| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| C E Adams, J A Stitzel, A C Collins, R Freedma. Alpha7-nicotinic receptor expression and the anatomical organization of hippocampal interneurons. Brain research. vol 922. issue 2. 2002-03-18. PMID:11743948. |
this study examines the relationship between genetic variation in alpha7 receptor subunit expression and gabaergic interneuron distribution in various regions and layers of the hippocampus in the two mouse strains. |
2002-03-18 |
2023-08-12 |
mouse |
| Thorsten Stühmer, Luis Puelles, Marc Ekker, John L R Rubenstei. Expression from a Dlx gene enhancer marks adult mouse cortical GABAergic neurons. Cerebral cortex (New York, N.Y. : 1991). vol 12. issue 1. 2002-01-28. PMID:11734534. |
we show that this population is largely identical with the adult cortical and hippocampal interneuron population, providing further evidence for their subpallial origin. |
2002-01-28 |
2023-08-12 |
mouse |
| R D Traub, N Kopell, A Bibbig, E H Buhl, F E LeBeau, M A Whittingto. Gap junctions between interneuron dendrites can enhance synchrony of gamma oscillations in distributed networks. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 21. issue 23. 2002-01-11. PMID:11717382. |
we showed previously that interneuron doublet firing can help to synchronize gamma oscillations, provided that sufficiently many pyramidal neurons are active; we also suggested that gap junctions, between the axons of principal neurons, could contribute to the long-range synchrony of gamma oscillations induced in the hippocampus by carbachol in vitro. |
2002-01-11 |
2023-08-12 |
Not clear |
| S R Sinha, P Sagga. Imaging of 4-AP-induced, GABA(A)-dependent spontaneous synchronized activity mediated by the hippocampal interneuron network. Journal of neurophysiology. vol 86. issue 1. 2001-08-30. PMID:11431518. |
imaging of 4-ap-induced, gaba(a)-dependent spontaneous synchronized activity mediated by the hippocampal interneuron network. |
2001-08-30 |
2023-08-12 |
Not clear |
| S R Sinha, P Sagga. Imaging of 4-AP-induced, GABA(A)-dependent spontaneous synchronized activity mediated by the hippocampal interneuron network. Journal of neurophysiology. vol 86. issue 1. 2001-08-30. PMID:11431518. |
these studies suggest that hippocampal area ca1 has the highest propensity for sia, that multiple locations can serve as the site of origin, and that interneurons located in s. lacunosum moleculare or interneurons that specifically project to this region may be particularly important for synchronized interneuron activity. |
2001-08-30 |
2023-08-12 |
Not clear |
| J L Martin, R S Slovite. Focal inhibitory interneuron loss and principal cell hyperexcitability in the rat hippocampus after microinjection of a neurotoxic conjugate of saporin and a peptidase-resistant analog of Substance P. The Journal of comparative neurology. vol 436. issue 2. 2001-08-30. PMID:11438920. |
these data establish the efficacy of [sar(9), met(o(2))(11)] substance p-saporin for producing a selective and spatially extensive ablation of hippocampal inhibitory interneurons in vivo and a highly focal disinhibition that was restricted to the site of interneuron loss. |
2001-08-30 |
2023-08-12 |
rat |
| A K Shetty, D A Turne. Glutamic acid decarboxylase-67-positive hippocampal interneurons undergo a permanent reduction in number following kainic acid-induced degeneration of ca3 pyramidal neurons. Experimental neurology. vol 169. issue 2. 2001-07-05. PMID:11358442. |
at 1 month postlesion, gad-67-positive interneuron density was significantly reduced in all strata of every hippocampal region except stratum pyramidale of ca1. |
2001-07-05 |
2023-08-12 |
rat |
| A K Shetty, D A Turne. Glutamic acid decarboxylase-67-positive hippocampal interneurons undergo a permanent reduction in number following kainic acid-induced degeneration of ca3 pyramidal neurons. Experimental neurology. vol 169. issue 2. 2001-07-05. PMID:11358442. |
the reduction in gad-67-positive interneuron density either persisted or exacerbated at 4 and 6 months postlesion in every stratum of all hippocampal regions. |
2001-07-05 |
2023-08-12 |
rat |
| A K Shetty, D A Turne. Glutamic acid decarboxylase-67-positive hippocampal interneurons undergo a permanent reduction in number following kainic acid-induced degeneration of ca3 pyramidal neurons. Experimental neurology. vol 169. issue 2. 2001-07-05. PMID:11358442. |
collectively, these results suggest that persistent reductions in gad-67-positive interneuron density observed throughout the hippocampus following ca3 lesion are largely due to a permanent loss of gad-67 expression in a significant fraction of interneurons, rather than widespread degeneration of interneurons. |
2001-07-05 |
2023-08-12 |
rat |
| A K Shetty, D A Turne. Glutamic acid decarboxylase-67-positive hippocampal interneurons undergo a permanent reduction in number following kainic acid-induced degeneration of ca3 pyramidal neurons. Experimental neurology. vol 169. issue 2. 2001-07-05. PMID:11358442. |
nevertheless, a persistent decrease in interneuron activity, as evidenced by permanent down-regulation of gad-67 in a major fraction of interneurons, would likely enhance the degree of hyperexcitability in the ca3-lesioned hippocampus. |
2001-07-05 |
2023-08-12 |
rat |
| R S Sloviter, L Ali-Akbarian, K D Horvath, K A Menken. Substance P receptor expression by inhibitory interneurons of the rat hippocampus: enhanced detection using improved immunocytochemical methods for the preservation and colocalization of GABA and other neuronal markers. The Journal of comparative neurology. vol 430. issue 3. 2001-05-03. PMID:11169468. |
one issue was the longstanding inability to detect gamma-aminobutyric acid (gaba) in the somata of several hippocampal interneuron subpopulations, which has prevented the unequivocal identification of all hippocampal interneurons as gaba neurons. |
2001-05-03 |
2023-08-12 |
rat |
| R S Sloviter, L Ali-Akbarian, K D Horvath, K A Menken. Substance P receptor expression by inhibitory interneurons of the rat hippocampus: enhanced detection using improved immunocytochemical methods for the preservation and colocalization of GABA and other neuronal markers. The Journal of comparative neurology. vol 430. issue 3. 2001-05-03. PMID:11169468. |
using newly developed methods designed to copreserve and colocalize gaba and polypeptide immunoreactivities with increased sensitivity, the authors report that virtually all hippocampal interneuron somata that are immunoreactive for parvalbumin (pv), calbindin, calretinin, somatostatin (ss), neuropeptide y, cholecystokinin, and vasoactive intestinal peptide exhibited clearly detectable, somal, gaba-like immunoreactivity (li). |
2001-05-03 |
2023-08-12 |
rat |
| R S Sloviter, L Ali-Akbarian, K D Horvath, K A Menken. Substance P receptor expression by inhibitory interneurons of the rat hippocampus: enhanced detection using improved immunocytochemical methods for the preservation and colocalization of GABA and other neuronal markers. The Journal of comparative neurology. vol 430. issue 3. 2001-05-03. PMID:11169468. |
these results demonstrate for the first time that all identified interneuron subpopulations of the rat hippocampus are gaba-immunoreactive, and that many inhibitory interneurons of all subtypes in all subregions of the rat hippocampus express sprs constitutively. |
2001-05-03 |
2023-08-12 |
rat |
| A K Shetty, D A Turne. Fetal hippocampal grafts containing CA3 cells restore host hippocampal glutamate decarboxylase-positive interneuron numbers in a rat model of temporal lobe epilepsy. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 20. issue 23. 2001-02-08. PMID:11102487. |
fetal hippocampal grafts containing ca3 cells restore host hippocampal glutamate decarboxylase-positive interneuron numbers in a rat model of temporal lobe epilepsy. |
2001-02-08 |
2023-08-12 |
rat |
| A K Shetty, D A Turne. Fetal hippocampal grafts containing CA3 cells restore host hippocampal glutamate decarboxylase-positive interneuron numbers in a rat model of temporal lobe epilepsy. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 20. issue 23. 2001-02-08. PMID:11102487. |
it also leads to persistent reductions in hippocampal glutamate decarboxylase (gad) interneuron numbers without diminution in nissl-stained interneuron numbers, indicating loss of gad expression in a majority of interneurons. |
2001-02-08 |
2023-08-12 |
rat |
| A K Shetty, D A Turne. Fetal hippocampal grafts containing CA3 cells restore host hippocampal glutamate decarboxylase-positive interneuron numbers in a rat model of temporal lobe epilepsy. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 20. issue 23. 2001-02-08. PMID:11102487. |
we hypothesize that enduring loss of gad expression in hippocampal interneurons after intracerebroventricular ka is attributable to degeneration of their ca3 afferent input; therefore, fetal ca3 grafts can restore gad interneuron numbers through graft axon reinnervation of the host. |
2001-02-08 |
2023-08-12 |
rat |
| A K Shetty, D A Turne. Fetal hippocampal grafts containing CA3 cells restore host hippocampal glutamate decarboxylase-positive interneuron numbers in a rat model of temporal lobe epilepsy. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 20. issue 23. 2001-02-08. PMID:11102487. |
we analyzed gad interneuron density in the adult rat hippocampus at 6 months after ka administration after grafting of fetal mixed hippocampal, ca3 or ca1 cells into the ca3 region at 45 d after lesion, in comparison with "lesion-only" and intact hippocampus. |
2001-02-08 |
2023-08-12 |
rat |
| A K Shetty, D A Turne. Fetal hippocampal grafts containing CA3 cells restore host hippocampal glutamate decarboxylase-positive interneuron numbers in a rat model of temporal lobe epilepsy. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 20. issue 23. 2001-02-08. PMID:11102487. |
in dentate and ca1 regions of the lesioned hippocampus receiving grafts of either mixed hippocampal or ca3 cells, gad interneuron density was both significantly greater than lesion-only hippocampus and comparable with the intact hippocampus. |
2001-02-08 |
2023-08-12 |
rat |
| A K Shetty, D A Turne. Fetal hippocampal grafts containing CA3 cells restore host hippocampal glutamate decarboxylase-positive interneuron numbers in a rat model of temporal lobe epilepsy. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 20. issue 23. 2001-02-08. PMID:11102487. |
in the ca3 region, gad interneuron density was significantly greater than lesion-only hippocampus but less than the intact hippocampus. |
2001-02-08 |
2023-08-12 |
rat |
| A K Shetty, D A Turne. Fetal hippocampal grafts containing CA3 cells restore host hippocampal glutamate decarboxylase-positive interneuron numbers in a rat model of temporal lobe epilepsy. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 20. issue 23. 2001-02-08. PMID:11102487. |
collectively, the overall gad interneuron density in the lesioned hippocampus receiving either mixed hippocampal or ca3 grafts was restored to that in the intact hippocampus. |
2001-02-08 |
2023-08-12 |
rat |