| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Zengguang Wang, Zhenglin Dong, Yiming Li, Xin Jiao, Yihao Liu, Hanwen Chang, Yaokai Ga. Verapamil Attenuates the Severity of Tendinopathy by Mitigating Mitochondrial Dysfunction through the Activation of the Nrf2/HO-1 Pathway. Biomedicines. vol 12. issue 4. 2024-04-27. PMID:38672259. |
the in vitro findings highlighted the remarkable ability of verapamil to attenuate extracellular matrix degradation and apoptosis triggered by inflammation in tenocytes stimulated by il-1β. |
2024-04-27 |
2024-04-29 |
rat |
| Weilu Gao, Rui Liu, Keke Huang, Wenhan Fu, Anquan Wang, Gongwen Du, Hao Tang, Li Yin, Zongsheng S Yi. CHMP5 attenuates osteoarthritis via inhibiting chondrocyte apoptosis and extracellular matrix degradation: involvement of NF-κB pathway. Molecular medicine (Cambridge, Mass.). vol 30. issue 1. 2024-04-26. PMID:38664616. |
chmp5 attenuates osteoarthritis via inhibiting chondrocyte apoptosis and extracellular matrix degradation: involvement of nf-κb pathway. |
2024-04-26 |
2024-04-28 |
Not clear |
| Weilu Gao, Rui Liu, Keke Huang, Wenhan Fu, Anquan Wang, Gongwen Du, Hao Tang, Li Yin, Zongsheng S Yi. CHMP5 attenuates osteoarthritis via inhibiting chondrocyte apoptosis and extracellular matrix degradation: involvement of NF-κB pathway. Molecular medicine (Cambridge, Mass.). vol 30. issue 1. 2024-04-26. PMID:38664616. |
osteoarthritis (oa), the most common joint disease, is linked with chondrocyte apoptosis and extracellular matrix (ecm) degradation. |
2024-04-26 |
2024-04-28 |
Not clear |
| P G Roopashree, Shilpa S Shetty, Vijith Vittal Shetty, P C Suhasini, Kumari N Sucheth. Inhibitory effects of medium-chain fatty acids on the proliferation of human breast cancer cells via suppression of Akt/mTOR pathway and modulating the Bcl-2 family protein. Journal of cellular biochemistry. 2024-04-26. PMID:38666486. |
to investigate the apoptosis-inducing effect of mcfas in breast cancer cells, cell viability assay, colony formation assay, cell migration assay, cell invasion assay, nuclear morphology, cell cycle assay, intracellular reactive oxygen species (ros), matrix metalloproteinase (mmp), apoptosis, rt-qpcr analysis, and western blot analysis were performed. |
2024-04-26 |
2024-04-28 |
human |
| Binbin Hu, Guihong Liu, Kejia Zhao, Gao Zhan. Diversity of extracellular HSP70 in cancer: advancing from a molecular biomarker to a novel therapeutic target. Frontiers in oncology. vol 14. 2024-04-22. PMID:38646439. |
ehsp70 is involved in a broad range of cancer-related events, including cell proliferation and apoptosis, extracellular matrix (ecm) remodeling, epithelial-mesenchymal transition (emt), angiogenesis, and immune response. |
2024-04-22 |
2024-04-24 |
Not clear |
| Sung Su Park, Wonjun Cho, Do Su Lim, Hyeon Ji Gwon, Sung Woo Choi, A M Abd El-Aty, Hacı Ahmet Aydemir, Ji Hoon Jeong, Tae Woo Jun. AMPK/autophagy-mediated alleviation of tendinopathy by IL-38: A novel strategy for the treatment of obesity-related tendinopathy. Tissue & cell. vol 88. 2024-04-21. PMID:38643674. |
these results suggest that il-38 alleviates er stress through the ampk/autophagy pathway, thereby reducing apoptosis and preventing extracellular matrix (ecm) degradation in tenocytes under hyperlipidemic conditions. |
2024-04-21 |
2024-04-24 |
human |
| Mengwei Li, Xiaojun Yu, Xin Chen, Yongqiao Jiang, Yunqian Zeng, Ranyue Ren, Mingbo Nie, Ziyang Zhang, Yuan Bao, Hao Kan. Genkwanin alleviates intervertebral disc degeneration via regulating ITGA2/PI3K/AKT pathway and inhibiting apoptosis and senescence. International immunopharmacology. vol 133. 2024-04-19. PMID:38640717. |
in conclusion, this study suggest that genkwanin inhibits inflammation in nucleus pulposus cells, promotes extracellular matrix remodeling, suppresses cellular senescence and apoptosis, through the itga2/pi3k/akt, nf-κb and mapk signaling pathways. |
2024-04-19 |
2024-04-22 |
rat |
| Xiang-Ning He, Wei-Dan Jiang, Pei Wu, Yang Liu, Hong-Mei Ren, Xiao-Wan Jin, Sheng-Yao Kuang, Ling Tang, Shu-Wei Li, Lin Feng, Xiao-Qiu Zho. Aflatoxin B1 inhibited the development of primary myoblasts of grass carp (Ctenopharyngodon idella) by degrading extracellular matrix. Ecotoxicology and environmental safety. vol 276. 2024-04-16. PMID:38626608. |
as a result, our findings suggested that afb1 damaged the cell morphology, induced oxidative damage and apoptosis, degraded ecm components, in turn inhibiting myoblast development by activating the p38mapk/urokinase-type plasminogen activator (upa)/matrix metalloproteinase (mmps)/extracellular matrix (ecm) signaling pathway. |
2024-04-16 |
2024-04-19 |
cat |
| Yingxin Lu, Ying Huang, Jiyu Jin, Jiahui Yu, Wei Lu, Shulei Zh. Design, synthesis, and biological evaluation of cathepsin B cleavage albumin-binding SN38 prodrug in breast cancer. Bioorganic chemistry. vol 147. 2024-04-15. PMID:38621338. |
histological immunohistochemical analyses further illuminate the multifaceted impact of our prodrug, showcasing elevated levels of apoptosis, downregulated expression of matrix metalloproteinases, and inhibition of angiogenesis, all critical factors contributing to the anti-metastatic effect observed. |
2024-04-15 |
2024-04-18 |
human |
| Hang Lv, Peiran Liu, Hai Hu, Xiaodong Li, Pengfei L. MiR-98-5p plays suppressive effects on IL-1β-induced chondrocyte injury associated with osteoarthritis by targeting CASP3. Journal of orthopaedic surgery and research. vol 19. issue 1. 2024-04-13. PMID:38615043. |
this study aims to explore how mir-98-5p affects osteoarthritis, focusing on its role in chondrocyte inflammation, apoptosis, and extracellular matrix (ecm) degradation. |
2024-04-13 |
2024-04-16 |
Not clear |
| Valentina Fustaino, Giuliana Papoff, Francesca Ruberti, Giovina Rubert. Co-Expression Network Analysis Unveiled lncRNA-mRNA Links Correlated to Epidermal Growth Factor Receptor-Tyrosine Kinase Inhibitor Resistance and/or Intermediate Epithelial-to-Mesenchymal Transition Phenotypes in a Human Non-Small Cell Lung Cancer Cellular Model System. International journal of molecular sciences. vol 25. issue 7. 2024-04-13. PMID:38612674. |
processes enriched in the selected modules included rho (a, b, c) gtpase and regulatory signaling pathways, apoptosis, inflammatory and interleukin signaling pathways, cell adhesion, cell migration, cell and extracellular matrix organization, metabolism, and lipid metabolism. |
2024-04-13 |
2024-04-15 |
human |
| Haizhu Gao, Zhongxin Li, Lijun Gan, Xueying Che. The Role and Potential Mechanisms of Rehabilitation Exercise Improving Cardiac Remodeling. Journal of cardiovascular translational research. 2024-04-01. PMID:38558377. |
exercise training can mitigate cardiomyocyte apoptosis, reduce extracellular matrix deposition and fibrosis, promote angiogenesis, and regulate inflammatory response to improve cardiac remodeling. |
2024-04-01 |
2024-04-04 |
Not clear |
| Ieva Vanaga, Oksana Kolesova, Aleksandrs Kolesovs, Gunta Sture, Elvira Hagina, Jelena Storozenko, Liene Nikitina-Zake, Ludmila Viksn. Association of human leukocyte antigen class II alleles with epithelial cell apoptosis and extracellular matrix production in acute COVID-19. Central-European journal of immunology. vol 48. issue 4. 2024-04-01. PMID:38558559. |
association of human leukocyte antigen class ii alleles with epithelial cell apoptosis and extracellular matrix production in acute covid-19. |
2024-04-01 |
2024-04-04 |
human |
| Ieva Vanaga, Oksana Kolesova, Aleksandrs Kolesovs, Gunta Sture, Elvira Hagina, Jelena Storozenko, Liene Nikitina-Zake, Ludmila Viksn. Association of human leukocyte antigen class II alleles with epithelial cell apoptosis and extracellular matrix production in acute COVID-19. Central-European journal of immunology. vol 48. issue 4. 2024-04-01. PMID:38558559. |
our study assessed the relationships between hla class ii alleles and covid-19 severity and blood-based indicators of systemic inflammation and organ damage, serum markers of epithelial cell apoptosis such as caspase-cleaved ck18 fragment m30 (ck18-m30) and the extracellular matrix product hyaluronic acid (ha). |
2024-04-01 |
2024-04-04 |
human |
| Abedeh Rezaei, Amin Moqadami, Mohammad Khalaj-Kondori, Mohammad Ali Hosseinpour Feiz. Minocycline induced apoptosis and suppressed expression of matrix metalloproteinases 2 and 9 in the breast cancer MCF-7 cells. Molecular biology reports. vol 51. issue 1. 2024-03-29. PMID:38551800. |
minocycline induced apoptosis and suppressed expression of matrix metalloproteinases 2 and 9 in the breast cancer mcf-7 cells. |
2024-03-29 |
2024-04-01 |
Not clear |
| Chun-Yen Wu, Da-Fong Song, Zhi-Jia Chen, Chao-Sheng Hu, David Pei-Cheng Lin, Han-Hsin Chan. Absence of the Klotho Function Causes Cornea Degeneration with Specific Features Resembling Fuchs Endothelial Corneal Dystrophy and Bullous Keratopathy. Biology. vol 13. issue 3. 2024-03-27. PMID:38534403. |
the mechanism analysis showed multi-fold abnormalities, including oxidative stress-induced cornea epithelium apoptosis and inflammation, extracellular matrix remodeling in the stroma, and a disruption of epithelial repair, presumably through the epithelial-mesenchymal transition. |
2024-03-27 |
2024-03-29 |
mouse |
| Ye Feng, Zhengzhe Li, Heather Wang, Bi-Cheng Liu, Kyung Lee, John Cijiang H. HIPK2 C-terminal domain inhibits NF-κB signaling and renal inflammation in kidney injury. JCI insight. 2024-03-21. PMID:38512421. |
it acts as a central effector of multiple signaling pathways implicated in kidney injury, such as tgf-β/smad3-mediated extracellular matrix accumulation, nf-κb-mediated inflammation, and p53-mediated apoptosis. |
2024-03-21 |
2024-03-24 |
mouse |
| Amin Moqadami, Mohammad Khalaj-Kondori, Mohammad Ali Hosseinpour Feizi, Behzad Baradara. Minocycline declines interleukin-1ß-induced apoptosis and matrix metalloproteinase expression in C28/I2 chondrocyte cells: an in vitro study on osteoarthritis. EXCLI journal. vol 23. 2024-03-15. PMID:38487083. |
minocycline declines interleukin-1ß-induced apoptosis and matrix metalloproteinase expression in c28/i2 chondrocyte cells: an in vitro study on osteoarthritis. |
2024-03-15 |
2024-03-17 |
human |
| Amin Moqadami, Mohammad Khalaj-Kondori, Mohammad Ali Hosseinpour Feizi, Behzad Baradara. Minocycline declines interleukin-1ß-induced apoptosis and matrix metalloproteinase expression in C28/I2 chondrocyte cells: an in vitro study on osteoarthritis. EXCLI journal. vol 23. 2024-03-15. PMID:38487083. |
interleukin-1 beta (il-1β) is increased in the injured joints and contributes to the oa pathobiology by inducing chondrocyte apoptosis and up-regulation of matrix metalloproteinases (mmps). |
2024-03-15 |
2024-03-17 |
human |
| Yaling Yu, Yixin Jiang, Hongfan Ge, Xiaoli Fan, Hang Gao, Zhenlei Zho. HIF-1α in cartilage homeostasis, apoptosis, and glycolysis in mice with steroid-induced osteonecrosis of the femoral head. Journal of cellular physiology. 2024-03-14. PMID:38481029. |
in this study, sonfh models were established using methylprednisolone (mps) in mouse and its proliferating chondrocytes to investigate the role of hif-1α in cartilage differentiation, extracellular matrix (ecm) homeostasis, apoptosis and glycolysis in sonfh mice. |
2024-03-14 |
2024-03-16 |
mouse |