| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Qing-Shan Xue, Wolfgang J Strei. Microglial pathology in Down syndrome. Acta neuropathologica. vol 122. issue 4. 2012-07-09. PMID:21847625. |
our findings using both iba1 and anti-ferritin immunostaining of microglial cells show that coincident with the appearance of tau pathology in ds subjects there is consistent presence of dystrophic microglial cells and conspicuous absence of activated microglia using both markers. |
2012-07-09 |
2023-08-12 |
human |
| Tomasz Jaworski, Benoit Lechat, David Demedts, Lies Gielis, Herman Devijver, Peter Borghgraef, Hans Duimel, Fons Verheyen, Sebastian Kügler, Fred Van Leuve. Dendritic degeneration, neurovascular defects, and inflammation precede neuronal loss in a mouse model for tau-mediated neurodegeneration. The American journal of pathology. vol 179. issue 4. 2012-01-23. PMID:21839061. |
in cx3cr1(egfp/egfp)-deficient mice, microglia were recruited early to neurons expressing human tau. |
2012-01-23 |
2023-08-12 |
mouse |
| T Pflanzner, C R Kuhlmann, C U Pietrzi. Blood-brain-barrier models for the investigation of transporter- and receptor-mediated amyloid-β clearance in Alzheimer's disease. Current Alzheimer research. vol 7. issue 7. 2011-11-23. PMID:20704558. |
besides the main neuropathological hallmarks of ad, provoked by the accumulation of amyloid-β (aβ) and tau hyperphosphorylation, other cells and cellular systems such as microglia and the neurovascular unit establishing the blood-brain-barrier (bbb) have been implicated to play a role in ad etiopathology. |
2011-11-23 |
2023-08-12 |
Not clear |
| Caroline C Rodger. Dental X-ray exposure and Alzheimer's disease: a hypothetical etiological association. Medical hypotheses. vol 77. issue 1. 2011-09-26. PMID:21458164. |
degenerated microglia lose their neuroprotective properties, resulting in the formation of neurofibrillary tau tangles and consequently, the neuronal death that causes alzheimer's dementia. |
2011-09-26 |
2023-08-12 |
human |
| Ricardo B Maccioni, Gonzalo Farías, Inelia Morales, Leonardo Navarret. The revitalized tau hypothesis on Alzheimer's disease. Archives of medical research. vol 41. issue 3. 2010-12-06. PMID:20682182. |
these activate microglia cells, releasing proinflammatory cytokines and producing neuronal degeneration and tau pathological modifications. |
2010-12-06 |
2023-08-12 |
Not clear |
| Edo Richard, Anna Carrano, Jeroen J Hoozemans, Jack van Horssen, Elise S van Haastert, Lisa S Eurelings, Helga E de Vries, Dietmar R Thal, Piet Eikelenboom, Willem A van Gool, Annemieke J M Rozemulle. Characteristics of dyshoric capillary cerebral amyloid angiopathy. Journal of neuropathology and experimental neurology. vol 69. issue 11. 2010-11-12. PMID:20940625. |
deposits of hyperphosphorylated tau and ubiquitin and clusters of activated microglia, resembling the changes around aβ plaques, were found around capcaa but were absent around larger vessel caa. |
2010-11-12 |
2023-08-12 |
Not clear |
| Yun Ding, Aimin Qiao, Guo-Huang Fa. Indirubin-3'-monoxime rescues spatial memory deficits and attenuates beta-amyloid-associated neuropathology in a mouse model of Alzheimer's disease. Neurobiology of disease. vol 39. issue 2. 2010-09-10. PMID:20381617. |
this was accompanied by a marked decrease in several ad-like phenotypes, including abeta deposition, tau hyperphosphorylation, accumulation of activated microglia and astrocytes around abeta plaques, and loss of synaptophysin immunoreactivity. |
2010-09-10 |
2023-08-12 |
mouse |
| Makoto Higuch. [In-vivo imaging for pursuing molecular cascades in the pathogenesis of neurodegenerative diseases]. Rinsho shinkeigaku = Clinical neurology. vol 49. issue 11. 2010-09-02. PMID:20030251. |
comparative pet assays of humans and animal models in conjunction with cognitive, biochemical and histopathological assessments have revealed toxic subspecies of amyloid beta peptide, tau proteins and microglia detectable by specific molecular probes. |
2010-09-02 |
2023-08-12 |
Not clear |
| Wolfgang J Streit, Heiko Braak, Qing-Shan Xue, Ingo Bechman. Dystrophic (senescent) rather than activated microglial cells are associated with tau pathology and likely precede neurodegeneration in Alzheimer's disease. Acta neuropathologica. vol 118. issue 4. 2009-10-08. PMID:19513731. |
although several works suggest that chronic neuroinflammation caused by activated microglia contributes to neurofibrillary degeneration, anti-inflammatory drugs do not prevent or reverse neuronal tau pathology. |
2009-10-08 |
2023-08-12 |
human |
| Kazuaki Ichihara, Toshiki Uchihara, Ayako Nakamura, Yoshio Suzuki, Tomohiko Mizutan. Selective deposition of 4-repeat tau in cerebral infarcts. Journal of neuropathology and experimental neurology. vol 68. issue 9. 2009-10-01. PMID:19680140. |
although this staining profile is characteristic of degenerative processes with 4r-tau deposition, lack of at8 immunoreactivity and of fibrillary structures in neurons, astrocytes, and microglia indicates that selective 4r-tau deposition represents a stage without tau phosphorylation or fibril formation in cerebral infarcts. |
2009-10-01 |
2023-08-12 |
Not clear |
| Philipp Gorlovoy, Sergey Larionov, Thao Thi Hien Pham, Harald Neuman. Accumulation of tau induced in neurites by microglial proinflammatory mediators. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 23. issue 8. 2009-08-18. PMID:19289607. |
coculture of neurons with activated microglia induced aggregation of tau in neurites. |
2009-08-18 |
2023-08-12 |
human |
| Philipp Gorlovoy, Sergey Larionov, Thao Thi Hien Pham, Harald Neuman. Accumulation of tau induced in neurites by microglial proinflammatory mediators. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 23. issue 8. 2009-08-18. PMID:19289607. |
these data demonstrate that activated microglia and the microglial-derived proinflammatory cytokine tnf can induce accumulation of the aggregation-prone tau molecules in neurites via reactive oxygen species. |
2009-08-18 |
2023-08-12 |
human |
| Norbert Zilka, Zuzana Stozicka, Andrej Kovac, Emil Pilipcinec, Ondrej Bugos, Michal Nova. Human misfolded truncated tau protein promotes activation of microglia and leukocyte infiltration in the transgenic rat model of tauopathy. Journal of neuroimmunology. vol 209. issue 1-2. 2009-06-22. PMID:19232747. |
human misfolded truncated tau protein promotes activation of microglia and leukocyte infiltration in the transgenic rat model of tauopathy. |
2009-06-22 |
2023-08-12 |
human |
| b' Johanna Ojala, Irina Alafuzoff, Sanna-Kaisa Herukka, Thomas van Groen, Heikki Tanila, Tuula Pirttil\\xc3\\xa. Expression of interleukin-18 is increased in the brains of Alzheimer\'s disease patients. Neurobiology of aging. vol 30. issue 2. 2009-02-19. PMID:17658666.' |
immunohistochemistry of ad brain samples detected il-18 in microglia, astrocytes, and surprisingly in neurons, and it is also co-localized not only with amyloid-beta plaques but also with tau. |
2009-02-19 |
2023-08-12 |
Not clear |
| Atsushi Sasaki, Takeshi Kawarabayashi, Tetsuro Murakami, Etsuro Matsubara, Masaki Ikeda, Haruo Hagiwara, David Westaway, Peter S George-Hyslop, Mikio Shoji, Yoichi Nakazat. Microglial activation in brain lesions with tau deposits: comparison of human tauopathies and tau transgenic mice TgTauP301L. Brain research. vol 1214. 2008-09-19. PMID:18457819. |
the aim of this study is to clarify the relationship of microglia to phosphorylated tau accumulation and the characteristics of microglial activation in brain lesions of human tauopathies in comparison to mutant tau transgenic (tg) mice. |
2008-09-19 |
2023-08-12 |
mouse |
| Atsushi Sasaki, Takeshi Kawarabayashi, Tetsuro Murakami, Etsuro Matsubara, Masaki Ikeda, Haruo Hagiwara, David Westaway, Peter S George-Hyslop, Mikio Shoji, Yoichi Nakazat. Microglial activation in brain lesions with tau deposits: comparison of human tauopathies and tau transgenic mice TgTauP301L. Brain research. vol 1214. 2008-09-19. PMID:18457819. |
in human tauopathies, iba1- and major histocompatibility complex (mhc) class ii-positive activated microglia increased in regions of phosphorylated tau (at8) accumulation. |
2008-09-19 |
2023-08-12 |
mouse |
| Atsushi Sasaki, Takeshi Kawarabayashi, Tetsuro Murakami, Etsuro Matsubara, Masaki Ikeda, Haruo Hagiwara, David Westaway, Peter S George-Hyslop, Mikio Shoji, Yoichi Nakazat. Microglial activation in brain lesions with tau deposits: comparison of human tauopathies and tau transgenic mice TgTauP301L. Brain research. vol 1214. 2008-09-19. PMID:18457819. |
this comparative study of human tauopathies and tau tg mice indicated that microglial activation was closely related to phosphorylated tau accumulation, and that activated microglia of the tg mice may have the low expression of mhc class ii and sra compared with those of human tauopathies. |
2008-09-19 |
2023-08-12 |
mouse |
| Shabnam Baig, Gordon K Wilcock, Seth Lov. Loss of perineuronal net N-acetylgalactosamine in Alzheimer's disease. Acta neuropathologica. vol 110. issue 4. 2007-10-19. PMID:16133543. |
we have investigated the relative preservation of wisteria floribunda agglutinin (wfa)-positive pns and parvalbumin-positive neurons in alzheimer's disease (ad), and the relationship of wfa-positive pns to parenchymal tau, amyloid beta-peptide (abeta) and mhc class ii antigen (a marker of activated microglia), in paraffin sections of 100 cases with ad and 45 controls. |
2007-10-19 |
2023-08-12 |
Not clear |
| Masashi Kitazawa, Tritia R Yamasaki, Frank M LaFerl. Microglia as a potential bridge between the amyloid beta-peptide and tau. Annals of the New York Academy of Sciences. vol 1035. 2006-07-13. PMID:15681802. |
microglia as a potential bridge between the amyloid beta-peptide and tau. |
2006-07-13 |
2023-08-12 |
Not clear |
| Masashi Kitazawa, Tritia R Yamasaki, Frank M LaFerl. Microglia as a potential bridge between the amyloid beta-peptide and tau. Annals of the New York Academy of Sciences. vol 1035. 2006-07-13. PMID:15681802. |
however, mounting evidence indicates that chronic activation of microglia, presumably via the secretion of cytokines and reactive molecules, may exacerbate plaque pathology as well as enhance the hyperphosphorylation of tau and the subsequent development of neurofibrillary tangles. |
2006-07-13 |
2023-08-12 |
Not clear |