| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Joel E Schlosburg, Brittany L A Carlson, Divya Ramesh, Rehab A Abdullah, Jonathan Z Long, Benjamin F Cravatt, Aron H Lichtma. Inhibitors of endocannabinoid-metabolizing enzymes reduce precipitated withdrawal responses in THC-dependent mice. The AAPS journal. vol 11. issue 2. 2009-08-12. PMID:19430909. |
however, new genetic and pharmacological tools are available to increase endocannabinoid levels by targeting fatty acid amide hydrolase (faah) or monoacylglycerol lipase (magl), the enzymes responsible for the degradation of the endogenous cannabinoid ligands anandamide and 2-arachidonoylglycerol, respectively. |
2009-08-12 |
2023-08-12 |
mouse |
| Anuradha Nallapaneni, Jing Liu, Subramanya Karanth, Carey Pop. Pharmacological enhancement of endocannabinoid signaling reduces the cholinergic toxicity of diisopropylfluorophosphate. Neurotoxicology. vol 29. issue 6. 2009-03-26. PMID:18765251. |
we first evaluated the relative in vitro and in vivo (2.5mg/kg, sc) effects of dfp on cholinesterase, fatty acid amide hydrolase (faah, an endocannabinoid degrading enzyme), monoacylglycerol lipase (magl, another endocannabinoid degrading enzyme) and cannabinoid receptor (cb1) binding in rat hippocampus. |
2009-03-26 |
2023-08-12 |
rat |
| Jonathan Z Long, Weiwei Li, Lamont Booker, James J Burston, Steven G Kinsey, Joel E Schlosburg, Franciso J Pavón, Antonia M Serrano, Dana E Selley, Loren H Parsons, Aron H Lichtman, Benjamin F Cravat. Selective blockade of 2-arachidonoylglycerol hydrolysis produces cannabinoid behavioral effects. Nature chemical biology. vol 5. issue 1. 2009-01-15. PMID:19029917. |
endocannabinoid signaling is terminated by enzymatic hydrolysis, a process that for anandamide is mediated by fatty acid amide hydrolase (faah), and for 2-ag is thought to involve monoacylglycerol lipase (magl). |
2009-01-15 |
2023-08-12 |
mouse |
| Giorgio Ortar, Tiziana Bisogno, Alessia Ligresti, Enrico Morera, Marianna Nalli, Vincenzo Di Marz. Tetrahydrolipstatin analogues as modulators of endocannabinoid 2-arachidonoylglycerol metabolism. Journal of medicinal chemistry. vol 51. issue 21. 2008-11-28. PMID:18831576. |
three of the novel compounds, i.e., 11, 13, and 15, inhibited 2-ag formation via the diacylglycerol lipase alpha (daglalpha) with ic 50 values lower than 50 nm (ic 50 of thl = 1 microm) and were between 23- and 375-fold selective vs 2-ag hydrolysis by monoacylglycerol lipase (magl) as well as vs cannabinoid cb 1 and cb 2 receptors and anandamide hydrolysis by fatty acid amide hydrolase (faah). |
2008-11-28 |
2023-08-12 |
Not clear |
| James J Burston, Laura J Sim-Selley, John P Harloe, Anu Mahadevan, Raj K Razdan, Dana E Selley, Jenny L Wile. N-arachidonyl maleimide potentiates the pharmacological and biochemical effects of the endocannabinoid 2-arachidonylglycerol through inhibition of monoacylglycerol lipase. The Journal of pharmacology and experimental therapeutics. vol 327. issue 2. 2008-11-13. PMID:18682568. |
inhibition of the metabolism of the endocannabinoids, anandamide (aea) and 2-arachidonyl glycerol (2-ag), by their primary metabolic enzymes, fatty acid amide hydrolase (faah) and monoacylglycerol lipase (magl), respectively, has the potential to increase understanding of the physiological functions of the endocannabinoid system. |
2008-11-13 |
2023-08-12 |
mouse |
| Alma Viso, José A Cisneros, Silvia Ortega-Gutiérre. The medicinal chemistry of agents targeting monoacylglycerol lipase. Current topics in medicinal chemistry. vol 8. issue 3. 2008-03-07. PMID:18289090. |
monoacylglycerol lipase (magl) has been recently proposed as the main enzymatic activity responsible for the in vivo hydrolysis of the most abundant endocannabinoid in the brain, the 2-arachidonoylglycerol (2-ag). |
2008-03-07 |
2023-08-12 |
Not clear |
| F Comelli, G Giagnoni, I Bettoni, M Colleoni, B Cost. The inhibition of monoacylglycerol lipase by URB602 showed an anti-inflammatory and anti-nociceptive effect in a murine model of acute inflammation. British journal of pharmacology. vol 152. issue 5. 2008-02-25. PMID:17700715. |
2-arachidonoylglycerol (2-ag) is an endocannabinoid whose hydrolysis is predominantly catalysed by the enzyme monoacylglycerol lipase (magl). |
2008-02-25 |
2023-08-12 |
Not clear |
| M D Jhaveri, D Richardson, V Chapma. Endocannabinoid metabolism and uptake: novel targets for neuropathic and inflammatory pain. British journal of pharmacology. vol 152. issue 5. 2008-02-25. PMID:17704819. |
an alternative approach that can be used to harness the potential therapeutic effects of cannabinoids is to maximise the effects of the endocannabinoids, the actions of which are terminated by re-uptake and metabolism by various enzymes, including fatty acid amide hydrolase (faah), monoacylglycerol lipase (magl) and cyclooxygenase type 2 (cox2). |
2008-02-25 |
2023-08-12 |
Not clear |
| Geoffray Labar, Cédric Bauvois, Giulio G Muccioli, Johan Wouters, Didier M Lamber. Disulfiram is an inhibitor of human purified monoacylglycerol lipase, the enzyme regulating 2-arachidonoylglycerol signaling. Chembiochem : a European journal of chemical biology. vol 8. issue 11. 2007-09-14. PMID:17579916. |
monoacylglycerol lipase (magl) is a key enzyme responsible for the termination of endocannabinoid signaling. |
2007-09-14 |
2023-08-12 |
human |
| Haibin Wang, Huirong Xie, Xiaofei Sun, Philip J Kingsley, Lawrence J Marnett, Benjamin F Cravatt, Sudhansu K De. Differential regulation of endocannabinoid synthesis and degradation in the uterus during embryo implantation. Prostaglandins & other lipid mediators. vol 83. issue 1-2. 2007-03-29. PMID:17259073. |
we also provide evidence that region- and stage-specific uterine expression of n-acylphosphatidylethanolamine-specific phospholipase d (nape-pld) and fatty acid amide hydrolase (faah), and sn-1-diacylglycerol (dag) lipase alpha (daglalpha) and monoacylglycerol lipase (magl) for synthesis and hydrolysis of anandamide and 2-ag, respectively, creates endocannabinoid gradients conducive to implantation. |
2007-03-29 |
2023-08-12 |
mouse |
| Tiziana Bisogno, Maria Grazia Cascio, Bijali Saha, Anu Mahadevan, Paolo Urbani, Alberto Minassi, Giovanni Appendino, Carmela Saturnino, Billy Martin, Raj Razdan, Vincenzo Di Marz. Development of the first potent and specific inhibitors of endocannabinoid biosynthesis. Biochimica et biophysica acta. vol 1761. issue 2. 2006-05-31. PMID:16466961. |
enzymes for the biosynthesis and degradation of the endocannabinoid 2-arachidonoyl glycerol (2-ag) have been cloned and are the sn-1-selective-diacylglycerol lipases alpha and beta (daglalpha and beta) and the monoacylglycerol lipase (magl), respectively. |
2006-05-31 |
2023-08-12 |
human |
| Séverine Vandevoorde, Bijali Saha, Anu Mahadevan, Raj K Razdan, Roger G Pertwee, Billy R Martin, Christopher J Fowle. Influence of the degree of unsaturation of the acyl side chain upon the interaction of analogues of 1-arachidonoylglycerol with monoacylglycerol lipase and fatty acid amide hydrolase. Biochemical and biophysical research communications. vol 337. issue 1. 2005-11-14. PMID:16181610. |
little is known as to the structural requirements of the acyl side chain for interaction of acylglycerols with monoacylglycerol lipase (magl), the enzyme chiefly responsible for the metabolism of the endocannabinoid 2-arachidonoylglycerol (2-ag) in the brain. |
2005-11-14 |
2023-08-12 |
Not clear |
| C Somma-Delpéro, A Valette, J Lepetit-Thévenin, O Nobili, J Boyer, A Vérin. Purification and properties of a monoacylglycerol lipase in human erythrocytes. The Biochemical journal. vol 312 ( Pt 2). 1996-01-25. PMID:8526865. |
a membrane-bound monoacylglycerol lipase (magl) activity, previously demonstrated in intact human erythrocytes [boyer, somma, vérine, l'hôte, finidori, merger and arnaud (1981) j. clin. |
1996-01-25 |
2023-08-12 |
human |