| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| A McRae, E A Ling, R Polinsky, C G Gottfries, A Dahlströ. Antibodies in the cerebrospinal fluid of some Alzheimer's disease patients recognize amoeboid microglial cells in the developing rat central nervous system. Neuroscience. vol 41. issue 2-3. 1991-09-13. PMID:1870709. |
the unexpected recognition of amoeboid microglia by antibodies in alzheimer's disease-cerebrospinal fluid is particularly interesting since these cells proliferate in response to nervous system disease and also engulf debris. |
1991-09-13 |
2023-08-11 |
rat |
| J P Blass, L Ko, H M Wisniewsk. Pathology of Alzheimer's disease. The Psychiatric clinics of North America. vol 14. issue 2. 1991-08-02. PMID:2062726. |
the characteristic alzheimer amyloid derives, in part, by action of microglia, from a precursor protein that is well characterized at the protein and gene levels. |
1991-08-02 |
2023-08-11 |
Not clear |
| N F Hassan, D E Campbell, S Rifat, S D Dougla. Isolation and characterization of human fetal brain-derived microglia in in vitro culture. Neuroscience. vol 41. issue 1. 1991-07-29. PMID:1647502. |
human brain microglia may play a central role in immunopathogenesis of cns diseases including hiv infection, multiple sclerosis and alzheimer's disease. |
1991-07-29 |
2023-08-11 |
human |
| T Ohgami, T Kitamoto, R W Shin, Y Kaneko, K Ogomori, J Tateish. Increased senile plaques without microglia in Alzheimer's disease. Acta neuropathologica. vol 81. issue 3. 1991-07-26. PMID:2058362. |
increased senile plaques without microglia in alzheimer's disease. |
1991-07-26 |
2023-08-11 |
Not clear |
| T Ohgami, T Kitamoto, R W Shin, Y Kaneko, K Ogomori, J Tateish. Increased senile plaques without microglia in Alzheimer's disease. Acta neuropathologica. vol 81. issue 3. 1991-07-26. PMID:2058362. |
to clarify the association of microglia with senile plaques, the brains from 13 patients with alzheimer's disease (ad) and 23 nondemented aged controls were investigated immunohistochemically by a double-labeling method using anti-beta-protein antiserum and anti-ferritin antibody, which is a recently reported microglia marker. |
1991-07-26 |
2023-08-11 |
Not clear |
| L S Perlmutter, E Barron, H C Chu. Morphologic association between microglia and senile plaque amyloid in Alzheimer's disease. Neuroscience letters. vol 119. issue 1. 1991-07-19. PMID:2097581. |
morphologic association between microglia and senile plaque amyloid in alzheimer's disease. |
1991-07-19 |
2023-08-11 |
Not clear |
| J Bauer, G König, S Strauss, U Jonas, U Ganter, A Weidemann, U Mönning, C L Masters, B Volk, M Berge. In-vitro matured human macrophages express Alzheimer's beta A4-amyloid precursor protein indicating synthesis in microglial cells. FEBS letters. vol 282. issue 2. 1991-07-02. PMID:1903718. |
microglia which are consistently associated with alzheimer's disease (ad) senile plaques are part of the mononuclear phagocyte system. |
1991-07-02 |
2023-08-11 |
human |
| H Akiyama, T Kawamata, S Dedhar, P L McGee. Immunohistochemical localization of vitronectin, its receptor and beta-3 integrin in Alzheimer brain tissue. Journal of neuroimmunology. vol 32. issue 1. 1991-04-17. PMID:1705945. |
a polyclonal antibody to this integrin weakly stained resting microglia in white matter of control brain and strongly stained reactive microglia in both gray and white matter of alzheimer brain. |
1991-04-17 |
2023-08-11 |
Not clear |
| K Selmaj, C S Raine, B Cannella, C F Brosna. Identification of lymphotoxin and tumor necrosis factor in multiple sclerosis lesions. The Journal of clinical investigation. vol 87. issue 3. 1991-04-10. PMID:1999503. |
no lt or tnf reactivity was detected in alzheimer's or parkinson's disease brain tissues but was present at lower levels in central nervous system (cns) tissue from other inflammatory conditions, except for adrenoleucodystrophy which displayed high levels of lt in microglia. |
1991-04-10 |
2023-08-11 |
Not clear |
| L A Mattiace, P Davies, S H Yen, D W Dickso. Microglia in cerebellar plaques in Alzheimer's disease. Acta neuropathologica. vol 80. issue 5. 1991-01-17. PMID:2251906. |
microglia in cerebellar plaques in alzheimer's disease. |
1991-01-17 |
2023-08-11 |
human |
| L A Mattiace, P Davies, S H Yen, D W Dickso. Microglia in cerebellar plaques in Alzheimer's disease. Acta neuropathologica. vol 80. issue 5. 1991-01-17. PMID:2251906. |
cerebellar amyloid deposits in alzheimer's disease were studied by immunocytochemistry and with a series of antibodies that recognize human microglia, including anti-hla-dr, ln-1, leu-m5 and leukocyte common antigen. |
1991-01-17 |
2023-08-11 |
human |
| L A Mattiace, P Davies, S H Yen, D W Dickso. Microglia in cerebellar plaques in Alzheimer's disease. Acta neuropathologica. vol 80. issue 5. 1991-01-17. PMID:2251906. |
these results raise the possibility that microglia may play a fundamental role in the pathogenesis of amyloid deposition in the cerebellum in alzheimer's disease. |
1991-01-17 |
2023-08-11 |
human |
| H Akiyama, P L McGee. Brain microglia constitutively express beta-2 integrins. Journal of neuroimmunology. vol 30. issue 1. 1990-12-07. PMID:1977769. |
the intensity of expression of each of these antigens was enhanced on reactive microglia in alzheimer disease tissue. |
1990-12-07 |
2023-08-11 |
Not clear |
| H Akiyama, P L McGee. Brain microglia constitutively express beta-2 integrins. Journal of neuroimmunology. vol 30. issue 1. 1990-12-07. PMID:1977769. |
hla-dr was detected on only a few microglia in control tissue, but was intensely expressed on large numbers of reactive microglia in alzheimer tissue. |
1990-12-07 |
2023-08-11 |
Not clear |
| I Tooyama, H Kimura, H Akiyama, P L McGee. Reactive microglia express class I and class II major histocompatibility complex antigens in Alzheimer's disease. Brain research. vol 523. issue 2. 1990-10-23. PMID:2400911. |
reactive microglia express class i and class ii major histocompatibility complex antigens in alzheimer's disease. |
1990-10-23 |
2023-08-11 |
Not clear |
| I Tooyama, H Kimura, H Akiyama, P L McGee. Reactive microglia express class I and class II major histocompatibility complex antigens in Alzheimer's disease. Brain research. vol 523. issue 2. 1990-10-23. PMID:2400911. |
monoclonal antibodies to class i antigens stained reactive microglia weakly to moderately and vascular endothelial cells strongly in alzheimer's gray and white matter. |
1990-10-23 |
2023-08-11 |
Not clear |
| I Tooyama, H Kimura, H Akiyama, P L McGee. Reactive microglia express class I and class II major histocompatibility complex antigens in Alzheimer's disease. Brain research. vol 523. issue 2. 1990-10-23. PMID:2400911. |
in alzheimer cases, hla-dr positive reactive microglia were more numerous and more strongly staining than mhc class i positive reactive microglia but many cells appeared to express both classes of antigen. |
1990-10-23 |
2023-08-11 |
Not clear |
| P Cras, M Kawai, S Siedlak, P Mulvihill, P Gambetti, D Lowery, P Gonzalez-DeWhitt, B Greenberg, G Perr. Neuronal and microglial involvement in beta-amyloid protein deposition in Alzheimer's disease. The American journal of pathology. vol 137. issue 2. 1990-09-17. PMID:2117395. |
the greatest concurrence of app immunoreactivity and reactive microglia was seen in the subiculum and area ca1, regions with a high density of congophilic plaques and subject to intense alzheimer's pathology. |
1990-09-17 |
2023-08-11 |
human |
| L A Mattiace, P Davies, D W Dickso. Detection of HLA-DR on microglia in the human brain is a function of both clinical and technical factors. The American journal of pathology. vol 136. issue 5. 1990-07-09. PMID:1693471. |
in subjects who died of chronic debilitating illness, such as alzheimer's disease and carcinomatosis, anti-hla-dr labeled numerous microglia throughout both the gray and white matter. |
1990-07-09 |
2023-08-11 |
human |
| L A Mattiace, P Davies, D W Dickso. Detection of HLA-DR on microglia in the human brain is a function of both clinical and technical factors. The American journal of pathology. vol 136. issue 5. 1990-07-09. PMID:1693471. |
in alzheimer's disease, microglia were aggregated in compact senile plaques, but loosely associated with diffuse amyloid deposits. |
1990-07-09 |
2023-08-11 |
human |