| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Mauro Montalbano, Elizabeth Jaworski, Stephanie Garcia, Anna Ellsworth, Salome McAllen, Andrew Routh, Rakez Kaye. Tau Modulates mRNA Transcription, Alternative Polyadenylation Profiles of hnRNPs, Chromatin Remodeling and Spliceosome Complexes. Frontiers in molecular neuroscience. vol 14. 2021-12-20. PMID:34924950. |
tau protein is a known contributor in several neurodegenerative diseases, including alzheimer's disease (ad) and frontotemporal dementia (ftd). |
2021-12-20 |
2023-08-13 |
human |
| Pei-Pei Guan, Long-Long Cao, Yi Yang, Pu Wan. Calcium Ions Aggravate Alzheimer's Disease Through the Aberrant Activation of Neuronal Networks, Leading to Synaptic and Cognitive Deficits. Frontiers in molecular neuroscience. vol 14. 2021-12-20. PMID:34924952. |
alzheimer's disease (ad) is a neurodegenerative disease that is characterized by the production and deposition of β-amyloid protein (aβ) and hyperphosphorylated tau, leading to the formation of β-amyloid plaques (aps) and neurofibrillary tangles (nfts). |
2021-12-20 |
2023-08-13 |
Not clear |
| Enrique Luengo, Paula Trigo-Alonso, Cristina Fernández-Mendívil, Ángel Nuñez, Marta Del Campo, César Porrero, Nuria García-Magro, Pilar Negredo, Sergio Senar, Cristina Sánchez-Ramos, Juan A Bernal, Alberto Rábano, Jeroen Hoozemans, Ana I Casas, Harald H H W Schmidt, Manuela G Lópe. Implication of type 4 NADPH oxidase (NOX4) in tauopathy. Redox biology. vol 49. 2021-12-18. PMID:34922273. |
aggregates of the microtubule-associated protein tau are a common marker of neurodegenerative diseases collectively termed as tauopathies, such as alzheimer's disease (ad) and frontotemporal dementia. |
2021-12-18 |
2023-08-13 |
mouse |
| Maria Ricci, Andrea Cimini, Riccardo Camedda, Agostino Chiaravalloti, Orazio Schillac. Tau Biomarkers in Dementia: Positron Emission Tomography Radiopharmaceuticals in Tauopathy Assessment and Future Perspective. International journal of molecular sciences. vol 22. issue 23. 2021-12-10. PMID:34884804. |
we also describe the distribution patterns of tau tracers in ad, in atypical ad, and further neurodegenerative diseases in the dementia field. |
2021-12-10 |
2023-08-13 |
Not clear |
| Airi Tarutani, Haruka Miyata, Takashi Nonaka, Kazuko Hasegawa, Mari Yoshida, Yuko Saito, Shigeo Murayama, Andrew C Robinson, David M A Mann, Taisuke Tomita, Masato Hasegaw. Human tauopathy-derived tau strains determine the substrates recruited for templated amplification. Brain : a journal of neurology. vol 144. issue 8. 2021-12-08. PMID:33693528. |
tauopathies are a subset of neurodegenerative diseases characterized by abnormal tau inclusions. |
2021-12-08 |
2023-08-13 |
human |
| Ana Damianich, Carolina Lucia Facal, Javier Andrés Muñiz, Camilo Mininni, Mariano Soiza-Reilly, Magdalena Ponce De León, Leandro Urrutia, German Falasco, Juan Esteban Ferrario, María Elena Aval. Tau mis-splicing correlates with motor impairments and striatal dysfunction in a model of tauopathy. Brain : a journal of neurology. vol 144. issue 8. 2021-12-08. PMID:34059893. |
tauopathies are neurodegenerative diseases caused by the abnormal metabolism of the microtubule associated protein tau (mapt), which is highly expressed in neurons and critically involved in microtubule dynamics. |
2021-12-08 |
2023-08-13 |
mouse |
| Danny M Hatter. Flipping the switch: How cysteine oxidation directs tau amyloid conformations. The Journal of biological chemistry. vol 297. issue 5. 2021-12-08. PMID:34656563. |
tau can adopt distinct fibril conformations in different human neurodegenerative diseases, which may invoke distinct pathological mechanisms. |
2021-12-08 |
2023-08-13 |
human |
| Gesine Respondek, Lea Krey, Meret Huber, Henning Pflugrad, Florian Wegner, Günter U Höglinge. [Neuroprotective treatment of tauopathies]. Der Nervenarzt. vol 92. issue 12. 2021-12-07. PMID:34652482. |
tau pathology is now considered to be the main cause of a wide spectrum of neurodegenerative diseases, which are collectively referred to as tauopathies. |
2021-12-07 |
2023-08-13 |
Not clear |
| Rodrigo Diaz-Espinoz. Recent High-Resolution Structures of Amyloids Involved in Neurodegenerative Diseases. Frontiers in aging neuroscience. vol 13. 2021-12-07. PMID:34867305. |
tau and α-sn aggregates are also present in other neurodegenerative diseases. |
2021-12-07 |
2023-08-13 |
Not clear |
| Lubov A Ezerskiy, Kathleen M Schoch, Chihiro Sato, Mariana Beltcheva, Kanta Horie, Frank Rigo, Ryan Martynowicz, Celeste M Karch, Randall J Bateman, Timothy M Mille. Astrocytic 4R tau expression drives astrocyte reactivity and dysfunction. JCI insight. 2021-12-07. PMID:34874917. |
the protein tau and its isoforms are associated with several neurodegenerative diseases, many of which are characterized by greater deposition of the 4r tau isoform; however, the role of 4r tau in disease pathogenesis remains unclear. |
2021-12-07 |
2023-08-13 |
mouse |
| Lubov A Ezerskiy, Kathleen M Schoch, Chihiro Sato, Mariana Beltcheva, Kanta Horie, Frank Rigo, Ryan Martynowicz, Celeste M Karch, Randall J Bateman, Timothy M Mille. Astrocytic 4R tau expression drives astrocyte reactivity and dysfunction. JCI insight. 2021-12-07. PMID:34874917. |
these findings support a novel pathway by which astrocytic 4r tau mediates reactivity and dysfunction and suggest that astrocyte-targeted therapeutics against 4r tau may mitigate neurodegenerative disease progression. |
2021-12-07 |
2023-08-13 |
mouse |
| Kaoru Yagita, Hiroyuki Honda, Tomoyuki Ohara, Hideomi Hamasaki, Sachiko Koyama, Hideko Noguchi, Akane Mihara, Taro Nakazawa, Jun Hata, Toshiharu Ninomiya, Toru Iwak. A Comparative Study of Site-Specific Distribution of Aging-Related Tau Astrogliopathy and Its Risk Factors Between Alzheimer Disease and Cognitive Healthy Brains: The Hisayama Study. Journal of neuropathology and experimental neurology. 2021-12-07. PMID:34875089. |
knowledge of aging-related tau astrogliopathy (artag) in healthy elderly individuals remains incomplete and studies to date have not focused on the olfactory nerve, which is a vulnerable site of various neurodegenerative disease pathologies. |
2021-12-07 |
2023-08-13 |
Not clear |
| Leonie Beyer, Matthias Brende. Imaging of Tau Pathology in Neurodegenerative Diseases: An Update. Seminars in nuclear medicine. vol 51. issue 3. 2021-12-02. PMID:33353724. |
imaging of tau pathology in neurodegenerative diseases: an update. |
2021-12-02 |
2023-08-13 |
Not clear |
| Leonie Beyer, Matthias Brende. Imaging of Tau Pathology in Neurodegenerative Diseases: An Update. Seminars in nuclear medicine. vol 51. issue 3. 2021-12-02. PMID:33353724. |
pathological accumulated misfolded tau underlies various neurodegenerative diseases and associated clinical syndromes. |
2021-12-02 |
2023-08-13 |
Not clear |
| Ahmed Soliman, Lidia Bakota, Roland Brand. Microtubule-modulating agents in the fight against neurodegeneration: Will it ever work? Current neuropharmacology. 2021-12-02. PMID:34852744. |
many neurodegenerative diseases are characterized by changes in the structure and organization of microtubules and microtubule-regulating proteins such as the microtubule-associated protein tau, which exhibits characteristic changes in a whole class of diseases collectively referred to as tauopathies. |
2021-12-02 |
2023-08-13 |
Not clear |
| Ahmed Soliman, Lidia Bakota, Roland Brand. Microtubule-modulating agents in the fight against neurodegeneration: Will it ever work? Current neuropharmacology. 2021-12-02. PMID:34852744. |
in this article, we review current microtubule-directed approaches for the treatment of neurodegenerative diseases with microtubules as drug target, tau as drug target, and posttranslational modifications as potential modifiers of the microtubule system. |
2021-12-02 |
2023-08-13 |
Not clear |
| Meihua Jin, Hiroki Shiwaku, Hikari Tanaka, Takayuki Obita, Sakurako Ohuchi, Yuki Yoshioka, Xiaocen Jin, Kanoh Kondo, Kyota Fujita, Hidenori Homma, Kazuyuki Nakajima, Mineyuki Mizuguchi, Hitoshi Okazaw. Tau activates microglia via the PQBP1-cGAS-STING pathway to promote brain inflammation. Nature communications. vol 12. issue 1. 2021-11-30. PMID:34782623. |
collectively, pqbp1 is an intracellular receptor in the cgas-sting pathway not only for cdna of human immunodeficiency virus (hiv) but also for the transmissible neurodegenerative disease protein tau. |
2021-11-30 |
2023-08-13 |
mouse |
| Valentina Latina, Giacomo Giacovazzo, Pietro Calissano, Anna Atlante, Federico La Regina, Francesca Malerba, Marco Dell'Aquila, Egidio Stigliano, Bijorn Omar Balzamino, Alessandra Micera, Roberto Coccurello, Giuseppina Amador. Tau Cleavage Contributes to Cognitive Dysfunction in Strepto-Zotocin-Induced Sporadic Alzheimer's Disease (sAD) Mouse Model. International journal of molecular sciences. vol 22. issue 22. 2021-11-30. PMID:34830036. |
tau cleavage plays a crucial role in the onset and progression of alzheimer's disease (ad), a widespread neurodegenerative disease whose incidence is expected to increase in the next years. |
2021-11-30 |
2023-08-13 |
mouse |
| Mar Pacheco-Herrero, Luis O Soto-Rojas, Heidy Reyes-Sabater, Linda Garcés-Ramirez, Fidel de la Cruz López, Ignacio Villanueva-Fierro, José Luna-Muño. Current Status and Challenges of Stem Cell Treatment for Alzheimer's Disease. Journal of Alzheimer's disease : JAD. vol 84. issue 3. 2021-11-29. PMID:34633316. |
neurodegenerative diseases called tauopathies, such as alzheimer's disease (ad), frontotemporal dementia, progressive supranuclear palsy, and parkinson's disease, among others, are characterized by the pathological processing and accumulation of tau protein. |
2021-11-29 |
2023-08-13 |
Not clear |
| Miguel Portillo, Ekaterina Eremenko, Shai Kaluski, Alfredo Garcia-Venzor, Lior Onn, Daniel Stein, Zeev Slobodnik, Adam Zaretsky, Uwe Ueberham, Monica Einav, Martina K Brückner, Thomas Arendt, Debra Toibe. SIRT6-CBP-dependent nuclear Tau accumulation and its role in protein synthesis. Cell reports. vol 35. issue 4. 2021-11-24. PMID:33910019. |
several neurodegenerative diseases present tau accumulation as the main pathological marker. |
2021-11-24 |
2023-08-13 |
human |