| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| David M Rajathei, Subbiah Parthasarathy, Samuel Selvara. QSAR Analysis of Multimodal Antidepressants Vortioxetine Analogs Using Physicochemical Descriptors and MLR Modeling. Current computer-aided drug design. vol 15. issue 4. 2019-12-16. PMID:30317998. |
series of vortioxetine analogs have been reported as multi antidepressant compounds and they block serotonin transport into the neuronal cells, activate the postsynaptic 5-ht1a receptors and eliminate the low activity of 5-ht3a receptors. |
2019-12-16 |
2023-08-13 |
Not clear |
| Liang Xie, Jin Chen, Yong-Min Ding, Xian-Wei Gui, Lan-Xiang Wu, Sheng Tian, Wei W. MicroRNA-26a-2 maintains stress resiliency and antidepressant efficacy by targeting the serotonergic autoreceptor HTR1A. Biochemical and biophysical research communications. vol 511. issue 2. 2019-12-16. PMID:30808545. |
previous research on serotonergic (5-ht) neurons identified microrna-26a (mir-26a) targeting of the serotonin autoreceptor, 5-ht receptor 1a (htr1a). |
2019-12-16 |
2023-08-13 |
mouse |
| Winberg, Nilsso. Multiple high-affinity binding sites for The Journal of experimental biology. vol 199. issue Pt 11. 2019-11-20. PMID:9320352. |
the results provide evidence for at least three different high-affinity [3h]5-ht binding sites, one of them showing a pharmacological profile strikingly similar to that of the mammalian 5-ht1a receptor. |
2019-11-20 |
2023-08-12 |
Not clear |
| Monti, Janto. Dose-dependent effects of the 5-HT1A receptor agonist 8-OH-DPAT on sleep and wakefulness in the rat. Journal of sleep research. vol 1. issue 3. 2019-11-20. PMID:10607047. |
the opposite effects, observed on the waking eeg after activation of either serotonin autoreceptors or postsynaptic 5-ht1a receptors with adequate doses of 8-oh-dpat, tend to indicate an active role for the 5-ht1a receptor in the control of the waking state. |
2019-11-20 |
2023-08-12 |
rat |
| H. Bras, E. Jankowska, B. Noga, B. Skoo. Comparison of Effects of Various Types of NA and 5-HT Agonists on Transmission from Group II Muscle Afferents in the Cat. The European journal of neuroscience. vol 2. issue 12. 2019-11-20. PMID:12106064. |
the results suggest that this depression may involve different membrane receptors at different locations, primarily alpha2 adrenoceptors in the intermediate zone/ventral horn and 5-ht1a serotonin receptors in the dorsal horn. |
2019-11-20 |
2023-08-12 |
cat |
| Constantino Sotelo, Béatrice Cholley, Salah El Mestikawy, Henri Gozlan, Michel Hamo. Direct Immunohistochemical Evidence of the Existence of 5-HT1A Autoreceptors on Serotoninergic Neurons in the Midbrain Raphe Nuclei. The European journal of neuroscience. vol 2. issue 12. 2019-11-20. PMID:12106075. |
double immunohistochemical staining using the anti-5-ht1a receptor antibodies and an anti-serotonin (5-ht) antiserum showed that all the 5-ht1a receptor immunoreactive neurons in the dorsal raphe, and the vast majority of them in the median raphe, are serotoninergic neurons. |
2019-11-20 |
2023-08-12 |
Not clear |
| John F. Cryan, Brian E. Leonar. 5-HT1A and beyond: the role of serotonin and its receptors in depression and the antidepressant response. Human psychopharmacology. vol 15. issue 2. 2019-11-20. PMID:12404340. |
5-ht1a and beyond: the role of serotonin and its receptors in depression and the antidepressant response. |
2019-11-20 |
2023-08-12 |
human |
| M C O Citó, M I G Silva, L K X Santos, M L Fernandes, F H C Melo, J A C Aguiar, I S Lopes, P B Sousa, S M M Vasconcelos, D S Macêdo, F C F Sous. Antidepressant-like effect of Hoodia gordonii in a forced swimming test in mice: evidence for involvement of the monoaminergic system. Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas. vol 48. issue 1. 2019-11-20. PMID:25493384. |
the anti-immobility effect of h. gordonii was prevented by pretreatment of mice with pcpa [an inhibitor of serotonin (5-ht) synthesis], nan-190 (a 5-ht1a antagonist), ritanserin (a 5-ht2a/2c antagonist), ondansetron (a 5-ht3a antagonist), prazosin (an α1-adrenoceptor antagonist), sch23390 (a d1 receptor antagonist), yohimbine (an α2-adrenoceptor antagonist), and sulpiride (a d2 receptor antagonist). |
2019-11-20 |
2023-08-13 |
mouse |
| P P Fong, R Deguchi, K Kyozuk. Serotonergic Ligands Induce Spawning but not Oocyte Maturation in the Bivalve Mactra chinensis from Central Japan. The Biological bulletin. vol 191. issue 1. 2019-11-20. PMID:29220216. |
the vertebrate 5-ht2 receptor agonist alpha-methyl 5-ht and the selective 5ht1a agonist 8-oh-dpat were also effective at inducing spawning. |
2019-11-20 |
2023-08-13 |
Not clear |
| Shunsuke Tanahashi, Satoshi Yamamura, Masanori Nakagawa, Eishi Motomura, Motohiro Okad. Corrigendum to "Dopamine D2 and serotonin 5-HT1A receptors mediate the actions of aripiprazole in mesocortical and mesoaccumbens transmission" [Neuropharmacology 62 (2012) 765-774]. Neuropharmacology. vol 148. 2019-11-20. PMID:30733044. |
corrigendum to "dopamine d2 and serotonin 5-ht1a receptors mediate the actions of aripiprazole in mesocortical and mesoaccumbens transmission" [neuropharmacology 62 (2012) 765-774]. |
2019-11-20 |
2023-08-13 |
Not clear |
| Kathryn Lanza, Christopher Bisho. Serotonergic targets for the treatment of L-DOPA-induced dyskinesia. Journal of neural transmission (Vienna, Austria : 1996). vol 125. issue 8. 2019-11-04. PMID:29305656. |
this review discusses the rationale for continued investigation of several potential anti-dyskinetic strategies including 5-ht stimulation of 5-ht1a and 5-ht1b receptors and blockade of 5-ht2a receptors and sert. |
2019-11-04 |
2023-08-13 |
Not clear |
| Tristan J Philippe, Faranak Vahid-Ansari, Zoe R Donaldson, Brice Le François, Amin Zahrai, Valérie Turcotte-Cardin, Mireille Daigle, Jonathan James, René Hen, Zul Merali, Paul R Alber. Loss of MeCP2 in adult 5-HT neurons induces 5-HT1A autoreceptors, with opposite sex-dependent anxiety and depression phenotypes. Scientific reports. vol 8. issue 1. 2019-10-15. PMID:29636529. |
loss of mecp2 in adult 5-ht neurons induces 5-ht1a autoreceptors, with opposite sex-dependent anxiety and depression phenotypes. |
2019-10-15 |
2023-08-13 |
mouse |
| Tristan J Philippe, Faranak Vahid-Ansari, Zoe R Donaldson, Brice Le François, Amin Zahrai, Valérie Turcotte-Cardin, Mireille Daigle, Jonathan James, René Hen, Zul Merali, Paul R Alber. Loss of MeCP2 in adult 5-HT neurons induces 5-HT1A autoreceptors, with opposite sex-dependent anxiety and depression phenotypes. Scientific reports. vol 8. issue 1. 2019-10-15. PMID:29636529. |
the 5-ht1a autoreceptor mediates feedback inhibition of serotonin (5-ht) neurons, and is implicated in major depression. |
2019-10-15 |
2023-08-13 |
mouse |
| Tristan J Philippe, Faranak Vahid-Ansari, Zoe R Donaldson, Brice Le François, Amin Zahrai, Valérie Turcotte-Cardin, Mireille Daigle, Jonathan James, René Hen, Zul Merali, Paul R Alber. Loss of MeCP2 in adult 5-HT neurons induces 5-HT1A autoreceptors, with opposite sex-dependent anxiety and depression phenotypes. Scientific reports. vol 8. issue 1. 2019-10-15. PMID:29636529. |
these mice exhibited increased 5-ht1a autoreceptor levels and function, consistent with mecp2 enhancement of deaf1 repression in 5-ht neurons. |
2019-10-15 |
2023-08-13 |
mouse |
| Morteza Kosari-Nasab, Ghaffar Shokouhi, Maryam Azarfarin, Maryam Bannazadeh Amirkhiz, Mehran Mesgari Abbasi, Ali-Akbar Salar. Serotonin 5-HT1A receptors modulate depression-related symptoms following mild traumatic brain injury in male adult mice. Metabolic brain disease. vol 34. issue 2. 2019-08-13. PMID:30607822. |
serotonin 5-ht1a receptors modulate depression-related symptoms following mild traumatic brain injury in male adult mice. |
2019-08-13 |
2023-08-13 |
mouse |
| Morteza Kosari-Nasab, Ghaffar Shokouhi, Maryam Azarfarin, Maryam Bannazadeh Amirkhiz, Mehran Mesgari Abbasi, Ali-Akbar Salar. Serotonin 5-HT1A receptors modulate depression-related symptoms following mild traumatic brain injury in male adult mice. Metabolic brain disease. vol 34. issue 2. 2019-08-13. PMID:30607822. |
the aim of this study was to determine whether serotonin 5-hydroxytryptamine-1a (5-ht1a) receptor is involved in the regulation of depression-related behaviors following mild traumatic brain injury in mice. |
2019-08-13 |
2023-08-13 |
mouse |
| Morteza Kosari-Nasab, Ghaffar Shokouhi, Maryam Azarfarin, Maryam Bannazadeh Amirkhiz, Mehran Mesgari Abbasi, Ali-Akbar Salar. Serotonin 5-HT1A receptors modulate depression-related symptoms following mild traumatic brain injury in male adult mice. Metabolic brain disease. vol 34. issue 2. 2019-08-13. PMID:30607822. |
our results indicated that mtbi induction increased depression-like symptoms through altering serotonin 5-ht1a receptor activity in the brain. |
2019-08-13 |
2023-08-13 |
mouse |
| Haiyan Li, Chihiro Ishikawa, Takashi Shig. Effects of postnatal handling on adult behavior and brain mRNA expression of serotonin receptor, brain-derived neurotrophic factor and GABA-A receptor subunit. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience. vol 68. 2019-08-06. PMID:29678562. |
next, to elucidate mechanisms underlying the behavioral effects, we evaluated mrna expression of the serotonin 1a (5-ht1a) receptor, brain-derived neurotrophic factor (bdnf), and gaba-a receptor subunits in the medial prefrontal cortex, amygdala, dorsal and ventral hippocampi, and dorsal raphe nucleus by quantitative rt-pcr, since these genes and brain regions have been shown to be involved in cognition and emotion. |
2019-08-06 |
2023-08-13 |
mouse |
| Paul R Albert, Faranak Vahid-Ansar. The 5-HT1A receptor: Signaling to behavior. Biochimie. vol 161. 2019-07-08. PMID:31079617. |
the 5-ht1a receptor is highly expressed both in 5-ht neurons as a presynaptic inhibitory autoreceptor, and in many brain regions innervated by 5-ht as a post-synaptic heteroreceptor. |
2019-07-08 |
2023-08-13 |
Not clear |
| Paul R Albert, Faranak Vahid-Ansar. The 5-HT1A receptor: Signaling to behavior. Biochimie. vol 161. 2019-07-08. PMID:31079617. |
this review examines the signaling of 5-ht1a receptors to regulate 5-ht activity and behavior. |
2019-07-08 |
2023-08-13 |
Not clear |