| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Kathryn A Moynihan, Andrew A Grimm, Marie M Plueger, Ernesto Bernal-Mizrachi, Eric Ford, Corentin Cras-Méneur, M Alan Permutt, Shin-Ichiro Ima. Increased dosage of mammalian Sir2 in pancreatic beta cells enhances glucose-stimulated insulin secretion in mice. Cell metabolism. vol 2. issue 2. 2005-09-30. PMID:16098828. |
pancreatic perfusion experiments further demonstrate that sirt1 enhances insulin secretion in response to glucose and kcl. |
2005-09-30 |
2023-08-12 |
mouse |
| Kathryn A Moynihan, Andrew A Grimm, Marie M Plueger, Ernesto Bernal-Mizrachi, Eric Ford, Corentin Cras-Méneur, M Alan Permutt, Shin-Ichiro Ima. Increased dosage of mammalian Sir2 in pancreatic beta cells enhances glucose-stimulated insulin secretion in mice. Cell metabolism. vol 2. issue 2. 2005-09-30. PMID:16098828. |
microarray analyses of beta cell lines reveal that sirt1 regulates genes involved in insulin secretion, including uncoupling protein 2 (ucp2). |
2005-09-30 |
2023-08-12 |
mouse |
| Undurti N Da. A defect in the activity of Delta6 and Delta5 desaturases may be a factor predisposing to the development of insulin resistance syndrome. Prostaglandins, leukotrienes, and essential fatty acids. vol 72. issue 5. 2005-09-27. PMID:15850715. |
in addition, sirt1 repressed ppar-gamma, and overexpression of sirt1 attenuated adipogenesis, and upregulation of sirt in differentiated fat cells triggered lipolysis and loss of fat, events that are known to attenuate insulin resistance and prolong life span. |
2005-09-27 |
2023-08-12 |
human |
| Anne Brunet, Lora B Sweeney, J Fitzhugh Sturgill, Katrin F Chua, Paul L Greer, Yingxi Lin, Hien Tran, Sarah E Ross, Raul Mostoslavsky, Haim Y Cohen, Linda S Hu, Hwei-Ling Cheng, Mark P Jedrychowski, Steven P Gygi, David A Sinclair, Frederick W Alt, Michael E Greenber. Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase. Science (New York, N.Y.). vol 303. issue 5666. 2004-04-22. PMID:14976264. |
we show that in mammalian cells, the sir2 homolog sirt1 appears to control the cellular response to stress by regulating the foxo family of forkhead transcription factors, a family of proteins that function as sensors of the insulin signaling pathway and as regulators of organismal longevity. |
2004-04-22 |
2023-08-12 |
Not clear |