| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Maria Soltero-Rivera, Claire Shaw, Boaz Arzi, Milinda Lommer, Bart C Weime. Feline Chronic Gingivostomatitis Diagnosis and Treatment through Transcriptomic Insights. Pathogens (Basel, Switzerland). vol 13. issue 3. 2024-03-27. PMID:38535535. |
in conjunction, the enzymes caspase 4 (casp4), matrix metalloproteinase-8 (mmp8), and prostaglandin-endoperoxide synthase 2 (ptgs2) were identified as potential biomarkers for the prediction of treatment response outcomes. |
2024-03-27 |
2024-03-29 |
Not clear |
| Bowen Yang, Qiuwen Zhu, Xiaodong Wang, Jingxin Mao, Shuqing Zho. Using network pharmacology and molecular docking verification to explore the mechanism of ursolic acid in the treatment of osteoporosis. Medicine. vol 101. issue 49. 2023-01-10. PMID:36626454. |
a total of 24 core target genes were obtained, mainly including tumor protein p53 (tp53), vascular endothelial growth factor a (vegfa), interleukin-6 (il6), tumor necrosis factor (tnf), caspase3 (casp3), matrix metallo protein (mmp9), transcription factor ap-1 (jun), activator of transcription 3 (stat3), mitogen-activated protein kinase 8 (mapk8), and prostaglandin endoperoxidase 2 (ptgs2), respectively. |
2023-01-10 |
2023-08-14 |
Not clear |
| Ruolan Li, Jirong Xie, Wei Xu, Ling Zhang, Huimin Lin, Wanjun Huan. LPS-induced PTGS2 manipulates the inflammatory response through trophoblast invasion in preeclampsia via NF-κB pathway. Reproductive biology. vol 22. issue 4. 2022-11-03. PMID:36327673. |
quantitative real-time polymerase chain reaction (qrt-pcr), western blotting, and immunofluorence assays were performed to quantify the expressions of ptgs2 and involved genes (matrix metallopeptidase 2 (mmp-2), tissue inhibitors of metalloproteinase-2 (timp-2), p65, p-p65, iκb-α, p-iκb-α, ptgis, cav1, agtr1). |
2022-11-03 |
2023-08-14 |
Not clear |
| Hongkuan Han, Cheng Qian, Gangfan Zong, Huan Liu, Feihui Wang, Ruizhi Tao, Peng Cheng, Zhonghong Wei, Yang Zhao, Yin L. Systemic pharmacological verification of Salvia miltiorrhiza-Ginseng Chinese herb pair in inhibiting spontaneous breast cancer metastasis. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 156. 2022-10-29. PMID:36308918. |
then, based on systematic pharmacology combined with gene expression omnibus (geo) database, potential targets of drugs were identified such as vascular endothelial growth factor a (vegfa), matrix metalloproteinase (mmp9), prostaglandin endoperoxide synthase2 (ptgs2), etc. |
2022-10-29 |
2023-08-14 |
Not clear |
| Ze-Yu Li, Er-Wei Hao, Rui Cao, Si Lin, Shu-Ying Chen, Xian-Ting Huang, Wan-Ru Xu, Xiao-Tao Hou, Jia-Gang Den. [Medication law and mechanism of traditional Chinese medicine in prevention and treatment of epidemic diseases: based on traditional Chinese medicine theory of cold pestilence]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 47. issue 17. 2022-09-27. PMID:36164884. |
it was determined that the key targets were tumor necrosis factor(tnf), endothelial growth factor a(vegfa), serum creatinine(src), epidermal growth factor receptor(egfr), matrix metalloproteinase 9(mmp9), mitogen-activated protein kinase 14(mapk14), and prostaglandin-endoperoxide synthase 2(ptgs2), which were involved the mitogen-activated protein kinase(mapk) pathway, advanced glycation end-products(age)-receptor for age(rage) pathway, covid-19 pathway, and mtor pathway. |
2022-09-27 |
2023-08-14 |
Not clear |
| Yongqiang Sha, Beibei Zhang, Liping Chen, Chunli Wang, Tao Su. Dehydrocorydaline Accelerates Cell Proliferation and Extracellular Matrix Synthesis of TNFα-Treated Human Chondrocytes by Targeting Cox2 through JAK1-STAT3 Signaling Pathway. International journal of molecular sciences. vol 23. issue 13. 2022-07-09. PMID:35806272. |
we found that tnfα treatment significantly reduced cell proliferation and mrna and protein expression levels of aggrecan and type ii collagen, but caused an increase in mrna and protein expression levels of type i collagen, matrix metalloproteinase 1/13 (mmp1/13), and prostaglandin-endoperoxide synthase 2 (ptgs2, also known as cox2) in human chondrocytes. |
2022-07-09 |
2023-08-14 |
human |
| Zhen Wang, Hui Liu, Yunxiang Cao, Tiantian Zhang, Hongyan Guo, Bin Wan. A novel method for investigating the mechanism of anti-rheumatoid arthritis activity of Angelicae pubescentis Radix by integrating UHPLC-QTOF/MS and network pharmacology. Biomedical chromatography : BMC. 2022-04-29. PMID:35484722. |
subsequently, molecular docking was performed by establishing a mixed matrix network including the absorbed component, corresponding target, and signaling pathway with two key compounds (osthole and columbianadin) and two important targets (ptgs2 and ptgs1). |
2022-04-29 |
2023-08-13 |
rat |
| Rui Dong, Renxuan Huang, Xiaohua Shi, Zhongxin Xu, Jing Man. Exploration of the Mechanism of Luteolin Against Ischemic Stroke Based on Network Pharmacology, Molecular Docking and Experimental Verification. Bioengineered. 2021-12-13. PMID:34898370. |
from 95 candidate luteolin target genes, our analysis identified six core target genes through protein-protein interaction (ppi) network analysis including matrix metalloproteinase 9 (mmp9), mitogen-activated protein kinase 3 (mapk3), prostaglandin h synthase 2 (ptgs2), jun, interleukins-1β(il1b), tumor necrosis factor (tnf). |
2021-12-13 |
2023-08-13 |
Not clear |
| Huimin Pei, Shaokang Wu, Lijun Zheng, Hanxun Wang, Xiangrong Zhan. Identification of the active compounds and their mechanisms of medicinal and edible Shanzha based on network pharmacology and molecular docking. Journal of food biochemistry. 2021-11-26. PMID:34825377. |
the key targets were prostaglandin-endoperoxide synthase 2 (ptgs2), serine/threonine-protein kinase mtor (mtor), heat shock protein hsp 90-alpha (hsp90aa1), mitogen-activated protein kinase 1 (mapk1), mapk3, e3 ubiquitin-protein ligase mdm2 (mdm2), receptor tyrosine-protein kinase erbb-2 (erbb2), caspase-3 (casp3), matrix metalloproteinase-9 (mmp9), estrogen receptor (esr1), tumor necrosis factor (tnf), phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (pik3ca), and peroxisome proliferator-activated receptor gamma (pparg), which played the vital roles in tnf, prostate cancer, thyroid hormone, hepatitis b and estrogen signaling pathway. |
2021-11-26 |
2023-08-13 |
Not clear |
| Adam J Ziecik, Jan Klos, Katarzyna Gromadzka-Hliwa, Mariola A Dietrich, Mariola Slowinska, Pawel Likszo, Katarzyna Knapczyk-Stwora, Zdzislaw Gajewski, Monika M Kaczmare. Endocrine and molecular milieus of ovarian follicles are diversely affected by human chorionic gonadotropin and gonadotropin-releasing hormone in prepubertal and mature gilts. Scientific reports. vol 11. issue 1. 2021-11-08. PMID:34188064. |
trigger- and/or maturity-dependent changes in the abundance of hormone receptors (fshr and lhcgr) and proteins associated with lipid metabolism and steroidogenesis (e.g., star, hsd3b1, and cyp11a1), prostaglandin synthesis (ptgs2 and ptgfs), extracellular matrix remodeling (mmp1 and timp1), protein folding (hsps), molecular transport (tf), and cell function and survival (e.g., vim) were observed. |
2021-11-08 |
2023-08-13 |
human |
| Hsien-Tsung Lu, Jeng-Wei Lu, Chian-Her Lee, Yi-Jen Peng, Herng-Sheng Lee, You-Hsiang Chu, Yi-Jung Ho, Feng-Cheng Liu, Pei-Hung Shen, Chih-Chien Wan. Attenuative Effects of Platelet-Rich Plasma on 30 kDa Fibronectin Fragment-Induced MMP-13 Expression Associated with TLR2 Signaling in Osteoarthritic Chondrocytes and Synovial Fibroblasts. Journal of clinical medicine. vol 10. issue 19. 2021-10-16. PMID:34640514. |
this study observed an increase in the protein expression of matrix metalloproteinases (mmps), toll-like receptor 2 (tlr2), nitric oxide synthase 2 (nos2), prostaglandin-endoperoxide synthase (ptgs2), and cyclooxygenase 2 (cox2) in articular chondrocytes, meniscal fibrochondrocytes, and synovial fibroblasts following insult with 30 kda fn-f. upregulation of these genes was significantly attenuated by prp treatment. |
2021-10-16 |
2023-08-13 |
human |
| Jing Ma, Yue Ren, Jia-Ning Zhang, Li Lin, Yan-Ling Zhan. [Analysis on targets of regulating Qi and activating blood based on activity spectrum of targets]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 46. issue 15. 2021-09-03. PMID:34472274. |
the enrichment analysis of topology, go and kegg showed that tcm for activating blood circulation mainly exerted its anti-inflammatory, neuroprotective and angiogenic effects on signaling cascade pathway mediated by vegf/vegfr2, erk signaling pathway, calcium signaling pathway and pi3 k-akt signaling pathway, and the key targets included mitogen activated protein kinases 3(mapk3), proto-oncogene tyrosine-protein kinase src(src), mitogen activated protein kinases 1(mapk1), epidermal growth factor receptor(egfr), phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(pik3 ca), peroxisome proliferators-activated receptor gamma(pparg), nitric oxide synthase 3(nos3), prostaglandin g/h synthetase 2(ptgs2), matrix metalloproteinase-9(mmp9), and vascular endothelial growth factor a(vegfa). |
2021-09-03 |
2023-08-13 |
Not clear |
| Mingmin Wang, Shuangjie Yang, Mingyan Shao, Qian Zhang, Xiaoping Wang, Linghui Lu, Sheng Gao, Yong Wang, Wei Wan. Identification of Potential Bioactive Ingredients and Mechanisms of the Guanxin Suhe Pill on Angina Pectoris by Integrating Network Pharmacology and Molecular Docking. Evidence-based complementary and alternative medicine : eCAM. vol 2021. 2021-08-24. PMID:34422068. |
protein-protein interaction identified vegfa (vascular endothelial growth factor a), tnf (tumor necrosis factor), ccl2 (c-c motif chemokine ligand 2), fn1 (fibronectin 1), mmp9 (matrix metallopeptidase 9), ptgs2 (prostaglandin-endoperoxide synthase 2), il10 (interleukin 10), cxcl8 (c-x-c motif chemokine ligand 8), il6 (interleukin 6), and ins (insulin) as hub targets for gsp, which were involved in the inflammatory process, ecm proteolysis, glucose metabolism, and lipid metabolism. |
2021-08-24 |
2023-08-13 |
Not clear |
| Yoshitaka Hosokawa, Ikuko Hosokawa, Kazumi Ozak. Nobiletin Decreases Inflammatory Mediator Expression in Tumor Necrosis Factor-Stimulated Human Periodontal Ligament Cells. Mediators of inflammation. vol 2021. 2021-08-03. PMID:34335088. |
our results demonstrated that nobiletin treatment could decrease the expressions of inflammatory cytokines (c-x-c motif chemokine ligand (cxcl)10, c-c motif chemokine ligand (ccl)2, and interleukin- (il-) 8), matrix metalloproteinases (mmps) (mmp1 and mmp3), and prostaglandin-endoperoxide synthase 2 (ptgs2) in tnf-stimulated hpdlcs. |
2021-08-03 |
2023-08-13 |
human |
| C Neidlinger-Wilke, A Ekkerlein, R M Goncalves, J R Ferreira, A Ignatius, H J Wilke, G Q Teixeir. Mesenchymal stem cell secretome decreases the inflammatory response in annulus fibrosus organ cultures. European cells & materials. vol 41. 2021-08-02. PMID:34235715. |
a 4 d treatment of the cts + il-1β-stimulated af-ocs with msc secretome downregulated the expression of inflammation markers [il-6, il-8, prostaglandin-endoperoxide synthase 2 (ptgs2)], complement system regulators [cluster of differentiation (cd)46, cd55, cd59] and matrix metalloproteinase 1 but also of tissue inhibitors of metalloproteinases (timp-1, timp-2) and collagen type i. |
2021-08-02 |
2023-08-13 |
cattle |
| Jae-Jun Song, Yoon Young Go, Jong Kyou Lee, Bum Sang Lee, Su-Kyoung Park, Harry Jung, Jun Ho Lee, Jiwon Chan. Transcriptomic analysis of tobacco-flavored E-cigarette and menthol-flavored E-cigarette exposure in the human middle ear. Scientific reports. vol 10. issue 1. 2021-03-22. PMID:33247188. |
under menthol-flavored e-liquid treatment, mmp9 (matrix metallopeptidase 9), ptgs2 (prostaglandin-endoperoxide synthase 2), myc (myc proto-oncogene, bhlh transcription factor), hmox1 (heme oxygenase 1), nos3 (nitric oxide synthase 3), and cav1 (caveolin 1) were predicted as key genes. |
2021-03-22 |
2023-08-13 |
human |
| Qionglong Jin, Jie Lu, Renhui Gao, Jiaying Xu, Xiaoyan Pan, Lichang Wan. Systematically Deciphering the Pharmacological Mechanism of Fructus Aurantii via Network Pharmacology. Evidence-based complementary and alternative medicine : eCAM. vol 2021. 2021-02-06. PMID:33542744. |
prostaglandin g/h synthase 2 (ptgs2), heat shock protein 90 (hsp90), cell division protein kinase 6 (cdk6), caspase 3 (casp3), apoptosis regulator bcl-2 (bcl-2), and matrix metalloproteinase-9 (mmp9) were identified as key targets of fa in the treatment of multiple diseases. |
2021-02-06 |
2023-08-13 |
Not clear |
| Li Shao, Ri-Cheng Chian, Yixin Xu, Zhengjie Yan, Yihui Zhang, Chao Gao, Li Gao, Jiayin Liu, Yugui Cu. Genomic expression profiles in cumulus cells derived from germinal vesicle and MII mouse oocytes. Reproduction, fertility, and development. 2019-11-20. PMID:25989843. |
genes related to epidermal growth factor, extracellular matrix (ptgs2, ereg, tnfaip6 and efemp1), mitochondrial metabolism (fdx1 and aifm2), gap junctions and the cell cycle (gja1, gja4, ccnd2, ccna2 and ccnb2) were highlighted as being differentially expressed between the two development stages. |
2019-11-20 |
2023-08-13 |
mouse |
| Olga Krupkova, Marian Hlavna, Julie Amir Tahmasseb, Joel Zvick, Dominik Kunz, Keita Ito, Stephen J Ferguson, Karin Wuertz-Koza. An Inflammatory Nucleus Pulposus Tissue Culture Model to Test Molecular Regenerative Therapies: Validation with Epigallocatechin 3-Gallate. International journal of molecular sciences. vol 17. issue 10. 2019-11-20. PMID:27689996. |
on the other hand, il-1β and tnf-α significantly increased the mrna expression of inflammatory mediators il-6, il-8, inducible nitric oxide synthase (inos), prostaglandin-endoperoxide synthase 2 (ptgs2) and matrix metalloproteinases (mmp1, mmp3, and mmp13). |
2019-11-20 |
2023-08-13 |
cattle |
| Jian Zhou, Chenxi Li, Anqi Yu, Shuo Jie, Xiadong Du, Tang Liu, Wanchun Wang, Yingquan Lu. Bioinformatics analysis of differentially expressed genes involved in human developmental chondrogenesis. Medicine. vol 98. issue 27. 2019-07-11. PMID:31277141. |
the top 30 developmental chondrogenesis associated genes were identified, including matrix metalloproteinase (mmp)1, mmp3, mmp13, prostaglandin-endoperoxide synthase 2 (ptgs2), and so on. |
2019-07-11 |
2023-08-13 |
human |