| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Shao-Hua Yang, Yuanhong Sun, Raymond Berry, Gourav Roy Choudhury, Ali Winters, Kiran Chaudhari, Ran Li. Glutamate Provides Cytoprotective Effect for Astrocytes Against Ischemic Insult and Promotes Astrogliosis. Aging and disease. 2024-02-20. PMID:38377020. |
furthermore, glutamate exposure resulted in astrocyte activation, evidenced by an increase in astrocyte size and gfap expression. |
2024-02-20 |
2024-02-23 |
Not clear |
| Leoné Malan, Mark Hamer, Roland von Känel, Roelof D van Wyk, Annemarie Wentzel, Hendrik S Steyn, Pieter van Vuuren, Nico T Mala. Retinal-glia ischemia and inflammation induced by chronic stress: The SABPA study. Brain, behavior, & immunity - health. vol 2. 2024-02-20. PMID:38377420. |
however, gfap decreases revealed astrocyte pathology in the prefrontal cortex of depression/suicide cases; and might be a key mechanism in stress - disease pathways. |
2024-02-20 |
2024-02-23 |
Not clear |
| V R Varma, Y An, P R Kac, M Bilgel, A Moghekar, T Loeffler, D Amschl, J Troncoso, K Blennow, H Zetterberg, N J Ashton, S M Resnick, M Thambisett. Longitudinal progression of blood biomarkers reveals a key role of astrocyte reactivity in preclinical Alzheimer's disease. medRxiv : the preprint server for health sciences. 2024-02-12. PMID:38343809. |
we show that increased astrocyte reactivity, assessed by elevated glial fibrillary acidic protein (gfap) levels is an early event in the progression of blood biomarker changes in preclinical ad. |
2024-02-12 |
2024-02-15 |
mouse |
| Ruyan Gao, Tahir Ali, Zizhen Liu, Axiang Li, Liangliang Hao, Liufang He, Xiaoming Yu, Shupeng L. Ceftriaxone averts neuroinflammation and relieves depressive-like behaviors via GLT-1/TrkB signaling. Biochemical and biophysical research communications. vol 701. 2024-02-04. PMID:38310688. |
lps-treated mice displayed depressive symptoms, neuroinflammation, dysregulated glutamate and its transporter (glt-1) expression, altered expression of astrocyte reactive markers (gfap, cxcl10, steap4, gbp2, and srgn), and dysregulated bdnf/trkb signaling. |
2024-02-04 |
2024-02-07 |
mouse |
| Hadi Bayat, Maryam Mirahmadi, Zohreh Azarshin, Hamid Ohadi, Ahmad Delbari, Mina Ohad. CRISPR/Cas9-mediated deletion of a GA-repeat in human GPM6B leads to disruption of neural cell differentiation from NT2 cells. Scientific reports. vol 14. issue 1. 2024-01-25. PMID:38273037. |
compared to the control cells, the edited cells showed dramatic decrease of the astrocyte and neural cell markers, including gfap (0.77-fold), tubb3 (0.57-fold), and map2 (0.2-fold). |
2024-01-25 |
2024-01-28 |
human |
| Honour O Adewumi, Gabriela I Berniac, Emily A McCarthy, Timothy M O'She. Ischemic and hemorrhagic stroke lesion environments differentially alter the glia repair potential of neural progenitor cell and immature astrocyte grafts. Experimental neurology. 2024-01-20. PMID:38244885. |
ima maintain proliferation rates at comparable levels to npc but showed robust immature astrocyte marker expression including gfap and vimentin. |
2024-01-20 |
2024-01-23 |
Not clear |
| Laura L Trebucq, Nicolas Salvatore, Paula M Wagner, Diego A Golombek, Juan J Chies. Circadian Clock Gene bmal1 Acts as a Tumor Suppressor Gene in a Mice Model of Human Glioblastoma. Molecular neurobiology. 2024-01-05. PMID:38180613. |
for that aim, a bmal1 knock-down was generated in ln229 cells by crispr/cas9 gene editing tool, and tumor progression was followed in male mice by measuring survival, tumor growth, cell proliferation and prognosis with cd44 marker, as well as astrocyte activation in the tumor microenvironment with gfap and nestin markers. |
2024-01-05 |
2024-01-07 |
mouse |
| J J Rodríguez, E Gardenal, F Zallo, A Arrue, Joan Cabot, X Busquet. Astrocyte S100β expression and selective differentiation to GFAP and GS in the entorhinal cortex during ageing in the 3xTg-Alzheimer's disease mouse model. Acta histochemica. vol 126. issue 1. 2023-12-30. PMID:38159478. |
astrocyte s100β expression and selective differentiation to gfap and gs in the entorhinal cortex during ageing in the 3xtg-alzheimer's disease mouse model. |
2023-12-30 |
2024-01-05 |
mouse |
| Niklas Zimmer, Emily R Trzeciak, Andreas Müller, Philipp Licht, Bettina Sprang, Petra Leukel, Volker Mailänder, Clemens Sommer, Florian Ringel, Jochen Tuettenberg, Ella Kim, Andrea Tuettenber. Nuclear Glycoprotein A Repetitions Predominant (GARP) Is a Common Trait of Glioblastoma Stem-like Cells and Correlates with Poor Survival in Glioblastoma Patients. Cancers. vol 15. issue 24. 2023-12-23. PMID:38136258. |
rather, garp correlated inversely with the expression of gfap and pdgfr-α, markers of astrocyte or oligodendrocyte differentiation. |
2023-12-23 |
2023-12-25 |
human |
| Fernanda B de M Monte, Tadeu L Montagnoli, Bruno E Dematté, Fernanda Gubert, Vitória S Ventura, Jaqueline S da Silva, Margarete M Trachez, Rosalia Mendez-Otero, Gisele Zapata-Sud. Antinociceptive Effect of the Combination of a Novel α4β2* Agonist with Donepezil in a Chronic Pain Model. Biomedicines. vol 11. issue 12. 2023-12-23. PMID:38137470. |
the combination also modulated neuroinflammation by reducing astrocyte activation, evident in the decreased expression of glial fibrillary acidic protein (gfap) in the spinal cord. |
2023-12-23 |
2023-12-25 |
rat |
| Ki-Don Park, Jo-Young Son, Hak-Kyun Kim, Yu-Mi Kim, Jin-Sook Ju, Min-Jeong Jo, Min-Kyoung Park, Min-Kyung Lee, Dong-Kuk Ah. Differential Regulation of Intracisternally Injected Angiotensin II-Induced Mechanical Allodynia and Thermal Hyperalgesia in Rats. Biomedicines. vol 11. issue 12. 2023-12-23. PMID:38137500. |
immunofluorescence analyses revealed the co-localization of at1r with the astrocyte marker gfap in the trigeminal subnucleus caudalis and co-localization of at2r with cgrp-positive neurons in the trigeminal ganglion. |
2023-12-23 |
2023-12-25 |
rat |
| Xue-Qin Fu, Man-Man Wang, Rui Lan, Yong Zhang, Xu-Huan Zou, Wei-Wei Wang, Chen Tang, Shuang Liu, Hong-Yu L. [Effect of Xiaoxuming Decoction on activation of astrocytes in acute cerebral ischemia/reperfusion injury]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 48. issue 21. 2023-12-19. PMID:38114179. |
these results indicate that xxmd can improve cerebral ir injury, possibly by inhibiting astrocyte activation and down-regulating the expression of gfap and tsp1. |
2023-12-19 |
2023-12-23 |
rat |
| Sigal Liraz Zaltsman, Shirley Sharabi, David Guez, Diann Daniels, Itzik Cooper, Chen Shemesh, Dana Atrakchi, Orly Ravid, Liora Omesi, Daniel Rand, Abigail Livny, Michal Schnaider Beeri, Yael Friedman-Levi, Esther Shohami, Yael Mardor, David Las. Application of Delayed Contrast Extravasation Magnetic Resonance Imaging for Depicting Subtle Blood-Brain Barrier Disruption in a Traumatic Brain Injury Model. Journal of neurotrauma. 2023-12-06. PMID:37776183. |
at each time point, 2-6 animals were sacrificed and their brains were extracted, sectioned, and stained for bbb biomarkers including: blood microvessel coverage by astrocyte using gfap, aqp4, zo-1 gaps, and igg leakage. |
2023-12-06 |
2023-12-10 |
mouse |
| Ling Zeng, Qian Ying, Hongdou Lou, Feifei Wang, Yulian Pang, Haijian Hu, Ziqiao Zhang, Yuning Song, Peiyu Liu, Xu Zhan. Protective effect of the natural flavonoid naringenin in mouse models of retinal injury. European journal of pharmacology. 2023-12-05. PMID:38052414. |
naringenin ameliorated the abovementioned indications but also demonstrated that high concentrations of naringenin significantly inhibited retinal astrocyte activation and inhibited damage-induced increases in the expression of gfap, nlrp 3, and cd38 proteins, while sirt1 protein expression was upregulated. |
2023-12-05 |
2023-12-10 |
mouse |
| Ângela Beatris Zemniaçak, Rafael Teixeira Ribeiro, Camila Vieira Pinheiro, Sâmela de Azevedo Cunha, Tailine Quevedo Tavares, Ediandra Tissot Castro, Guilhian Leipnitz, Moacir Wajner, Alexandre Umpierrez Amara. In Vivo Intracerebral Administration of α-Ketoisocaproic Acid to Neonate Rats Disrupts Brain Redox Homeostasis and Promotes Neuronal Death, Glial Reactivity, and Myelination Injury. Molecular neurobiology. 2023-11-01. PMID:37910283. |
furthermore, a reduction of neun, mbp, and cnpase, and an increase of gfap levels were observed at postnatal day 15, suggesting neuronal loss, myelination injury, and astrocyte reactivity, respectively. |
2023-11-01 |
2023-11-08 |
rat |
| Octavio Fabián Mercado-Gómez, Virginia Selene Arriaga-Ávila, Angélica Vega-García, Sandra Orozco-Suarez, Vadim Pérez-Koldenkova, Juan José Camarillo-Sánchez, Marcelino Álvarez-Herrera, Rosalinda Guevara-Guzmá. Daytime-Restricted Feeding Ameliorates Oxidative Stress by Increasing NRF2 Transcriptional Factor in the Rat Hippocampus in the Pilocarpine-Induced Acute Seizure Model. Brain sciences. vol 13. issue 10. 2023-10-30. PMID:37891811. |
nrf2 immunoreactivity and the astrocyte marker gfap also increased their colocalization under drf conditions. |
2023-10-30 |
2023-11-08 |
rat |
| Julianna M Santos, Rui Wang, Viren Bhakta, Zarek Driver, Yakhnitsa Vadim, Takaki Kiritoshi, Guangchen Ji, Volker Neugebauer, Chwan-Li She. Turmeric Bioactive Compounds Alleviate Spinal Nerve Ligation-Induced Neuropathic Pain by Suppressing Glial Activation and Improving Mitochondrial Function in Spinal Cord and Amygdala. Nutrients. vol 15. issue 20. 2023-10-30. PMID:37892476. |
increased mechanical hypersensitivity and increased gene expression of markers for microglial activation (iba-1 in the amygdala and cd11b in the spinal cord), astrocyte activation (gfap in the spinal cord), mitochondrial dysfunction (pgc1α in the amygdala), and oxidative stress (tlr4 in the spinal cord and amygdala) were found in untreated snl rats. |
2023-10-30 |
2023-11-08 |
rat |
| Xiang Cheng, Yanan Geng, Yaqun Jiang, Tong Zhao, Lingling Zhu, Yulin Den. [Characterization and identification of primarily cultured astrocytes and microglia]. Sheng wu gong cheng xue bao = Chinese journal of biotechnology. vol 39. issue 10. 2023-10-26. PMID:37877402. |
moreover, 95.7 % of the high purity astrocytes could be obtained by astrocyte cell surface antigen-2 (acsa-2) magnetic beads separation, and there was no significant difference in the morphology of glial fibrillary acidic protein (gfap) positive astrocyte and the proportion of a1 and a2 phenotype among the p0, p1 and p2 generations of astrocyte isolated by the above methods. |
2023-10-26 |
2023-11-08 |
mouse |
| Elina Kc, Jaisan Islam, Hyong Kyu Kim, Young Seok Par. GFAP-NpHR mediated optogenetic inhibition of trigeminal nucleus caudalis attenuates hypersensitive behaviors and thalamic discharge attributed to infraorbital nerve constriction injury. The journal of headache and pain. vol 24. issue 1. 2023-10-11. PMID:37821818. |
orofacial hyperalgesia and thalamic hyperexcitability were both accompanied by medullary astrocyte hyperactivity, marked by upregulated gfap. |
2023-10-11 |
2023-10-15 |
rat |
| Xiaojun Ye, Sen Shao, Yanbo Wang, Wenwen S. Ginsenoside Rg2 alleviates neurovascular damage in 3xTg-AD mice with Alzheimer's disease through the MAPK-ERK pathway. Journal of chemical neuroanatomy. 2023-10-07. PMID:37805189. |
in particular, neun and cd31 levels were inhibited and gfap level was elevated in 3xtg-ad mice that were observed through immunofluorescence, and these levels were all antagonized by rg2, suggesting the effects of rg2 on neurovascular damage, astrocyte activation, and neuronal loss. |
2023-10-07 |
2023-10-15 |
mouse |