| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jun Endo, Takahisa Sasho, Ryuichiro Akagi, Yuta Muramatsu, Atsuya Watanabe, Yorikazu Akatsu, Taisuke Fukawa, Masamichi Tahara, Satoshi Yamaguch. Comparative Analysis of Gene Expression between Cartilage and Menisci in Early-Phase Osteoarthritis of the Knee-An Animal Model Study. The journal of knee surgery. vol 31. issue 7. 2018-11-02. PMID:28915521. |
representative proteases including adamts2, 4, mmp2, 12, 13, 14, 16, extracellular matrix genes including versican (vcan), lumican (lum), syndecan1 (sdc1), and prostaglandin endoperoxide synthase2 (ptgs2) were up-regulated in menisci, but were not up-regulated in cartilage. |
2018-11-02 |
2023-08-13 |
rat |
| Xiang Jin, Zhiyong Ji, Xiaodan Li, Rui Liu, Yinghui Gua. Bioinformatics analysis and verification of key genes associated with recurrent respiratory tract infections. International journal of molecular medicine. vol 42. issue 1. 2018-09-26. PMID:29693136. |
there was statistical significance between case and control groups for peroxisome proliferator-activated receptor-γ (pparg), prostaglandin-endoperoxide synthase 2 (ptgs2), transferrin (tf) and interleukin-10 (il-10) (p<0.05), and there was no statistical significance between case and control groups for timp metallopeptidase inhibitor 1 (timp1) and matrix metallopeptidase 1 (mmp1). |
2018-09-26 |
2023-08-13 |
human |
| Seok Hee Lee, Hyun Ju Oh, Min Jung Kim, Geon A Kim, Yoo Bin Choi, Young Kwang Jo, Erif Maha Nugraha Setyawan, Byeong Chun Le. Effect of co-culture canine cumulus and oviduct cells with porcine oocytes during maturation and subsequent embryo development of parthenotes in vitro. Theriogenology. vol 106. 2018-07-18. PMID:29049922. |
moreover, the levels of gdf9, prostaglandin-endoperoxide synthase 2 (ptgs2), wnt3a and matrix metalloproteinase 2 (mmp2) were significantly up-regulated in blastocysts from the coc group. |
2018-07-18 |
2023-08-13 |
Not clear |
| Patricia G Tremblay, Marc-André Sirar. Transcriptomic analysis of gene cascades involved in protein kinase A and C signaling in the KGN line of human ovarian granulosa tumor cells†. Biology of reproduction. vol 96. issue 4. 2018-03-12. PMID:28383663. |
gene associations with seven major ovarian functions were identified: prostaglandin- endoperoxide synthase 2 (ptgs2), interleukin 8 (il8), and interleukin 6 (il6) with inflammation; steroidogenic acute regulatory protein (star), cytochrome p450scc (cyp11a1), and cytochrome p450 family 19 subfamily a member 1 (cyp19a1) with steroidogenesis; vascular endothelial growth factor c (vegfc), vascular endothelial growth factor a (vegfa), and c-x-c chemokine receptor type 4 (cxcr4) with angiogenesis; amphiregulin (areg), epidermal growth factor receptor (egfr), and sprouty rtk signaling antagonist 2 (spry2) with differentiation, bcl2 associated x (bax), bcl2 like 12 (bcl2l12), and caspase 1(casp1) with apoptosis, cyclin d1 (ccnd1), cyclin b1 (ccnb1), and cyclin b2 (ccnb2) with division; and matrix metalloproteinase-1 (mmp1), matrix metallopeptidase 9 (mmp9), and timp metallopeptidase inhibitor 1 (timp1) with ovulation. |
2018-03-12 |
2023-08-13 |
human |
| Ji-Long Liu, Ru-Juan Zuo, Ying Peng, Yong-Sheng F. The Impact of Multiparity on Uterine Gene Expression and Decidualization in Mice. Reproductive sciences (Thousand Oaks, Calif.). vol 23. issue 5. 2017-01-19. PMID:26494701. |
quantitative reverse transcription (rt) polymerase chain reaction (qrt-pcr) analysis confirmed a decreased expression of 4 genes (klk1, kallikrein 1; h2-eb1, histocompatibility 2 class ii antigen e beta; mmp7, matrix metallopeptidase 7; pdpn, podoplanin) and an increase in expression of 2 genes (thy1, thymus cell antigen 1; ptgs2, prostaglandin-endoperoxide synthase 2) in sp. |
2017-01-19 |
2023-08-13 |
mouse |
| Martha Lappa. NOD1 expression is increased in the adipose tissue of women with gestational diabetes. The Journal of endocrinology. vol 222. issue 1. 2014-09-28. PMID:24829218. |
in both omental and subcutaneous adipose tissues from ngt and gdm women, the nod1 ligand g-d-glutamyl-meso-diaminopimelic acid (ie-dap) significantly induced the expression and secretion of the pro-inflammatory cytokine interleukin 6 (il6) and chemokine il8; cox2 (ptgs2) gene expression and subsequent prostaglandin production; the expression and secretion of the extracellular matrix remodelling enzyme matrix metalloproteinase 9 (mmp9) and the gene expression and secretion of the adhesion molecules icam1 and vcam1. |
2014-09-28 |
2023-08-13 |
Not clear |
| Ming Du, Xiangwei Fu, Yanhua Zhou, Shien Zh. Effects of Trichostatin A on Cumulus Expansion during Mouse Oocyte Maturation. Asian-Australasian journal of animal sciences. vol 26. issue 11. 2014-07-22. PMID:25049740. |
to determine the underlying mechanism, the expression levels of several key factors that play crucial roles in cumulus expansion including components of extracellular matrix (ecm) (has2, ptgs2, ptx3, and tnfaip6) and growth differentiation factor 9 (gdf9) were measured in control and tsa treated samples by real-time pcr. |
2014-07-22 |
2023-08-13 |
mouse |
| Ratana Lim, Gillian Barker, Martha Lappa. A novel role for FOXO3 in human labor: increased expression in laboring myometrium, and regulation of proinflammatory and prolabor mediators in pregnant human myometrial cells. Biology of reproduction. vol 88. issue 6. 2013-10-21. PMID:23636809. |
we found that the loss of foxo3 in myometrial cells was associated with a significant decrease in il1b-induced il6 and il8 expression and production, cyclooxygenase ([cox]-2, official symbol ptgs2) expression and subsequent prostaglandin (pge2 and pgf2alpha) release, and matrix metalloproteinase 9 (mmp9) and mrna expression and activity. |
2013-10-21 |
2023-08-12 |
human |
| Koichi Goto, Masako Imaoka, Mayumi Goto, Isamu Kikuchi, Takami Suzuki, Toshimasa Jindo, Wataru Takasak. Effect of body-weight loading onto the articular cartilage on the occurrence of quinolone-induced chondrotoxicity in juvenile rats. Toxicology letters. vol 216. issue 2-3. 2013-05-03. PMID:23201441. |
animals were sacrificed at 8h post-dose, and then the distal femoral articular cartilage was subjected to a histological examination and an investigation for gene expression of tumor necrosis factor receptor superfamily, member 12a (tnfrsf12a); prostaglandin-endoperoxide synthase 2 (ptgs2); plasminogen activator, urokinase receptor (plaur); and matrix metalloproteinase 3 (mmp3) by qrt-pcr analysis. |
2013-05-03 |
2023-08-12 |
rat |
| b' Claire Gillaux, C\\xc3\\xa9line M\\xc3\\xa9hats, Daniel Vaiman, Dominique Cabrol, Michelle Breuiller-Fouch\\xc3\\xa. Functional screening of TLRs in human amniotic epithelial cells. Journal of immunology (Baltimore, Md. : 1950). vol 187. issue 5. 2011-10-19. PMID:21775685.' |
activation by tlr5 and tlr6/2 agonists produces il-6 and il-8, concomitantly with the activation of nf-κb signaling pathway, matrix metalloproteinase-9 induction, and ptgs2 expression. |
2011-10-19 |
2023-08-12 |
human |
| Siyoung Yang, Jonghwan Kim, Je-Hwang Ryu, Hwanhee Oh, Churl-Hong Chun, Byoung Ju Kim, Byoung Hyun Min, Jang-Soo Chu. Hypoxia-inducible factor-2alpha is a catabolic regulator of osteoarthritic cartilage destruction. Nature medicine. vol 16. issue 6. 2010-06-22. PMID:20495569. |
hif-2alpha directly induces the expression in chondrocytes of genes encoding catabolic factors, including matrix metalloproteinases (mmp1, mmp3, mmp9, mmp12 and mmp13), aggrecanase-1 (adamts4), nitric oxide synthase-2 (nos2) and prostaglandin-endoperoxide synthase-2 (ptgs2). |
2010-06-22 |
2023-08-12 |
mouse |
| Armin Gerger, Uwe Langsenlehner, Wilfried Renner, Werner Weitzer, Tanja Eder, Babak Yazdani-Biuki, Günter Hofmann, Hellmut Samonigg, Peter Kripp. A multigenic approach to predict breast cancer risk. Breast cancer research and treatment. vol 104. issue 2. 2007-11-27. PMID:17058024. |
cart analysis of the data identified the heterozygous vascular endothelial growth factor (vegf) and matrix metalloproteinase 3 (mmp3) genotype and homozygous cyclooxygenase-2 (ptgs2) mutant as the initial splits, indicating that these genotypes exert the greatest impact on the classification process. |
2007-11-27 |
2023-08-12 |
human |
| Claire M Kershaw, Rex J Scaramuzzi, Michael R McGowan, Caroline P D Wheeler-Jones, Muhammad Khali. The expression of prostaglandin endoperoxide synthase 2 messenger RNA and the proportion of smooth muscle and collagen in the sheep cervix during the estrous cycle. Biology of reproduction. vol 76. issue 1. 2007-02-20. PMID:16971557. |
we propose that prior to the lh surge, estradiol may stimulate ptgs2 mrna expression and hence prostaglandin e2 synthesis in the sheep cervix to regulate cervical relaxation, most likely through the rearrangement of collagen bundles within the cervical extracellular matrix. |
2007-02-20 |
2023-08-12 |
Not clear |