| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| C R Almli, T J Levy, B H Han, A R Shah, J M Gidday, D M Holtzma. BDNF protects against spatial memory deficits following neonatal hypoxia-ischemia. Experimental neurology. vol 166. issue 1. 2000-12-07. PMID:11031087. |
the present study explored potential relationships between neural protective and behavioral protective strategies in this neonatal h-i model by determining if neonatal h-i was associated with behavioral spatial learning and memory deficits and whether the neurotrophin bdnf was protective against both brain injury and spatial learning/memory dysfunction. |
2000-12-07 |
2023-08-12 |
human |
| C R Almli, T J Levy, B H Han, A R Shah, J M Gidday, D M Holtzma. BDNF protects against spatial memory deficits following neonatal hypoxia-ischemia. Experimental neurology. vol 166. issue 1. 2000-12-07. PMID:11031087. |
postnatal day seven rats received vehicle or bdnf pretreatments (intracerebroventricular injections) followed by h-i or sham treatments and then tested for spatial learning and memory on the simple place task in the morris water maze from postnatal days 20 to 30, and their brains were histologically analyzed at 4 weeks following treatments. |
2000-12-07 |
2023-08-12 |
human |
| M Mizuno, K Yamada, A Olariu, H Nawa, T Nabeshim. Involvement of brain-derived neurotrophic factor in spatial memory formation and maintenance in a radial arm maze test in rats. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 20. issue 18. 2000-10-18. PMID:10995859. |
to clarify the causal relation between bdnf mrna expression and spatial memory formation, we examined the effects of antisense bdnf treatment on spatial learning and memory. |
2000-10-18 |
2023-08-12 |
rat |
| M J Schaaf, R M Sibug, R Duurland, M F Fluttert, M S Oitzl, E R De Kloet, E Vreugdenhi. Corticosterone effects on BDNF mRNA expression in the rat hippocampus during morris water maze training. Stress (Amsterdam, Netherlands). vol 3. issue 2. 2000-09-14. PMID:10938578. |
hence, our results suggest that in this situation bdnf is resistant to regulation by endogenous corticosterone, which may be important for learning and memory processes. |
2000-09-14 |
2023-08-12 |
rat |
| D Liu, J Diorio, J C Day, D D Francis, M J Meane. Maternal care, hippocampal synaptogenesis and cognitive development in rats. Nature neuroscience. vol 3. issue 8. 2000-08-15. PMID:10903573. |
thus, the offspring of mothers that show high levels of pup licking and grooming and arched-back nursing showed increased expression of nmda receptor subunit and brain-derived neurotrophic factor (bdnf) mrna, increased cholinergic innervation of the hippocampus and enhanced spatial learning and memory. |
2000-08-15 |
2023-08-12 |
rat |
| C Aoki, K Wu, A Elste, G w Len, S y Lin, G McAuliffe, I B Blac. Localization of brain-derived neurotrophic factor and TrkB receptors to postsynaptic densities of adult rat cerebral cortex. Journal of neuroscience research. vol 59. issue 3. 2000-03-16. PMID:10679783. |
brain-derived neurotrophic factor (bdnf) rapidly increases synaptic transmission in hippocampal neurons, and enhances long-term potentiation (ltp), a cellular and molecular model of learning and memory. |
2000-03-16 |
2023-08-12 |
rat |
| R R Hicks, V B Martin, L Zhang, K B Seroog. Mild experimental brain injury differentially alters the expression of neurotrophin and neurotrophin receptor mRNAs in the hippocampus. Experimental neurology. vol 160. issue 2. 2000-01-14. PMID:10619564. |
neurotrophins, such as brain-derived neurotrophic factor (bdnf), have been identified as having a role in learning and memory. |
2000-01-14 |
2023-08-12 |
rat |
| B Lu, A Cho. Neurotrophins and hippocampal synaptic transmission and plasticity. Journal of neuroscience research. vol 58. issue 1. 1999-11-04. PMID:10491573. |
more consistent evidence has been obtained for the role of bdnf in long-term potentiation (ltp), a cellular model for learning and memory. |
1999-11-04 |
2023-08-12 |
Not clear |
| J S Mu, W P Li, Z B Yao, X F Zho. Deprivation of endogenous brain-derived neurotrophic factor results in impairment of spatial learning and memory in adult rats. Brain research. vol 835. issue 2. 1999-09-28. PMID:10415381. |
the present study was under taken to investigate whether endogenous bdnf was required for spatial learning and memory in a rat model. |
1999-09-28 |
2023-08-12 |
rat |
| J S Mu, W P Li, Z B Yao, X F Zho. Deprivation of endogenous brain-derived neurotrophic factor results in impairment of spatial learning and memory in adult rats. Brain research. vol 835. issue 2. 1999-09-28. PMID:10415381. |
these results suggest that endogenous bdnf is required for spatial learning and memory in adult rats. |
1999-09-28 |
2023-08-12 |
rat |
| J P Kesslak, V So, J Choi, C W Cotman, F Gomez-Pinill. Learning upregulates brain-derived neurotrophic factor messenger ribonucleic acid: a mechanism to facilitate encoding and circuit maintenance? Behavioral neuroscience. vol 112. issue 4. 1999-03-09. PMID:9733207. |
brain-derived neurotrophic factor (bdnf) promotes neuron survival, enhances sprouting, protects neurons against insult, and may be involved in several aspects of learning and memory. |
1999-03-09 |
2023-08-12 |
rat |
| V Lessman. Neurotrophin-dependent modulation of glutamatergic synaptic transmission in the mammalian CNS. General pharmacology. vol 31. issue 5. 1998-12-23. PMID:9809461. |
in addition, long-term potentiation (a potential cellular correlate for learning and memory formation in mammals) in the rodent hippocampus depends on endogenous supply of neurons with bdnf. |
1998-12-23 |
2023-08-12 |
Not clear |
| L Shen, A Figurov, B L. Recent progress in studies of neurotrophic factors and their clinical implications. Journal of molecular medicine (Berlin, Germany). vol 75. issue 9. 1998-01-30. PMID:9351702. |
physiological experiments indicate that bdnf may serve as regulatory factors for synaptic transmission as well as for learning and memory. |
1998-01-30 |
2023-08-12 |
Not clear |
| B Lu, A Figuro. Role of neurotrophins in synapse development and plasticity. Reviews in the neurosciences. vol 8. issue 1. 1998-01-30. PMID:9402641. |
gene targeting and physiological experiments demonstrate that brain-derived neurotrophic factor (bdnf) plays an important role in long-term potentiation (ltp), a cellular model for learning and memory. |
1998-01-30 |
2023-08-12 |
Not clear |
| A Montkowski, F Holsboe. Intact spatial learning and memory in transgenic mice with reduced BDNF. Neuroreport. vol 8. issue 3. 1997-07-03. PMID:9106766. |
intact spatial learning and memory in transgenic mice with reduced bdnf. |
1997-07-03 |
2023-08-12 |
mouse |
| E S Levine, C F Dreyfus, I B Black, M R Plumme. Brain-derived neurotrophic factor rapidly enhances synaptic transmission in hippocampal neurons via postsynaptic tyrosine kinase receptors. Proceedings of the National Academy of Sciences of the United States of America. vol 92. issue 17. 1995-09-21. PMID:7644540. |
in the hippocampus, an area critically involved in learning and memory, we have found that brain-derived neurotrophic factor (bdnf) rapidly enhanced synaptic efficacy through a previously unreported mechanism--increased postsynaptic responsiveness via a phosphorylation-dependent pathway. |
1995-09-21 |
2023-08-12 |
Not clear |
| W Fischer, A Sirevaag, S J Wiegand, R M Lindsay, A Björklun. Reversal of spatial memory impairments in aged rats by nerve growth factor and neurotrophins 3 and 4/5 but not by brain-derived neurotrophic factor. Proceedings of the National Academy of Sciences of the United States of America. vol 91. issue 18. 1994-10-04. PMID:8078930. |
aged rats, displaying impairments in spatial learning and memory associated with marked cellular atrophy of forebrain cholinergic neurons, received intracerebroventricular infusions of one of the four neurotrophins nerve growth factor (ngf), brain-derived neurotrophic factor (bdnf), neurotrophin 3 (nt-3), or neurotrophin 4/5 (nt-4/5), or a combination of ngf and bdnf, or vehicle. |
1994-10-04 |
2023-08-12 |
rat |