| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| R B Banati, J Gehrmann, M Kellner, F Holsboe. Antibodies against microglia/brain macrophages in the cerebrospinal fluid of a patient with acute amyotrophic lateral sclerosis and presenile dementia. Clinical neuropathology. vol 14. issue 4. 1996-01-19. PMID:8521621. |
our data provide evidence for a close link between neurodegeneration and the activation of microglia; a possible local antigen production against microglia/brain macrophages, which might regulate the concomitant glial activation in neurodegenerative diseases; and the presence of microglia-binding cerebrospinal antibodies as a marker for the acuity of the disease process underlying the acute deterioration of the neurological and cognitive performance in patients with, e.g., als. |
1996-01-19 |
2023-08-12 |
human |
| R B Banati, J Gehrmann, C Czech, U Mönning, L L Jones, G König, K Beyreuther, G W Kreutzber. Early and rapid de novo synthesis of Alzheimer beta A4-amyloid precursor protein (APP) in activated microglia. Glia. vol 9. issue 3. 1994-02-28. PMID:7507467. |
such immune-mediated amyloidogenesis initiated by microglia might have implications for the treatment of neurodegenerative diseases. |
1994-02-28 |
2023-08-12 |
Not clear |
| D M Reid, V H Perry, P B Andersson, S Gordo. Mitosis and apoptosis of microglia in vivo induced by an anti-CR3 antibody which crosses the blood-brain barrier. Neuroscience. vol 56. issue 3. 1994-01-13. PMID:8255420. |
microglia become activated in many neuropathological conditions including chronic neurodegenerative diseases and human immunodeficiency virus neuropathology, yet little is known of the mechanisms involved. |
1994-01-13 |
2023-08-12 |
human |
| E R Whittemore, A R Korotzer, A Etebari, C W Cotma. Carbachol increases intracellular free calcium in cultured rat microglia. Brain research. vol 621. issue 1. 1993-12-09. PMID:8106116. |
furthermore, since cholinergic fibers have been shown to infiltrate neuritic plaques in alzheimer's disease (ad) and microglia have been reported to be activated in plaques, these results suggest that interactions between select neurotransmitters and microglia may play a key role in neurodegenerative diseases. |
1993-12-09 |
2023-08-12 |
rat |
| C C Chao, T W Molitor, S H. Neuroprotective role of IL-4 against activated microglia. Journal of immunology (Baltimore, Md. : 1950). vol 151. issue 3. 1993-08-26. PMID:8335941. |
microglia have been proposed to play a pathogenetic role in immunologically mediated neurodegenerative diseases. |
1993-08-26 |
2023-08-12 |
Not clear |
| A Sasaki, S W Levison, J P Tin. Differential suppression of interferon-gamma-induced Ia antigen expression on cultured rat astroglia and microglia by second messengers. Journal of neuroimmunology. vol 29. issue 1-3. 1990-11-05. PMID:2170439. |
these findings may explain the frequent observation of ia+ microglia (or macrophages) but not astroglia in various neurodegenerative diseases. |
1990-11-05 |
2023-08-11 |
rat |