| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| K W Falenski, R E Blair, L J Sim-Selley, B R Martin, R J DeLorenz. Status epilepticus causes a long-lasting redistribution of hippocampal cannabinoid type 1 receptor expression and function in the rat pilocarpine model of acquired epilepsy. Neuroscience. vol 146. issue 3. 2007-07-03. PMID:17433556. |
status epilepticus causes a long-lasting redistribution of hippocampal cannabinoid type 1 receptor expression and function in the rat pilocarpine model of acquired epilepsy. |
2007-07-03 |
2023-08-12 |
rat |
| K W Falenski, R E Blair, L J Sim-Selley, B R Martin, R J DeLorenz. Status epilepticus causes a long-lasting redistribution of hippocampal cannabinoid type 1 receptor expression and function in the rat pilocarpine model of acquired epilepsy. Neuroscience. vol 146. issue 3. 2007-07-03. PMID:17433556. |
activation of the cannabinoid type 1 (cb1) receptor, a major g-protein-coupled receptor in brain, acts to regulate neuronal excitability and has been shown to mediate the anticonvulsant effects of cannabinoids in several animal models of seizure, including the rat pilocarpine model of acquired epilepsy. |
2007-07-03 |
2023-08-12 |
rat |
| Laxmikant S Deshpande, Sompong Sombati, Robert E Blair, Dawn S Carter, Billy R Martin, Robert J DeLorenz. Cannabinoid CB1 receptor antagonists cause status epilepticus-like activity in the hippocampal neuronal culture model of acquired epilepsy. Neuroscience letters. vol 411. issue 1. 2007-01-26. PMID:17110038. |
cannabinoid cb1 receptor antagonists cause status epilepticus-like activity in the hippocampal neuronal culture model of acquired epilepsy. |
2007-01-26 |
2023-08-12 |
Not clear |
| Laxmikant S Deshpande, Sompong Sombati, Robert E Blair, Dawn S Carter, Billy R Martin, Robert J DeLorenz. Cannabinoid CB1 receptor antagonists cause status epilepticus-like activity in the hippocampal neuronal culture model of acquired epilepsy. Neuroscience letters. vol 411. issue 1. 2007-01-26. PMID:17110038. |
this study was initiated to evaluate the role of cb1 receptor-dependent endocannabinoid synaptic transmission towards preventing the development of status epilepticus-like activity in the well-characterized hippocampal neuronal culture model of acquired epilepsy using patch clamp electrophysiology. |
2007-01-26 |
2023-08-12 |
Not clear |
| Mohamed Ben Ama. Cannabinoids in medicine: A review of their therapeutic potential. Journal of ethnopharmacology. vol 105. issue 1-2. 2006-12-22. PMID:16540272. |
cannabinoids present an interesting therapeutic potential as antiemetics, appetite stimulants in debilitating diseases (cancer and aids), analgesics, and in the treatment of multiple sclerosis, spinal cord injuries, tourette's syndrome, epilepsy and glaucoma. |
2006-12-22 |
2023-08-12 |
human |
| Jarogniew J Luszczki, Piotr Czuczwar, Anna Cioczek-Czuczwar, Stanislaw J Czuczwa. Arachidonyl-2'-chloroethylamide, a highly selective cannabinoid CB1 receptor agonist, enhances the anticonvulsant action of valproate in the mouse maximal electroshock-induced seizure model. European journal of pharmacology. vol 547. issue 1-3. 2006-12-15. PMID:16930590. |
endogenous cannabinoid ligands and cannabinoid cb(1) receptor agonists have been shown to exert potent anticonvulsant effects in various experimental models of epilepsy. |
2006-12-15 |
2023-08-12 |
mouse |
| Nina Wettschureck, Mario van der Stelt, Hiroshi Tsubokawa, Heinz Krestel, Alexandra Moers, Stefania Petrosino, Günther Schütz, Vincenzo Di Marzo, Stefan Offermann. Forebrain-specific inactivation of Gq/G11 family G proteins results in age-dependent epilepsy and impaired endocannabinoid formation. Molecular and cellular biology. vol 26. issue 15. 2006-09-19. PMID:16847339. |
forebrain-specific inactivation of gq/g11 family g proteins results in age-dependent epilepsy and impaired endocannabinoid formation. |
2006-09-19 |
2023-08-12 |
mouse |
| Robert E Blair, Laxmikant S Deshpande, Sompong Sombati, Katherine W Falenski, Billy R Martin, Robert J DeLorenz. Activation of the cannabinoid type-1 receptor mediates the anticonvulsant properties of cannabinoids in the hippocampal neuronal culture models of acquired epilepsy and status epilepticus. The Journal of pharmacology and experimental therapeutics. vol 317. issue 3. 2006-06-26. PMID:16469864. |
cannabinoids have been shown to have anticonvulsant properties, but no studies have evaluated the effects of cannabinoids in the hippocampal neuronal culture models of acquired epilepsy (ae) and status epilepticus (se). |
2006-06-26 |
2023-08-12 |
Not clear |
| Robert E Blair, Laxmikant S Deshpande, Sompong Sombati, Katherine W Falenski, Billy R Martin, Robert J DeLorenz. Activation of the cannabinoid type-1 receptor mediates the anticonvulsant properties of cannabinoids in the hippocampal neuronal culture models of acquired epilepsy and status epilepticus. The Journal of pharmacology and experimental therapeutics. vol 317. issue 3. 2006-06-26. PMID:16469864. |
activation of the cannabinoid type-1 receptor mediates the anticonvulsant properties of cannabinoids in the hippocampal neuronal culture models of acquired epilepsy and status epilepticus. |
2006-06-26 |
2023-08-12 |
Not clear |
| Paul F Smit. Cannabinoids as potential anti-epileptic drugs. Current opinion in investigational drugs (London, England : 2000). vol 6. issue 7. 2006-04-18. PMID:16044663. |
since the action of cannabinoids is complex, and there is a dearth of clinical trial data, it is currently unclear whether cannabinoids might be both efficacious and safe in the treatment of epilepsy. |
2006-04-18 |
2023-08-12 |
Not clear |
| Paul F Smit. Cannabinoids as potential anti-epileptic drugs. Current opinion in investigational drugs (London, England : 2000). vol 6. issue 7. 2006-04-18. PMID:16044663. |
the potential problem in delivering a cannabinoid drug to treat epilepsy is the inability to control its actions at different cannabinoid receptors regulating the release of different neurotransmitters. |
2006-04-18 |
2023-08-12 |
Not clear |
| Marc Steffens, Andreas Schulze-Bonhage, Rainer Surges, Thomas J Feuerstei. Fatty acid amidohydrolase in human neocortex-activity in epileptic and non-epileptic brain tissue and inhibition by putative endocannabinoids. Neuroscience letters. vol 385. issue 1. 2005-09-23. PMID:15923084. |
increased levels of the endocannabinoid anandamide (aea) have been observed in connection with neuronal disorders like epilepsy. |
2005-09-23 |
2023-08-12 |
human |
| C Bernard, M Milh, Y M Morozov, Y Ben-Ari, T F Freund, H Gozla. Altering cannabinoid signaling during development disrupts neuronal activity. Proceedings of the National Academy of Sciences of the United States of America. vol 102. issue 26. 2005-08-11. PMID:15964987. |
endocannabinoid signaling thus is able to keep population discharge patterns within a narrow physiological time window, balancing between epilepsy on one side and sparse activity on the other, which may result in impaired developmental plasticity. |
2005-08-11 |
2023-08-12 |
human |
| Toru Kobayashi, Kazuo Washiyama, Kazutaka Iked. Modulators of G protein-activated inwardly rectifying K+ channels: potentially therapeutic agents for addictive drug users. Annals of the New York Academy of Sciences. vol 1025. 2005-02-18. PMID:15542767. |
therefore, girk channel modulators might be potential agents for the treatment of users of addictive drugs, such as cocaine, opioids, cannabinoids, and ethanol, as well as for the treatment of epilepsy and pain. |
2005-02-18 |
2023-08-12 |
mouse |
| Alison J Drysdale, Bettina Plat. Cannabinoids: mechanisms and therapeutic applications in the CNS. Current medicinal chemistry. vol 10. issue 24. 2004-02-02. PMID:14529462. |
a number of both in vitro and in vivo models have provided promising but diverse evidence for cannabinoid protection in glutamate-mediated excitotoxicity, hypoxia and glucose deprivation, brain trauma, epilepsy and ms. |
2004-02-02 |
2023-08-12 |
Not clear |
| R Mechoulam, A H Lichtma. Neuroscience. Stout guards of the central nervous system. Science (New York, N.Y.). vol 302. issue 5642. 2003-10-24. PMID:14526067. |
showing that activation of the cannabinoid receptor cb1 by the endocannabinoid anandamide protects against excitotoxic damage in a mouse model of kainic acid-induced epilepsy. |
2003-10-24 |
2023-08-12 |
mouse |
| Melisa J Wallace, Robert E Blair, Katherine W Falenski, Billy R Martin, Robert J DeLorenz. The endogenous cannabinoid system regulates seizure frequency and duration in a model of temporal lobe epilepsy. The Journal of pharmacology and experimental therapeutics. vol 307. issue 1. 2003-10-23. PMID:12954810. |
however, the anticonvulsant potential of cannabinoids and, moreover, the role of the endogenous cannabinoid system in regulating seizure activity has not been tested in an in vivo model of epilepsy that is characterized by spontaneous, recurrent seizures. |
2003-10-23 |
2023-08-12 |
rat |