| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| S Korsching, G Auburger, R Heumann, J Scott, H Thoene. Levels of nerve growth factor and its mRNA in the central nervous system of the rat correlate with cholinergic innervation. The EMBO journal. vol 4. issue 6. 1985-10-03. PMID:2411537. |
relatively high ngf levels (0.4-1.4 ng ngf/g wet weight) were found both in the regions innervated by the magnocellular cholinergic neurons of the basal forebrain (hippocampus, olfactory bulb, neocortex) and in the regions containing the cell bodies of these neurons (septum, nucleus of the diagonal band of broca, nucleus basalis of meynert). |
1985-10-03 |
2023-08-11 |
rat |
| S Korsching, G Auburger, R Heumann, J Scott, H Thoene. Levels of nerve growth factor and its mRNA in the central nervous system of the rat correlate with cholinergic innervation. The EMBO journal. vol 4. issue 6. 1985-10-03. PMID:2411537. |
this suggests that magnocellular cholinergic neurons of the basal forebrain are supplied with ngf via retrograde axonal transport from their fields of innervation. |
1985-10-03 |
2023-08-11 |
rat |
| S Korsching, G Auburger, R Heumann, J Scott, H Thoene. Levels of nerve growth factor and its mRNA in the central nervous system of the rat correlate with cholinergic innervation. The EMBO journal. vol 4. issue 6. 1985-10-03. PMID:2411537. |
these results, taken together with those of previous studies showing that these neurons are responsive to ngf, support the concept that ngf acts as trophic factor for magnocellular cholinergic neurons. |
1985-10-03 |
2023-08-11 |
rat |
| L M Vicentini, F Di Virgilio, A Ambrosini, T Pozzan, J Meldoles. Tumor promoter phorbol 12-myristate, 13-acetate inhibits phosphoinositide hydrolysis and cytosolic Ca2+ rise induced by the activation of muscarinic receptors in PC12 cells. Biochemical and biophysical research communications. vol 127. issue 1. 1985-04-15. PMID:2983712. |
preincubation of pc12 cells (used both before and after differentiation by ngf) with phorbol myristate acetate (pma) was without effect on the basal concentration of inositol phosphates (metabolites of phosphoinositide hydrolysis) and of free cytosolic ca2+, but inhibited considerably the increases induced by the cholinergic agonist carbachol via the activation of the muscarinic receptor. |
1985-04-15 |
2023-08-11 |
Not clear |
| M Seiler, M E Schwa. Specific retrograde transport of nerve growth factor (NGF) from neocortex to nucleus basalis in the rat. Brain research. vol 300. issue 1. 1984-08-07. PMID:6203605. |
[125i]labeled ngf injected in very small quantities into the frontal or dorsal anterior occipital cortex of adult rats, was specifically taken up and transported retrogradely to large, presumably cholinergic neurons in the nucleus basalis region (lateral preoptic nucleus, anterior lateral hypothalamic nucleus, substantia innominata, ventral globus pallidus and internal capsule), as revealed by light microscopic autoradiography. |
1984-08-07 |
2023-08-12 |
rat |
| M Seiler, M E Schwa. Specific retrograde transport of nerve growth factor (NGF) from neocortex to nucleus basalis in the rat. Brain research. vol 300. issue 1. 1984-08-07. PMID:6203605. |
this high selectivity for uptake and retrograde transport of ngf indicates the presence of membrane receptors for ngf or a closely related molecule on these cholinergic neurons of the basal forebrain innervating the cerebral cortex. |
1984-08-07 |
2023-08-12 |
rat |
| F Hefti, A Dravid, J Hartikk. Chronic intraventricular injections of nerve growth factor elevate hippocampal choline acetyltransferase activity in adult rats with partial septo-hippocampal lesions. Brain research. vol 293. issue 2. 1984-04-17. PMID:6697222. |
nerve growth factor (ngf) was injected intraventricularly during 4 weeks into adult rats with unilateral partial lesions of the cholinergic septo-hippocampal pathway. |
1984-04-17 |
2023-08-12 |
rat |
| C M Amy, E L Bennet. Increased sodium ion conductance through nicotinic acetylcholine receptor channels in PC12 cells exposed to nerve growth factors. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 3. issue 8. 1983-09-20. PMID:6308184. |
22na+ uptake in response to cholinergic stimulation was measured in pc12 cells grown in media containing either beta-nerve growth factor (ngf) from mouse submaxillary gland or a component of bungarus multicinctus venom (fraction 9b) which has nerve growth factor activity. |
1983-09-20 |
2023-08-12 |
mouse |
| P Honegger, D Lenoi. Nerve growth factor (NGF) stimulation of cholinergic telencephalic neurons in aggregating cell cultures. Brain research. vol 255. issue 2. 1982-04-20. PMID:7055724. |
nerve growth factor (ngf) stimulation of cholinergic telencephalic neurons in aggregating cell cultures. |
1982-04-20 |
2023-08-12 |
rat |
| P Honegger, D Lenoi. Nerve growth factor (NGF) stimulation of cholinergic telencephalic neurons in aggregating cell cultures. Brain research. vol 255. issue 2. 1982-04-20. PMID:7055724. |
ngf treatments during different culture periods showed that the cholinergic neurons remained responsive for at least 19 days. |
1982-04-20 |
2023-08-12 |
rat |
| D Edgar, Y A Barde, H Thoene. Subpopulations of cultured chick sympathetic neurones differ in their requirements for survival factors. Nature. vol 289. issue 5795. 1981-03-24. PMID:7453824. |
those subpopulations responding to hcm and ngf are shown to differ not only in their requirements for survival factors but also in their contents of the cholinergic and adrenergic marker enzymes choline acetyltransferase (chat) and tyrosine hydroxylase (th). |
1981-03-24 |
2023-08-12 |
chicken |
| L L Chun, P H Patterso. Role of nerve growth factor in the development of rat sympathetic neurons in vitro. III. Effect on acetylcholine production. The Journal of cell biology. vol 75. issue 3. 1978-01-27. PMID:925077. |
the effect of nerve growth factor (ngf) on the development of cholinergic sympathetic neurons was studied in cultures grown either on monolayers of dissociated rat heart cells or in medium conditioned by them. |
1978-01-27 |
2023-08-11 |
rat |
| L L Chun, P H Patterso. Role of nerve growth factor in the development of rat sympathetic neurons in vitro. III. Effect on acetylcholine production. The Journal of cell biology. vol 75. issue 3. 1978-01-27. PMID:925077. |
as cholinergic neurons developed in culture, they became less dependent on ngf for survival and ach production, but even in older cultures approximately 40% of the neurons died when ngf was withdrawn. |
1978-01-27 |
2023-08-11 |
rat |
| L L Chun, P H Patterso. Role of nerve growth factor in the development of rat sympathetic neurons in vitro. III. Effect on acetylcholine production. The Journal of cell biology. vol 75. issue 3. 1978-01-27. PMID:925077. |
thus, ngf is as necessary for survival, growth, and differentiation of sympathetic neurons when the neurons express cholinergic functions as when the neurons express adrenergic functions (4, 5). |
1978-01-27 |
2023-08-11 |
rat |
| E Giacobin. Neuronal control of neurotransmitters biosynthesis during development. Journal of neuroscience research. vol 1. issue 3-4. 1976-08-02. PMID:5613. |
principally the effect of a) the administration of drugs and precursors such as l-dopa, 3h-dopa, 6-oh dopa; b) the prenatal administration of reserpine; c) the blockade of cholinergic receptors; d) the nerve growth factor (ngf) is analyzed. |
1976-08-02 |
2023-08-11 |
chicken |