All Relations between btk and microglial cell
| Publication | Sentence | Publish Date | Extraction Date | Species |
|---|---|---|---|---|
| James Keaney, Julien Gasser, Gaëlle Gillet, Diana Scholz, Irena Kadi. Inhibition of Bruton's Tyrosine Kinase Modulates Microglial Phagocytosis: Therapeutic Implications for Alzheimer's Disease. Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology. vol 14. issue 3. 2020-09-18. PMID:30758770. | similarly, blocking btk function ex vivo in acute brain slices reduced microglial phagocytosis and maintained numbers of resting microglia. | 2020-09-18 | 2023-08-13 | mouse |
| James Keaney, Julien Gasser, Gaëlle Gillet, Diana Scholz, Irena Kadi. Inhibition of Bruton's Tyrosine Kinase Modulates Microglial Phagocytosis: Therapeutic Implications for Alzheimer's Disease. Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology. vol 14. issue 3. 2020-09-18. PMID:30758770. | however, the role of btk in microglia, the resident innate immune cells of the central nervous system, and its involvement in the pathobiology of neurodegenerative disease has not been explored. | 2020-09-18 | 2023-08-13 | mouse |
| James Keaney, Julien Gasser, Gaëlle Gillet, Diana Scholz, Irena Kadi. Inhibition of Bruton's Tyrosine Kinase Modulates Microglial Phagocytosis: Therapeutic Implications for Alzheimer's Disease. Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology. vol 14. issue 3. 2020-09-18. PMID:30758770. | using potent btk inhibitors and small interfering rna (sirna) against btk, we observed that blockade of btk activity decreased activation of phospholipase gamma 2, a recently identified genetic risk factor in alzheimer's disease (ad), and reduced phagocytosis in rodent microglia and human monocyte-derived macrophages. | 2020-09-18 | 2023-08-13 | mouse |