| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Rory B Conolly, Julia S Kimbell, Derek Janszen, Paul M Schlosser, Darin Kalisak, Julian Preston, Frederick J Mille. Human respiratory tract cancer risks of inhaled formaldehyde: dose-response predictions derived from biologically-motivated computational modeling of a combined rodent and human dataset. Toxicological sciences : an official journal of the Society of Toxicology. vol 82. issue 1. 2005-02-22. PMID:15254341. |
the key elements of their approach were: (1) use of a three-dimensional computer reconstruction of the rat nasal passages and computational fluid dynamics (cfd) modeling to predict regional dosimetry of formaldehyde; (2) association of the flux of formaldehyde into the nasal mucosa, as predicted by the cfd model, with formation of dna-protein cross-links (dpx) and with cytolethality/regenerative cellular proliferation (crcp); and (3) use of a two-stage clonal growth model to link dpx and crcp with tumor formation. |
2005-02-22 |
2023-08-12 |
human |
| Kai Zhao, Peter W Scherer, Shoreh A Hajiloo, Pamela Dalto. Effect of anatomy on human nasal air flow and odorant transport patterns: implications for olfaction. Chemical senses. vol 29. issue 5. 2005-01-31. PMID:15201204. |
using computational fluid dynamics (cfd) techniques, we have developed a method to quickly (nasal ct scans from an individual patient into an anatomically accurate 3-d numerical nasal model that can be used to predict airflow and odorant transport, which may ultimately determine olfactory sensitivity. |
2005-01-31 |
2023-08-12 |
human |
| Paul M Schlosser, Patrick D Lilly, Rory B Conolly, Derek B Janszen, Julie S Kimbel. Benchmark dose risk assessment for formaldehyde using airflow modeling and a single-compartment, DNA-protein cross-link dosimetry model to estimate human equivalent doses. Risk analysis : an official publication of the Society for Risk Analysis. vol 23. issue 3. 2003-08-15. PMID:12836840. |
one model used computational fluid dynamics (cfd) alone to determine rates of delivery of inhaled formaldehyde to the nasal lining. |
2003-08-15 |
2023-08-12 |
human |
| Melvin E Andersen, Trevor Green, Clay B Frederick, Matthew S Bogdanff. Physiologically based pharmacokinetic (PBPK) models for nasal tissue dosimetry of organic esters: assessing the state-of-knowledge and risk assessment applications with methyl methacrylate and vinyl acetate. Regulatory toxicology and pharmacology : RTP. vol 36. issue 3. 2003-05-06. PMID:12473408. |
mathematical models have been developed to describe nasal epithelial tissue dosimetry with two compounds, vinyl acetate (va) and methyl methacrylate (mma), that cause toxicity in these tissues these models couple computational fluid dynamics (cfd) calculations that map airflow patterns within the nose with physiologically based pharmacokinetic (pbpk) models that integrate diffusion, metabolism, and tissue interactions of these compounds. |
2003-05-06 |
2023-08-12 |
human |
| Clay B Frederick, Larry G Lomax, Kurt A Black, Lavorgie Finch, Harvey E Scribner, Julia S Kimbell, Kevin T Morgan, Ravi P Subramaniam, John B Morri. Use of a hybrid computational fluid dynamics and physiologically based inhalation model for interspecies dosimetry comparisons of ester vapors. Toxicology and applied pharmacology. vol 183. issue 1. 2002-09-24. PMID:12217639. |
previously, a hybrid computational fluid dynamics (cfd) and physiologically based pharmacokinetic (pbpk) dosimetry model was constructed to estimate the regional tissue dose of organic acids in the rodent and human nasal cavity. |
2002-09-24 |
2023-08-12 |
human |
| Frederic J-M Moulin, Karrie A Brenneman, Julia S Kimbell, David C Dorma. Predicted regional flux of hydrogen sulfide correlates with distribution of nasal olfactory lesions in rats. Toxicological sciences : an official journal of the Society of Toxicology. vol 66. issue 1. 2002-06-25. PMID:11861968. |
to investigate whether the location of the olfactory lesion is dependent on regional gas uptake patterns, a comparison was made between lesion locations and regions of high h(2)s flux predicted using a 3-dimensional, anatomically accurate computational fluid dynamics (cfd) model of rat nasal passages. |
2002-06-25 |
2023-08-12 |
human |
| J S Kimbell, J H Overton, R P Subramaniam, P M Schlosser, K T Morgan, R B Conolly, F J Mille. Dosimetry modeling of inhaled formaldehyde: binning nasal flux predictions for quantitative risk assessment. Toxicological sciences : an official journal of the Society of Toxicology. vol 64. issue 1. 2002-02-21. PMID:11606807. |
three-dimensional, anatomically realistic, computational fluid dynamics (cfd) models of nasal airflow and formaldehyde gas transport in the f344 rat, rhesus monkey, and human were used to predict local patterns of wall mass flux (pmol/[mm(2)-h-ppm]). |
2002-02-21 |
2023-08-12 |
human |
| J H Overton, J S Kimbell, F J Mille. Dosimetry modeling of inhaled formaldehyde: the human respiratory tract. Toxicological sciences : an official journal of the Society of Toxicology. vol 64. issue 1. 2002-02-21. PMID:11606808. |
the first model (which is the subject of another investigation) used computational fluid dynamics (cfd) to estimate local fluxes in a 3-dimensional model of the nasal region. |
2002-02-21 |
2023-08-12 |
mouse |
| J H Overton, J S Kimbell, F J Mille. Dosimetry modeling of inhaled formaldehyde: the human respiratory tract. Toxicological sciences : an official journal of the Society of Toxicology. vol 64. issue 1. 2002-02-21. PMID:11606808. |
the two types of modeling approaches were made consistent by requiring that the 1-dimensional version of the nasal passages have the same inspiratory air-flow rate and uptake during inspiration as the cfd simulations for 4 daily human activity levels. |
2002-02-21 |
2023-08-12 |
mouse |
| J H Overton, J S Kimbell, F J Mille. Dosimetry modeling of inhaled formaldehyde: the human respiratory tract. Toxicological sciences : an official journal of the Society of Toxicology. vol 64. issue 1. 2002-02-21. PMID:11606808. |
(2) the cfd predictions for inspiration, modified to account for the difference in inspiration and complete breath times, are a good approximation to uptake in the nasal airways during a single breath. |
2002-02-21 |
2023-08-12 |
mouse |
| J S Kimbell, R P Subramania. Use of computational fluid dynamics models for dosimetry of inhaled gases in the nasal passages. Inhalation toxicology. vol 13. issue 5. 2001-06-28. PMID:11295865. |
computational fluid dynamics (cfd) models of the nasal passages of a rat, monkey, and human are being used (1) to determine important factors affecting nasal uptake, (2) to make interspecies dosimetric comparisons, (3) to provide detailed anatomical information for the rat, monkey, and human nasal passages, and (4) to provide estimates of regional air-phase mass transport coefficients (a measure of the resistance to gas transport from inhaled air to airway walls) in the nasal passages of all three species. |
2001-06-28 |
2023-08-12 |
human |
| J S Kimbell, R P Subramania. Use of computational fluid dynamics models for dosimetry of inhaled gases in the nasal passages. Inhalation toxicology. vol 13. issue 5. 2001-06-28. PMID:11295865. |
since direct measurement of airflow and uptake is experimentally difficult, cfd models are used here to predict uptake patterns quantitatively in three-dimensional reconstructions of the f344 rat, rhesus monkey, and human nasal passages. |
2001-06-28 |
2023-08-12 |
human |
| J S Kimbell, R P Subramania. Use of computational fluid dynamics models for dosimetry of inhaled gases in the nasal passages. Inhalation toxicology. vol 13. issue 5. 2001-06-28. PMID:11295865. |
for uptake of gases like vinyl acetate and acrylic acid vapors, physiologically based pharmacokinetic uptake models incorporating anatomical and physical information from the cfd models were developed to estimate nasal tissue dose in animals and humans. |
2001-06-28 |
2023-08-12 |
human |
| C B Frederick, P R Gentry, M L Bush, L G Lomax, K A Black, L Finch, J S Kimbell, K T Morgan, R P Subramaniam, J B Morris, J S Ultma. A hybrid computational fluid dynamics and physiologically based pharmacokinetic model for comparison of predicted tissue concentrations of acrylic acid and other vapors in the rat and human nasal cavities following inhalation exposure. Inhalation toxicology. vol 13. issue 5. 2001-06-28. PMID:11295868. |
to assist in interspecies dosimetry comparisons for risk assessment of the nasal effects of organic acids, a hybrid computational fluid dynamics (cfd) and physiologically based pharmacokinetic (pbpk) dosimetry model was constructed to estimate the regional tissue dose of inhaled vapors in the rat and human nasal cavity. |
2001-06-28 |
2023-08-12 |
human |
| C B Frederick, P R Gentry, M L Bush, L G Lomax, K A Black, L Finch, J S Kimbell, K T Morgan, R P Subramaniam, J B Morris, J S Ultma. A hybrid computational fluid dynamics and physiologically based pharmacokinetic model for comparison of predicted tissue concentrations of acrylic acid and other vapors in the rat and human nasal cavities following inhalation exposure. Inhalation toxicology. vol 13. issue 5. 2001-06-28. PMID:11295868. |
similar analysis of cfd data and cfd-pbpk model simulations with a simpler one-compartment model of the whole nasal cavities of rats and humans provides comparable results to averaging over the compartments of the seven-compartment model. |
2001-06-28 |
2023-08-12 |
human |
| M Andersen, R Sarangapani, R Gentry, H Clewell, T Covington, C B Frederic. Application of a hybrid CFD-PBPK nasal dosimetry model in an inhalation risk assessment: an example with acrylic acid. Toxicological sciences : an official journal of the Society of Toxicology. vol 57. issue 2. 2000-11-21. PMID:11006361. |
advances in physiologically based pharmacokinetic (pbpk) modeling, specifically the incorporation of computational fluid dynamic (cfd) models, now make it possible to estimate the flux of inhaled chemicals within the nasal cavity of experimental species, specifically rats. |
2000-11-21 |
2023-08-12 |
mouse |
| C B Frederick, M L Bush, L G Lomax, K A Black, L Finch, J S Kimbell, K T Morgan, R P Subramaniam, J B Morris, J S Ultma. Application of a hybrid computational fluid dynamics and physiologically based inhalation model for interspecies dosimetry extrapolation of acidic vapors in the upper airways. Toxicology and applied pharmacology. vol 152. issue 1. 1998-11-20. PMID:9772217. |
a hybrid computational fluid dynamics (cfd) and physiologically based pharmacokinetic (pbpk) dosimetry model was constructed to estimate the regional tissue dose of organic acids in the rodent and human nasal cavity. |
1998-11-20 |
2023-08-12 |
human |
| J S Kimbell, E A Gross, R B Richardson, R B Conolly, K T Morga. Correlation of regional formaldehyde flux predictions with the distribution of formaldehyde-induced squamous metaplasia in F344 rat nasal passages. Mutation research. vol 380. issue 1-2. 1997-12-10. PMID:9385395. |
in a previous study, a three-dimensional, anatomically accurate computational fluid dynamics (cfd) model of the anterior f344 rat nasal passages was used to simulate inspiratory airflow and inhaled formaldehyde transport. |
1997-12-10 |
2023-08-12 |
human |
| E A Hubal, P M Schlosser, R B Conolly, J S Kimbel. Comparison of inhaled formaldehyde dosimetry predictions with DNA-protein cross-link measurements in the rat nasal passages. Toxicology and applied pharmacology. vol 143. issue 1. 1997-04-17. PMID:9073591. |
pharmacol, 121, 253-263, 1993) developed a computational fluid dynamics (cfd) model of a f344 rat nasal passage to quantify local wall mass flux (uptake rate) of inhaled chemical. |
1997-04-17 |
2023-08-12 |
rat |
| E A Hubal, P M Schlosser, R B Conolly, J S Kimbel. Comparison of inhaled formaldehyde dosimetry predictions with DNA-protein cross-link measurements in the rat nasal passages. Toxicology and applied pharmacology. vol 143. issue 1. 1997-04-17. PMID:9073591. |
in this study, a mathematical model of the nasal lining was modified to link cfd dosimetry predictions for inhaled formaldehyde with measured tissue disposition of inhaled gas. |
1997-04-17 |
2023-08-12 |
rat |