell, Scott M Oster, Jamie E Toalston, Tylene J Pommer, William J McBride, James M Murph. Serotonin-3 receptors in the posterior ventral tegmental area regulate ethanol self-administration of alcohol-preferring (P) rats. Alcohol (Fayetteville, N.Y.). vol 44. issue 3. 2010-11-30. PMID:20682192. |
the objective of this study was to determine the involvement of 5-ht(3) receptors within the ventral tegmental area (vta) in regulating ethanol self-administration by alcohol-preferring (p) rats. |
2010-11-30 |
2023-08-12 |
rat |
| Zachary A Rodd, Richard L Bell, Scott M Oster, Jamie E Toalston, Tylene J Pommer, William J McBride, James M Murph. Serotonin-3 receptors in the posterior ventral tegmental area regulate ethanol self-administration of alcohol-preferring (P) rats. Alcohol (Fayetteville, N.Y.). vol 44. issue 3. 2010-11-30. PMID:20682192. |
standard two-lever operant chambers (coulbourn instruments, allentown, pa) were used to examine the effects of seven consecutive bilateral microinfusions of ics 205-930 (ics), a 5-ht(3) receptor antagonist, directly into the posterior vta on the acquisition and maintenance of 15% (vol/vol) ethanol self-administration. |
2010-11-30 |
2023-08-12 |
rat |
| Zachary A Rodd, Richard L Bell, Scott M Oster, Jamie E Toalston, Tylene J Pommer, William J McBride, James M Murph. Serotonin-3 receptors in the posterior ventral tegmental area regulate ethanol self-administration of alcohol-preferring (P) rats. Alcohol (Fayetteville, N.Y.). vol 44. issue 3. 2010-11-30. PMID:20682192. |
overall, the results of this study suggest that 5-ht(3) receptors in the posterior vta of the p rat may be involved in regulating ethanol self-administration. |
2010-11-30 |
2023-08-12 |
rat |
| Zachary A Rodd, Richard L Bell, Scott M Oster, Jamie E Toalston, Tylene J Pommer, William J McBride, James M Murph. Serotonin-3 receptors in the posterior ventral tegmental area regulate ethanol self-administration of alcohol-preferring (P) rats. Alcohol (Fayetteville, N.Y.). vol 44. issue 3. 2010-11-30. PMID:20682192. |
in addition, chronic operant ethanol self-administration and/or repeated treatments with a 5-ht(3) receptor antagonist may alter neuronal circuitry within the posterior vta. |
2010-11-30 |
2023-08-12 |
rat |
| Bruno P Guiard, Mostafa El Mansari, Pierre Blie. Prospect of a dopamine contribution in the next generation of antidepressant drugs: the triple reuptake inhibitors. Current drug targets. vol 10. issue 11. 2010-09-27. PMID:19702555. |
indeed, it is well established that the increase in central dopaminergic transmission regulates the neuronal activity of 5-ht and ne in the dorsal raphe (dr) and locus coeruleus (lc), respectively, while in turn, the ventral tegmental area (vta), is sensitive to changes in 5-ht and ne release. |
2010-09-27 |
2023-08-12 |
Not clear |
| Giuseppe Di Giovanni, Ennio Esposito, Vincenzo Di Matte. Role of serotonin in central dopamine dysfunction. CNS neuroscience & therapeutics. vol 16. issue 3. 2010-09-22. PMID:20557570. |
in spite of a direct effect of 5-ht by its receptors located on da cells, 5-ht can modulate their activity indirectly, modifying gamma-aminobutyric (gaba)-ergic and glutamatergic input to the ventral tegmental area (vta) and substantia nigra pars compacta (snc). |
2010-09-22 |
2023-08-12 |
Not clear |
| J E Olijslagers, T R Werkman, A C McCreary, C G Kruse, W J Wadma. Modulation of midbrain dopamine neurotransmission by serotonin, a versatile interaction between neurotransmitters and significance for antipsychotic drug action. Current neuropharmacology. vol 4. issue 1. 2010-06-10. PMID:18615139. |
moreover, it has been reported that electrophysiological interactions between da and 5-ht show subtle, but important, differences between the sn and the vta which could explain (in part) the effectiveness and lower propensity to induce side-effects of the newer atypical antipsychotic drugs. |
2010-06-10 |
2023-08-12 |
Not clear |
| Hideo Suzuki, S Duke Han, Louis R Luca. Chronic passive exposure to aggression decreases D2 and 5-HT 1B receptor densities. Physiology & behavior. vol 99. issue 5. 2010-06-09. PMID:20114057. |
however, receptor binding autoradiography identified lower densities of dopamine d(2) receptors in the cortical-accumbal regions (shell of the nucleus accumbens and cingulate and motor cortices) and lower 5-ht(1b) receptor densities in the tegmental regions (ventral tegmental area, substantia nigra pars compacta, and periaqueductal gray) among observers exposed to aggression, compared to controls. |
2010-06-09 |
2023-08-12 |
rat |
| Susan M Ferguson, Nolan A Sandygren, John F Neumaie. Pairing mild stress with increased serotonin-1B receptor expression in the nucleus accumbens increases susceptibility to amphetamine. The European journal of neuroscience. vol 30. issue 8. 2010-01-05. PMID:19817843. |
we report that the increasing expression of 5-ht(1b) receptors on the terminals of nac shell neurons that project to the ventral tegmental area and repeatedly exposing rats to mild stress subsequently enhance the acute locomotor-activating effects of amphetamine. |
2010-01-05 |
2023-08-12 |
rat |
| Stella Dracheva, Rebecca Lyddon, Kevin Barley, Sue M Marcus, Yasmin L Hurd, William M Byn. Editing of serotonin 2C receptor mRNA in the prefrontal cortex characterizes high-novelty locomotor response behavioral trait. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 34. issue 10. 2009-10-29. PMID:19494808. |
5-ht(2c)r mrna expression and editing were significantly higher in the nuac shell compared with both the pfc and vta, implying significant differences in function (including constitutive activity) among 5-ht(2c)r neuronal populations within the circuitry. |
2009-10-29 |
2023-08-12 |
rat |
| Dave J Hayes, Robert Clements, Andrew J Greensha. Effects of systemic and intra-nucleus accumbens 5-HT2C receptor compounds on ventral tegmental area self-stimulation thresholds in rats. Psychopharmacology. vol 203. issue 3. 2009-09-28. PMID:19031071. |
to date, no studies have investigated the possible role of 5-ht(2c) receptors in ventral tegmental area (vta) intracranial self-stimulation (icss). |
2009-09-28 |
2023-08-12 |
rat |