| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Christian Limberger, Eduardo R Zimme. Blood GFAP reflects astrocyte reactivity to Alzheimer's pathology in post-mortem brain tissue. Brain : a journal of neurology. 2024-04-18. PMID:38634672. |
blood gfap reflects astrocyte reactivity to alzheimer's pathology in post-mortem brain tissue. |
2024-04-18 |
2024-04-20 |
Not clear |
| Pascual Sánchez-Juan, Elizabeth Valeriano-Lorenzo, Alicia Ruiz-González, Ana Belén Pastor, Hector Rodrigo Lara, Francisco López-González, María Ascensión Zea-Sevilla, Meritxell Valentí, Belen Frades, Paloma Ruiz, Laura Saiz, Iván Burgueño-García, Miguel Calero, Teodoro Del Ser, Alberto Rában. Serum GFAP levels correlate with astrocyte reactivity, post-mortem brain atrophy and neurofibrillary tangles. Brain : a journal of neurology. 2024-04-18. PMID:38634687. |
serum gfap levels correlate with astrocyte reactivity, post-mortem brain atrophy and neurofibrillary tangles. |
2024-04-18 |
2024-04-20 |
Not clear |
| Pascual Sánchez-Juan, Elizabeth Valeriano-Lorenzo, Alicia Ruiz-González, Ana Belén Pastor, Hector Rodrigo Lara, Francisco López-González, María Ascensión Zea-Sevilla, Meritxell Valentí, Belen Frades, Paloma Ruiz, Laura Saiz, Iván Burgueño-García, Miguel Calero, Teodoro Del Ser, Alberto Rában. Serum GFAP levels correlate with astrocyte reactivity, post-mortem brain atrophy and neurofibrillary tangles. Brain : a journal of neurology. 2024-04-18. PMID:38634687. |
glial fibrillary acidic protein (gfap), a proxy of astrocyte reactivity, has been proposed as biomarker of alzheimer's disease. |
2024-04-18 |
2024-04-20 |
Not clear |
| Pascual Sánchez-Juan, Elizabeth Valeriano-Lorenzo, Alicia Ruiz-González, Ana Belén Pastor, Hector Rodrigo Lara, Francisco López-González, María Ascensión Zea-Sevilla, Meritxell Valentí, Belen Frades, Paloma Ruiz, Laura Saiz, Iván Burgueño-García, Miguel Calero, Teodoro Del Ser, Alberto Rában. Serum GFAP levels correlate with astrocyte reactivity, post-mortem brain atrophy and neurofibrillary tangles. Brain : a journal of neurology. 2024-04-18. PMID:38634687. |
finally, serum gfap levels were revealed to be correlated with astrocyte reactivity, using the brain gfap-immunostained area as a proxy (ρ = 0.21; p = 0.02). |
2024-04-18 |
2024-04-20 |
Not clear |
| Pengjun Wang, Chen Chen, Min Sha. Vincamine alleviates brain injury by attenuating neuroinflammation and oxidative damage in a mouse model of Parkinson's disease through the NF-κB and Nrf2/HO-1 signaling pathways. Journal of biochemical and molecular toxicology. vol 38. issue 5. 2024-04-17. PMID:38629493. |
microglial and astrocyte activation was examined through immunofluorescence staining of iba-1 (microglia marker) and gfap (astrocyte marker) in the sn. |
2024-04-17 |
2024-04-19 |
mouse |
| Simin Zheng, Yunpeng Teng, Hongtao Liu, Jiaxuan He, Shaobo Zhang, Hongfei Xion. Syringaresinol attenuates Tau phosphorylation and ameliorates cognitive dysfunction induced by sevoflurane in aged rats. Journal of neuropathology and experimental neurology. 2024-04-16. PMID:38622895. |
syr treatment mitigated sevoflurane-induced cognitive decline, reduced microglial and astrocyte activation (decreased iba-1 and gfap expression), and countered neuronal apoptosis (reduced bax, cleaved-caspase3, and cleaved-parp expression). |
2024-04-16 |
2024-04-18 |
rat |
| Ji-Yong Liu, Wen-Li Zhang, Jun Liao, Li-Juan Hu, Guo-Zuo Wang, Jin-Wen Ge, Zhi-Gang Me. [Effect of Naotaifang on microglial polarization and glial scar following cerebral ischemia reperfusion injury]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 49. issue 4. 2024-04-15. PMID:38621906. |
compared with the sham, model 7 d and model 14 d groups showed cerebral infarction of different degrees, severe pathological injury of cerebral cortex and hippocampus, neurological impairment, reduced spatial learning and memory, cognitive dysfunction, severe anxiety, astrocyte hyperplasia, thickening penumbra glial scar, and up-regulated protein levels of il-1β, il-6, gfap, neurocan, phosphacan, cd206, and arg-1(p<0.01). |
2024-04-15 |
2024-04-18 |
rat |
| Ji-Yong Liu, Wen-Li Zhang, Jun Liao, Li-Juan Hu, Guo-Zuo Wang, Jin-Wen Ge, Zhi-Gang Me. [Effect of Naotaifang on microglial polarization and glial scar following cerebral ischemia reperfusion injury]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 49. issue 4. 2024-04-15. PMID:38621906. |
compared with the model group, ntf 7 d and ntf 14 d groups improved spatial learning, memory, and cognitive function, reduced anxiety, improved nerve function, reduced cerebral infarction volume, reduced astrocyte hyperplasia, thinned penumbra glial scar, down-regulated the protein levels of gfap, neurocan, phosphacan, il-6, and il-1β, and up-regulated the protein levels of il-4, cd206, and arg-1(p<0.05 or p<0.01). |
2024-04-15 |
2024-04-18 |
rat |
| Ing Chee Wee, Alina Arulsamy, Frances Corrigan, Lyndsey Collins-Prain. Long-Term Impact of Diffuse Traumatic Brain Injury on Neuroinflammation and Catecholaminergic Signaling: Potential Relevance for Parkinson's Disease Risk. Molecules (Basel, Switzerland). vol 29. issue 7. 2024-04-13. PMID:38611750. |
at 12 months post-injury, astrocyte reactivity (gfap) and microglial levels (iba1) were assessed in the striatum (str), substantia nigra (sn), and prefrontal cortex (pfc) using immunohistochemistry. |
2024-04-13 |
2024-04-15 |
rat |
| Joseph Matthew Holden, Lauren Katie Wareham, David John Calkin. Morphological and electrophysiological characterization of a novel displaced astrocyte in the mouse retina. Glia. 2024-04-09. PMID:38591270. |
in this work, we report on a novel glial population found in the inner plexiform layer and ganglion cell layer which expresses the canonical astrocyte markers gfap, s100β, connexin-43, sox2 and sox9. |
2024-04-09 |
2024-04-11 |
mouse |
| Hoang Kieu Chi Ngo, Hoang Le, Samuel J Ayer, Grace F Crotty, Michael A Schwarzschild, Rachit Baksh. Short-term lipopolysaccharide treatment leads to astrocyte activation in LRRK2 G2019S knock-in mice without loss of dopaminergic neurons. Research square. 2024-04-02. PMID:38562908. |
lps treatment caused a greater increase in the activated astrocyte marker glial fibrillary acidic protein (gfap) in the striatum and substantia nigra of lrrk2 g2019s mice than in those of wt mice. |
2024-04-02 |
2024-04-04 |
mouse |
| Nicholas J Ashton, Guglielmo Di Molfetta, Kübra Tan, Kaj Blennow, Henrik Zetterberg, Albee Messin. Plasma concentrations of glial fibrillary acidic protein, neurofilament light, and tau in Alexander disease. Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology. 2024-04-01. PMID:38558318. |
alexander disease (axd) is a rare leukodystrophy caused by dominant gain-of-function mutations in the gene encoding the astrocyte intermediate filament, glial fibrillary acidic protein (gfap). |
2024-04-01 |
2024-04-04 |
Not clear |
| Jéssica Taday, Fernanda Telles Fróes, Marina Seady, Carlos Alberto Gonçalves, Marina Concli Leit. In Vitro Astroglial Dysfunction Induced by Neurotoxins: Mimicking Astrocytic Metabolic Alterations of Alzheimer's Disease. Metabolites. vol 14. issue 3. 2024-03-27. PMID:38535311. |
the dysfunction of these cells is widely associated with brain disorders, which are often characterized by variations in the astrocyte protein markers gfap and s100b, in addition to alterations in some of its metabolic functions. |
2024-03-27 |
2024-03-29 |
Not clear |
| Jéssica Taday, Fernanda Telles Fróes, Marina Seady, Carlos Alberto Gonçalves, Marina Concli Leit. In Vitro Astroglial Dysfunction Induced by Neurotoxins: Mimicking Astrocytic Metabolic Alterations of Alzheimer's Disease. Metabolites. vol 14. issue 3. 2024-03-27. PMID:38535311. |
we showed that mg, lps, stz and fc similarly caused astrocyte dysfunction by increasing gfap and reducing s100b secretion. |
2024-03-27 |
2024-03-29 |
Not clear |
| Ju-Bin Kang, Hyun-Kyoung Son, Murad-Ali Shah, Phil-Ok Ko. Retinoic acid attenuates ischemic injury-induced activation of glial cells and inflammatory factors in a rat stroke model. PloS one. vol 19. issue 3. 2024-03-25. PMID:38527023. |
ionized calcium-binding adapter molecule-1 (iba-1) and glial fibrillary acidic protein (gfap) were used as markers of microglial and astrocyte activation, respectively. |
2024-03-25 |
2024-03-28 |
rat |
| Haichao Wei, Joseph Withrow, Jyotirmoy Rakshit, Faiz Ul Amin, Joshua Nahm, Francesca E Mowry, Zhengmei Mao, Meenakshi B Bhattacharjee, Jay-Jiguang Zhu, Yongjie Yang, Jia Qian W. The identification of a Distinct Astrocyte Subtype that Diminishes in Alzheimer's Disease. Aging and disease. 2024-03-19. PMID:38502590. |
our findings revealed the existence of a specific astrocyte subpopulation marked by low levels of gfap and the presence of aqp4 and cd63 expression, which showed functional enrichment in aβ clearance and tau protein binding, and diminished in ad. |
2024-03-19 |
2024-03-23 |
mouse |
| Zhuoran Zhang, Xiaoyan Li, Limin Ma, Shanshan Wang, Jingsi Zhang, Yue Zhou, Xin Guo, Qiao Ni. LNC000152 Mediates Aluminum-Induced Proliferation of Reactive Astrocytes. ACS omega. vol 9. issue 10. 2024-03-18. PMID:38496998. |
glial fibrillary acidic protein (gfap) is widely used as a marker of reactive astrocyte proliferation in response to pathological injury of the central nervous system. |
2024-03-18 |
2024-03-20 |
rat |
| Khaled S Abd-Elrahman, Tash-Lynn L Colson, Shaarika Sarasija, Stephen S G Ferguso. A M1 muscarinic acetylcholine receptor-specific positive allosteric modulator VU0486846 reduces neurogliosis in female Alzheimer's mice. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 173. 2024-03-09. PMID:38460371. |
to investigate, we treated nine-month-old app/ps1 and wildtype mice with vu0486846 for 8 weeks and analyzed brain slices for markers of microglial activation (ionized calcium binding adaptor molecule 1, iba1) and astrocyte activation (glial fibrillary acidic protein, gfap). |
2024-03-09 |
2024-03-12 |
mouse |
| Nicholas Pintori, Rafaela Mostallino, Enrica Spano, Valeria Orrù, Maria Grazia Piras, Maria Paola Castelli, Maria Antonietta De Luc. Immune and glial cell alterations in the rat brain after repeated exposure to the synthetic cannabinoid JWH-018. Journal of neuroimmunology. vol 389. 2024-03-03. PMID:38432046. |
moreover, microglial (ionized calcium-binding adaptor molecule 1, iba-1) and astrocyte (glial fibrillary acidic protein, gfap) activation markers were evaluated in the caudate-putamen (cpu). |
2024-03-03 |
2024-03-06 |
rat |
| Shao-Hua Yang, Yuanhong Sun, Raymond Berry, Gourav Roy Choudhury, Ali Winters, Kiran Chaudhari, Ran Li. Glutamate Provides Cytoprotective Effect for Astrocytes Against Ischemic Insult and Promotes Astrogliosis. Aging and disease. 2024-02-20. PMID:38377020. |
furthermore, glutamate exposure resulted in astrocyte activation, evidenced by an increase in astrocyte size and gfap expression. |
2024-02-20 |
2024-02-23 |
Not clear |